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Gene: Cdk19 MGI:1925584

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Gene Summary

Name:
cyclin dependent kinase 19
Synonyms:
2700084L06Rik,  Cdc2l6

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased heart weight Cdk19em1(IMPC)J HET   Early adult 4.71×10-05
increased grip strength Cdk19em1(IMPC)J HET Early adult 4.61×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

23 Images

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X-ray

XRay Images Skull Lateral Orientation

23 Images

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Eye Morphology

Images Ophthalmoscopy

10 Images

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X-ray

XRay Images Forepaw

23 Images

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X-ray

XRay Images Whole Body Lateral Orientation

23 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

23 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Sleep Wake

Wake state (bmp file)

5 Images

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Interactive Embryo Viewer Interactive Embryo Viewer
MicroCT E18.5

Embryo reconstruction

2 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

12 Images

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PDF thumbnail PDF
Electroretinography 2

Rod and cone PDF

4 Images

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Human diseases caused by Cdk19 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cdk19 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Non-Specific Early-Onset Epileptic Encephalopathy
ORPHA:442835
Developmental And Epileptic Encephalopathy 87
OMIM:618916

The table below shows human diseases predicted to be associated to Cdk19 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ethanolaminosis
Cardiomegaly OMIM:227150
Cardiomyopathy, Dilated, 1I
Cardiomegaly, Dilated cardiomyopathy OMIM:604765
Cardiomyopathy, Familial Hypertrophic, 27
Cardiomyocyte hypertrophy, Hypertrophic cardiomyopathy, Concentric hypertrophic cardiomyopathy, E... OMIM:618052
Congenital Tricuspid Valve Dysplasia
Abnormal tricuspid valve annulus morphology, Patent foramen ovale, Cardiomegaly, Tricuspid valve ... ORPHA:555874
Aorta Coarctation
Hypoplastic left heart, Tetralogy of Fallot, Cardiomegaly, Bicuspid aortic valve, Perimembranous ... ORPHA:1457
Non-Specific Early-Onset Epileptic Encephalopathy
ORPHA:442835
Developmental And Epileptic Encephalopathy 87
OMIM:618916

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdk19

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdk19.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. The Journal of clinical investigation (October 2022) Cdk19em1(IMPC)J PMC9566890

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MGI Allele Allele Type Produced
Cdk19tm269906(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cdk19em1(IMPC)J Indel Mice

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