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Gene: Zmym3 MGI:1927231

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

zinc finger, MYM-type 3

Synonyms:

DXS6673El, DXS6673E, Zfp261, 9030216B10Rik, DXHXS6673E

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmym3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Zmym3 (0 diseases)
Human diseases predicted to be associated with Zmym3 (194 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zmym3 by phenotypic similarity.

Disease	Matching phenotypes	Source
Partial Chromosome Y Deletion	Decreased testicular size, Cryptorchidism, Non-obstructive azoospermia, Male infertility, Abnorma...	ORPHA:1646
Spermatogenic Failure 25	Decreased testicular size, Early spermatogenesis maturation arrest, Cryptozoospermia, Non-obstruc...	OMIM:617960
Spermatogenic Failure 63	Reduced progressive sperm motility, Decreased testicular size, Oligospermia, Male infertility	OMIM:619689
Spermatogenic Failure 30	Cryptorchidism, Spermatogenesis maturation arrest, Cryptozoospermia, Azoospermia, Male infertility	OMIM:618110
Male Infertility Due To Acephalic Spermatozoa	Acephalic spermatozoa, Reduced sperm motility, Male infertility, Androgen insufficiency, Oligospe...	ORPHA:529970
Spermatogenic Failure, X-Linked, 3	Reduced sperm motility, Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tai...	OMIM:301059
Spermatogenic Failure 1	Male infertility, Oligospermia, Cryptozoospermia	OMIM:258150
Spermatogenic Failure 40	Immotile sperm, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertil...	OMIM:618664
Spermatogenic Failure 76	Reduced sperm motility, Short sperm flagella, Irregularly shaped sperm tail, Absent sperm flagell...	OMIM:620084
Spermatogenic Failure 80	Reduced progressive sperm motility, Short sperm flagella, Coiled sperm flagella, Absent sperm fla...	OMIM:620222
Spermatogenic Failure 65	Reduced sperm motility, Reduced progressive sperm motility, Short sperm flagella, Coiled sperm fl...	OMIM:619712
Spermatogenic Failure 48	Azoospermia, Spermatogenesis maturation arrest, Oligospermia, Male infertility	OMIM:619108
Spermatogenic Failure 56	Reduced sperm motility, Reduced progressive sperm motility, Short sperm flagella, Coiled sperm fl...	OMIM:619515
Spermatogenic Failure 47	Immotile sperm, Short sperm flagella, Absent sperm flagella, Male infertility, Oligospermia	OMIM:619102
Spermatogenic Failure 54	Reduced sperm motility, Cryptozoospermia, Short sperm flagella, Coiled sperm flagella, Abnormal s...	OMIM:619379
Spermatogenic Failure 11	Abnormal sperm morphology, Oligospermia, Male infertility, Reduced sperm motility	OMIM:615081
Spermatogenic Failure 10	Abnormal sperm morphology, Oligospermia, Male infertility, Reduced sperm motility	OMIM:614822
Spermatogenic Failure 79	Coiled sperm flagella, Oligospermia, Male infertility, Reduced sperm motility	OMIM:620196
Spermatogenic Failure 58	Immotile sperm, Reduced progressive sperm motility, Short sperm flagella, Irregularly shaped sper...	OMIM:619585
Spermatogenic Failure 39	Reduced sperm motility, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male ...	OMIM:618643
Spermatogenic Failure 41	Immotile sperm, Short sperm flagella, Male infertility, Tapered sperm head, Oligospermia	OMIM:618670
Spermatogenic Failure 7	Immotile sperm, Oligospermia, Male infertility, Reduced sperm motility	OMIM:612997
Spermatogenic Failure 57	Non-obstructive azoospermia, Decreased testicular size, Spermatogenesis maturation arrest, Male i...	OMIM:619528
Spermatogenic Failure 22	Non-obstructive azoospermia, Male infertility, Cryptozoospermia	OMIM:617706
Spermatogenic Failure 70	Azoospermia, Oligospermia, Male infertility, Reduced sperm motility	OMIM:619828
Spermatogenic Failure 64	Abnormal sperm head morphology, Reduced progressive sperm motility, Oligospermia, Male infertility	OMIM:619696
Spermatogenic Failure 50	Azoospermia, Decreased testicular size, Spermatogenesis maturation arrest, Male infertility	OMIM:619145
Spermatogenic Failure 51	Macrocephalic sperm head, Microcephalic sperm head, Reduced sperm motility, Absent sperm axoneme ...	OMIM:619177
Spermatogenic Failure 35	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:618341
Spermatogenic Failure 32	Non-obstructive azoospermia, Sertoli cell-only phenotype, Male infertility	OMIM:618115
Spermatogenic Failure 71	Non-obstructive azoospermia, Sertoli cell-only phenotype, Male infertility	OMIM:619831
Spermatogenic Failure 20	Coiled sperm flagella, Absent sperm flagella, Male infertility, Short sperm flagella	OMIM:617593
Isochromosomy Yp	Decreased testicular size, Ambiguous genitalia, Primary gonadal insufficiency, Azoospermia, Male ...	ORPHA:98797
Spermatogenic Failure 72	Absent sperm axoneme central pair complex, Reduced progressive sperm motility, Short sperm flagel...	OMIM:619867
Spermatogenic Failure 34	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:618153
Spermatogenic Failure 37	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:618429
Spermatogenic Failure 18	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:617576
Spermatogenic Failure 46	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:619095
Spermatogenic Failure 27	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:617965
Spermatogenic Failure 33	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:618152
Spermatogenic Failure 62	Non-obstructive azoospermia, Male infertility, Early spermatogenesis maturation arrest	OMIM:619673
Spermatogenic Failure 61	Non-obstructive azoospermia, Male infertility, Early spermatogenesis maturation arrest	OMIM:619672
Spermatogenic Failure 43	Absent sperm axoneme central pair complex, Coiled sperm flagella, Absent sperm flagella, Male inf...	OMIM:618751
Spermatogenic Failure 45	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:619094
Spermatogenic Failure 19	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:617592
Spermatogenic Failure 49	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:619144
Spermatogenic Failure 73	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619878
Spermatogenic Failure 59	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619645
Spermatogenic Failure 60	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619646
Spermatogenic Failure 74	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619937
Spermatogenic Failure 8	Azoospermia, Oligospermia, Cryptozoospermia	OMIM:613957
Spermatogenic Failure 78	Microcephalic sperm head, Male infertility, Tapered sperm head	OMIM:620170
Spermatogenic Failure 36	Abnormal sperm morphology, Male infertility	OMIM:618420
Spermatogenic Failure 42	Microcephalic sperm head, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Mal...	OMIM:618745
Isochromosomy Yq	Decreased testicular size, Ambiguous genitalia, Primary gonadal insufficiency, Varicocele, Azoosp...	ORPHA:98798
Spermatogenic Failure 17	Male infertility	OMIM:617214
Spermatogenic Failure 29	Non-obstructive azoospermia, Immotile sperm, Male infertility	OMIM:618091
Spermatogenic Failure 5	Macrocephalic sperm head, Multiflagellar spermatozoa, Male infertility	OMIM:243060
Spermatogenic Failure, X-Linked, 2	Azoospermia, Spermatogenesis maturation arrest, Testicular atrophy, Male infertility	OMIM:309120
Spermatogenic Failure 44	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:619044
Spermatogenic Failure 16	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:617187
Spermatogenic Failure 21	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:617644
Spermatogenic Failure, Y-Linked, 2	Azoospermia, Male infertility	OMIM:415000
Spermatogenic Failure 4	Azoospermia, Male infertility	OMIM:270960
Spermatogenic Failure 52	Azoospermia, Male infertility	OMIM:619202
Spermatogenic Failure 23	Azoospermia, Male infertility	OMIM:617707
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm	Abnormal sperm morphology, Immotile sperm, Male infertility	OMIM:608653
Spermatogenic Failure 31	Acephalic spermatozoa, Male infertility	OMIM:618112
Spermatogenic Failure 26	Acephalic spermatozoa, Male infertility	OMIM:617961
Spermatogenic Failure 53	Tapered sperm head, Male infertility	OMIM:619258
Spermatogenic Failure 38	Abnormal sperm head morphology, Abnormal axonemal organization of respiratory motile cilia, Reduc...	OMIM:618433
Spermatogenic Failure 12	Infertility, Abnormal male germ cell morphology, Azoospermia	OMIM:615413
Deafness-Infertility Syndrome	Abnormal sperm head morphology, Abnormal sperm tail morphology, Male infertility, Abnormal sperma...	OMIM:611102
Deafness-Infertility Syndrome	Azoospermia, Male infertility	ORPHA:94064
Spermatogenic Failure 3	Reduced sperm motility, Male infertility	OMIM:606766
Spermatogenic Failure, Y-Linked, 1	Reduced sperm motility, Male infertility	OMIM:400042
Spermatogenic Failure 55	Reduced sperm motility, Male infertility	OMIM:619380
Persistent Mullerian Duct Syndrome, Types I And Ii	Decreased cirrculating antimullerian hormone circulation, Bilateral cryptorchidism, Male infertility	OMIM:261550
Spermatogenic Failure 77	Cryptorchidism, Abnormal circulating luteinizing hormone concentration, Elevated circulating foll...	OMIM:620103
Spermatogenic Failure 2	Abnormal circulating luteinizing hormone concentration, Non-obstructive azoospermia, Azoospermia,...	OMIM:108420
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation	Decreased testicular size, Obstructive azoospermia, Non-obstructive azoospermia, Azoospermia, Inc...	ORPHA:399805
Young Syndrome	Decreased fertility, Obstructive azoospermia	ORPHA:3471
Familial Peripheral Male-Limited Precocious Puberty	Male infertility, Long penis, Macroorchidism, Oligospermia, Precocious puberty	ORPHA:3000
Spermatogenic Failure 75	Non-obstructive azoospermia, Elevated circulating follicle stimulating hormone level, Male infert...	OMIM:619949
Congenital Bilateral Absence Of Vas Deferens	Absent vas deferens, Obstructive azoospermia, Male infertility, Oligospermia	ORPHA:48
Hypogonadism, Male	Male hypogonadism, Testicular atrophy, Micropenis, Hypospadias	OMIM:241100
Spinocerebellar Ataxia Type 32	Azoospermia, Testicular atrophy, Male infertility	ORPHA:276183
Azoospermia, Obstructive, With Nephrolithiasis	Male infertility, Obstructive azoospermia, Spermatocele	OMIM:301060
Spermatogenic Failure 24	Microcephalic sperm head, Short sperm flagella, Coiled sperm flagella, Tapered sperm head, Reduce...	OMIM:617959
Male Infertility With Teratozoospermia Due To Single Gene Mutation	Globozoospermia, Abnormal sperm morphology, Decreased testicular size, Abnormal sperm tail morpho...	ORPHA:399808
Spermatogenic Failure 13	Azoospermia	OMIM:615841
Deleted in azoospermia	Azoospermia	OMIM:400003
Spinocerebellar Ataxia 32	Infertility, Azoospermia, Testicular atrophy	OMIM:613909
Spermatogenic Failure 6	Globozoospermia, Decreased acrosin in sperm head, Male infertility	OMIM:102530
Spermatogenic Failure 15	Spermatogenesis maturation arrest, Abnormal circulating luteinizing hormone concentration, Non-ob...	OMIM:616950
Hypogonadism With Low-Grade Mental Deficiency And Microcephaly	Male hypogonadism, Azoospermia	OMIM:241000
Female Infertility Due To Oocyte Meiotic Arrest	Abnormal meiosis, Polycystic ovaries, Oocyte arrest at metaphase I, Female infertility, Abnormal ...	ORPHA:488191
Spermatogenic Failure 66	Globozoospermia, Male infertility	OMIM:619799
Spermatogenic Failure 67	Globozoospermia, Male infertility	OMIM:619803
Spermatogenic Failure 68	Globozoospermia, Male infertility	OMIM:619805
Spermatogenic Failure 9	Globozoospermia, Male infertility	OMIM:613958
Spermatogenic Failure 69	Globozoospermia, Male infertility	OMIM:619826
Ring Chromosome Y Syndrome	Perineal hypospadias, Cryptorchidism, Ambiguous genitalia, Gonadoblastoma, Ambiguous genitalia, m...	ORPHA:261529
Isolated Follicle Stimulating Hormone Deficiency	Oligomenorrhea, Abnormal sperm morphology, Decreased testicular size, Delayed puberty, Testicular...	ORPHA:52901
Spermatogenic Failure 28	Decreased testicular size, Elevated circulating follicle stimulating hormone level, Non-obstructi...	OMIM:618086
Morbid Obesity And Spermatogenic Failure	Infertility, Azoospermia, Type II diabetes mellitus, Oligospermia	OMIM:615703
Vas Deferens, Congenital Bilateral Aplasia Of, X-Linked	Absent vas deferens, Azoospermia, Male infertility	OMIM:300985
Vas Deferens, Congenital Bilateral Aplasia Of	Azoospermia, Absent vas deferens, Male infertility	OMIM:277180
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia	Decreased testicular size, Hypogonadism, Primary amenorrhea, Decreased circulating follicle stimu...	OMIM:229070
Kennedy Disease	Decreased fertility, Erectile dysfunction, Type II diabetes mellitus, Testicular atrophy	ORPHA:481
Spermatogenic Failure 14	Abnormal circulating luteinizing hormone concentration, Elevated circulating follicle stimulating...	OMIM:615842
46,Xx Testicular Difference Of Sex Development	Polycystic ovaries, Male hypogonadism, Decreased testicular size, Ambiguous genitalia	ORPHA:393
Young Syndrome	Azoospermia	OMIM:279000
Testicular Regression Syndrome	Decreased testicular size, Absent testis, Agonadism, Abnormal morphology of female internal genit...	ORPHA:983
Spermatogenic Failure, X-Linked, 4	Elevated circulating follicle stimulating hormone level, Abnormal prolactin level, Azoospermia, M...	OMIM:301077
Premature Ovarian Failure 10	Premature ovarian insufficiency, Hypoplasia of the ovary, Decreased testicular size, Primary amen...	OMIM:612885
Androgen Insensitivity, Partial	Perineal hypospadias, Cryptorchidism, Micropenis, Hypogonadism, Infertility, Azoospermia, Absent ...	OMIM:312300
Adrenal Hypoplasia, Congenital	Delayed puberty, Adrenal hypoplasia, Cryptorchidism, Decreased circulating cortisol level, Decrea...	OMIM:300200
Hypogonadism-Cataract Syndrome	Infertility, Male hypogonadism, Elevated circulating follicle stimulating hormone level, Hypogona...	OMIM:240950
Functioning Gonadotropic Adenoma	Delayed puberty, Isosexual precocious puberty, Abnormality of the menstrual cycle, Adrenocorticot...	ORPHA:91348
Spinal And Bulbar Muscular Atrophy, X-Linked 1	Decreased fertility, Testicular atrophy	OMIM:313200
Androgen Insensitivity Syndrome	Aplasia/Hypoplasia of the fallopian tube, Delayed puberty, Cryptorchidism, Abnormal morphology of...	ORPHA:754
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Micropenis, Primary amenorrhea, Absence of pubertal de...	OMIM:614837
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia	Oligomenorrhea, Delayed puberty, Secondary amenorrhea, Abnormality of the Leydig cells, Micropeni...	OMIM:228300
47,Xyy Syndrome	Increased serum testosterone level, Cryptorchidism, Micropenis, Varicocele, Azoospermia, Increase...	ORPHA:8
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Micropenis, Hypogonadism, Primary amenorrhea, Decrease...	OMIM:614897
Diethylstilbestrol Syndrome	Decreased fertility in females, Cryptorchidism, Premature ovarian insufficiency, Micropenis, Abno...	ORPHA:1916
Ciliary Dyskinesia, Primary, 45	Male infertility, Absent inner and outer dynein arms	OMIM:618801
Partial Androgen Insensitivity Syndrome	Ambiguous genitalia, Primary amenorrhea, Fused labia majora, Bilateral cryptorchidism, Male infer...	ORPHA:90797
Torticollis, Keloids, Cryptorchidism, And Renal Dysplasia	Cryptorchidism, Oligospermia	OMIM:314300
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Testicular atrophy, Micropenis, Decreased circulating ...	OMIM:308700
Ciliary Dyskinesia, Primary, 49, Without Situs Inversus	Coiled sperm flagella, Male infertility, Short sperm flagella	OMIM:620197
46,Xy Partial Gonadal Dysgenesis	Delayed puberty, Ambiguous genitalia, Primary amenorrhea, Elevated circulating follicle stimulati...	ORPHA:251510
Hemochromatosis, Type 2A	Infertility, Amenorrhea, Azoospermia, Hypogonadotropic hypogonadism	OMIM:602390
Leukoencephalopathy With Dystonia And Motor Neuropathy	Azoospermia, Hypergonadotropic hypogonadism	OMIM:613724
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility	Male infertility	OMIM:618948
Ciliary Dyskinesia, Primary, 34	Immotile sperm, Male infertility, Absent central microtubular pair morphology of respiratory moti...	OMIM:617091
Pituitary Dermoid And Epidermoid Cysts	Oligomenorrhea, Hyperpituitarism, Hypogonadism, Increased circulating prolactin concentration, Ne...	ORPHA:91351
Ciliary Dyskinesia, Primary, 36, X-Linked	Male infertility	OMIM:300991
Complete Androgen Insensitivity Syndrome	Aplasia/Hypoplasia of the fallopian tube, Delayed puberty, Increased serum testosterone level, Ab...	ORPHA:99429
Hydrocephalus-Obesity-Hypogonadism Syndrome	Azoospermia, Abnormality of the hypothalamus-pituitary axis, Hypergonadotropic hypogonadism	ORPHA:2183
Kallmann Syndrome With Spastic Paraplegia	Cryptorchidism, Testicular atrophy, Micropenis, Decreased circulating follicle stimulating hormon...	OMIM:308750
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency	Delayed puberty, Primary amenorrhea, Elevated circulating follicle stimulating hormone level, Inc...	ORPHA:90793
Mayer-Rokitansky-Küster-Hauser Syndrome Type 2	Aplasia/hypoplasia of the uterus, Azoospermia, Bicornuate uterus	ORPHA:2578
Normosmic Congenital Hypogonadotropic Hypogonadism	Delayed puberty, Hypoplasia of the ovary, Cryptorchidism, Decreased testicular size, Micropenis, ...	ORPHA:432
Hemochromatosis, Type 1	Testicular atrophy, Diabetes mellitus, Azoospermia, Impotence, Hypogonadotropic hypogonadism, Ame...	OMIM:235200
Generalized Glucocorticoid Resistance Syndrome	Oligomenorrhea, Adrenal hyperplasia, Increased circulating ACTH level, Ambiguous genitalia, Incre...	ORPHA:786
46,Xx Sex Reversal 2	Perineal hypospadias, Decreased serum testosterone concentration, Micropenis, Hypoplasia of the v...	OMIM:278850
46,Xx Sex Reversal 1	Clitoral hypertrophy, Elevated circulating follicle stimulating hormone level, Azoospermia, Ovote...	OMIM:400045
Ciliary Dyskinesia, Primary, 18	Absent outer dynein arms, Immotile sperm, Male infertility, Absent inner dynein arms	OMIM:614874
Ciliary Dyskinesia, Primary, 40	Infertility, Absent outer dynein arms, Azoospermia, Patent ductus arteriosus	OMIM:618300
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency	Increased circulating androstenedione concentration, Premature adrenarche, Abnormal labia majora ...	ORPHA:90791
Testicular Germ Cell Tumor	Azoospermia	OMIM:273300
Myotonic Dystrophy 2	Elevated circulating follicle stimulating hormone level, Type II diabetes mellitus, Oligospermia,...	OMIM:602668
Lead Poisoning	Abnormal sperm morphology, Delayed puberty, Reduced sperm motility, Decreased male libido, Decrea...	ORPHA:330015
Ciliary Dyskinesia, Primary, 9	Absent outer dynein arms, Male infertility	OMIM:612444
Ciliary Dyskinesia, Primary, 14	Abnormal axonemal organization of respiratory motile cilia, Immotile sperm, Absent inner dynein a...	OMIM:613807
Moyamoya Angiopathy-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome	Delayed puberty, Decreased testicular size, Decreased response to growth hormone stimulation test...	ORPHA:280679
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland	Parathyroid agenesis, Congenital hypoparathyroidism, Male infertility	ORPHA:2239
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull	Testicular atrophy	OMIM:601163
Classic Galactosemia	Oligomenorrhea, Delayed puberty, Premature ovarian insufficiency, Decreased fertility in females,...	ORPHA:79239
Myotonic Dystrophy 1	Cholelithiasis, Testicular atrophy, Hypogonadism	OMIM:160900
Bone Marrow Failure Syndrome 5	Testicular atrophy, Hypogonadism	OMIM:618165
Hereditary Amyloidosis With Primary Renal Involvement	Hypogonadism, Primary testicular failure, Male infertility, Abnormal testis morphology, Oligospermia	ORPHA:85450
Anemia, Hypochromic Microcytic, With Iron Overload 2	Azoospermia, Hypogonadism	OMIM:615234
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies	Azoospermia, Hypoplasia of the uterus, Bicornuate uterus	OMIM:601076
Aromatase Deficiency	Cryptorchidism, Primary amenorrhea, Hypergonadotropic hypogonadism, Female infertility, Type II d...	ORPHA:91
Heterotaxy, Visceral, 10, Autosomal, With Male Infertility	Male infertility	OMIM:619607
Ciliary Dyskinesia, Primary, 19	Male infertility, Absent inner and outer dynein arms	OMIM:614935
45,X/46,Xy Mixed Gonadal Dysgenesis	Delayed puberty, Ambiguous genitalia, Abnormal internal genitalia, Streak ovary, Bilateral crypto...	ORPHA:1772
Dyskeratosis Congenita, Autosomal Recessive 2	Testicular atrophy	OMIM:613987
Gapo Syndrome	Dysmenorrhea, Oligospermia, Amenorrhea, Hypogonadism	ORPHA:2067
Symptomatic Form Of Hfe-Related Hemochromatosis	Testicular atrophy, Diabetes mellitus, Infertility, Erectile dysfunction, Hypogonadotropic hypogo...	ORPHA:465508
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency	Delayed puberty, Increased size of the clitoris, Ambiguous genitalia, Primary amenorrhea, Fused l...	ORPHA:95699
Wolfram Syndrome 1	Diabetes mellitus, Diabetes insipidus, Testicular atrophy, Hypothyroidism	OMIM:222300
Carney Complex	Abnormal morphology of female internal genitalia, Euthyroid multinodular goiter, Increased circul...	ORPHA:1359
Aarskog-Scott Syndrome	Delayed puberty, Cryptorchidism, Testicular atrophy, Shawl scrotum, Elevated circulating follicle...	OMIM:305400
Short Stature, Onychodysplasia, Facial Dysmorphism, And Hypotrichosis	Diabetes mellitus, Clitoral hypoplasia, Oligospermia, Breast hypoplasia	OMIM:614813
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts	Hypogonadism, Adrenal insufficiency, Azoospermia, Hypothyroidism, Abnormality of the hypothalamus...	ORPHA:300298
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1	Premature ovarian insufficiency, Testicular atrophy, Primary amenorrhea, Hypergonadotropic hypogo...	OMIM:157640
Bloom Syndrome	Premature ovarian insufficiency, Diabetes mellitus, Azoospermia, Male infertility, Oligospermia	ORPHA:125
Ciliary Dyskinesia, Primary, 1	Absent outer dynein arms, Male infertility	OMIM:244400
Primary Ciliary Dyskinesia	Female infertility, Abnormal sperm motility, Male infertility	ORPHA:244
Lesch-Nyhan Syndrome	Testicular atrophy	OMIM:300322
Fanconi Anemia, Complementation Group A	Cryptorchidism, Male infertility, Hypergonadotropic hypogonadism	OMIM:227650
Renal Cysts And Diabetes Syndrome	Pancreatic hypoplasia, Diabetes mellitus, Hypoplasia of the uterus, Epididymal cyst, Atretic vas ...	OMIM:137920
Tetrasomy 9P	Cryptorchidism, Micropenis, Infertility, Absent gallbladder, Oligospermia	ORPHA:3310
X-Linked Intellectual Disability, Snyder Type	Cryptorchidism, Testicular atrophy, Abnormality of the Leydig cells, Hypospadias	ORPHA:3063
Steinert Myotonic Dystrophy	Secondary hyperparathyroidism, Testicular atrophy, Decreased serum testosterone concentration, Di...	ORPHA:273
Von Hippel-Lindau Syndrome	Neoplasm of the pancreas, Pheochromocytoma, Paraganglioma, Papillary cystadenoma of the epididymi...	OMIM:193300
Noonan Syndrome 1	Cryptorchidism, Hypogonadism, Male infertility, Patent ductus arteriosus, Hypospadias	OMIM:163950
Cystinosis, Nephropathic	Delayed puberty, Diabetes mellitus, Male infertility, Primary hypothyroidism, Male hypogonadism	OMIM:219800
Alström Syndrome	Decreased testicular size, Micropenis, Polycystic ovaries, Precocious puberty in females, Testicu...	ORPHA:64
Cystic Fibrosis	Male infertility	OMIM:219700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmym3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmym3.

There are 1 publication which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex.	PloS one (March 2019)	Zmym3^{tm1(NCOM)Mfgc}	PMC6424451

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MGI Allele	Allele Type	Produced
Zmym3^{tm1(NCOM)Mfgc}	Reporter-tagged deletion allele (with selection cassette)	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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