Atl2 | atlastin GTPase 2

GeneMGI:1929492Synonyms: Aip-2, Arl6ip2, +1 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Adipose tissue Growth/size/body region Hematopoietic system Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues

Phenotypes

decreased mean corpuscular volume1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult3.76x10-5 
increased total body fat amount1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult4.65x10-7 
decreased red blood cell distribution width1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult4.27x10-7 
increased lymphocyte cell number1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult6.92x10-8 
decreased spleen weight1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult9.7x10-5 
decreased lean body mass1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult3.67x10-5 
embryonic lethality prior to organogenesis1 supporting datasetAtl2tm2b(EUCOMM)HmguhomozygoteE9.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetAtl2tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased neutrophil cell number1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult2.42x10-10 
increased hemoglobin content1 supporting datasetAtl2tm2b(EUCOMM)HmguheterozygoteEarly adult3.92x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (1/1)0.7% (4/570)
aortaheterozygoten/a100% (1/1)0.19% (1/533)
boneheterozygoten/a100% (1/1)0% (0/394)
brainheterozygoten/a100% (1/1)0.86% (5/579)
brainstemheterozygoten/a100% (1/1)0.41% (2/490)
brown adipose tissueheterozygoten/a100% (1/1)0% (0/588)
cartilage tissueheterozygoten/a100% (1/1)0.22% (1/454)
cerebellumheterozygoten/a100% (1/1)0.56% (3/532)
cerebral cortexheterozygoten/a100% (1/1)0.41% (2/491)
esophagusheterozygoten/a100% (1/1)1.67% (7/419)
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Histopathology

IMPC related publications

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Atl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Atl2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Atl2tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Atl2tm2b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Atl2tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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