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Gene: Mtor

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Name
mechanistic target of rapamycin kinase
MGI ID
MGI:1928394
Synonyms
FKBP-rapamycin-associated protein FRAP 2610315D21Rik RAPT1 RAFT1 flat Frap1 mechanistic target of rapamycin (serine/threonine kinase)
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (165) All data table (383)
Expression & images (45) Disease models (0) Histopathology (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased mean corpuscular hemoglobin Mtortm1a(EUCOMM)Wtsi HET Early adult 8.04×10-07
increased mean corpuscular volume Mtortm1a(EUCOMM)Wtsi HET   Early adult 7.66×10-05
decreased blood urea nitrogen level Mtortm1a(EUCOMM)Wtsi HET Early adult 4.52×10-05
decreased circulating LDL cholesterol level Mtortm1a(EUCOMM)Wtsi HET Early adult 8.02×10-05
preweaning lethality, complete penetrance Mtortm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased circulating cholesterol level Mtortm1a(EUCOMM)Wtsi HET Early adult 5.40×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2) N/A
Aorta 2 No  (1/583) N/A
Blood vessel 2 No  (2/2) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2) N/A
Brainstem 2 No  (2/583) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (1/583)  (2/2) N/A
Cerebellum 2 No  (3/583) N/A
Cerebral cortex 2 No  (2/583) N/A
Eye 2 No N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/583)  (2/2) N/A
Hippocampus 2 No  (3/583) N/A
Hypothalamus 2 No  (2/583) N/A
Kidney 2 No  (21/583)  (2/2) N/A
Large intestine 2 No  (10/583)  (2/2) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No  (1/583)  (2/2) N/A
Lung 2 No  (2/583)  (2/2) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/583) N/A
Ovary 2 No  (1/583)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/583)  (2/2) N/A
Parathyroid gland 2 No  (1/563)  (2/2) N/A
Peripheral nervous system 2 No  (2/583)  (2/2) N/A
Peyer's patch 2 No  (1/176) N/A
Pituitary gland 2 No  (1/583)  (2/2) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle tissue 2 No  (2/2) N/A
Skin 2 No  (1/583)  (2/2) N/A
Small intestine 2 No  (9/583)  (2/2) N/A
Spinal cord 2 No  (3/583)  (2/2) N/A
Spleen 2 No  (3/583)  (2/2) N/A
Stomach 2 No  (13/583)  (2/2) N/A
Striatum 2 No  (3/583) N/A
Testis 2 No  (6/583)  (1/2) N/A
Thymus 2 No  (1/583)  (2/2) N/A
Thyroid gland 2 No  (17/583)  (2/2) N/A
Trachea 2 No  (3/583)  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Mtortm1a(EUCOMM)Wtsi
heart, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
liver, gall bladder, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skin, skin muscle, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI

View all 28 images

Mtortm1a(EUCOMM)Wtsi
heart, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
liver, gall bladder, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
thymus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI

View all 16 images

Mtortm1a(EUCOMM)Wtsi
liver, gall bladder, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
stomach, oesophagus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
thymus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
spleen, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
small intestine, peyer's patch, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
mesenteric lymph node, lymph node, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
pituitary gland, peripheral nervous system, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
brain, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
inguinal fat pad, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skin, skin muscle, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skin, tail, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skin, pinna, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
inguinal fat pad, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
heart, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
adrenal gland, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skeletal muscle tissue, blood vessel, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Mtortm1a(EUCOMM)Wtsi
ovary, oviduct, uterus, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
lung, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
eye, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
skin, pinna, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
urinary bladder, lower urinary tract, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
kidney, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Mtortm1a(EUCOMM)Wtsi
forearm, HET, Male, WTSI
Mtortm1a(EUCOMM)Wtsi
body, HET, Male, WTSI
Mtortm1a(EUCOMM)Wtsi
body, HET, Male, WTSI
Mtortm1a(EUCOMM)Wtsi
head, HET, Male, WTSI
Mtortm1a(EUCOMM)Wtsi
body, HET, Male, WTSI

View all 169 images

Mtortm1a(EUCOMM)Wtsi
back skin, WT, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
back skin, WT, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
eye, abnormal cornea morphology, HET, Female, WTSI
Mtortm1a(EUCOMM)Wtsi
tail skin, WT, Female, WTSI

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Mtortm608(L1L2_gt0_Del_LacZ) Targeting vectors
Mtortm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Mtortm608(pL1L2_GT0_DelLacZ_bsd) Targeting vectors

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