Cgn | cingulin
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Cardiovascular system Mortality/aging
13 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
43Embryo tissues
| abnormal forebrain morphology | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| cyanosis | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal neural tube closure | 1 supporting dataset | Cgntm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Cgn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cgn.
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| Cgntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cgntm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cgntm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |