Mtor - mechanistic target of rapamycin kinase | International Mouse Phenotyping Consortium

Genes Phenotypes

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Gene: Mtor

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Name

mechanistic target of rapamycin kinase

MGI ID

MGI:1928394

Synonyms

FKBP-rapamycin-associated protein FRAP 2610315D21Rik RAFT1 RAPT1 flat Frap1 mechanistic target of rapamycin (serine/threonine kinase)

Viability

Homozygous - Lethal

Embryo viewer

N/A

Phenotype	Allele	Zyg	Life Stage	P Value
preweaning lethality, complete penetrance	Mtor^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
decreased circulating LDL cholesterol level	Mtor^{tm1a(EUCOMM)Wtsi}	HET	Early adult	9.89×10^-11
decreased circulating cholesterol level	Mtor^{tm1a(EUCOMM)Wtsi}	HET	Early adult	4.86×10^-05
decreased blood urea nitrogen level	Mtor^{tm1a(EUCOMM)Wtsi}	HET	Early adult	5.53×10^-05
increased mean corpuscular hemoglobin	Mtor^{tm1a(EUCOMM)Wtsi}	HET	Early adult	1.04×10^-09

Expression

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	2	No	(3/589)	(2/2)	N/A
Aorta	2	No	(1/589)		N/A
Blood vessel	2	No		(2/2)	N/A
Bone	2	No			N/A
Brain	2	No	(3/589)	(2/2)	N/A
Brainstem	2	No	(2/589)		N/A
Brown adipose tissue	2	No		(2/2)	N/A
Cartilage tissue	2	No		(2/2)	N/A
Cerebellum	2	No	(3/589)		N/A
Cerebral cortex	2	No	(2/589)		N/A
Eye	2	No			N/A
Gall bladder	2	No		(1/2)	N/A
Heart	2	No	(1/589)	(2/2)	N/A
Hippocampus	2	No	(3/589)		N/A
Hypothalamus	2	No	(2/589)		N/A
Kidney	2	No	(20/589)	(2/2)	N/A
Large intestine	2	No	(10/589)	(2/2)	N/A
Liver	2	No		(1/2)	N/A
Lower urinary tract	2	No	(1/589)	(2/2)	N/A
Lung	2	No	(1/589)	(2/2)	N/A
Lymph node	2	No			N/A
Mammary gland	2	No			N/A
Esophagus	2	No		(2/2)	N/A
Olfactory lobe	2	No	(2/589)		N/A
Ovary	2	No	(1/589)	(1/2)	N/A
Oviduct	2	No		(1/2)	N/A
Pancreas	2	No	(5/589)	(2/2)	N/A
Parathyroid gland	2	No		(2/2)	N/A
Peripheral nervous system	2	No	(1/589)	(2/2)	N/A
Peyer's patch	2	No			N/A
Pituitary gland	2	No	(1/589)	(2/2)	N/A
Prostate gland	2	No	(12/589)		N/A
Skeletal muscle tissue	2	No		(2/2)	N/A
Skin	2	No		(2/2)	N/A
Small intestine	2	No	(9/589)	(2/2)	N/A
Spinal cord	2	No	(2/589)	(2/2)	N/A
Spleen	2	No	(2/589)	(2/2)	N/A
Stomach	2	No	(13/589)	(2/2)	N/A
Striatum	2	No	(3/589)		N/A
Testis	2	No	(5/589)	(1/2)	N/A
Thymus	2	No		(2/2)	N/A
Thyroid gland	2	No	(16/589)	(2/2)	N/A
Trachea	2	No	(2/589)	(2/2)	N/A
Uterus	2	No		(1/2)	N/A
White adipose tissue	2	No			N/A

LacZ Wholemount Images

LacZ Section Images

Mtor^{tm1a(EUCOMM)Wtsi}
brain, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
ovary, oviduct, uterus, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
adrenal gland, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
brown adipose tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
spleen, HET, Female, WTSI

View all 28 images

Mtor^{tm1a(EUCOMM)Wtsi}
ovary, oviduct, uterus, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
adrenal gland, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
spleen, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
kidney, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
stomach, oesophagus, HET, Female, WTSI

View all 16 images

Mtor^{tm1a(EUCOMM)Wtsi}
stomach, oesophagus, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
small intestine, peyer's patch, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
large intestine, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
liver, gall bladder, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
spleen, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
mesenteric lymph node, lymph node, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
thymus, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
small intestine, peyer's patch, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
brain, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
pituitary gland, peripheral nervous system, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
brain, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
spinal cord, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
brown adipose tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skin, skin muscle, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skin, tail, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skin, pinna, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
brown adipose tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
heart, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skeletal muscle tissue, blood vessel, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
adrenal gland, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
thyroid gland, trachea, parathyroid gland, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skeletal muscle tissue, blood vessel, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
ovary, oviduct, uterus, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
testis, HET, Male, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
lung, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
thyroid gland, trachea, parathyroid gland, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
eye, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
skin, pinna, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
kidney, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
urinary bladder, lower urinary tract, HET, Female, WTSI

No Embryo expression data was found for this gene.

Associated Images

Legacy Phenotype Associated Images

Mtor^{tm1a(EUCOMM)Wtsi}
head, HET, Male, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
body, HET, Male, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
head, HET, Male, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
body, HET, Male, WTSI

View all 169 images

Mtor^{tm1a(EUCOMM)Wtsi}
back skin, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
back skin, WT, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
eye, abnormal cornea morphology, HET, Female, WTSI

Mtor^{tm1a(EUCOMM)Wtsi}
tail skin, WT, Female, WTSI

Disease Models

By Annotation and Orthology (0)
By phenotypic Similarity (0)

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MGI Allele	Allele Type	Produced
Mtor^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells
Mtor^{tm608(L1L2_gt0_Del_LacZ)}		Targeting vectors
Mtor^{tm608(pL1L2_GT0_DelLacZ_bsd)}		Targeting vectors

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Gene: Mtor

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Expression

IMPC lacZ Expression Data

LacZ Wholemount Images

LacZ Section Images

LacZ Section Images

Associated Images

Legacy Phenotype Associated Images

Disease Models

Order Mouse and ES Cells

This service may be affected by the Covid-19 pandemic. See how

The IMPC Newsletter

Access Data Release 12.0 Data