Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

GeneMGI:1928849Synonyms: 4833413O10Rik, 1110021D17Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Limbs/digits/tail Hematopoietic system Mortality/aging Cardiovascular system

15 No significant impact

3 Not tested

Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

edema1 supporting datasetSvep1tm1b(EUCOMM)HmguhomozygoteE18.5N/A * 
abnormal skin appearance1 supporting datasetSvep1tm1b(EUCOMM)HmguhomozygoteE18.5N/A * 
decreased circulating glucose level1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteEarly adult1.64x10-5 
abnormal tail morphology1 supporting datasetSvep1tm1b(EUCOMM)HmguhomozygoteE18.5N/A * 
edema1 supporting datasetSvep1tm1b(EUCOMM)HmguhomozygoteE15.5N/A * 
increased hemoglobin content1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteEarly adult2.67x10-5 
prolonged QRS complex duration1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteLate adult9.1x10-5 
decreased circulating phosphate level1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteEarly adult6.81x10-6 
increased erythrocyte cell number1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteEarly adult2.93x10-5 
decreased circulating sodium level1 supporting datasetSvep1tm1b(EUCOMM)HmguheterozygoteEarly adult6.69x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Svep1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Svep1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Svep1tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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