Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

MTOR associated protein, LST8 homolog (S. cerevisiae)
Gbl,  0610033N12Rik,  mLST8

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mlst8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mlst8 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Congenital Factor X Deficiency
Menorrhagia, Subarachnoid hemorrhage, Gingival bleeding, Post-partum hemorrhage, Prolonged prothr... ORPHA:328
Klippel-Trénaunay Syndrome
Abnormal tricuspid valve morphology, Patent ductus arteriosus, Gastrointestinal hemorrhage, Atria... ORPHA:90308
Congenital Fibrinogen Deficiency
Gingival bleeding, Right ventricular hypertrophy, Prolonged prothrombin time, Tachycardia, Subcut... ORPHA:335
Acquired Purpura Fulminans
Shock, Intracranial hemorrhage, Macular purpura, Prolonged prothrombin time, Internal hemorrhage ORPHA:49566
Rhabdoid Tumor
Hypertension, Internal hemorrhage ORPHA:69077
Crimean-Congo Hemorrhagic Fever
Myocarditis, Subdural hemorrhage, Melena, Diffuse alveolar hemorrhage, Abnormal left ventricular ... ORPHA:99827
Wiskott-Aldrich Syndrome
Intracranial hemorrhage, Gingival bleeding, Petechiae, Epistaxis, Recurrent intrapulmonary hemorr... ORPHA:906
Hemorrhagic Fever-Renal Syndrome
Ecchymosis, Hypertension, Shock, Intracranial hemorrhage, Petechiae, Palpitations, Subconjunctiva... ORPHA:340
Inhalational Anthrax
Internal hemorrhage, Hypotension ORPHA:247257
Marburg Hemorrhagic Fever
Shock, Pericarditis, Petechiae, Prolonged prothrombin time, Subconjunctival hemorrhage, Tachycard... ORPHA:99826
Superficial Siderosis
Abnormal corpus callosum morphology, Dysgyria, Abnormal bleeding, Internal hemorrhage, Persistent... ORPHA:247245
Tuberous Sclerosis Complex
Cardiac rhabdomyoma, Hypertension, Noncommunicating hydrocephalus, Cortical tubers, Pituitary ade... ORPHA:805
Hellp Syndrome
Prolonged prothrombin time, Internal hemorrhage, Hypotension, Cerebral hemorrhage ORPHA:244242
Yellow Fever
Shock, Reduced ejection fraction, Prolonged prothrombin time, Bradycardia, Excessive bleeding aft... ORPHA:99829
Hepatocellular Carcinoma
Portal hypertension, Hypotension, Internal hemorrhage, Budd-Chiari syndrome ORPHA:88673
Vascular Ehlers-Danlos Syndrome
Hypertension, Mitral valve prolapse, Short stature, Renovascular hypertension, Telangiectasia of ... ORPHA:286


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mlst8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mlst8.

No publications found that use IMPC mice or data for Mlst8.

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MGI Allele Allele Type Produced
Mlst8tm108520(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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