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Gene: Bola3 MGI:1925903

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Gene Summary

Name:
bolA family member 3
Synonyms:
1810056O20Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bola3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bola3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
OMIM:614299

The table below shows human diseases predicted to be associated to Bola3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
OMIM:614299

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bola3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bola3.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Bola3tm1b(EUCOMM)Wtsi PMC7263671
The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. American journal of human genetics (October 2019) Bola3tm1a(EUCOMM)Wtsi 31668704
Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nature metabolism (September 2019) Bola3tm1a(EUCOMM)Wtsi PMC7169975
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Bola3tm1b(EUCOMM)Wtsi PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bola3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bola3tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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