Gene: Diaph3

Order

Name diaphanous related formin 3

Synonyms
  • Diap3
  • 4930417P13Rik
  • Drf3
  • p134MDia2
  • mDia2

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1927222    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Diaph3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Diaph3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
abnormal embryo size Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal embryo turning Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal pericardium morphology Diaph3tm1b(KOMP)Mbp HOM Male embryonic day 12.5 0.0
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HET Female Male embryonic day 12.5 0.0
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
pallor Diaph3tm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Diaph3tm1b(KOMP)Mbp HOM Female Male n/a 0.0
decreased circulating free fatty acid level Diaph3tm1b(KOMP)Mbp HET Female Male postnatal 7.28E-10
decreased circulating triglyceride level Diaph3tm1b(KOMP)Mbp HET Female Male postnatal 2.21E-8
increased mean corpuscular hemoglobin concentration Diaph3tm1b(KOMP)Mbp HET Female Male postnatal 1.32E-6
decreased blood urea nitrogen level Diaph3tm1b(KOMP)Mbp HET Female Male postnatal 4.98E-6
decreased mean corpuscular volume Diaph3tm1b(KOMP)Mbp HET Female Male postnatal 7.5E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No
Uterus 2 No
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse reproductive system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (1/3)
Dorsal root ganglion 2 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485) (2/3)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Fronto-nasal process 2 (1/48)
Hand 2 (1/485)
Head 2 (5/485) (1/3)
Heart 2 (1/485) (2/3)
Hindbrain 2 (6/485) (1/3)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Nose 2 (1/51)
Oral cavity 2 (1/485) Image Only
Skin 2 (1/485)
Spinal cord 2 (1/50) (1/3)
Tail 2 (1/485) (1/3)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Sleep Wake: Wake state (bmp file)
    13 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Gross Morphology Embryo E9.5
    4 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • Electroretinography 2: Rod and cone PDF
    6 Images
  • Gross Morphology Embryo E12.5
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Diaph3tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Diaph3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Diaph3tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Diaph3tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene