Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
dual specificity phosphatase 10
Synonyms:
MKP5,  2610306G15Rik,  MKP-5

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dusp10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dusp10 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 24
Decreased circulating IgG level, Reduced antigen-specific T cell proliferation, Decreased proport... OMIM:615897
Immunoglobulin A Deficiency 2
Autoimmunity, Abnormal lymphocyte morphology, Decreased circulating IgA level OMIM:609529
Retinal Telangiectasia And Hypogammaglobulinemia
Decreased circulating IgG level, Reduced delayed hypersensitivity OMIM:267900
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Autoimmunity, Increased CD4:CD8 ratio, Decreased specific pneumococcal antibody level, Colitis, I... OMIM:617006
Immunodeficiency, Common Variable, 5
Antinuclear antibody positivity, Chronic decreased circulating total IgG OMIM:613495
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Sinusitis, Recurrent otitis media, Recurrent pneumonia, Autoimmunity, T lymphocytopenia, Lack of ... ORPHA:277
Autoimmune Lymphoproliferative Syndrome
Eosinophilia, Increased circulating IgG level, Rheumatoid factor positive, Increased circulating ... OMIM:601859
Cernunnos-Xlf Deficiency
Autoimmunity, T lymphocytopenia, Decreased circulating antibody level, Thrombocytopenia, Anemia, ... ORPHA:169079
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Autoimmunity, Abnormal circulating interleukin... ORPHA:158061
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Autoimmunity, Recurrent otitis media, Autoimmune hemolytic anemia, Splenomegaly, Increased circul... OMIM:618495
Immunodeficiency 64
Decreased circulating IgG level, Increased circulating IgG level, Hepatosplenomegaly, Increased c... OMIM:618534
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancytopenia, Autoimmunity, Monocytosis, Leukemia, Autoimmune thrombocytopenia, Splenomegaly, Inc... OMIM:614470
Chilblain Lupus
Rheumatoid factor positive, Chronic myelomonocytic leukemia, Antiphospholipid antibody positivity... ORPHA:90280
Persistent Polyclonal B-Cell Lymphocytosis
Decreased circulating total IgM, Lymphocytosis, Splenomegaly OMIM:606445
Insulin Autoimmune Syndrome
Autoimmunity, Autoimmune antibody positivity, Systemic lupus erythematosus, Arthralgia/arthritis,... ORPHA:411593
Immunodeficiency 25
Eosinophilia, Recurrent pneumonia, T lymphocytopenia, Increased circulating IgG level, Antimitoch... OMIM:610163
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Autoimmunity, Recurrent otitis media, Autoimmune thrombocytopenia, Autoimmune hemolytic anemia, S... ORPHA:444463
Immunodeficiency, Common Variable, 1
Decreased circulating IgG level, Recurrent otitis media, Recurrent pneumonia, Pneumonia, Decrease... OMIM:607594
Immunoglobulin A Deficiency 1
Autoimmunity, Decreased circulating IgA level OMIM:137100
Caspase 8 Deficiency
Decreased T cell activation, Decreased circulating total IgM, Decreased circulating IgG level, Pn... OMIM:607271
Autoimmune Lymphoproliferative Syndrome, Type Iia
Rheumatoid factor positive, Autoimmune hemolytic anemia, Iron deficiency anemia, Malar rash, Elev... OMIM:603909
Autoimmune Disease
Autoimmunity, Autoimmune antibody positivity OMIM:109100
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
Pancytopenia, Autoimmunity, Recurrent pneumonia, Thrombocytosis, Megaloblastic anemia, Anemia of ... OMIM:617780
Pulmonary Nodular Lymphoid Hyperplasia, Familial
Rheumatoid arthritis, Antinuclear antibody positivity, Increased circulating antibody level, Syst... OMIM:178610
Immunodeficiency, Common Variable, 2
Decreased circulating IgG level, Recurrent otitis media, Recurrent pneumonia, Autoimmunity, Decre... OMIM:240500
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Reduced n... ORPHA:540
Reticular Dysgenesis
Leukopenia, Lack of T cell function, Congenital agranulocytosis, Impaired T cell function, Hypopl... OMIM:267500
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Decreased circulating IgG level, Reduced antigen-specific T cell proliferation, Decreased circula... ORPHA:331206
Autoimmune Lymphoproliferative Syndrome, Type Iii
Autoimmunity, Recurrent otitis media, Decreased proportion of memory B cells, Hepatosplenomegaly,... OMIM:615559
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Pancytopenia, Splenomegaly, Cutaneous anergy, Decreased helper T cell proportion, Hypersplenism OMIM:183350
Immunodeficiency By Defective Expression Of Mhc Class Ii
Pancytopenia, Sinusitis, Autoimmunity, Sclerosing cholangitis, T lymphocytopenia, Lack of T cell ... ORPHA:572
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Decreased circulating IgG level, Autoimmunity, Decreased proportion of CD3-positive T cells, Hash... ORPHA:275
Sweet Syndrome
Increased circulating interleukin 6 concentration, Sterile abscess, Myositis, Abnormal circulatin... ORPHA:3243
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:70578
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Acute pan... ORPHA:178320
Immunodeficiency 36
Autoimmunity, Splenomegaly, Decreased circulating antibody level, Bronchiectasis, Chronic lymphat... OMIM:616005
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Eosinophilia, T lymphocytopenia, Increased circulating IgG level, Decreased proportion of CD3-pos... ORPHA:169154
Immunodeficiency 81
Reduced antigen-specific T cell proliferation, Impaired neutrophil chemotaxis, Reduced natural ki... OMIM:619374
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Reduced antigen-specific T cell proliferation, Decreased proportion of CD8-positive T cells, Incr... OMIM:617241
Lymphoproliferative Syndrome, X-Linked, 1
Pancytopenia, Decreased circulating IgG level, Reduced natural killer cell activity, Increased ci... OMIM:308240
Immunodeficiency 92
Decreased circulating IgG level, Sclerosing cholangitis, Pneumonia, Leukocytosis, Cholangitis, Th... OMIM:619652
Immunodeficiency 89 And Autoimmunity
Crohn's disease, Increased circulating IgG level, Rheumatoid factor positive, Decreased eosinophi... OMIM:619632
Aregenerative Anemia
Pancytopenia, Bone marrow hypocellularity, Abnormality of interleukin secretion, Decreased propor... ORPHA:101096
Subcorneal Pustular Dermatosis
Autoimmunity, Systemic lupus erythematosus, Rheumatoid arthritis, Increased circulating antibody ... ORPHA:48377
C1Q Deficiency
Membranoproliferative glomerulonephritis, Autoimmunity, Systemic lupus erythematosus OMIM:613652
Autoimmune Lymphoproliferative Syndrome
Decreased circulating IgG level, Autoimmunity, Uveitis, Rheumatoid factor positive, Autoimmune he... ORPHA:3261
Lymphoproliferative Syndrome 1
Pancytopenia, Decreased circulating IgG level, Autoimmunity, Leukopenia, Autoimmune hemolytic ane... OMIM:613011
Psoriasis-Related Juvenile Idiopathic Arthritis
Autoimmunity, Uveitis, Iritis, Abnormality of tumor necrosis factor secretion, Sacroiliac arthrit... ORPHA:85436
Eosinophilopenia
Autoimmunity, Allergic rhinitis, Decreased eosinophil count OMIM:131430
Pgm3-Cdg
Autoimmunity, Decreased proportion of CD3-positive T cells, Rheumatoid factor positive, Decreased... ORPHA:443811
Oligoarticular Juvenile Idiopathic Arthritis
Autoimmunity, Abnormal circulating interleukin concentration, Uveitis, Knee osteoarthritis, Rheum... ORPHA:85410
Igg4-Related Aortitis
Autoimmunity, Hypereosinophilia, Increased circulating IgG4 level, Increased inflammatory respons... ORPHA:449400
Systemic Lupus Erythematosus
Lupus nephritis, Leukopenia, Antiphospholipid antibody positivity, Systemic lupus erythematosus, ... OMIM:152700
Selective Igm Deficiency
Autoimmunity, Decreased proportion of CD3-positive T cells, Hashimoto thyroiditis, Rheumatoid art... ORPHA:331235
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Recurrent otitis media, T lymphocytopenia, Pneumonia, Absent natural killer cells, Abnormality of... OMIM:600802
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Decreased circulating IgG level, Recurrent pneumonia, Decreased circulating total IgM, T lymphocy... ORPHA:35078
Combined Immunodeficiency Due To Partial Rag1 Deficiency
Autoimmunity, T lymphocytopenia, Autoimmune hemolytic anemia, Interstitial pneumonitis, Splenomeg... ORPHA:231154
X-Linked Lymphoproliferative Disease
Pancytopenia, Decreased circulating IgG level, Autoimmunity, Absent natural killer cells, Histioc... ORPHA:2442
Thymoma
Autoimmunity, Myositis, Abnormal lymphocyte proliferation, Leukemia, Abnormal lymphocyte physiolo... ORPHA:99867
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Abnormali... ORPHA:542323
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Autoimmunity, Hepatosplenomegaly, Autoimmune hemolytic anemia, Interstitial pneumonitis, Autoimmu... OMIM:615952
X-Linked Agammaglobulinemia
Sinusitis, Recurrent pneumonia, Autoimmunity, Agammaglobulinemia, Arthritis, Thrombocytopenia, Ne... ORPHA:47
Unclassified Myelodysplastic Syndrome
Autoimmunity, Acute myeloid leukemia, Leukocytosis, Bone marrow hypocellularity ORPHA:98827
Iga Pemphigus
Neutrophilic infiltration of the skin, Eosinophilia, Cutaneous abscess, Autoimmune antibody posit... ORPHA:555905
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Decreased circulating IgG level, Recurrent otitis media, Viral hepatitis, Autoimmunity, Cholangit... ORPHA:183675
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Autoimmunity, Leukocytosis, Agammaglobulinemia, Interface hepatitis, Thrombocytosis, Autoimmune h... OMIM:243150
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Sclerosing cholangitis, Increased circulating IgG level, Antimitochondrial antibody positivity, I... ORPHA:562639
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Autoimmunity, Autoimmune hemolytic anemia, Insulin receptor antibody positivity, Membranous nephr... ORPHA:37042
Autoimmune Polyendocrinopathy Type 4
Autoimmunity, Aplasia/Hypoplasia of the spleen, Leukopenia, Autoimmune antibody positivity, Autoi... ORPHA:227990
Idiopathic Chronic Eosinophilic Pneumonia
Autoimmunity, Hypereosinophilia, Leukocytosis, Atopic dermatitis, Increased circulating IgE level ORPHA:2902
Thymic Tumor
Dysgammaglobulinemia, Autoimmunity, Pericarditis ORPHA:100100
Autoimmune Polyendocrinopathy Type 3
Autoimmunity, Aplasia/Hypoplasia of the spleen, Leukopenia, Autoimmune antibody positivity, Hashi... ORPHA:227982
Immunodeficiency 22
Autoimmunity, Panniculitis, Decreased proportion of CD4-positive helper T cells OMIM:615758
Wiskott-Aldrich Syndrome, Autosomal Dominant
Decreased mean platelet volume, Sinusitis, Decreased circulating total IgM, Pneumonia, Increased ... OMIM:600903
Thymic Aplasia
Sinusitis, Autoimmunity, T lymphocytopenia, Pneumonia, Coombs-positive hemolytic anemia, Decrease... ORPHA:83471
Wiskott-Aldrich Syndrome
Decreased mean platelet volume, Decreased circulating total IgM, Recurrent otitis media, Recurren... OMIM:301000
Gamma-Heavy Chain Disease
Autoimmunity, Abnormal lymphocyte morphology, Autoimmune hemolytic anemia, Autoimmune thrombocyto... ORPHA:100026
Pemphigus Erythematosus
Autoimmunity, Systemic lupus erythematosus, Malar rash, Anti-acetylcholine receptor antibody posi... ORPHA:79480
Igg4-Related Thyroid Disease
Autoimmunity, Sclerosing cholangitis, Hashimoto thyroiditis, Increased circulating IgG4 level, An... ORPHA:64744
T-Cell Lymphoma, Subcutaneous Panniculitis-Like
Pancytopenia, Autoimmunity, Hemophagocytosis, Splenomegaly, Anemia, Panniculitis OMIM:618398
Sjogren Syndrome
Rheumatoid arthritis, Keratoconjunctivitis sicca, Autoimmunity, Tubulointerstitial nephritis OMIM:270150
Infection-Related Hemolytic Uremic Syndrome
Increased circulating interleukin 6 concentration, Pneumonia, Leukocytosis, Myocarditis, Acute co... ORPHA:544482
Igg4-Related Submandibular Gland Disease
Autoimmunity, Eosinophilia, Increased circulating IgG level, Cholangitis, Increased circulating I... ORPHA:449432
Igg4-Related Dacryoadenitis And Sialadenitis
Autoimmunity, Myositis, Increased circulating IgM level, Increased circulating IgA level, Increas... ORPHA:79078
Parenteral Nutrition-Associated Cholestasis
Splenomegaly, Abnormality of cytokine secretion ORPHA:567983
Ectodermal Dysplasia And Immunodeficiency 2
Defective production of NFKB1-dependent cytokines OMIM:612132
Sarcoidosis
Eosinophilia, Uveitis, Erythema nodosum, Leukopenia, Parotitis, Increased T cell count, Maculopap... ORPHA:797

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dusp10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dusp10.

No publications found that use IMPC mice or data for Dusp10.

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MGI Allele Allele Type Produced
Dusp10tm371808(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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