Svep1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Limbs/digits/tail Hematopoietic system Mortality/aging Cardiovascular system
15 No significant impact
3 Not tested
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
edema | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
abnormal skin appearance | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
decreased circulating glucose level | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.64x10-5 | ||
abnormal tail morphology | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
edema | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
increased hemoglobin content | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.67x10-5 | ||
prolonged QRS complex duration | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Late adult | 9.1x10-5 | ||
decreased circulating phosphate level | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.81x10-6 | ||
increased erythrocyte cell number | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.93x10-5 | ||
decreased circulating sodium level | 1 supporting dataset | Svep1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.69x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
External links
No external links available for Svep1.
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Svep1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Svep1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Svep1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |