Gene: Cgn MGI:1927237
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal neural tube closure | Cgntm1b(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
hemorrhage | Cgntm1b(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
cyanosis | Cgntm1b(KOMP)Wtsi | HOM | E18.5 | 0.00 | ||
preweaning lethality, complete penetrance | Cgntm1b(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
abnormal forebrain morphology | Cgntm1b(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
abnormal embryo size | Cgntm1b(KOMP)Wtsi | HOM | E18.5 | 0.00 | ||
abnormal tail morphology | Cgntm1b(KOMP)Wtsi | HOM | E18.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Epididymis | Section images | heterozygote | 50% (1 of 2) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Eye | Section images | heterozygote | 100% (2 of 2) |
Kidney | Section images | heterozygote | 100% (2 of 2) |
Large intestine | Section images | heterozygote | 100% (2 of 2) |
Lung | Section images | heterozygote | 100% (2 of 2) |
Pancreas | Section images | heterozygote | 100% (2 of 2) |
Pituitary gland | Section images | heterozygote | 100% (2 of 2) |
Skin | Section images | heterozygote | 100% (2 of 2) |
Small intestine | Section images | heterozygote | 100% (2 of 2) |
Stomach | Section images | heterozygote | 100% (2 of 2) |
Submandibular gland | Section images | heterozygote | 100% (2 of 2) |
Testis | Section images | heterozygote | 50% (1 of 2) |
Trachea | Section images | heterozygote | 100% (2 of 2) |
Urinary bladder | Section images | heterozygote | 100% (2 of 2) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 0.0% (0 of 2) |
Oviduct | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | Not available |
Prostate gland | N/A | heterozygote | Not available |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
Striatum | N/A | heterozygote | Not available |
Thalamus | N/A | heterozygote | 0.0% (0 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Uterus | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Embryo | N/A | heterozygote | 100% (1 of 1) |
Embryo | N/A | homozygote | 100% (1 of 1) |
Brain | N/A | heterozygote | 0.0% (0 of 1) |
Brain | N/A | homozygote | 100% (1 of 1) |
Ear | N/A | heterozygote | 0.0% (0 of 1) |
Ear | N/A | homozygote | 100% (1 of 1) |
Eye | N/A | heterozygote | 100% (1 of 1) |
Eye | N/A | homozygote | 100% (1 of 1) |
Footplate | N/A | heterozygote | 100% (1 of 1) |
Footplate | N/A | homozygote | 100% (1 of 1) |
Forebrain | N/A | heterozygote | 0.0% (0 of 1) |
Forebrain | N/A | homozygote | 0.0% (0 of 1) |
Forelimb | N/A | heterozygote | 100% (1 of 1) |
Forelimb | N/A | homozygote | 100% (1 of 1) |
Handplate | N/A | heterozygote | 100% (1 of 1) |
Handplate | N/A | homozygote | 100% (1 of 1) |
Head | N/A | heterozygote | 100% (1 of 1) |
Head | N/A | homozygote | 100% (1 of 1) |
Heart | N/A | heterozygote | 0.0% (0 of 1) |
Heart | N/A | homozygote | 0.0% (0 of 1) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 1) |
Hindbrain | N/A | homozygote | 100% (1 of 1) |
Hindlimb | N/A | heterozygote | 100% (1 of 1) |
Hindlimb | N/A | homozygote | 100% (1 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 1) |
Liver | N/A | homozygote | 100% (1 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 1) |
Lung | N/A | homozygote | 100% (1 of 1) |
Mandibular process | N/A | heterozygote | 100% (1 of 1) |
Mandibular process | N/A | homozygote | 100% (1 of 1) |
Maxillary process | N/A | heterozygote | 100% (1 of 1) |
Maxillary process | N/A | homozygote | 100% (1 of 1) |
Midbrain | N/A | heterozygote | 0.0% (0 of 1) |
Midbrain | N/A | homozygote | 0.0% (0 of 1) |
N/A | Ambiguous | ||
Nose | N/A | homozygote | 100% (1 of 1) |
Oral cavity | N/A | heterozygote | 100% (1 of 1) |
Oral cavity | N/A | homozygote | 100% (1 of 1) |
Skin | N/A | heterozygote | 0.0% (0 of 1) |
Skin | N/A | homozygote | 0.0% (0 of 1) |
Tail somite | N/A | heterozygote | 0.0% (0 of 1) |
Tail somite | N/A | homozygote | 0.0% (0 of 1) |
Tail | N/A | heterozygote | 100% (1 of 1) |
Tail | N/A | homozygote | 100% (1 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thalamus | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
urinary bladder | |
uterus | 0.0% |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
skin | 0.0% |
tail | 0.0% |
tail somite group | 0.0% |
Human diseases caused by Cgn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cgn by phenotypic similarity.
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cgn.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Igh-6tm1Cgn | PMC7263671 |
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. | Scientific data (September 2017) | Ighmtm1Cgn | PMC5827107 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Cgntm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Cgntm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Cgntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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