Gene: Diaph3

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Name
diaphanous related formin 3
MGI ID
MGI:1927222
Synonyms
Diap3 4930417P13Rik Drf3 p134MDia2 mDia2
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased blood urea nitrogen level Diaph3tm1b(KOMP)Mbp HET postnatal 4.98×10-06
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HET embryonic day 12.5 0.00
increased mean corpuscular hemoglobin concentration Diaph3tm1b(KOMP)Mbp HET postnatal 1.32×10-06
decreased circulating free fatty acid level Diaph3tm1b(KOMP)Mbp HET postnatal 7.28×10-10
abnormal pericardium morphology Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
abnormal embryo size Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Diaph3tm1b(KOMP)Mbp HOM n/a 0.00
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
abnormal embryo turning Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
decreased circulating triglyceride level Diaph3tm1b(KOMP)Mbp HET postnatal 2.21×10-08
pallor Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
embryonic lethality prior to tooth bud stage Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
decreased mean corpuscular volume Diaph3tm1b(KOMP)Mbp HET postnatal 7.50×10-06
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
abnormal craniofacial morphology Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (1/3) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485)  (2/3) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (1/3) N/A
Heart 2  (1/485)  (2/3) N/A
Hindbrain 2  (6/485)  (1/3) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) Image Only N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) Image Only N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50)  (1/3) N/A
Tail 2  (1/485)  (1/3) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Electroretinography 2: Rod and cone PDF
6 Images
Gross Morphology Embryo E12.5
4 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Sleep Wake: Wake state (bmp file)
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images
Gross Morphology Embryo E9.5
4 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Diaph3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Diaph3tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Diaph3tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Diaph3tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice

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