Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

placental specific protein 1
Epcs26,  DXWsu72e,  Oosp2l

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plac1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Plac1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254534
Placental Insufficiency
Eclampsia, Preeclampsia, Intrauterine growth retardation, Maternal hypertension, Spontaneous abor... ORPHA:439167
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Intrauterine growth retardation, Large placenta, Umbilical hernia, Polyhydramnios ORPHA:254528
Kagami-Ogata Syndrome
Premature birth, Large placenta, Polyhydramnios ORPHA:254519
Mosaic Trisomy 16
Maternal diabetes, Preeclampsia, Intrauterine growth retardation, Premature birth, Single umbilic... ORPHA:1708
Trichohepatoenteric Syndrome 1
Abnormalities of placenta or umbilical cord, Intrauterine growth retardation, Large placenta, Pol... OMIM:222470
Meckel Syndrome, Type 1
Intrauterine growth retardation, Breech presentation, Single umbilical artery, Oligohydramnios, L... OMIM:249000
Restrictive Dermopathy
Short umbilical cord, Premature delivery because of cervical insufficiency or membrane fragility,... ORPHA:1662
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Severe intrauterine growth retardation, Intrauterine growth retardation, Small placenta ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Oligohydramnios, Intrauterine growth retardation, Small placenta ORPHA:397590
Restrictive Dermopathy 1
Short umbilical cord, Premature rupture of membranes, Intrauterine growth retardation, Premature ... OMIM:275210
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Intrauterine growth retardation, Premature birth, Spontaneous abortion, Polyhydramnios, Spinal dy... ORPHA:96334
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Premature birth, Polyhydramnios, Large placenta, Umbilical hernia ORPHA:116
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Intrauterine growth retardation, Fetal akinesia sequence, Premature birth, ... OMIM:208150
Neu-Laxova Syndrome 1
Short umbilical cord, Intrauterine growth retardation, Decreased fetal movement, Polyhydramnios, ... OMIM:256520


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plac1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plac1.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Plac1 (placenta-specific 1) is widely expressed during fetal development and is associated with a lethal form of hydrocephalus. Birth defects research. Part A, Clinical and molecular teratology (September 2013) Plac1tm1(KOMP)Vlcg 24014101
Plac1 (placenta-specific 1) is essential for normal placental and embryonic development. Molecular reproduction and development (July 2012) Plac1tm1(KOMP)Vlcg PMC4594876

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MGI Allele Allele Type Produced
Plac1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Plac1tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Plac1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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