Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

limb-bud and heart
1810009F10Rik,  6720416L16Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lbh mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lbh by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Ectodermal Dysplasia With Adrenal Cyst
Breast hypoplasia, Hypoplastic nipples OMIM:129550
Isolated Follicle Stimulating Hormone Deficiency
Sparse pubic hair, Male hypogonadism, Decreased testicular size, Delayed menarche, Azoospermia, D... ORPHA:52901
Becker Nevus Syndrome
Unilateral breast hypoplasia OMIM:604919
Bullous Lichen Planus
Breast aplasia ORPHA:33408
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Secondary growth hormone deficiency, Anterior hypopituitarism, Breast hypoplasia, Decreased ferti... ORPHA:2235
Normosmic Congenital Hypogonadotropic Hypogonadism
Male hypogonadism, Wide intermamillary distance, Sparse body hair, Breast hypoplasia, Decreased t... ORPHA:432
Nipples, Supernumerary
Supernumerary nipple OMIM:163700
Estrogen Resistance Syndrome
Enlarged polycystic ovaries, Breast hypoplasia, Primary amenorrhea, Increased circulating gonadot... ORPHA:785
Adult Syndrome
Absent nipple, Wide intermamillary distance, Fair hair, Breast hypoplasia, Alopecia of scalp, Spa... OMIM:103285
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Small pituitary gland, Sparse pubic hair, Alopecia, Sparse eyebrow, Abnormal eyebrow morphology, ... ORPHA:2232
Kallmann Syndrome
Breast hypoplasia, Decreased testicular size, Gynecomastia, Cryptorchidism, Decreased fertility, ... ORPHA:478
Adult Syndrome
Alopecia, Absent nipple, Fine hair, Breast hypoplasia, Hypoplastic nipples, Sparse scalp hair ORPHA:978
Familial Supernumerary Nipples
Supernumerary nipple ORPHA:2456
Meier-Gorlin Syndrome 4
Breast hypoplasia, Cryptorchidism OMIM:613804
Ring Chromosome 12 Syndrome
Breast hypoplasia, Dystrophic toenail, Cryptorchidism, Hirsutism ORPHA:1439
Sheehan Syndrome
Secondary growth hormone deficiency, Sparse pubic hair, Breast hypoplasia, Panhypopituitarism, De... ORPHA:91355
Microcephalic Primordial Dwarfism, Dauber Type
Bilateral breast hypoplasia, Primary amenorrhea ORPHA:319675
Chromosome 10Q22.3-Q23.2 Deletion Syndrome
Breast aplasia OMIM:612242
Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 1
Aplasia/Hypoplasia of the nipples, Absent nipple, Hypoplastic areola, Aplasia/Hypoplasia of the b... OMIM:113700
Incontinentia Pigmenti
Alopecia, Coarse hair, Fine hair, Supernumerary nipple, Breast aplasia, Breast hypoplasia, Atroph... OMIM:308300
Meier-Gorlin Syndrome 2
Breast hypoplasia OMIM:613800
Brachycephaly, Deafness, Cataract, Microstomia, And Impaired Intellectual Development
Breast hypoplasia, Long eyelashes, Cryptorchidism, Absent axillary hair OMIM:601353
Craniofrontonasal Syndrome
Breast hypoplasia, Cryptorchidism, Low posterior hairline, Unilateral breast hypoplasia, Curly ha... OMIM:304110
Short Stature, Onychodysplasia, Facial Dysmorphism, And Hypotrichosis
Breast hypoplasia, Sparse hair, Oligozoospermia OMIM:614813
Limb-Mammary Syndrome
Alopecia, Sparse eyebrow, Absent nipple, Breast aplasia, Aplasia of the ovary, Hypoplastic nipple... ORPHA:69085
Gapo Syndrome
Alopecia, Sparse eyebrow, Breast hypoplasia, Sparse eyelashes, Hypoplastic nipples, Sparse hair OMIM:230740
Leydig Cell Hypoplasia
Male hypogonadism, Breast aplasia, Hypoplasia of the Leydig cells, Testicular gonadoblastoma, Cry... ORPHA:755
Estrogen Resistance
Breast aplasia, Primary amenorrhea, Polycystic ovaries OMIM:615363
Meier-Gorlin Syndrome 3
Breast hypoplasia, Sparse pubic hair, Sparse axillary hair, Cryptorchidism OMIM:613803
Ablepharon Macrostomia Syndrome
Aplasia/Hypoplasia of the nipples, Fine hair, Breast hypoplasia, Absent eyelashes, Abnormal hair ... ORPHA:920
Hidrotic Ectodermal Dysplasia, Halal Type
Irregular menstruation, Supernumerary nipple, Sparse body hair, Absent eyelashes, Trichodysplasia... ORPHA:1809
Cerebellar Ataxia-Hypogonadism Syndrome
Supernumerary nipple, Hypogonadism, Decreased fertility, Gynecomastia, Hypogonadotropic hypogonadism ORPHA:1173
Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted
Unilateral breast hypoplasia, Hypertrichosis OMIM:300968
Aymé-Gripp Syndrome
Breast hypoplasia, Long eyelashes, Cryptorchidism, Sparse scalp hair ORPHA:1272
Dyrk1A-Related Intellectual Disability Syndrome
Breast hypoplasia, Cryptorchidism, Anterior pituitary hypoplasia ORPHA:464306
Meier-Gorlin Syndrome 1
Breast hypoplasia, Long eyelashes, Cryptorchidism OMIM:224690
Intellectual Disability-Dysmorphism-Hypogonadism-Diabetes Mellitus Syndrome
Sparse pubic hair, Elevated circulating luteinizing hormone level, Breast aplasia, Decreased test... ORPHA:3044
Ulnar-Mammary Syndrome
Ectopic posterior pituitary, Axillary apocrine gland hypoplasia, Sparse lateral eyebrow, Breast h... OMIM:181450
Barber-Say Syndrome
Breast aplasia, Sparse or absent eyelashes, Generalized hirsutism, Hypoplastic nipples, Aplasia/H... ORPHA:1231
Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 2
Highly arched eyebrow, Absent nipple, Cryptorchidism, Hypoplastic nipples, Hypoplastic areola OMIM:616001
Woods Syndrome
Frontal hirsutism, Supernumerary nipple OMIM:615236
Gabriele-De Vries Syndrome
Sparse eyebrow, Decreased response to growth hormone stimulation test, Breast hypoplasia, Frontal... ORPHA:506358
Choroidal Atrophy-Alopecia Syndrome
Fine hair, Supernumerary nipple, Thin eyebrow, Sparse or absent eyelashes, Sparse hair ORPHA:1433
Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities
Synophrys, Supernumerary nipple OMIM:616083
Hypohidrotic Ectodermal Dysplasia
Generalized hypopigmentation of hair, Breast aplasia, Trichorrhexis nodosa, Aplasia/Hypoplasia of... ORPHA:238468
Ulnar-Mammary Syndrome
Breast aplasia, Decreased fertility, Cryptorchidism, Hypoplastic nipples, Absent axillary hair ORPHA:3138
Mandibuloacral Dysplasia With Type A Lipodystrophy
Absent eyelashes, Abnormal eyebrow morphology, Alopecia, Breast aplasia ORPHA:90153
10Q22.3Q23.3 Microdeletion Syndrome
Breast aplasia ORPHA:276413
Moebius Syndrome
Breast aplasia, Hypogonadotropic hypogonadism ORPHA:570
Ectodermal Dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant
Sparse hair, Absent nipple, Brittle hair, Absent hair OMIM:614940
Scalp-Ear-Nipple Syndrome
Breast aplasia, Aplasia/Hypoplasia of the nipples, Sparse hair ORPHA:2036
Scalp-Ear-Nipple Syndrome
Sparse pubic hair, Aplasia/Hypoplasia of the nipples, Fine hair, Breast aplasia, Sparse axillary ... OMIM:181270
Meier-Gorlin Syndrome 7
Breast aplasia, Thin eyebrow, Cryptorchidism OMIM:617063
Ear-Patella-Short Stature Syndrome
Breast aplasia, Cryptorchidism ORPHA:2554
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Decreased response to growth hormone stimulation test, Breast aplasia, Cryptorchidism, Chordee, P... ORPHA:268261


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lbh

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lbh.

No publications found that use IMPC mice or data for Lbh.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lbhtm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Lbhtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lbhtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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