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Gene: Tnip1

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Name
TNFAIP3 interacting protein 1
MGI ID
MGI:1926194
Synonyms
A20-binding inhibitor of NF-kappa B activation ABIN1 VAN Nef
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (22) Measurements chart (146) All data table (332)
Expression & images (67) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating HDL cholesterol level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 3.38×10-13
increased mean platelet volume Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.67×10-10
increased circulating alkaline phosphatase level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 5.30×10-19
decreased lymphocyte cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.05×10-13
increased circulating aspartate transaminase level Tnip1tm1b(EUCOMM)Hmgu HOM   Early adult 2.03×10-05
decreased circulating triglyceride level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 4.90×10-05
decreased hemoglobin content Tnip1tm1b(EUCOMM)Hmgu HOM   Early adult 2.20×10-05
increased monocyte cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.01×10-14
decreased circulating serum albumin level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 2.58×10-12
increased large unstained cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 6.78×10-06
decreased circulating glucose level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.09×10-05
increased spleen weight Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.59×10-18
decreased hematocrit Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 7.59×10-15
decreased circulating cholesterol level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.19×10-12
decreased erythrocyte cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 6.33×10-17
increased circulating potassium level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 8.50×10-06
increased basophil cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 4.70×10-05
decreased circulating fructosamine level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 7.51×10-21
increased red blood cell distribution width Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.95×10-19
thrombocytopenia Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.50×10-17
decreased circulating iron level Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 1.66×10-12
increased neutrophil cell number Tnip1tm1b(EUCOMM)Hmgu HOM Early adult 4.30×10-08

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583) N/A
Aorta 2 No  (1/583) N/A
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583) N/A
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583)  (2/2)  Wholemount images
Esophagus 2 No  (7/407) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583)  (2/2)  Wholemount images
Lymph node 2 No  (1/583)  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/583)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/583) N/A
Parathyroid gland 2 No  (1/563)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/583) N/A
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583)  (2/2)  Wholemount images
Small intestine 2 No  (9/583)  (2/2)  Wholemount images
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583)  (2/2)  Wholemount images
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583)  (2/2)  Wholemount images
Thyroid gland 2 No  (17/583)  (1/2)  Wholemount images
Trachea 2 No  (3/583) N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
MA:0000072
digestive system (4)
Large Intestine expression
MA:0000333
endocrine system (1)
Thyroid gland expression
Parathyroid gland expression
MA:0000128
MA:0000129
immune system (3)
Lymph Node expression
MA:0000139
integumental system (1)
Skin expression
MA:0000151
nervous system (4)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (19)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
reproductive system (2)
Ovary expression
Oviduct expression
Uterus expression
MA:0000384
MA:0000389
MA:0000385
respiratory system (2)
Lung expression
MA:0000415
trunk (10)
Heart expression
MA:0000072
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
1  (6/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/506) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (5/505) Image Only N/A
1  (1/505) Image Only N/A
1  (6/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/503) Image Only N/A
1  (1/503) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/503) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A
1  (1/505) Image Only N/A

 Associated Images

thumbnail
Adult LacZ: LacZ Images Wholemount
19 Images
thumbnail
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tnip1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tnip1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Tnip1tm33632(L1L2_gt1) Targeting vectors
Tnip1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells