Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
RPTOR independent companion of MTOR, complex 2
Synonyms:
6030405M08Rik,  D530039E11Rik,  4921505C17Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rictor mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rictor by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nuchal Bleb, Familial
Hydrops fetalis, Stillbirth, Fetal cystic hygroma OMIM:257350
Hydrops Fetalis, Nonimmune
Hydrops fetalis, Nonimmune hydrops fetalis OMIM:236750
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pleural effusion, Generalized edema, Stillbirth, Peric... OMIM:618773
Hydrops Fetalis, Nonimmune, With Gracile Bones And Dysmorphism
Polyhydramnios, Hydrops fetalis, Nonimmune hydrops fetalis OMIM:613124
Fetal Parvovirus Syndrome
Hydrops fetalis, Increased nuchal translucency, Ascites ORPHA:295
Placental Insufficiency
Preeclampsia, Small placenta, Eclampsia, Abnormal umbilical cord blood vessel morphology, Abnorma... ORPHA:439167
Lymphatic Malformation 12
Fetal pericardial effusion, Nonimmune hydrops fetalis, Neonatal death, Polyhydramnios, Lymphedema... OMIM:620014
Achondrogenesis, Type Ib
Hydrops fetalis, Polyhydramnios, Edema, Umbilical hernia, Stillbirth, Breech presentation OMIM:600972
Chondrodysplasia, Blomstrand Type
Polyhydramnios, Hydrops fetalis, Stillbirth, Premature birth OMIM:215045
Indomethacin Embryofetopathy
Oligohydramnios, Hydrops fetalis, Premature birth ORPHA:1909
Developmental And Epileptic Encephalopathy 96
Hydrops fetalis OMIM:619340
Ulnar Agenesis And Endocardial Fibroelastosis
Hydrops fetalis, Neonatal death OMIM:276822
Hydrops Fetalis
Nonimmune hydrops fetalis, Polyhydramnios, Twin-to-twin transfusion, Increased placental thicknes... ORPHA:1041
Dysplastic Cortical Hyperostosis
Polyhydramnios, Hydrops fetalis ORPHA:2204
Cardiomyopathy, Familial Restrictive, 6
Hydrops fetalis, Ascites OMIM:619433
Diffuse Neonatal Hemangiomatosis
Polyhydramnios, Hydrops fetalis, Premature birth, Ascites ORPHA:2123
Achondrogenesis
Thickened nuchal skin fold, Polyhydramnios, Hydrops fetalis, Umbilical hernia ORPHA:932
Lymphatic Malformation 7
Facial edema, Pulmonary edema, Nonimmune hydrops fetalis, Lymphedema, Edema, Pericardial effusion OMIM:617300
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Polyhydramnios, Hydrops fetalis, Single umbilical artery ORPHA:3405
Sialidosis Type 2
Ascites, Hydrops fetalis, Pedal edema, Umbilical hernia ORPHA:87876
Hb Bart'S Hydrops Fetalis
Oligohydramnios, Polyhydramnios, Preeclampsia, Hydrops fetalis ORPHA:163596
Achondrogenesis Type 1B
Thickened nuchal skin fold, Polyhydramnios, Hydrops fetalis, Umbilical hernia ORPHA:93298
Idiopathic Neonatal Atrial Flutter
Hydrops fetalis, Maternal diabetes, Fetal distress ORPHA:45452
Achondrogenesis Type 1A
Thickened nuchal skin fold, Polyhydramnios, Hydrops fetalis, Umbilical hernia ORPHA:93299
Glycogen Storage Disease Iv
Hydrops fetalis, Polyhydramnios, Edema, Ascites, Decreased fetal movement OMIM:232500
Long Qt Syndrome 3
Hydrops fetalis, Nonimmune hydrops fetalis OMIM:603830
Congenital Disorder Of Glycosylation, Type Ik
Nonimmune hydrops fetalis, Abnormality of the amniotic fluid OMIM:608540
Mitochondrial Complex I Deficiency, Nuclear Type 35
Nonimmune hydrops fetalis, Neonatal death OMIM:619003
Chromosome 1P36.33 Duplication Syndrome, Atad3 Gene Cluster, Autosomal Dominant
Hydrops fetalis, Fetal akinesia sequence OMIM:618815
Congenital Pulmonary Lymphangiectasia
Hydrops fetalis, Ascites, Pleural effusion, Chylopericardium ORPHA:2414
Fetal Gaucher Disease
Hydrops fetalis, Neonatal death, Stillbirth, Fetal akinesia sequence, Decreased fetal movement ORPHA:85212
Achondrogenesis, Type Ii
Polyhydramnios, Hydrops fetalis, Stillbirth, Edema OMIM:200610
Lymphatic Malformation 1
Hyperkeratosis over edematous areas, Predominantly lower limb lymphedema, Nonimmune hydrops fetalis OMIM:153100
Transaldolase Deficiency
Hydrops fetalis, Edema ORPHA:101028
Boomerang Dysplasia
Polyhydramnios, Hydrops fetalis ORPHA:1263
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Predominantly lower limb lymphedema, Palpebral edema, Hydrops fetalis, Pleural effusion, Ascites ORPHA:69735
Infantile Sialic Acid Storage Disease
Hydrops fetalis, Premature birth, Ascites OMIM:269920
Lymphangiectasia, Pulmonary, Congenital
Facial edema, Chylothorax, Chylous ascites, Palpebral edema, Nonimmune hydrops fetalis, Polyhydra... OMIM:265300
Silver-Russell Syndrome Due To A Point Mutation
Small placenta, Oligohydramnios ORPHA:397590
Combined Oxidative Phosphorylation Defect Type 27
Nonimmune hydrops fetalis ORPHA:477774
Minicore Myopathy With External Ophthalmoplegia
Polyhydramnios, Hydrops fetalis, Decreased fetal movement OMIM:255320
Hemochromatosis, Neonatal
Oligohydramnios, Nonimmune hydrops fetalis OMIM:231100
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small placenta ORPHA:73272
Alpha-Thalassemia
Hydrops fetalis ORPHA:846
Congenital Enterovirus Infection
Hydrops fetalis, Polyhydramnios, Pericardial effusion, Pleural effusion, Fetal ascites, Fetal dis... ORPHA:292
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Umbilical hernia, Large placenta ORPHA:254534
Free Sialic Acid Storage Disease
Hydrops fetalis, Ascites ORPHA:834
Neuraminidase Deficiency
Hydrops fetalis, Facial edema, Ascites OMIM:256550
Hypotrichosis-Lymphedema-Telangiectasia Syndrome
Predominantly lower limb lymphedema, Palpebral edema, Nonimmune hydrops fetalis OMIM:607823
Mulibrey Nanism
Hydrops fetalis, Ascites OMIM:253250
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Hydrops fetalis ORPHA:766
Lymphedema, Cardiac Septal Defects, And Characteristic Facies
Oligohydramnios, Hydrops fetalis, Lymphedema OMIM:601927
Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 2
Hydrops fetalis OMIM:616738
Klippel-Trénaunay Syndrome
Hydrops fetalis, Ascites, Edema ORPHA:90308
Lymphatic Malformation 6
Facial edema, Chylothorax, Genital edema, Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, ... OMIM:616843
Combined Oxidative Phosphorylation Deficiency 41
Nonimmune hydrops fetalis, Premature birth OMIM:618838
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Hydrops fetalis, Polyhydramnios, Pleural effusion, Ascites, Single umbilical artery OMIM:616897
Combined Oxidative Phosphorylation Deficiency 40
Neonatal death, Nonimmune hydrops fetalis, Premature birth OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Neonatal death, Nonimmune hydrops fetalis, Premature birth OMIM:618839
Alg8-Cdg
Hydrops fetalis, Edema, Oligohydramnios, Premature birth, Ascites ORPHA:79325
Mucopolysaccharidosis Type 7
Hydrops fetalis, Ascites, Lymphedema, Umbilical hernia ORPHA:584
Platyspondylic Dysplasia, Torrance Type
Polyhydramnios, Hydrops fetalis ORPHA:85166
Schneckenbecken Dysplasia
Polyhydramnios, Stillbirth, Nonimmune hydrops fetalis, Umbilical hernia OMIM:269250
Lethal Congenital Contracture Syndrome 10
Oligohydramnios, Hydrops fetalis, Fetal akinesia sequence OMIM:617022
Trisomy 1Q
Polyhydramnios, Hydrops fetalis, Increased nuchal translucency ORPHA:261344
Fetal Akinesia Deformation Sequence 1
Short umbilical cord, Premature birth, Small placenta, Polyhydramnios, Stillbirth, Fetal akinesia... OMIM:208150
Trisomy 13
Hydrops fetalis ORPHA:3378
Campomelia, Cumming Type
Oligohydramnios, Hydrops fetalis, Lymphedema ORPHA:1318
Dyssegmental Dysplasia, Silverman-Handmaker Type
Increased placental thickness, Encephalocele, Hydrops fetalis, Single umbilical artery ORPHA:1865
Achondrogenesis, Type Ia
Hydrops fetalis, Absence of stomach bubble on fetal sonography, Polyhydramnios, Stillbirth, Incre... OMIM:200600
Cholestasis, Progressive Familial Intrahepatic, 5
Ascites, Nonimmune hydrops fetalis, Pleural effusion OMIM:617049
Mitochondrial Trifunctional Protein Deficiency
Prenatal maternal abnormality, Hydrops fetalis, Abnormality of the amniotic fluid OMIM:609015
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Polyhydramnios, Ascites, Nonimmune hydrops fetalis, Fetal akinesia sequence ORPHA:367
Cardiac Valvular Dysplasia 1
Hydrops fetalis, Edema OMIM:212093
Neu-Laxova Syndrome 1
Short umbilical cord, Hydranencephaly, Small placenta, Polyhydramnios, Generalized edema, Spina b... OMIM:256520
Greenberg Dysplasia
Echogenic fetal bowel, Hydrops fetalis, Nonimmune hydrops fetalis, Neonatal death, Polyhydramnios... OMIM:215140
Gaucher Disease, Perinatal Lethal
Nonimmune hydrops fetalis, Neonatal death, Polyhydramnios, Desquamation of skin soon after birth,... OMIM:608013
Osteogenesis Imperfecta, Type Ii
Nonimmune hydrops fetalis, Premature birth OMIM:166210
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hydrops fetalis, Polyhydramnios, Edema, Fetal polyuria, Premature birth OMIM:602522
Galactosialidosis
Nonimmune hydrops fetalis OMIM:256540
Mosaic Trisomy 9
Hydrops fetalis, Polyhydramnios, Oligohydramnios, Single umbilical artery, Spina bifida ORPHA:99776
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Hydrops fetalis, Ascites OMIM:614091
Cardiomyopathy, Familial Hypertrophic 27
Nonimmune hydrops fetalis OMIM:618052
Fraser Syndrome 3
Hydrops fetalis OMIM:617667
Gm1 Gangliosidosis
Hydrops fetalis, Premature birth ORPHA:354
Fibrochondrogenesis 1
Hydrops fetalis, Stillbirth OMIM:228520
Mucopolysaccharidosis, Type Vii
Hydrops fetalis, Umbilical hernia OMIM:253220
S-Adenosylhomocysteine Hydrolase Deficiency
Hydrops fetalis ORPHA:88618
Gm1-Gangliosidosis, Type I
Hydrops fetalis OMIM:230500
Restrictive Dermopathy
Short umbilical cord, Small placenta, Polyhydramnios, Premature delivery because of cervical insu... ORPHA:1662
Farber Disease
Joint swelling, Hydrops fetalis, Ascites ORPHA:333
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Nonimmune hydrops fetalis, Pericardial effusion OMIM:619313
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polyhydramnios, Hydrops fetalis, Anencephaly OMIM:616546
Pyruvate Kinase Deficiency Of Red Cells
Nonimmune hydrops fetalis OMIM:266200
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Polyhydramnios, Umbilical hernia, Large placenta ORPHA:254528
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Palpebral edema, Lymphedema, Nonimmune hydrops fetalis OMIM:137940
Anemia, Congenital Dyserythropoietic, Type Ia
Hydrops fetalis OMIM:224120
Gm1 Gangliosidosis Type 1
Abnormal placenta morphology, Hydrops fetalis ORPHA:79255
Hereditary Elliptocytosis
Hydrops fetalis ORPHA:288
Congenital Disorder Of Glycosylation, Type Ia
Edema, Nonimmune hydrops fetalis, Pericardial effusion, Abnormality of the amniotic fluid OMIM:212065
Alg9-Cdg
Thickened nuchal skin fold, Hydrops fetalis, Oligohydramnios, Pericardial effusion, Decreased fet... ORPHA:79328
Multiple Pterygium Syndrome, Escobar Variant
Hydrops fetalis, Umbilical hernia, Decreased fetal movement OMIM:265000
Kagami-Ogata Syndrome
Polyhydramnios, Premature birth, Large placenta ORPHA:254519
Mgat2-Cdg
Hydrops fetalis ORPHA:79329
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Hydrops fetalis, Bilateral fetal pyelectasis, Polyhydramnios, Fetal distress, Breech presentation OMIM:300868
Mosaic Trisomy 16
Single umbilical artery, Preeclampsia, Maternal diabetes, Premature birth, Large placenta ORPHA:1708
Blomstrand Lethal Chondrodysplasia
Polyhydramnios, Hydrops fetalis, Premature birth ORPHA:50945
Hennekam Syndrome
Chylothorax, Hydrops fetalis, Lymphedema, Ascites, Pericardial effusion ORPHA:2136
Anemia, Congenital Dyserythropoietic, Type Iv
Hydrops fetalis OMIM:613673
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Dehydration, Hydrops fetalis ORPHA:79282
Capillary Malformation-Arteriovenous Malformation
Lymphedema, Nonimmune hydrops fetalis, Chylothorax ORPHA:137667
Phocomelia, Schinzel Type
Hydrops fetalis, Meningocele ORPHA:2879
Trichohepatoenteric Syndrome 1
Abnormalities of placenta or umbilical cord, Polyhydramnios, Large placenta OMIM:222470
Mycophenolate Mofetil Embryopathy
Hydrops fetalis ORPHA:268249
Gaucher Disease Type 3
Hydrops fetalis, Pericardial effusion ORPHA:77261
Pearson Marrow-Pancreas Syndrome
Dehydration, Hydrops fetalis OMIM:557000
Restrictive Dermopathy 1
Premature rupture of membranes, Short umbilical cord, Neonatal death, Spontaneous chorioamniotic ... OMIM:275210
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Hydrops fetalis OMIM:263520
Cranioectodermal Dysplasia 2
Polyhydramnios, Hydrops fetalis OMIM:613610
Pearson Syndrome
Corneal stromal edema, Dehydration, Hydrops fetalis ORPHA:699
Autoimmune Lymphoproliferative Syndrome
Hydrops fetalis ORPHA:3261
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Thickened nuchal skin fold, Nonimmune hydrops fetalis, Neonatal death, Polyhydramnios, Pleural ef... OMIM:265380
Meckel Syndrome, Type 1
Anencephaly, Large placenta, Oligohydramnios, Occipital encephalocele, Single umbilical artery, B... OMIM:249000
Niemann-Pick Disease Type C
Fetal ascites, Hydrops fetalis, Ascites ORPHA:646
Hepatoerythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid ORPHA:95159
Yunis-Varon Syndrome
Increased nuchal translucency, Polyhydramnios, Hydrops fetalis, Arrhinencephaly ORPHA:3472
Gaucher Disease
Hydrops fetalis ORPHA:355
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Polyhydramnios, Umbilical hernia, Premature birth, Large placenta ORPHA:116
Generalized Arterial Calcification Of Infancy
Recurrent spontaneous abortion, Hydrops fetalis, Polyhydramnios, Edema, Fetal distress, Pericardi... ORPHA:51608
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Polyhydramnios, Spinal dysraphism, Premature birth, Large placenta ORPHA:96334
Congenital Erythropoietic Porphyria
Edema, Nonimmune hydrops fetalis, Abnormality of the amniotic fluid ORPHA:79277
Blackfan-Diamond Anemia
Nonimmune hydrops fetalis ORPHA:124
Yunis-Varon Syndrome
Polyhydramnios, Hydrops fetalis, Premature birth, Arrhinencephaly OMIM:216340
Short Rib-Polydactyly Syndrome, Verma-Naumoff Type
Hydrops fetalis ORPHA:93271

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rictor

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rictor.

No publications found that use IMPC mice or data for Rictor.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Rictortm1aNarl KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter