Gene: Prdm15 MGI:1930121

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Gene Summary

Name:
PR domain containing 15
Synonyms:
Zfp298,  E130018M06Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Prdm15tm1b(EUCOMM)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

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lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote Not available
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 0.0% (0 of 2)
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
bone 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cecum 2.97% (11 of 370)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
esophagus 1.72% (7 of 408)
eye 0.0%
gall bladder 0.0%
heart 0.34% (2 of 584)
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
mesenteric lymph node 0.0%
olfactory lobe 0.34% (2 of 584)
oral epithelium 0.0%
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
striatum 0.51% (3 of 584)
testis 1.03% (6 of 584)
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
trachea 0.51% (3 of 584)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vas deferens 3.67% (14 of 381)
vascular system 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Prdm15 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prdm15 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Holoprosencephaly With Fetal Akinesia/Hypokinesia Sequence
Intrauterine growth retardation, Holoprosencephaly, Microcephaly OMIM:306990
Acalvaria
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly, Microcephaly, Cerebral cortical atrophy ORPHA:2523
Vissers-Bodmer Syndrome
Intrauterine growth retardation, Holoprosencephaly, Short stature OMIM:619033
Holoprosencephaly 5
Semilobar holoprosencephaly, Holoprosencephaly, Alobar holoprosencephaly, Lobar holoprosencephaly... OMIM:609637
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Cerebral cortical atrophy, Hydranen... ORPHA:2570
Hydrocephalus, Congenital, 3, With Brain Anomalies
Holoprosencephaly, Hydranencephaly, Hydrocephalus OMIM:617967
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Aminopterin/Methotrexate Embryofetopathy
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Spinal dysraphism, Anencephaly, Men... ORPHA:1908
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly, Microcephaly, Short stature OMIM:612530
Hartsfield Syndrome
Intrauterine growth retardation, Aplasia/Hypoplasia of the corpus callosum, Lobar holoprosencephaly ORPHA:2117
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Agenesis of corpus callosum, Absent septum pellucidum, Holoprosencephaly, Aqueductal stenosis, Hy... ORPHA:2182
Distal Monosomy 13Q
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Anencephaly, Short stature, Microce... ORPHA:1590
Holoprosencephaly 11
Holoprosencephaly, Microcephaly, Agenesis of corpus callosum OMIM:614226
Ring Chromosome 21 Syndrome
Holoprosencephaly, Microcephaly, Short stature ORPHA:1445
Lambotte Syndrome
Semilobar holoprosencephaly, Microcephaly, Intrauterine growth retardation OMIM:245552
Distal Monosomy 7Q36
Holoprosencephaly, Microcephaly, Short stature ORPHA:1636
Holoprosencephaly, Recurrent Infections, And Monocytosis
Holoprosencephaly, Microcephaly, Agenesis of corpus callosum OMIM:610680
Triploidy
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Meningocele, Intrauterine growth re... ORPHA:3376
Thanatophoric Dysplasia Type 2
Holoprosencephaly, Hydrocephalus, Short stature ORPHA:93274
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Absent septum pellucidum OMIM:601357
Monosomy 18P
Holoprosencephaly, Microcephaly, Short stature ORPHA:1598
Chromosome 3Q13.31 Deletion Syndrome
Agenesis of corpus callosum, Alobar holoprosencephaly OMIM:615433
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly, Abnormality of the diencephalon, Microcephaly ORPHA:2165
Agnathia-Otocephaly Complex
Holoprosencephaly, Agenesis of corpus callosum OMIM:202650
Solitary Median Maxillary Central Incisor
Holoprosencephaly, Short stature, Microcephaly, Anterior hypopituitarism, Decreased response to g... OMIM:147250
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly, Growth delay, Short stature ORPHA:250999
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly, Microcephaly, Short stature ORPHA:2163
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Holoprosencephaly, Growth delay, Agenesis of corpus callosum, Hydrocephalus ORPHA:77298
Microform Holoprosencephaly
Panhypopituitarism, Holoprosencephaly, Short stature, Intrauterine growth retardation, Microcepha... ORPHA:280200
Microtia-Anotia
Holoprosencephaly OMIM:600674
Iniencephaly
Spina bifida, Holoprosencephaly, Rhizomelia, Spinal dysraphism, Anencephaly, Myelomeningocele, Hy... ORPHA:63259
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly, Agenesis of corpus callosum ORPHA:990
Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies
Semilobar holoprosencephaly, Colpocephaly, Umbilical hernia, Intrauterine growth retardation, Age... OMIM:618651
Trisomy 18
Spina bifida, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Growth delay, Anencep... ORPHA:3380
Microtia
Holoprosencephaly ORPHA:83463
49,Xxxxy Syndrome
Holoprosencephaly, Hypoplasia of the corpus callosum, Arrhinencephaly, Short stature ORPHA:96264
Pancreatic Agenesis-Holoprosencephaly Syndrome
Semilobar holoprosencephaly, Holoprosencephaly, Agenesis of corpus callosum, Intrauterine growth ... ORPHA:556955
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Pachygyria, Type II lissencephaly, Agenesis of corpus callosum, Holoprosencephaly, Polymicrogyria... OMIM:253800
16P13.11 Microdeletion Syndrome
Holoprosencephaly, Microcephaly, Agenesis of corpus callosum, Short stature ORPHA:261236
Pseudotrisomy 13 Syndrome
Agenesis of corpus callosum, Holoprosencephaly, Polymicrogyria, Microcephaly, Hydrocephalus OMIM:264480
Endocrine-Cerebroosteodysplasia
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Hydrocephalus OMIM:612651
Holoprosencephaly-Postaxial Polydactyly Syndrome
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Umbilical hernia, Microcephaly, Hyd... ORPHA:2166
Isolated Exencephaly
Holoprosencephaly, Agenesis of corpus callosum, Posterior pituitary agenesis, Anterior pituitary ... ORPHA:563612
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Pachygyria, Abnormal periventricular white matter morphology, Hypoplasia of the corpus callosum, ... ORPHA:468631
Pallister-Hall Syndrome
Panhypopituitarism, Hypothalamic hamartoma, Holoprosencephaly, Neonatal death, Short stature, Int... OMIM:146510
Holoprosencephaly
Panhypopituitarism, Aplasia/Hypoplasia of the corpus callosum, Branchial anomaly, Anterior hypopi... ORPHA:2162
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Anencephaly, Neonatal death, Intrauterine growth retardation, Hydrocephalus OMIM:269860
Jacobsen Syndrome
Intrauterine growth retardation, Holoprosencephaly, Microcephaly, Hydrocephalus OMIM:147791
Monosomy 13Q14
Holoprosencephaly, Hypoplasia of the corpus callosum, Short stature, Intrauterine growth retardat... ORPHA:1587
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Mosaic Variegated Aneuploidy Syndrome
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Growth delay, Short stature, Intrau... ORPHA:1052
Holoprosencephaly 9
Panhypopituitarism, Holoprosencephaly, Anterior pituitary agenesis, Decreased response to growth ... OMIM:610829
Holoprosencephaly 7
Semilobar holoprosencephaly, Panhypopituitarism, Agenesis of corpus callosum, Fusion of the left ... OMIM:610828
Holoprosencephaly 3
Holoprosencephaly, Central diabetes insipidus, Microcephaly OMIM:142945
Combined Pituitary Hormone Deficiencies, Genetic Forms
Ectopic anterior pituitary gland, Absent septum pellucidum, Holoprosencephaly, Growth delay, Ante... ORPHA:95494
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Holoprosencephaly 2
Anterior pituitary agenesis, Holoprosencephaly, Microcephaly, Agenesis of corpus callosum OMIM:157170
Genitourinary And/Or Brain Malformation Syndrome
Agenesis of corpus callosum, Absent septum pellucidum, Holoprosencephaly, Dysplastic corpus callo... OMIM:618820
Smith-Lemli-Opitz Syndrome
Holoprosencephaly, Hypoplasia of the corpus callosum, Growth delay, Short stature, Hypoplasia of ... OMIM:270400
Holoprosencephaly 13, X-Linked
Semilobar holoprosencephaly, Agenesis of corpus callosum, Alobar holoprosencephaly, Septo-optic d... OMIM:301043
Smith-Lemli-Opitz Syndrome
Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Growth delay, Rhizomelia, Short sta... ORPHA:818
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly, Microcephaly ORPHA:3186
Charge Syndrome
Holoprosencephaly, Aqueductal stenosis, Postnatal growth retardation, Delayed puberty, Short stat... ORPHA:138
Pallister-Hall Syndrome
Panhypopituitarism, Hypothalamic hamartoma, Holoprosencephaly, Arrhinencephaly, Pituitary hypothy... ORPHA:672
Ring Chromosome 7 Syndrome
Holoprosencephaly, Severe intrauterine growth retardation, Cerebral cortical atrophy, Short statu... ORPHA:1449
Hartsfield Syndrome
Microcephaly, Agenesis of corpus callosum, Lobar holoprosencephaly, Gonadotropin deficiency OMIM:615465
Charge Syndrome
Gonadotropin deficiency, Holoprosencephaly, Arrhinencephaly, Umbilical hernia, Postnatal growth r... OMIM:214800
Meckel Syndrome
Aplasia/Hypoplasia of the corpus callosum, Anencephaly, Lobar holoprosencephaly, Microcephaly, Hy... ORPHA:564
Orofaciodigital Syndrome Xiv
Holoprosencephaly, Hypoplasia of the corpus callosum, Polymicrogyria, Simplified gyral pattern, M... OMIM:615948
Holoprosencephaly 1
Ethmocephaly, Alobar holoprosencephaly, Short stature, Microcephaly, Agenesis of corpus callosum OMIM:236100
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Semilobar holoprosencephaly, Hypoplasia of the corpus callosum, Growth delay, Intrauterine growth... OMIM:301044
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly, Microcephaly, Central diabetes insipidus, Decreased response to grow... OMIM:129900
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prdm15

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prdm15.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. Nature communications (July 2020) Prdm15tm1a(EUCOMM)Wtsi PMC7360777
PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. Science Advances (January 2020) Prdm15tm1c(EUCOMM)Wtsi Prdm15tm1a(EUCOMM)Wtsi PMC6954057
PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling. Nature genetics (July 2017) Prdm15tm1a(EUCOMM)Wtsi 28740264

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MGI Allele Allele Type Produced
Prdm15tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Prdm15tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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