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Gene: Igsf3 MGI:1926158

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
immunoglobulin superfamily, member 3
Synonyms:
4833439O17Rik,  1700016K10Rik,  2810035F16Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Igsf3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Igsf3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lacrimal Duct Defect
OMIM:149700

The table below shows human diseases predicted to be associated to Igsf3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Diarrhea 5, With Tufting Enteropathy, Congenital
Villous atrophy, Crypt hyperplasia OMIM:613217
Diarrhea 2, With Microvillus Atrophy, With Or Without Cholestasis
Abnormal intestine morphology, Villous atrophy OMIM:251850
Diarrhea 9
Villous atrophy OMIM:618168
Diarrhea 11, Malabsorptive, Congenital
Villous atrophy OMIM:618662
Diarrhea 12, With Microvillus Atrophy
Villous atrophy, Microvillus inclusions, Microvillar PAS-positive secretory granules OMIM:619445
Lactose Intolerance, Adult Type
Decreased small intestinal mucosa lactase level OMIM:223100
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Diarrhea 7, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Villous atrophy OMIM:615863
Chronic Diarrhea Due To Glucoamylase Deficiency
Abnormal small intestinal mucosa morphology, Decreased small intestinal mucosa lactase level ORPHA:103907
Secondary Short Bowel Syndrome
Volvulus, Villous atrophy, Abnormal small intestine morphology, Aganglionic megacolon, Small inte... ORPHA:95427
Aganglionosis, Total Intestinal
Total intestinal aganglionosis OMIM:202550
Congenital Tufting Enteropathy
Optic disc coloboma, Abnormal large intestinal mucosa morphology, Villous atrophy, Abnormal small... ORPHA:92050
Congenital Disorder Of Glycosylation, Type Id
Bifid uvula, Joint contracture of the hand, Optic atrophy, Villous atrophy, High palate, Flexion ... OMIM:601110
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis OMIM:614328
Microvillus Inclusion Disease
Villous atrophy, Abnormal small intestinal villus morphology ORPHA:2290
Hirschsprung Disease, Susceptibility To, 3
Aganglionic megacolon, Total colonic aganglionosis, Long-segment aganglionic megacolon OMIM:613711
Lactase Deficiency, Congenital
Decreased small intestinal mucosa lactase level OMIM:223000
Chylomicron Retention Disease
Steatorrhea, Accumulation of lipid droplets in small-bowel enterocytes OMIM:246700
Autoinflammation With Infantile Enterocolitis
Villous atrophy, Enterocolitis OMIM:616050
Hirschsprung Disease, Susceptibility To, 1
Aganglionic megacolon, Abnormal enteric ganglion morphology, Enterocolitis OMIM:142623
Inflammatory Bowel Disease (Crohn Disease) 30
Protein-losing enteropathy, Esophagitis, Pancolitis, Ileitis, Abnormal intestine morphology, Gast... OMIM:619079
Congenital Disorder Of Glycosylation, Type Ib
Steatorrhea, Protein-losing enteropathy, Villous atrophy OMIM:602579
Trichohepatoenteric Syndrome 2
Colitis, Villous atrophy OMIM:614602
Proprotein Convertase 1/3 Deficiency
Villous atrophy OMIM:600955
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Volvulus, Intestinal pseudo-obstruction, Intestinal m... OMIM:619350
Netherton Syndrome
Recurrent infection of the gastrointestinal tract, Villous atrophy, Intestinal atresia OMIM:256500
Refractory Celiac Disease
Protein-losing enteropathy, Villous atrophy, Jejunitis ORPHA:398063
Primary Intestinal Lymphangiectasia
Intestinal lymphangiectasia, Increased stool alpha1-antitrypsin concentration, Functional abnorma... ORPHA:90362
Congenital Disorder Of Glycosylation, Type Il
Villous atrophy OMIM:608776
Immunodeficiency 85 And Autoimmunity
Villous atrophy OMIM:619510
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Jejunoileal ulceration, Small bowel diverticula OMIM:221400
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Villous atrophy, Ileus OMIM:304790
Mhc Class Ii Deficiency 1
Colitis, Villous atrophy OMIM:209920
Immunodeficiency, Common Variable, 8, With Autoimmunity
Atrophic gastritis, Colitis, Inflammation of the large intestine, Villous atrophy OMIM:614700
Congenital Short Bowel Syndrome
Congenital shortened small intestine, Decreased intestinal transit time, Intestinal malrotation, ... OMIM:615237
Mungan Syndrome
Barrett esophagus, Intestinal pseudo-obstruction, Abnormality of the autonomic nervous system, Me... OMIM:611376
Osteootohepatoenteric Syndrome
Increased intestinal transit time, Villous atrophy, Ileoileal intussusception OMIM:619377
Immunodeficiency 31C
Protein-losing enteropathy, Skeletal muscle atrophy, Villous atrophy, Gastrointestinal eosinophil... OMIM:614162
Congenital Disorder Of Glycosylation, Type Ia
Steatorrhea, Flexion contracture, Villous atrophy OMIM:212065
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Villous atrophy OMIM:606367
Pancreatic Lipase Deficiency
Steatorrhea, Fat malabsorption OMIM:614338
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Protein-losing enteropathy OMIM:619063
Alpha-Heavy Chain Disease
Abnormal small intestine morphology ORPHA:100025
Trichohepatoenteric Syndrome 1
Large placenta, Bifid uvula, Villous atrophy OMIM:222470
Alg9-Cdg
Bifid uvula, Hypoplasia of the musculature, Gastroesophageal reflux, Villous atrophy, Torticollis ORPHA:79328
Agammaglobulinemia 4, Autosomal Recessive
Protein-losing enteropathy OMIM:613502
Immunodeficiency 87 And Autoimmunity
Atrophic gastritis, Villous atrophy, Perianal dermatitis, Increased fecal calprotectin level, Nec... OMIM:619573
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal malrotation, Congenital shortened small intestine, Intestinal pseudo-obstruction, Pylo... OMIM:300048
Syndromic Diarrhea
Colitis, Hepatoblastoma, Villous atrophy, Gastritis ORPHA:84064
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Abnormal intestine morphology, Esophageal carcinoma, Villous atrophy, Enterocolitis ORPHA:391487
Vascular Hyalinosis
Protein-losing enteropathy, Hematochezia OMIM:277175
Pearson Marrow-Pancreas Syndrome
Steatorrhea, Villous atrophy OMIM:557000
Parenteral Nutrition-Associated Cholestasis
Villous atrophy ORPHA:567983
Visceral Myopathy 1
Microcolon, Intestinal pseudo-obstruction, Megaduodenum, Thinning of outer muscular layer of smal... OMIM:155310
Immunodeficiency 82 With Systemic Inflammation
Anoperineal fistula, Villous atrophy, Crohn's disease, Gastritis, Colitis, Duodenal ulcer OMIM:619381
Eosinophilic Gastroenteritis
Protein-losing enteropathy, Hematochezia, Abnormality of the gastrointestinal tract, Steatorrhea,... ORPHA:2070
Congenital Enterocyte Heparan Sulfate Deficiency
Protein-losing enteropathy, Hematochezia ORPHA:103910
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Protein-losing enteropathy, Hematochezia, Gastrointestinal carcinoma, Xerostomia, Glossitis, Hama... OMIM:175500
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Systemic Sclerosis
Barrett esophagus, Intestinal bleeding, Abnormal large intestine morphology, Gastroesophageal ref... ORPHA:90291
Juvenile Polyposis Of Infancy
High, narrow palate, Protein-losing enteropathy, Intestinal bleeding, Gastrointestinal hemorrhage... ORPHA:79076
Metachromatic Leukodystrophy
Abnormal stomach morphology, Decreased nerve conduction velocity, Abnormal duodenum morphology, N... ORPHA:512
Juvenile Polyposis Syndrome
Rectocele, Gastrointestinal hemorrhage, Protein-losing enteropathy, Hematochezia, Colon cancer, S... ORPHA:2929
Whim Syndrome
Abnormal small intestine morphology, Parotitis ORPHA:51636
Fraser Syndrome 1
Abnormal cortical gyration, Myelomeningocele, Abnormal small intestine morphology, Encephalocele,... OMIM:219000
Lacrimal Duct Defect
OMIM:149700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Igsf3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Igsf3.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Igsf3em1(IMPC)Wtsi PMC7263671

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MGI Allele Allele Type Produced
Igsf3tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Igsf3em1(IMPC)Wtsi Exon Deletion Mice

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