banner
Genes Phenotypes Help, News, Blog

Gene: Lbh MGI:1925139

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
limb-bud and heart
Synonyms:
1810009F10Rik,  6720416L16Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lbh mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lbh by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ectodermal Dysplasia With Adrenal Cyst
Hypoplastic nipples, Breast hypoplasia OMIM:129550
Becker Nevus Syndrome
Unilateral breast hypoplasia OMIM:604919
Isolated Follicle Stimulating Hormone Deficiency
Hyperplasia of the Leydig cells, Decreased female libido, Hypogonadotropic hypogonadism, Female h... ORPHA:52901
Bullous Lichen Planus
Breast aplasia ORPHA:33408
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Hypogonadotropic hypogonadism, Reduced circulating prolactin concentration, Decreased fertility, ... ORPHA:2235
Normosmic Congenital Hypogonadotropic Hypogonadism
Wide intermamillary distance, Hypogonadotropic hypogonadism, Female hypogonadism, Non-obstructive... ORPHA:432
Nipples, Supernumerary
Supernumerary nipple OMIM:163700
Estrogen Resistance Syndrome
Abnormality of the pubic hair, Enlarged polycystic ovaries, Increased circulating gonadotropin le... ORPHA:785
Adult Syndrome
Sparse scalp hair, Wide intermamillary distance, Absent nipple, Fair hair, Sparse axillary hair, ... OMIM:103285
Adult Syndrome
Sparse scalp hair, Alopecia, Absent nipple, Fine hair, Hypoplastic nipples, Breast hypoplasia ORPHA:978
Meier-Gorlin Syndrome 4
Cryptorchidism, Breast hypoplasia OMIM:613804
Familial Supernumerary Nipples
Supernumerary nipple ORPHA:2456
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Abnormal eyebrow morphology, Alopecia, Streak ovary, Sparse facial hair, Hypergonadotropic hypogo... ORPHA:2232
Kallmann Syndrome
Dyspareunia, Hypogonadotropic hypogonadism, Cryptorchidism, Breast hypoplasia, Decreased fertilit... ORPHA:478
Ring Chromosome 12 Syndrome
Cryptorchidism, Dystrophic toenail, Breast hypoplasia, Hirsutism ORPHA:1439
Sheehan Syndrome
Dyspareunia, Decreased female libido, Sparse axillary hair, Reduced circulating prolactin concent... ORPHA:91355
Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 1
Hypoplastic areola, Aplasia/Hypoplasia of the nipples, Absent nipple, Aplasia/Hypoplasia of the b... OMIM:113700
Microcephalic Primordial Dwarfism, Dauber Type
Bilateral breast hypoplasia, Primary amenorrhea ORPHA:319675
Chromosome 10Q22.3-Q23.2 Deletion Syndrome
Breast aplasia OMIM:612242
Incontinentia Pigmenti
Alopecia, Supernumerary nipple, Fine hair, Coarse hair, Breast aplasia, Hypoplastic nipples, Nail... OMIM:308300
Meier-Gorlin Syndrome 2
Breast hypoplasia OMIM:613800
Brachycephaly, Deafness, Cataract, Microstomia, And Impaired Intellectual Development
Cryptorchidism, Long eyelashes, Breast hypoplasia, Absent axillary hair OMIM:601353
Craniofrontonasal Syndrome
Curly hair, Cryptorchidism, Widow's peak, Low posterior hairline, Unilateral breast hypoplasia, B... OMIM:304110
Short Stature, Onychodysplasia, Facial Dysmorphism, And Hypotrichosis
Sparse hair, Breast hypoplasia, Oligozoospermia OMIM:614813
Gapo Syndrome
Alopecia, Sparse eyelashes, Sparse eyebrow, Hypoplastic nipples, Sparse hair, Breast hypoplasia OMIM:230740
Limb-Mammary Syndrome
Alopecia, Absent nipple, Sparse eyebrow, Primary amenorrhea, Bilateral breast hypoplasia, Breast ... ORPHA:69085
Estrogen Resistance
Breast aplasia, Primary amenorrhea, Polycystic ovaries OMIM:615363
Leydig Cell Hypoplasia
Hypergonadotropic hypogonadism, Female hypogonadism, Testicular gonadoblastoma, Cryptorchidism, I... ORPHA:755
Meier-Gorlin Syndrome 3
Sparse pubic hair, Cryptorchidism, Breast hypoplasia, Sparse axillary hair OMIM:613803
Ablepharon Macrostomia Syndrome
Absent eyebrow, Abnormal hair pattern, Absent eyelashes, Aplasia/Hypoplasia of the nipples, Fine ... ORPHA:920
Hidrotic Ectodermal Dysplasia, Halal Type
Sparse scalp hair, Absent eyebrow, Supernumerary nipple, Absent eyelashes, Irregular menstruation... ORPHA:1809
Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted
Unilateral breast hypoplasia, Hypertrichosis OMIM:300968
Aymé-Gripp Syndrome
Cryptorchidism, Long eyelashes, Sparse scalp hair, Breast hypoplasia ORPHA:1272
Cerebellar Ataxia-Hypogonadism Syndrome
Hypogonadotropic hypogonadism, Supernumerary nipple, Decreased fertility, Hypogonadism, Gynecomastia ORPHA:1173
Meier-Gorlin Syndrome 1
Cryptorchidism, Long eyelashes, Breast hypoplasia OMIM:224690
Dyrk1A-Related Intellectual Disability Syndrome
Cryptorchidism, Anterior pituitary hypoplasia, Breast hypoplasia ORPHA:464306
Intellectual Disability-Dysmorphism-Hypogonadism-Diabetes Mellitus Syndrome
Elevated circulating luteinizing hormone level, Sparse pubic hair, Breast aplasia, Elevated circu... ORPHA:3044
Ulnar-Mammary Syndrome
Inverted nipples, Ectopic posterior pituitary, Anterior pituitary hypoplasia, Sparse axillary hai... OMIM:181450
Breasts And/Or Nipples, Aplasia Or Hypoplasia Of, 2
Hypoplastic areola, Absent nipple, Highly arched eyebrow, Cryptorchidism, Hypoplastic nipples OMIM:616001
Barber-Say Syndrome
Sparse or absent eyelashes, Breast aplasia, Hypoplastic nipples, Generalized hirsutism, Aplasia/H... ORPHA:1231
Gabriele-De Vries Syndrome
Decreased response to growth hormone stimulation test, Sparse eyebrow, Cryptorchidism, Frontal up... ORPHA:506358
Woods Syndrome
Frontal hirsutism, Supernumerary nipple OMIM:615236
Choroidal Atrophy-Alopecia Syndrome
Supernumerary nipple, Fine hair, Sparse or absent eyelashes, Thin eyebrow, Sparse hair ORPHA:1433
Intellectual Developmental Disorder, Autosomal Dominant 30, With Speech Delay And Behavioral Abnormalities
Synophrys, Supernumerary nipple OMIM:616083
Hypohidrotic Ectodermal Dysplasia
Abnormal hair quantity, Slow-growing hair, Trichorrhexis nodosa, Breast aplasia, Generalized hypo... ORPHA:238468
Ulnar-Mammary Syndrome
Cryptorchidism, Decreased fertility, Breast aplasia, Hypoplastic nipples, Absent axillary hair ORPHA:3138
Mandibuloacral Dysplasia With Type A Lipodystrophy
Absent eyelashes, Abnormal eyebrow morphology, Alopecia, Breast aplasia ORPHA:90153
Global Developmental Delay With Speech And Behavioral Abnormalities
Cryptorchidism, Supernumerary nipple OMIM:619243
10Q22.3Q23.3 Microdeletion Syndrome
Breast aplasia ORPHA:276413
Moebius Syndrome
Breast aplasia, Hypogonadotropic hypogonadism ORPHA:570
Ectodermal Dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant
Sparse hair, Brittle hair, Absent nipple, Absent hair OMIM:614940
Scalp-Ear-Nipple Syndrome
Sparse hair, Aplasia/Hypoplasia of the nipples, Breast aplasia ORPHA:2036
Meier-Gorlin Syndrome 7
Cryptorchidism, Breast aplasia, Thin eyebrow OMIM:617063
Scalp-Ear-Nipple Syndrome
Sparse axillary hair, Sparse pubic hair, Aplasia/Hypoplasia of the nipples, Fine hair, Patchy alo... OMIM:181270
Ear-Patella-Short Stature Syndrome
Cryptorchidism, Breast aplasia ORPHA:2554
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Decreased response to growth hormone stimulation test, Cryptorchidism, Posterior pituitary hypopl... ORPHA:268261

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lbh

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lbh.

No publications found that use IMPC mice or data for Lbh.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lbhtm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Lbhtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lbhtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter