Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

basal cell adhesion molecule
1200005K12Rik,  Lu,  B-CAM

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bcam mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bcam by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Adenocarcinoma Of The Esophagus
Barrett esophagus, Obesity, Gastroesophageal reflux, Esophageal carcinoma ORPHA:99976
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Diarrhea 5, With Tufting Enteropathy, Congenital
Villous atrophy, Small for gestational age, Failure to thrive, Crypt hyperplasia OMIM:613217
Obesity, Increased waist to hip ratio OMIM:601665
Diarrhea 9
Villous atrophy, Failure to thrive OMIM:618168
Bardet-Biedl Syndrome 14
Obesity, Renal insufficiency OMIM:615991
Bile Acid Malabsorption, Primary, 1
Steatorrhea, Increased fecal bile acid, Fat malabsorption, Failure to thrive OMIM:613291
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Bardet-Biedl Syndrome 10
Renal cyst, Obesity, Renal insufficiency OMIM:615987
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Abnormal large intestine morphology, Gastroesophageal reflux, Abnorm... ORPHA:2198
Bardet-Biedl Syndrome 18
Obesity, Stage 5 chronic kidney disease, Renal insufficiency OMIM:615995
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Intestinal pseudo-obstruction, Volvulus, Megacystis, ... OMIM:619350
Diarrhea 7, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Villous atrophy, Failure to thrive OMIM:615863
Inflammatory Bowel Disease (Crohn Disease) 30
Protein-losing enteropathy, Esophagitis, Pancolitis, Ileitis, Abnormal intestine morphology, Gast... OMIM:619079
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Congenital Short Bowel Syndrome
Congenital shortened small intestine, Decreased intestinal transit time, Failure to thrive, Intes... OMIM:615237
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Syndromic X-Linked Intellectual Disability 7
Micropenis, Obesity, Hypoplasia of penis ORPHA:85274
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity ORPHA:293964
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Colitis, Obesity ORPHA:88643
Bardet-Biedl Syndrome 5
Micropenis, Obesity OMIM:615983
Macrosomia-Microphthalmia-Cleft Palate Syndrome
Large for gestational age, Median cleft palate ORPHA:2432
Small Bowel Atresia
Intestinal malrotation, Failure to thrive, Intestinal hypoplasia, Jejunal atresia ORPHA:1201
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Jejunoileal ulceration, Small bowel diverticula OMIM:221400
Hypercholanemia, Familial 1
Steatorrhea, Fat malabsorption, Failure to thrive OMIM:607748
Secondary Short Bowel Syndrome
Failure to thrive, Volvulus, Villous atrophy, Abnormal small intestine morphology, Aganglionic me... ORPHA:95427
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Protein-losing enteropathy, Lacticaciduria OMIM:619063
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Nephronophthisis 15
Obesity, Nephronophthisis OMIM:614845
Diarrhea 11, Malabsorptive, Congenital
Villous atrophy OMIM:618662
Chronic Diarrhea Due To Glucoamylase Deficiency
Abnormal small intestinal mucosa morphology, Decreased small intestinal mucosa lactase level ORPHA:103907
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Microcolon, Hydroureter, Megacystis, Intestinal malrotation, Hydronephrosis OMIM:619431
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Congenital shortened small intestine, Intestinal pseudo-obstruction, Intestinal malrotation, Hydr... OMIM:300048
Hepatic Veno-Occlusive Disease
Increased body weight, Renal insufficiency ORPHA:890
Congenital Enterocyte Heparan Sulfate Deficiency
Protein-losing enteropathy, Weight loss, Hematochezia ORPHA:103910
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity OMIM:618406
Visceral Myopathy 1
Microcolon, Urinary retention, Megacystis, Intestinal pseudo-obstruction, Megaduodenum, Vesicoure... OMIM:155310
Pancreatic Lipase Deficiency
Steatorrhea, Fat malabsorption OMIM:614338
Congenital Disorder Of Glycosylation, Type Ib
Protein-losing enteropathy, Proximal tubulopathy, Failure to thrive, Villous atrophy, Renal cyst,... OMIM:602579
Chylomicron Retention Disease
Steatorrhea, Accumulation of lipid droplets in small-bowel enterocytes, Failure to thrive OMIM:246700
Congenital Tufting Enteropathy
Failure to thrive, Abnormal large intestinal mucosa morphology, Villous atrophy, Abnormal small i... ORPHA:92050
Bardet-Biedl Syndrome 4
Renal cyst, Obesity OMIM:615982
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Alpha-Heavy Chain Disease
Abnormal small intestine morphology ORPHA:100025
Abcd Syndrome
Aganglionic megacolon, Large for gestational age, Total intestinal aganglionosis OMIM:600501
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Bardet-Biedl Syndrome 8
Obesity, Hypospadias OMIM:615985
Mungan Syndrome
Barrett esophagus, Renal hypoplasia, Intestinal pseudo-obstruction, Megaduodenum, Vesicoureteral ... OMIM:611376
Biemond Syndrome Type 2
Obesity, Hypospadias ORPHA:141333
Eosinophilic Gastroenteritis
Protein-losing enteropathy, Hematochezia, Abnormality of the gastrointestinal tract, Weight loss,... ORPHA:2070
Leptin Deficiency Or Dysfunction
Micropenis, Obesity OMIM:614962
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Failure to thrive, Duodenitis OMIM:614328
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Childhood-onset truncal obesity ORPHA:71529
Proprotein Convertase 1/3 Deficiency
Obesity, Villous atrophy OMIM:600955
Distal 16P11.2 Microdeletion Syndrome
Chronic kidney disease, Obesity, Vesicoureteral reflux, Proteinuria, Aganglionic megacolon ORPHA:261222
Bardet-Biedl Syndrome 21
Horseshoe kidney, Obesity, Overweight OMIM:617406
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body weight, Macroglossia, Increased body mass index OMIM:614450
Agammaglobulinemia 4, Autosomal Recessive
Protein-losing enteropathy OMIM:613502
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Microcolon, Multicystic kidney dysplasia, Hydroureter, Megacystis, Intestinal malrotation, Abnorm... ORPHA:2241
Nephrotic syndrome, Protein-losing enteropathy, Abnormality of the gastrointestinal tract, Renal ... ORPHA:79327
Protein-losing enteropathy, Macroglossia, Failure to thrive ORPHA:79320
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Bardet-Biedl Syndrome 3
Renal hypoplasia, Obesity OMIM:600151
Trigonocephaly 1
High, narrow palate, Long penis, Meckel diverticulum OMIM:190440
Microvillus Inclusion Disease
Nephrocalcinosis, Villous atrophy, Abnormal small intestinal villus morphology, Abnormal renal ph... ORPHA:2290
Martinez-Frias Syndrome
Intestinal malrotation, Jejunal atresia, Tracheoesophageal fistula, Intestinal hypoplasia, Hyposp... OMIM:601346
Vascular Hyalinosis
Protein-losing enteropathy, Hematochezia OMIM:277175
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight, Gastroesophageal reflux ORPHA:589905
Blue Diaper Syndrome
Increased body weight, Nephrocalcinosis, Blue urine ORPHA:94086
Protein-losing enteropathy, Gastrointestinal hemorrhage, Failure to thrive ORPHA:79319
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Hydronephrosis, Microcolon, Hydroureter OMIM:619362
Annular Pancreas
High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis OMIM:167750
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Laurence-Moon Syndrome
Micropenis, Obesity OMIM:245800
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Protein-losing enteropathy, Hematochezia, Gastrointestinal carcinoma, Xerostomia, Cachexia, Gloss... OMIM:175500
Nk-Cell Enteropathy
Hematochezia, Colonic diverticula, Gastroesophageal reflux, Stercoral ulcer, Abnormal gastric muc... ORPHA:263665
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Bardet-Biedl Syndrome 6
Renal cyst, Obesity, Hypospadias OMIM:605231
Colonic Atresia
Peptic ulcer, Colonic atresia, Duodenal stenosis ORPHA:1198
Meconium Ileus
Microcolon, Meconium ileus OMIM:614665
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Fliedner-Zweier Syndrome
Unilateral renal agenesis, Multicystic kidney dysplasia, Obesity, Hydronephrosis, Anal atresia, T... OMIM:620511
Pseudohypoparathyroidism, Type Ib
Low urinary cyclic AMP response to PTH administration, Obesity OMIM:603233
Protein-losing enteropathy, Failure to thrive ORPHA:95428
Systemic Sclerosis
Chronic kidney disease, Barrett esophagus, Acute kidney injury, Intestinal bleeding, Gastroesopha... ORPHA:90291
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased body weight, Increased urinary cortisol level, Abdominal obesity OMIM:615954
Refractory Celiac Disease
Villous atrophy, Weight loss, Protein-losing enteropathy, Jejunitis ORPHA:398063
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Senior-Loken Syndrome 9
Tubulointerstitial nephritis, Obesity, Nephronophthisis, Stage 5 chronic kidney disease OMIM:616629
Pancreatic Colipase Deficiency
Steatorrhea, Fat malabsorption ORPHA:309108
Serkal Syndrome
Abnormal penis morphology, Malrotation of small bowel, Hypospadias ORPHA:139466
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight, Micropenis, Horseshoe kidney OMIM:300860
Nephropathy, Glycosuria, Obesity, Large for gestational age, Renal cyst, Hepatocellular adenoma, ... ORPHA:552
Mitchell-Riley Syndrome
Meckel diverticulum, Anteriorly placed anus, Intestinal malrotation, Jejunal atresia, Acholic sto... OMIM:615710
Cat Eye Syndrome
Anal stenosis, Meckel diverticulum, Volvulus, Horseshoe kidney, Intestinal malrotation, Vesicoure... OMIM:115470
Congenital Disorder Of Glycosylation, Type Ih
Protein-losing enteropathy, Failure to thrive OMIM:608104
Juvenile Polyposis Of Infancy
High, narrow palate, Protein-losing enteropathy, Intestinal bleeding, Gastrointestinal hemorrhage... ORPHA:79076
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Impaired Intellectual Development Syndrome
Nephropathy, Hypospadias, Obesity, Renal insufficiency OMIM:194072
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Oculoskeletodental Syndrome
Protein-losing enteropathy, Hypercalciuria, Mucopolysacchariduria, Macroglossia, Small for gestat... OMIM:618440
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Small for gestational age OMIM:274300
Encephalomyopathy, Mitochondrial, Due To Voltage-Dependent Anion Channel Deficiency
Aminoaciduria, Ketonuria, Failure to thrive, Large for gestational age, High palate OMIM:614520
Mednik Syndrome
Microcolon, Volvulus, Jejunal atresia OMIM:609313
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Smith-Magenis Syndrome
Increased body weight, Velopharyngeal insufficiency OMIM:182290
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Glycosuria, Large for gestational age, Increased body weight, Proteinuria, Renal Fanconi syndrome ORPHA:263455
Fg Syndrome Type 1
Gastroesophageal reflux, Abnormal large intestine morphology, Slender build, Anal atresia, High p... ORPHA:93932
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Aminoaciduria, Nephrocalcinosis, Glycosuria, Large for gestational age, Hyperphosphaturia, Protei... OMIM:616026
Increased body weight, Zollinger-Ellison syndrome ORPHA:97279
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Microcolon, Ileal atresia, Anuria, Megacystis, Pyelonephritis OMIM:619351
Webb-Dattani Syndrome
Gastroesophageal reflux, Obesity, Vesicoureteral reflux, Hydronephrosis, Neurogenic bladder, Hypo... OMIM:615926
Tarp Syndrome
Meckel diverticulum, Failure to thrive, Horseshoe kidney, Hydronephrosis, High palate, Glossoptos... OMIM:311900
Juvenile Polyposis Syndrome
Rectocele, Gastrointestinal hemorrhage, Protein-losing enteropathy, Hematochezia, Failure to thri... ORPHA:2929
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Protein-losing enteropathy, Intestinal lymphangiectasia, Horseshoe kidney, Vesicoureteral reflux,... OMIM:235510
Bardet-Biedl Syndrome 12
Hydronephrosis, Obesity, Hydroureter, Cystic renal dysplasia OMIM:615989
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Renal tubular acidosis, Increased body weight, Myoglobinuria, Hepatocellular a... ORPHA:264580
Primary Intestinal Lymphangiectasia
Increased stool alpha1-antitrypsin concentration, Intestinal lymphangiectasia, Functional abnorma... ORPHA:90362
Sotos Syndrome
High, narrow palate, Narrow palate, Gastroesophageal reflux, Tall stature, Increased body weight,... OMIM:117550
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Protein-losing enteropathy, Hydronephrosis, Micropenis, High palate, Cleft palate OMIM:235255
Immunodeficiency 31C
Protein-losing enteropathy, Villous atrophy, Weight loss, Gastrointestinal eosinophilia, Intussus... OMIM:614162
Pericardial And Diaphragmatic Defect
Intestinal malrotation, Meckel diverticulum, Abnormal gastrointestinal tract morphology ORPHA:2847
Low Phospholipid-Associated Cholelithiasis
Obesity, Overweight, Neoplasm of the liver, Hepatocellular carcinoma ORPHA:69663
Wilson Disease
Increased body weight, Weight loss, Failure to thrive ORPHA:905
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Perlman Syndrome
Distal ileal atresia, Large for gestational age, Volvulus, Renal hamartoma OMIM:267000
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Renal tubular acidosis, Increased body weight, Myoglobinuria, Hepatocellular adenoma, Hepatocellu... ORPHA:79240
Tarp Syndrome
Failure to thrive, Horseshoe kidney, Hydronephrosis, Abnormal duodenum morphology, Glossoptosis, ... ORPHA:2886
Abnormal jejunum morphology ORPHA:449280
Acrocephalopolydactylous Dysplasia
Hypoplastic colon, Hypoplasia of the small intestine, Enlarged kidney, Cystic renal dysplasia OMIM:200995
Fryns Syndrome
Meckel diverticulum, Intestinal malrotation, Large for gestational age, Hydronephrosis, Renal cys... OMIM:229850
Congenital Tracheal Stenosis
Meckel diverticulum, Duodenal stenosis, Abnormal stomach morphology, Abnormality of the ureter, A... ORPHA:141127
Bannayan-Riley-Ruvalcaba Syndrome
Abnormal large intestine morphology, Tall stature, Intestinal polyposis, Cachexia, Narrow palate,... ORPHA:109
Intestinal malrotation, Abnormality of the ureter, Meckel diverticulum ORPHA:1666
Heart Defects, Congenital, And Other Congenital Anomalies
Colon perforation, Microcolon, Glycosuria, Failure to thrive, Intestinal malrotation, Ureteral du... OMIM:600001
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hydronephrosis, Protein-losing enteropathy, High palate, Micropenis ORPHA:1655
Adrenocortical Carcinoma
Increased body weight, Increased urinary cortisol level, Abnormality of urine homeostasis, Weight... ORPHA:1501
Metachromatic Leukodystrophy
Abnormal stomach morphology, Abnormal duodenum morphology, Urinary incontinence, Neoplasm of the ... ORPHA:512
Magel2-Related Prader-Willi-Like Syndrome
Gastroesophageal reflux, Xerostomia, Failure to thrive, Increased body weight, Abdominal obesity,... ORPHA:398069
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased body weight OMIM:615830
Mosaic Trisomy 16
Meckel diverticulum, Anteriorly placed anus, Horseshoe kidney, Abnormality of the gastrointestina... ORPHA:1708
Joubert Syndrome 39
Overweight, Polycystic kidney dysplasia OMIM:619562
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Increased body weight, Increased urinary cortisol level, Nephrolithiasis, Abdominal obesity ORPHA:189427
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Aganglionic megacolon, Microcolon, Ileus ORPHA:163746
Autosomal Recessive Polycystic Kidney Disease
Protein-losing enteropathy, Acute kidney injury, Oliguria, Gastrointestinal hemorrhage, Reduced r... ORPHA:731
Insulin-Resistance Syndrome Type B
Nephritis, Glycosuria, Abnormality of body weight, Decreased body weight, Increased body weight, ... ORPHA:2298
Diarrhea 10, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Hematochezia, Polyuria OMIM:618183
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Congenital shortened small intestine, Hydroureter, Meckel diverticulum, Intestinal malrotation, H... OMIM:265380
Hellp Syndrome
Increased body weight, Proteinuria, Acute kidney injury, Hemoglobinuria ORPHA:244242
Autosomal Recessive Cutis Laxa Type 1
Multiple bladder diverticula, Urethral diverticulum, Small bowel diverticula, Pyelonephritis, Ves... ORPHA:90349
Whim Syndrome
Abnormal small intestine morphology, Parotitis ORPHA:51636
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Intestinal malrotation, Hydronephrosis, Hiatus hernia, Abnormal duodenum morphology, Nephrotic sy... OMIM:601776
Fraser Syndrome 1
Renal hypoplasia, Abnormal small intestine morphology, Abnormality of the anus, Micropenis, Hypos... OMIM:219000
Restrictive Dermopathy
Ureteral duplication, Microcolon, Hypospadias, Submucous cleft hard palate ORPHA:1662
Cushing Disease
Increased body weight, Increased urinary cortisol level, Truncal obesity, Abdominal obesity ORPHA:96253
Carney Complex
Tall stature, Esophageal neoplasm, Increased body weight, Neoplasm of the rectum, Abdominal obesi... ORPHA:1359
Cushing Syndrome Due To Ectopic Acth Secretion
Malignant gastrointestinal tract tumors, Neoplasm of the stomach, Increased urinary cortisol leve... ORPHA:99889
Liver Disease, Severe Congenital
Aminoaciduria, Protein-losing enteropathy, Failure to thrive, Chronic gastritis, Hydronephrosis, ... OMIM:619991


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bcam

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bcam.

No publications found that use IMPC mice or data for Bcam.

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MGI Allele Allele Type Produced
Bcamtm373339(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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