Gene Summary

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
Spo8,  2310024F18Rik,  M6A

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Mettl3em1(IMPC)Tcp HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Mettl3em1(IMPC)Tcp HOM   E12.5 0.00
embryonic lethality prior to organogenesis Mettl3em1(IMPC)Tcp HOM   E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Lateral Orientation

10 Images


XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Mettl3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mettl3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mettl3.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency. Nature cell biology (September 2023) Mettl3em1(IMPC)Tcp 37696947
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA. PLoS biology (July 2022) Mettl3tm1a(KOMP)Wtsi PMC9295969
A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease. Cell metabolism (April 2021) Mettl3tm1c(KOMP)Wtsi 33852874
Context-dependent functional compensation between Ythdf m6A reader proteins. Genes & development (September 2020) Mettl3tm1a(KOMP)Wtsi PMC7528697
m6A RNA methylation impacts fate choices during skin morphogenesis. eLife (August 2020) Mettl3tm1c(KOMP)Wtsi PMC7535931
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell reports (August 2019) Mettl3tm1a(KOMP)Wtsi PMC6818972
The Role of m6A/m-RNA Methylation in Stress Response Regulation. Neuron (July 2018) Mettl3tm1c(KOMP)Wtsi Mettl3tm1a(KOMP)Wtsi PMC6069762

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mettl3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Mettl3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Mettl3em1(IMPC)Tcp Intra-exon deletion Mice, Tissue

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