Gene: Diaph3

Name
diaphanous related formin 3
MGI ID
MGI:1927222
Synonyms
Diap3 4930417P13Rik Drf3 p134MDia2 mDia2
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
decreased circulating triglyceride level Diaph3tm1b(KOMP)Mbp HET postnatal 2.21×10-08
preweaning lethality, complete penetrance Diaph3tm1b(KOMP)Mbp HOM n/a 0.00
abnormal embryo turning Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
abnormal craniofacial morphology Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
decreased circulating free fatty acid level Diaph3tm1b(KOMP)Mbp HET postnatal 7.28×10-10
embryonic growth retardation Diaph3tm1b(KOMP)Mbp HET embryonic day 12.5 0.00
embryonic lethality prior to tooth bud stage Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
pallor Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
decreased mean corpuscular volume Diaph3tm1b(KOMP)Mbp HET postnatal 7.50×10-06
decreased blood urea nitrogen level Diaph3tm1b(KOMP)Mbp HET postnatal 4.98×10-06
abnormal pericardium morphology Diaph3tm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
abnormal embryo size Diaph3tm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
increased mean corpuscular hemoglobin concentration Diaph3tm1b(KOMP)Mbp HET postnatal 1.32×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (1/3) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485)  (2/3) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (1/3) N/A
Heart 2  (1/485)  (2/3) N/A
Hindbrain 2  (6/485)  (1/3) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) Image Only N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) Image Only N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50)  (1/3) N/A
Tail 2  (1/485)  (1/3) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
Gross Morphology Embryo E9.5
4 Images
Sleep Wake: Wake state (bmp file)
13 Images
Gross Morphology Embryo E12.5
4 Images
Electroretinography 2: Rod and cone PDF
6 Images
Embryo LacZ: LacZ images wholemount
12 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Diaph3tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Diaph3tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice
Diaph3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Diaph3tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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