Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

D-aspartate oxidase
5730402C02Rik,  5330420D20Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ddo mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ddo by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Spermatogenic Failure, X-Linked, 1
Sertoli cell-only phenotype, Obesity OMIM:305700
Maturity-Onset Diabetes Of The Young, Type 11
Overweight, Obesity OMIM:613375
Bardet-Biedl Syndrome 11
Hypogonadism, Obesity OMIM:615988
Increased waist to hip ratio, Obesity OMIM:601665
Hyperinsulinemic Hypoglycemia, Familial, 1
Pancreatic islet-cell hyperplasia, Large for gestational age OMIM:256450
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Hyperinsulinemic Hypoglycemia, Familial, 2
Pancreatic islet-cell hyperplasia, Large for gestational age OMIM:601820
Perineural Cyst
Dyspareunia, Retrograde ejaculation, Male sexual dysfunction, Impotence, Infertility, Female sexu... ORPHA:65250
Hypothyroidism, Central, With Testicular Enlargement
Overweight, Reduced TSH response to thyrotrophin-releasing hormone stimulation test, Hypothyroidi... OMIM:300888
Orthostatic Hypotension 1
Retrograde ejaculation, Reduced circulating prolactin concentration OMIM:223360
Bardet-Biedl Syndrome 10
Hypogonadism, Obesity OMIM:615987
Prolactin Deficiency With Obesity And Enlarged Testes
Macroorchidism, Obesity, Reduced circulating prolactin concentration OMIM:264120
Igg4-Related Retroperitoneal Fibrosis
Elevated circulating creatinine concentration, Weight loss, Hydrocele testis, Retrograde ejaculat... ORPHA:49041
Obesity Due To Prohormone Convertase I Deficiency
Decreased response to growth hormone stimulation test, Gonadotropin deficiency, Obesity, Pituitar... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Decreased response to growth hormone stimulation test, Gonadotropin deficiency, Obesity, Pituitar... ORPHA:71526
Dopamine Beta-Hydroxylase Deficiency
Retrograde ejaculation, Elevated circulating creatinine concentration ORPHA:230
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Obesity, Large for gestational age OMIM:240900
Polycystic Ovary Syndrome 1
Obesity, Oligomenorrhea, Amenorrhea OMIM:184700
Cortisone Reductase Deficiency 1
Obesity, Infertility, Oligomenorrhea OMIM:604931
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body mass index, Increased T3/T4 ratio, Increased body weight, Congenital hypothyroidis... OMIM:614450
Summitt Syndrome
Obesity OMIM:272350
Bardet-Biedl Syndrome 22
Hypogonadism, Obesity, Large for gestational age OMIM:617119
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity, Congenital hypothyroidism ORPHA:88643
Leptin Deficiency Or Dysfunction
Hypogonadism, Decreased testicular size, Primary amenorrhea, Obesity OMIM:614962
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Impaired social interactions ORPHA:329249
Morbid Obesity And Spermatogenic Failure
Azoospermia, Obesity, Infertility, Oligozoospermia OMIM:615703
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Decreased circulating cortisol level, Decreased response to growth hormone stimulation test, Adre... OMIM:609734
Biemond Syndrome Type 2
Hypogonadism, Hypogonadotropic hypogonadism, Obesity ORPHA:141333
Hypogonadism-Mitral Valve Prolapse-Intellectual Disability Syndrome
Abnormal testis morphology, Hypogonadism, Decreased fertility, Obesity ORPHA:2233
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased circulating free T4 concentration, Small for gestational age, Increased body weight, In... OMIM:274300
Leptin Receptor Deficiency
Obesity, Hypergonadotropic hypogonadism, Decreased response to growth hormone stimulation test, P... OMIM:614963
Body Mass Index Quantitative Trait Locus 20
Obesity, Tall stature OMIM:618406
Perrault Syndrome 4
Premature ovarian insufficiency, Increased circulating gonadotropin level, Obesity, Primary ameno... OMIM:615300
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Bardet-Biedl Syndrome 8
Hypogonadism, Obesity OMIM:615985
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pancreatic islet-cell hyperplasia, Increased body weight, Hyperhidrosis ORPHA:276608
Obesity Due To Melanocortin 4 Receptor Deficiency
Childhood-onset truncal obesity, Obesity ORPHA:71529
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Hypogonadotropic hypogonadism, Cryptorchidism, Obesity, Primary amenorrhea, Decreased testicular ... OMIM:610628
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Hypogonadotropic hypogonadism, Reduced circulating prolactin concentration, Decreased fertility, ... ORPHA:2235
Ring Chromosome Y Syndrome
Male infertility, Streak ovary, Unilateral cryptorchidism, Female infertility, Cryptorchidism, Ob... ORPHA:261529
Proprotein Convertase 1/3 Deficiency
Decreased circulating cortisol level, Hypogonadotropic hypogonadism, Obesity, Primary amenorrhea OMIM:600955
Male Hypergonadotropic Hypogonadism-Intellectual Disability-Skeletal Anomalies Syndrome
Eunuchoid habitus, Decreased fertility, Obesity, Hypogonadism, Decreased testicular size ORPHA:2234
Bdv Syndrome
Hypogonadotropic hypogonadism, Cryptorchidism, Obesity, Primary amenorrhea, Central hypothyroidis... OMIM:619326
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Cryptorchidism, Increased body weight ORPHA:589905
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
Cryptorchidism, Hypogonadism, Obesity OMIM:601794
Colobomatous Microphthalmia-Obesity-Hypogenitalism-Intellectual Disability Syndrome
Cryptorchidism, Hypogonadism, Obesity ORPHA:363741
Resistance To Thyrotropin-Releasing Hormone Syndrome
Reduced circulating prolactin concentration, Overweight, Pituitary hypothyroidism, Decreased circ... ORPHA:99832
Obesity Due To Congenital Leptin Deficiency
Hypergonadotropic hypogonadism, Pituitary hypothyroidism, Obesity, Primary amenorrhea, Hypoplasia... ORPHA:66628
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Elevated circulating growth hormone concentration, Large for gestational age, Multiple pancreatic... ORPHA:79644
Adrenocortical Carcinoma
Adrenocorticotropic hormone deficiency, Abnormality of reproductive system physiology, Increased ... ORPHA:1501
Sheehan Syndrome
Dyspareunia, Decreased circulating cortisol level, Decreased female libido, Reduced circulating p... ORPHA:91355
Obesity Due To Leptin Receptor Gene Deficiency
Hypergonadotropic hypogonadism, Pituitary hypothyroidism, Obesity, Primary amenorrhea, Hypoplasia... ORPHA:179494
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased circulating cortisol level, Increased body weight, Abdominal obesity OMIM:615954
Blue Diaper Syndrome
Decreased circulating T4 concentration, Increased body weight ORPHA:94086
Hair-pulling OMIM:613229
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Abnormality of the pancreatic islet cells, Primary hyperparathyroidism, Increased body weight, Hy... ORPHA:97279
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Large for gestational age, Pancreatic islet-cell hyperplasia, Increased body weight, Hyperhidrosis ORPHA:263455
Pigmented Nodular Adrenocortical Disease, Primary, 4
Primary hypercortisolism, Increased circulating cortisol level, Increased body weight OMIM:615830
Wilson Disease
Weight loss, Failure to thrive, Increased body weight, Abnormality of the menstrual cycle ORPHA:905
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Primary hyperparathyroidism, Irregular menstruation, Increased body weight, Increased circulating... ORPHA:189427
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Magel2-Related Prader-Willi-Like Syndrome
Cryptorchidism, Xerostomia, Increased body weight, Primary amenorrhea, Central hypothyroidism, Ab... ORPHA:398069
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Aromatase Deficiency
Male infertility, Macroorchidism, postpubertal, Eunuchoid habitus, Hypergonadotropic hypogonadism... ORPHA:91
Sotos Syndrome
Cryptorchidism, Overgrowth, Increased body weight, Tall stature OMIM:117550
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Dysmenorrhea, Irregular menstruation, Increased body weight, Oligomenorrhea, Failure to thrive ORPHA:264580
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Increased body weight, Irregular menstruation, Dysmenorrhea, Oligomenorrhea ORPHA:79240
Cushing Disease
Increased body weight, Secondary amenorrhea, Truncal obesity, Increased circulating cortisol leve... ORPHA:96253
Monosomy 22Q13.3
Hair-pulling, Obesity, Hypohidrosis ORPHA:48652
Carney Complex
Tall stature, Sertoli cell neoplasm, Testicular neoplasm, Elevated circulating growth hormone con... ORPHA:1359
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Decreased body weight, Increased body weight, Weight loss ORPHA:2298
Intellectual Developmental Disorder, Autosomal Dominant 38
Hair-pulling OMIM:616393
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hair-pulling ORPHA:447997
Hair-pulling, Socially inappropriate behavior, Weight loss ORPHA:2388
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Syndrome Due To Ectopic Acth Secretion
Increased body weight, Secondary amenorrhea, Weight loss, Truncal obesity, Increased circulating ... ORPHA:99889
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Hair-pulling OMIM:620330


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ddo

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ddo.

No publications found that use IMPC mice or data for Ddo.

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