Gene: Diaph3

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Name
diaphanous related formin 3
MGI ID
MGI:1927222
Synonyms
Drf3 mDia2 p134MDia2 Diap3 4930417P13Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
pallor Diaph3tm1b(KOMP)Mbp HOM E12.5 0.00
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HET E12.5 0.00
increased mean corpuscular hemoglobin concentration Diaph3tm1b(KOMP)Mbp HET Early adult 1.32×10-06
preweaning lethality, complete penetrance Diaph3tm1b(KOMP)Mbp HOM Early adult 0.00
decreased blood urea nitrogen level Diaph3tm1b(KOMP)Mbp HET Early adult 4.08×10-06
decreased circulating triglyceride level Diaph3tm1b(KOMP)Mbp HET Early adult 1.53×10-08
abnormal craniofacial morphology Diaph3tm1b(KOMP)Mbp HOM E12.5 0.00
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Diaph3tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal embryo size Diaph3tm1b(KOMP)Mbp HOM E9.5 0.00
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM E12.5 0.00
abnormal embryo turning Diaph3tm1b(KOMP)Mbp HOM E9.5 0.00
decreased circulating free fatty acid level Diaph3tm1b(KOMP)Mbp HET Early adult 6.78×10-10
decreased mean corpuscular volume Diaph3tm1b(KOMP)Mbp HET Early adult 7.50×10-06
abnormal pericardium morphology Diaph3tm1b(KOMP)Mbp HOM E12.5 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (1/3) N/A
Dorsal root ganglion 2  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/3)  Wholemount images
Eye 2  (1/504)  (2/3) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 2  (1/58) N/A
Hand 2  (1/503) N/A
Head 2  (5/504)  (1/3) N/A
Heart 2  (1/504)  (2/3) N/A
Hindbrain 2  (6/504)  (1/3) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) Image Only N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 2  (1/70) N/A
Oral cavity 2  (1/504) Image Only N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69)  (1/3) N/A
Tail 2  (1/504)  (1/3) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Electroretinography 2: Rod and cone PDF
6 Images
Eye Morphology: Images Ophthalmoscopy
2 Images
Embryo LacZ: LacZ images wholemount
12 Images
Gross Morphology Embryo E9.5
4 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Sleep Wake: Wake state (bmp file)
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Diaph3tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Diaph3tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice
Diaph3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Diaph3tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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