Gene: Nisch

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Nischtm1b(EUCOMM)Hmgu HET postnatal 1.64×10-06
head bobbing Nischtm1b(EUCOMM)Hmgu HOM postnatal 3.83×10-05
decreased lean body mass Nischtm1b(EUCOMM)Hmgu HOM postnatal 5.70×10-10
head bobbing Nischtm1b(EUCOMM)Hmgu HET postnatal 5.60×10-07
abnormal bone structure Nischtm1b(EUCOMM)Hmgu HOM postnatal 1.98×10-24
decreased bone mineral content Nischtm1b(EUCOMM)Hmgu HOM postnatal 6.96×10-22
decreased total body fat amount Nischtm1b(EUCOMM)Hmgu HOM postnatal 1.64×10-06
abnormal maxilla morphology Nischtm1b(EUCOMM)Hmgu HOM postnatal 2.97×10-05
decreased bone mineral density Nischtm1b(EUCOMM)Hmgu HOM postnatal 5.79×10-07
hypoactivity Nischtm1b(EUCOMM)Hmgu HOM postnatal 9.73×10-05
decreased lean body mass Nischtm1b(EUCOMM)Hmgu HET postnatal 8.99×10-05
abnormal cranium morphology Nischtm1b(EUCOMM)Hmgu HOM postnatal 7.71×10-05
decreased grip strength Nischtm1b(EUCOMM)Hmgu HOM postnatal 4.38×10-05
decreased bone mineral content Nischtm1b(EUCOMM)Hmgu HET postnatal 1.13×10-05
impaired glucose tolerance Nischtm1b(EUCOMM)Hmgu HOM postnatal 1.33×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (2/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (4/4) N/A
Foot 2  (1/485)  (2/4) N/A
Forebrain 2  (1/485)  (4/4) N/A
Forelimb 2  (1/485)  (4/4) N/A
Hand 2  (1/485)  (2/4) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485)  (2/4) N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485)  (4/4) N/A
Liver 2  (1/485)  (2/4) N/A
Lung 2  (1/485)  (2/4) N/A
Mandibular process 2  (1/485)  (2/4) N/A
Maxillary process 2  (1/485)  (2/4) N/A
Midbrain 2  (1/485)  (4/4) N/A
Oral cavity 2  (1/485)  (2/4) N/A
Skin 2  (1/485)  (4/4) N/A
Tail 2  (1/485)  (4/4) N/A
Tail somite 2  (1/485)  (4/4) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
15 Images
X-ray: XRay Images Dorso Ventral
16 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
6 Images
Adult LacZ: LacZ Images Wholemount
27 Images
Echo: M-Mode Images
52 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nischtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nischtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nischtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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