Gene: Crispld2

Name
cysteine-rich secretory protein LCCL domain containing 2
MGI ID
MGI:1926142
Synonyms
coffeecrisp 1810049K24Rik Lgl1
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Crispld2tm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal embryo size Crispld2tm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal heart morphology Crispld2tm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
decreased circulating triglyceride level Crispld2tm1.1(KOMP)Vlcg HET postnatal 9.54×10-06
increased circulating alanine transaminase level Crispld2tm1.1(KOMP)Vlcg HET postnatal 8.01×10-07
prenatal lethality prior to heart atrial septation Crispld2tm1.1(KOMP)Vlcg HOM embryonic day 14.5 0.00
decreased bone mineral density Crispld2tm1.1(KOMP)Vlcg HET postnatal 9.54×10-05

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 1 No  (1/1)  Section images
Brain 2 No  (1/2) N/A
Brainstem 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No N/A
Heart 2 No  (1/2)  Section images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2)  Section images
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Section images
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Tongue 1 No  (5/127)  (1/1) N/A
Trachea 2 No  (2/2)  Section images
Uterus 2 No  (1/2) N/A
Vascular system 2 No  (2/2)  Section images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 0  (1/51) N/A
Brain 0  (6/485) N/A
Central nervous system ganglion 0  (1/51)  (1/1) N/A
Ear 0  (1/485) N/A
Embryo 0  (1/485)  (1/1) N/A
Eye 0  (1/485)  (1/1) N/A
Foot 0  (1/485)  (1/1) N/A
Forebrain 0  (1/485) N/A
Forelimb 0  (1/485)  (1/1) N/A
Gut 0  (1/50)  (1/1) N/A
Hand 0  (1/485) N/A
Head 0  (5/485) N/A
Heart 0  (1/485) N/A
Hindbrain 0  (6/485) N/A
Hindlimb 0  (1/485)  (1/1) N/A
Liver 0  (1/485)  (1/1) N/A
Lung 0  (1/485) N/A
Mandibular process 0  (1/485) N/A
Maxillary process 0  (1/485) N/A
Midbrain 0  (1/485) N/A
Nose 0  (1/51)  (1/1) N/A
Oral cavity 0  (1/485) N/A
Skeleton 0  (1/51) N/A
Skin 0  (1/485) N/A
Spinal cord 0  (1/50) N/A
Tail 0  (1/485) N/A
Tail somite 0  (1/485)  (1/1) N/A
Trachea 0  (1/50)  (1/1) N/A
Urinary system 0  (1/50)  (1/1) N/A

 Associated Images

Histopathology
1 Images
Gross Morphology Embryo E9.5
1 Images
Eye Morphology: Images Ophthalmoscopy
7 Images
Adult LacZ: LacZ Images Section
16 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Dorso Ventral
11 Images
X-ray: XRay Images Lateral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
Eye Morphology: Images Slit Lamp
2 Images
Gross Pathology and Tissue Collection
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Crispld2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Crispld2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Crispld2tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Crispld2tm43718(L1L2_st0) Targeting vectors

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