Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
sortilin-related VPS10 domain containing receptor 1
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sorcs1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sorcs1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Amyloidosis, Cutaneous Bullous
Amyloidosis OMIM:204900
Amyloidosis, Primary Localized Cutaneous, 2
Cutaneous amyloidosis OMIM:613955
Myeloma, Multiple
Amyloidosis OMIM:254500
Amyloidosis Of Gingiva And Conjunctiva, With Mental Retardation
Amyloidosis OMIM:204850
Acys Amyloidosis
Amyloidosis, Cerebral amyloid angiopathy ORPHA:100008
Variant Abeta2M Amyloidosis
Cutaneous amyloidosis, Cardiac amyloidosis, Renal amyloidosis, Amyloidosis of peripheral nerves, ... ORPHA:314652
Amyloidosis, Finnish Type
Cardiac amyloidosis, Generalized amyloid deposition OMIM:105120
Cerebral Amyloid Angiopathy, Cst3-Related
Generalized amyloid deposition OMIM:105150
Amyloidosis, Primary Localized Cutaneous, 1
Amyloidosis OMIM:105250
Alzheimer Disease 4
Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:606889
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:117300
Palmoplantar Carcinoma, Multiple Self-Healing
Amyloidosis, Cutaneous macular amyloidosis OMIM:615225
Cerebral Amyloid Angiopathy, Itm2B-Related, 1
Cerebral amyloid angiopathy OMIM:176500
Inherited Creutzfeldt-Jakob Disease
Amyloidosis of peripheral nerves ORPHA:282166
Abeta Amyloidosis, Dutch Type
Cerebral amyloid angiopathy ORPHA:100006
Cerebral Amyloid Angiopathy, App-Related
Cerebral amyloid angiopathy OMIM:605714
Aa Amyloidosis
Amyloidosis, Renal amyloidosis ORPHA:85445
Amyloidosis, Hereditary, Transthyretin-Related
Amyloidosis OMIM:105210
Systemic Mastocytosis With Associated Hematologic Neoplasm
Amyloidosis ORPHA:98849
Familial Mediterranean Fever
Amyloidosis, Renal amyloidosis OMIM:249100
Q Fever
Amyloidosis ORPHA:781

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sorcs1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sorcs1.

No publications found that use IMPC mice or data for Sorcs1.

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MGI Allele Allele Type Produced
Sorcs1em2(IMPC)H Exon Deletion Mice
Sorcs1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Sorcs1em1(IMPC)H Exon Deletion Mice

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