banner
Genes Phenotypes Help, News, Blog

Gene: Ypel2 MGI:1925114

Log in to follow

Gene Summary

Name:
yippee like 2
Synonyms:
E130113K08Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased prepulse inhibition Ypel2em1(IMPC)Tcp HOM   Early adult 1.71×10-05
decreased body length Ypel2em1(IMPC)Tcp HOM Early adult 7.48×10-05
abnormal sternum morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
abnormal tooth morphology Ypel2em1(IMPC)Tcp HOM Early adult 4.08×10-06
abnormal eye morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
enlarged urinary bladder Ypel2em1(IMPC)Tcp HOM Early adult 0.00
prolonged QT interval Ypel2em1(IMPC)Tcp HOM Early adult 2.42×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Electrocardiogram (ECG)

Waveform Image

1 Images

View images
Eye Morphology

Images Slit Lamp

21 Images

View images
Eye Morphology

Images Ophthalmoscopy

47 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

10 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

View images
Gross Pathology and Tissue Collection

Images

9 Images

View images
X-ray

XRay Images Skull Lateral Orientation

10 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

10 Images

View images

Human diseases caused by Ypel2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ypel2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Jervell And Lange-Nielsen Syndrome 1
Sudden cardiac death, Torsade de pointes, Syncope, Prolonged QT interval, Prolonged QTc interval OMIM:220400
Long Qt Syndrome 2
Sudden cardiac death, Torsade de pointes, Cardiac arrest, Syncope, Prolonged QT interval, Notched... OMIM:613688
Long Qt Syndrome 13
Torsade de pointes, Pulmonary embolism, Permanent atrial fibrillation, Reduced left ventricular e... OMIM:613485
Long Qt Syndrome 10
Sudden cardiac death, T-wave alternans, Prolonged QT interval, Atrioventricular block, Atrial fib... OMIM:611819
Long Qt Syndrome 6
Sudden cardiac death, Torsade de pointes, Cardiac arrest, Syncope, Prolonged QT interval, Prolong... OMIM:613693
Long Qt Syndrome 14
T-wave alternans, Cardiac arrest, Prolonged QT interval, 2:1 atrioventricular block, Prolonged QT... OMIM:616247
Long Qt Syndrome 1
Sudden cardiac death, Torsade de pointes, Syncope, Prolonged QT interval, Prolonged QTc interval,... OMIM:192500
Atrial Fibrillation, Familial, 9
Permanent atrial fibrillation, Syncope, Palpitations, Prolonged QTc interval, Paroxysmal atrial f... OMIM:613980
Atrial Fibrillation, Familial, 3
Sudden cardiac death, Permanent atrial fibrillation, Syncope, Prolonged QTc interval, Atrial fibr... OMIM:607554
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3
Polymorphic ventricular tachycardia, Cardiac arrest, Syncope, Paroxysmal ventricular tachycardia,... OMIM:614021
Long Qt Syndrome 11
Syncope, Prolonged QTc interval OMIM:611820
Brugada Syndrome 9
Presyncope, Palpitations, Prolonged QT interval, ST segment elevation OMIM:616399
Long Qt Syndrome 9
Cardiac arrest, Ventricular arrhythmia, Syncope, Prolonged QT interval, Abnormal U wave, Sinus br... OMIM:611818
Regional Odontodysplasia
Gingivitis, Delayed eruption of teeth, Pulp calcification, Alveolar ridge overgrowth, Short denta... ORPHA:83450
Andersen-Tawil Syndrome
Polymorphic ventricular tachycardia, 2-3 toe syndactyly, Torsade de pointes, Micrognathia, Ventri... ORPHA:37553
Andersen Cardiodysrhythmic Periodic Paralysis
Short phalanx of finger, Toe syndactyly, Micrognathia, Clinodactyly of the 5th toe, Palpitations,... OMIM:170390
Cardiac Arrhythmia Syndrome, With Or Without Skeletal Muscle Weakness
Polymorphic ventricular tachycardia, Cardiac arrest, Syncope, Shock, Premature ventricular contra... OMIM:615441
Progressive Familial Heart Block, Type Ib
Right bundle branch block, Syncope, Shortened PR interval, Prolonged QT interval, Left anterior f... OMIM:604559
Jervell And Lange-Nielsen Syndrome 2
Sudden cardiac death, Torsade de pointes, Syncope, Premature ventricular contraction, Prolonged Q... OMIM:612347
Sick Sinus Syndrome 1
Ventricular escape rhythm, Prolonged QT interval, Atrioventricular block, Absent P wave, Sick sin... OMIM:608567
Long Qt Syndrome 8
Sudden cardiac death, Syncope, Ventricular fibrillation, Syndactyly, Aborted sudden cardiac death... OMIM:618447
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Right bundle branch block, Cardiac arrest, Paroxysmal supraventricular tachycardia, Congestive he... OMIM:616117
Cardiac Arrhythmia, Ankyrin-B-Related
Sudden cardiac death, Syncope, Prolonged QT interval, Atrial fibrillation, Sinus bradycardia OMIM:600919
Myofibrillar Myopathy 10
Mandibular prognathia, Increased QRS voltage, Left ventricular hypertrophy, Flexion contracture o... OMIM:619040
Long Qt Syndrome 16
T-wave alternans, Second degree atrioventricular block, Bradycardia, Prolonged QTc interval OMIM:618782
Cardiomyopathy, Dilated, 1D
Sudden cardiac death, Reduced left ventricular ejection fraction, Left ventricular hypertrophy, D... OMIM:601494
Long Qt Syndrome 12
Torsade de pointes, Syncope, Prolonged QTc interval, Ventricular fibrillation OMIM:612955
Long Qt Syndrome 5
Sudden cardiac death, Torsade de pointes, Syncope, Ventricular fibrillation, Prolonged QTc interv... OMIM:613695
Long Qt Syndrome 15
Polymorphic ventricular tachycardia, Ventricular ectopy, Cardiac arrest, Syncope, Ventricular fib... OMIM:616249
Sick Sinus Syndrome 2
Sudden cardiac death, Torsade de pointes, Cardiac arrest, Syncope, Left ventricular hypertrophy, ... OMIM:163800
Timothy Syndrome
Microdontia, Syndactyly, Thin upper lip vermilion, Prolonged QT interval, Cardiomegaly, Bradycard... OMIM:601005
Amelogenesis Imperfecta
Enamel hypoplasia, Yellow-brown discoloration of the teeth, Enamel hypomineralization, Widely spa... ORPHA:88661
Cardiomyopathy, Familial Hypertrophic, 27
Impaired myocardial contractility, Left ventricular diastolic dysfunction, Concentric hypertrophi... OMIM:618052
Atrial Fibrillation, Familial, 7
Permanent atrial fibrillation, Premature atrial contractions, Palpitations, Prolonged PR interval... OMIM:612240
Long Qt Syndrome 3
Sudden cardiac death, Torsade de pointes, Syncope, Ventricular flutter, Ventricular tachycardia, ... OMIM:603830
Dentin Dysplasia, Type I
Enamel hypoplasia, Microdontia, Oligodontia, Taurodontia, Pulp obliteration, Periapical bone loss... OMIM:125400
Sick Sinus Syndrome 4
Sinoatrial block, Syncope, Abnormal PR interval, Abnormal QRS complex, Chronotropic incompetence,... OMIM:619464
Cardiomyopathy, Familial Hypertrophic, 26
Sudden cardiac death, Permanent atrial fibrillation, Congestive heart failure, Hypertrophic cardi... OMIM:617047
Romano-Ward Syndrome
Sudden cardiac death, Torsade de pointes, Abnormal T-wave, Ventricular arrhythmia, Syncope, Prolo... ORPHA:101016
Amelogenesis Imperfecta, Type Ij
Enamel hypoplasia, Widely spaced teeth, Carious teeth, Amelogenesis imperfecta, Increased overbite OMIM:617297
Metaphyseal Chondrodysplasia, Spahr Type
Genu varum, Progressive leg bowing, Short lower limbs, Hip dysplasia, Metaphyseal chondrodysplasi... ORPHA:2501
Familial Short Qt Syndrome
Sudden cardiac death, Ventricular arrhythmia, Syncope, Ventricular fibrillation, Palpitations, At... ORPHA:51083
Jervell And Lange-Nielsen Syndrome
Torsade de pointes, Syncope, Arrhythmia, Prolonged QTc interval, Ventricular fibrillation ORPHA:90647
Brugada Syndrome 3
Sudden cardiac death, Ventricular arrhythmia, Syncope, J wave, Shortened QT interval, Atrial fibr... OMIM:611875
3-Methylglutaconic Aciduria, Type V
Sudden cardiac death, 3-Methylglutaconic aciduria, Noncompaction cardiomyopathy, Congestive heart... OMIM:610198
Tako-Tsubo Cardiomyopathy
Hypotension, T-wave inversion, Ventricular arrhythmia, Cardiogenic shock, Mildly reduced left ven... ORPHA:66529
Short Qt Syndrome 1
Sudden cardiac death, Cardiac arrest, Syncope, Palpitations, Shortened QT interval, Paroxysmal at... OMIM:609620
Oligodontia
Delayed eruption of teeth, Microdontia, Taurodontia, Abnormality of primary molar morphology, Sho... ORPHA:99798
Dental Ankylosis
Tooth agenesis, Mandibular prognathia, Clinodactyly of the 5th finger, Abnormal dental enamel mor... ORPHA:1077
Sinoatrial Node Dysfunction And Deafness
Abnormal QRS complex, Increased heart rate variability, Syncope, Bradycardia OMIM:614896
Dentinogenesis Imperfecta
Abnormal dental root morphology, Yellow-brown discoloration of the teeth, Finger joint hypermobil... ORPHA:49042
Incessant Infant Ventricular Tachycardia
Supraventricular tachycardia, Histiocytoid cardiomyopathy, Cardiac arrest, Wolff-Parkinson-White ... ORPHA:45453
Cirrhotic Cardiomyopathy
Elevated pulmonary artery pressure, Left ventricular diastolic dysfunction, Third heart sound, Re... ORPHA:57777
Short Qt Syndrome 7
Sudden cardiac death, Cardiac arrest, Syncope, Shortened QT interval, Ventricular fibrillation OMIM:620231
Short Qt Syndrome 2
Sudden cardiac death, Syncope, Ventricular fibrillation, Shortened QT interval, Bradycardia, Atri... OMIM:609621
Neonatal Lupus Erythematosus
Dilated cardiomyopathy, Abnormal electrophysiology of sinoatrial node origin, Heart block, Prolon... ORPHA:398124
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Enamel hypomineralization, Carious teeth, Amelogenesis imperfecta, Anterior open-bite malocclusio... OMIM:204700
Brugada Syndrome
Supraventricular tachycardia, Right bundle branch block, Trifascicular block, Cardiac arrest, Ven... ORPHA:130
Amelogenesis Imperfecta, Type Ia
Dental enamel pits, Enamel hypoplasia, Generalized microdontia, Taurodontia, Amelogenesis imperfecta OMIM:104530
Dentinogenesis Imperfecta, Shields Type Iii
Dental enamel pits, Dentinogenesis imperfecta, Odontodysplasia, Periapical bone loss, Anterior op... OMIM:125500
Otodental Dysplasia
Enamel hypoplasia, Long philtrum, Delayed eruption of teeth, Pulp calcification, Taurodontia, Age... OMIM:166750
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Prolonged QT interval, Arrhythmia ORPHA:2151
Pyle Disease
Genu valgum, Mandibular prognathia, Hypoplastic frontal sinuses, Delayed eruption of teeth, Absen... OMIM:265900
Idiopathic Neonatal Atrial Flutter
Supraventricular tachycardia, Reduced left ventricular ejection fraction, Abnormal EKG, Paroxysma... ORPHA:45452
Atrial Fibrillation, Familial, 11
Prolonged QRS complex, Atrial fibrillation, Reduced left ventricular ejection fraction, Prolonged... OMIM:614049
Familial Hyperaldosteronism Type Iii
Left ventricular hypertrophy, Intracranial hemorrhage, Hypertension, Epistaxis, Prolonged QT inte... ORPHA:251274
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 14
Prolonged QT interval OMIM:615351
Acquired Aneurysmal Subarachnoid Hemorrhage
Ischemic stroke, Cerebral hemorrhage, Cerebral ischemia, Syncope, Left ventricular hypertrophy, C... ORPHA:90065
Amelogenesis Imperfecta, Type Ic
Enamel hypomineralization, Taurodontia, Amelogenesis imperfecta, Anterior open-bite malocclusion,... OMIM:204650
Amelogenesis Imperfecta, Type Ih
Dental enamel pits, Enamel hypoplasia, Amelogenesis imperfecta, Anterior open-bite malocclusion, ... OMIM:616221
Amelogenesis Imperfecta, Type Iiia
Dental malocclusion, Amelogenesis imperfecta, Anterior open-bite malocclusion OMIM:130900
Wolff-Parkinson-White Syndrome
Sudden cardiac death, Wolff-Parkinson-White syndrome, Syncope, Ventricular preexcitation with mul... OMIM:194200
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis
Enamel hypoplasia, Genu valgum, Mandibular prognathia, Advanced ossification of carpal bones, Cox... OMIM:618363
Autoimmune Hypoparathyroidism
Ventricular arrhythmia, Abnormal left ventricular function, Prolonged QT interval, Calcium nephro... ORPHA:36913
Neurodevelopmental Disorder With Hypotonia, Language Delay, And Skeletal Defects With Or Without Seizures
Pulmonary arterial hypertension, Micrognathia, 3-4 finger cutaneous syndactyly, Camptodactyly, 2-... OMIM:620029
Short Qt Syndrome 3
Shortened QT interval, Palpitations, Tachycardia OMIM:609622
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Dilated cardiomyopathy, Prolonged QT interval, Ventricular tachycardia, Atrioventricular block, H... ORPHA:26793
Atrial Standstill
Right bundle branch block, Mobitz I atrioventricular block, Ischemic stroke, Reduced left ventric... ORPHA:1344
Brugada Syndrome 4
Shortened QT interval, Atrial fibrillation, Syncope OMIM:611876
Rett Syndrome
Abnormal T-wave, Short foot, Prolonged QTc interval, Abnormality of the dentition OMIM:312750
Simpson-Golabi-Behmel Syndrome
Camptodactyly of finger, Toe syndactyly, Hepatomegaly, Postaxial hand polydactyly, Abnormal rib m... ORPHA:373
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5
Sudden cardiac death, Right ventricular cardiomyopathy, Presyncope, Congestive heart failure, Pre... OMIM:604400
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Hypomature enamel, Anterior open-bite malocclusion, Amelogenesis imperfecta, Yellow-brown discolo... OMIM:612529
Muscular Dystrophy, Becker Type
Cardiomyopathy, Arrhythmia, Abnormal EKG OMIM:300376
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Hypocalcification of dental enamel, Anterior open-bite malocclusion, Yel... OMIM:618386
Cardiomyopathy, Familial Hypertrophic, 6
Wolff-Parkinson-White syndrome, Syncope, Congestive heart failure, Asymmetric septal hypertrophy,... OMIM:600858
Otodental Syndrome
Abnormal molar morphology, Odontoma, Long philtrum, Periodontitis, Delayed eruption of teeth, Pul... ORPHA:2791
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
Right ventricular cardiomyopathy, T-wave inversion, Ventricular arrhythmia, Syncope, Ventricular ... OMIM:611528
Muscular Dystrophy, Cardiac Type
Carnosinuria, Cardiomyopathy, Abnormal EKG OMIM:309930
Nathalie Syndrome
Abnormal EKG OMIM:255990
Pseudohypoparathyroidism Type 1B
Enamel hypoplasia, Low urinary cyclic AMP response to PTH administration, Delayed eruption of tee... ORPHA:94089
Cardiomyopathy, Familial Hypertrophic, 8
Sudden cardiac death, Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, T-w... OMIM:608751
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Carious teeth, Amelogenesis imperfecta, Yellow-brown discoloration of the teeth OMIM:615887
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Sudden cardiac death, Right bundle branch block, Right ventricular cardiomyopathy, Ventricular ar... OMIM:610193
Amelogenesis Imperfecta, Type If
Dental enamel pits, Enamel hypoplasia, Abnormality of dental color, Amelogenesis imperfecta OMIM:616270
Pseudohypoparathyroidism Type 1C
Broad distal phalanx of the thumb, Enamel hypoplasia, Short 4th metacarpal, Short 5th metacarpal,... ORPHA:79444
Epidermolysis Bullosa, Junctional 1A, Intermediate
Camptodactyly of finger, Enamel hypoplasia, Hypodontia, Oral mucosal blisters, Carious teeth OMIM:226650
Cocaine Intoxication
Tubulointerstitial nephritis, Hypotension, Ischemic stroke, Hypovolemia, Cerebral hemorrhage, Acu... ORPHA:90068
Cardiomyopathy, Familial Hypertrophic, 10
Sudden cardiac death, Supraventricular tachycardia, Systolic anterior motion of the mitral valve,... OMIM:608758
Amelogenesis Imperfecta, Type Iv
Enamel hypoplasia, Taurodontia, Amelogenesis imperfecta, Yellow-brown discoloration of the teeth OMIM:104510
Amelogenesis Imperfecta, Type Ie
Enamel hypoplasia, Anterior open-bite malocclusion, Amelogenesis imperfecta, Abnormal dentin morp... OMIM:301200
Ethylene Glycol Poisoning
Hypotension, Decreased urine output, Renal tubular epithelial necrosis, Hematuria, Congestive hea... ORPHA:31826
Lipodystrophy, Congenital Generalized, Type 4
Tachycardia, Prolonged QT interval, Hepatomegaly, Bradycardia, Splenomegaly, Atrial fibrillation OMIM:613327
Drug-Induced Lupus Erythematosus
Pericarditis, Hematuria, Prolonged QTc interval ORPHA:231111
Pseudohypoparathyroidism Type 1A
Broad distal phalanx of the thumb, Enamel hypoplasia, Short 4th metacarpal, Short 5th metacarpal,... ORPHA:79443
Dilated Cardiomyopathy With Ataxia
3-Methylglutaconic aciduria, Hypoplasia of penis, Dilated cardiomyopathy, Prolonged QT interval, ... ORPHA:66634
Gitelman Syndrome
Hypotension, Nocturia, Prolonged QT interval, Polyuria, Hypocalciuria, Palpitations, Ventricular ... OMIM:263800
Cerebral Creatine Deficiency Syndrome 1
Malar flattening, Prolonged QT interval, Mandibular prognathia OMIM:300352
Pseudohypoparathyroidism Type 2
Prolonged QT interval, Low urinary cyclic AMP response to PTH administration ORPHA:94090
Hypophosphatemic Rickets, Autosomal Recessive, 2
Genu varum, Genu valgum, Coxa valga, Hyperphosphaturia, Medullary nephrocalcinosis, Carious teeth... OMIM:613312
Cleidocranial Dysplasia
Tapered finger, Delayed eruption of teeth, Hypoplastic inferior ilia, Micrognathia, Abnormal rib ... ORPHA:1452
Brugada Syndrome 7
Prolonged P wave, Permanent atrial fibrillation, ST segment elevation, Atrial flutter, Paroxysmal... OMIM:613120
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Abnormal EKG, Arrhythmia, Prolonged QT interval, Ketonuria ORPHA:480864
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Torsade de pointes, Ketonuria, Cardiac arrest, Hypertrophic cardiomyopathy, Ventricular tachycard... OMIM:616878
Amelo-Onycho-Hypohidrotic Syndrome
Delayed eruption of teeth, Advanced eruption of teeth, Abnormality of dental morphology, Everted ... ORPHA:1028
Dentin Dysplasia, Type Ii
Abnormal dentin morphology, Pulp calcification, Dentinogenesis imperfecta limited to primary teeth OMIM:125420
Cardiomyopathy, Dilated, 1Nn
Reduced left ventricular ejection fraction, Ventricular arrhythmia, Congestive heart failure, Inc... OMIM:615916
17Q24.2 Microdeletion Syndrome
Vesicoureteral reflux, Upper limb undergrowth, Micrognathia, Short philtrum, Thin upper lip vermi... ORPHA:529962
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Dicarboxylic aciduria, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Prolonged QT interval... ORPHA:71212
Gitelman Syndrome
Tubulointerstitial nephritis, Urinary incontinence, Abnormal T-wave, Renal tubular acidosis, Prom... ORPHA:358
Attrv122I Amyloidosis
Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, Abnormal EKG, Left ventri... ORPHA:85451
Thyrotoxic Periodic Paralysis
Impaired myocardial contractility, Urinary retention, Shortened PR interval, Prolonged QT interva... ORPHA:79102
Cardiomyopathy, Familial Hypertrophic, 13
Right bundle branch block, Reduced left ventricular ejection fraction, Concentric hypertrophic ca... OMIM:613243
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Sudden cardiac death, Right ventricular cardiomyopathy, Cardiac arrest, Syncope, Epsilon wave, Pr... OMIM:609040
45,X/46,Xy Mixed Gonadal Dysgenesis
Urogenital sinus anomaly, High palate, Short 4th metacarpal, Hallux valgus, Micrognathia, Epispad... ORPHA:1772
Pycnodysostosis
Aplastic clavicle, Narrow palate, Delayed eruption of primary teeth, Micrognathia, Hypodontia, Ab... OMIM:265800
Craniometadiaphyseal Dysplasia
Genu varum, Genu valgum, Mandibular prognathia, Coxa valga, High palate, Natal tooth, Absent para... OMIM:269300
Turner Syndrome Due To Structural X Chromosome Anomalies
Short 4th metacarpal, Micrognathia, Abnormal forearm bone morphology, Enlargement of the distal f... ORPHA:99413
Turner Syndrome
Short 4th metacarpal, Micrognathia, Abnormal forearm bone morphology, Enlargement of the distal f... ORPHA:881
Mosaic Monosomy X
Short 4th metacarpal, Micrognathia, Abnormal forearm bone morphology, Enlargement of the distal f... ORPHA:99228
Monosomy X
Short 4th metacarpal, Micrognathia, Abnormal forearm bone morphology, Enlargement of the distal f... ORPHA:99226
Oculodentodigital Dysplasia, Autosomal Recessive
Dental malocclusion, Small hand, Long philtrum, Delayed eruption of teeth, 4-5 finger syndactyly,... OMIM:257850
Coronary Arterial Fistula
Pulmonary arterial hypertension, Systolic heart murmur, Abnormal EKG, Elevated jugular venous pre... ORPHA:2041
Glycogen Storage Disease Xv
Right bundle branch block, T-wave inversion, Paroxysmal ventricular tachycardia, ST segment eleva... OMIM:613507
Congenital Left Ventricular Aneurysm
Abnormal T-wave, Abnormal ST segment, Congestive heart failure, Arrhythmia ORPHA:1055
Wild Type Attr Amyloidosis
Orthostatic hypotension due to autonomic dysfunction, Nephrotic syndrome, Abnormal EKG, Congestiv... ORPHA:330001
Orofaciodigital Syndrome Iii
Short sternum, Bifid tongue, Tongue nodules, Microdontia, Bifid uvula, Supernumerary tooth, Posta... OMIM:258850
Tropical Endomyocardial Fibrosis
Systolic heart murmur, Restrictive cardiomyopathy, Left ventricular diastolic dysfunction, Cardio... ORPHA:75565
Cardiogenic Shock
Hypotension, Impaired myocardial contractility, Abnormal EKG, Elevated jugular venous pressure, C... ORPHA:97292
Atrial Septal Defect, Ostium Primum Type
Systolic heart murmur, Clubbing of fingers, Palpitations, Abnormal P wave, Tricuspid regurgitatio... ORPHA:99106
Complete Atrioventricular Septal Defect
Elevated pulmonary artery pressure, Systolic heart murmur, Right bundle branch block, Third heart... ORPHA:1329
Exercise-Induced Malignant Hyperthermia
Hypotension, Abnormal T-wave, Acute kidney injury, Sinus tachycardia, Abnormal pulse pressure, ST... ORPHA:466650
Dysosteosclerosis
Short diaphyses, Short sternum, Broad femoral neck, Broad ribs, High palate, Natal tooth, Short r... OMIM:224300
Multiple Synostoses Syndrome 1
Thick upper lip vermilion, 2-3 toe syndactyly, Dislocated radial head, Short hallux, Radial devia... OMIM:186500
Brugada Syndrome 6
Cardiac arrest, Ventricular fibrillation, ST segment elevation OMIM:613119
Cardiomyopathy, Familial Restrictive, 3
Hypotension, Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, Left axis de... OMIM:612422
Peripartum Cardiomyopathy
Pulmonary arterial hypertension, Abnormal T-wave, Reduced left ventricular ejection fraction, Hea... ORPHA:563
Brugada Syndrome 8
Ventricular tachycardia, Right bundle branch block, ST segment elevation OMIM:613123
Pulmonic Stenosis, Atrial Septal Defect, And Unique Electrocardiographic Abnormalities
Pulmonic stenosis, Abnormal EKG OMIM:178650
Brugada Syndrome 5
Bundle branch block, Ventricular fibrillation, ST segment elevation OMIM:612838
Atrial Fibrillation, Familial, 14
Prolonged PR interval, Paroxysmal atrial fibrillation, Hypertension, ST segment elevation OMIM:615378
Dpagt1-Cdg
Clinodactyly, Camptodactyly, Intracranial hemorrhage, Prolonged QT interval, Hepatomegaly, Arachn... ORPHA:86309
Enamel-Renal Syndrome
Impaired renal concentrating ability, Enuresis, Delayed eruption of teeth, Nephrocalcinosis, Hypo... ORPHA:1031
Familial Osteodysplasia, Anderson Type
Mandibular prognathia, Aplastic clavicle, Aplasia/hypoplasia of the femur, Missing ribs, Clinodac... ORPHA:2769
Amelogenesis Imperfecta, Type Ig
Impaired renal concentrating ability, Enuresis, Nephrocalcinosis, Dagger-shaped pulp calcificatio... OMIM:204690
Early-Onset Cerebellar Ataxia With Retained Tendon Reflexes
Cardiomyopathy, Abnormal EKG ORPHA:1177
Orofaciodigital Syndrome Type 2
Short tibia, Broad first metatarsal, Bifid tongue, Micrognathia, Taurodontia, Abnormal oral frenu... ORPHA:2751
Hyperparathyroidism-Jaw Tumor Syndrome
Mandibular pain, Renal hamartoma, Renal cyst, Nephrocalcinosis, Renal insufficiency, Shortened QT... ORPHA:99880
Cerebrocostomandibular Syndrome
Cleft soft palate, Micrognathia, Posterior rib gap, Cleft palate, Glossoptosis, Rib gap, Anomalou... OMIM:117650
Al Amyloidosis
Reduced left ventricular ejection fraction, Nephrotic syndrome, Abnormal EKG, Macroglossia, Hyper... ORPHA:85443
Parathyroid Carcinoma
Mandibular pain, Renal hamartoma, Renal cyst, Nephrocalcinosis, Renal insufficiency, Shortened QT... ORPHA:143
Congenital Aortic Valve Stenosis
Sudden cardiac death, Abnormal T-wave, Increased QRS voltage, Reduced left ventricular ejection f... ORPHA:3093
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Congenital Sialidosis Type 2
Polydactyly, Telangiectasia, Abnormal EKG, Hepatosplenomegaly, Protruding tongue, Hepatomegaly, G... ORPHA:93400
Coffin-Lowry Syndrome
Dental malocclusion, Mandibular prognathia, Coxa valga, Tapered finger, Short metacarpal, Hyperex... OMIM:303600
Dextrocardia
Abnormal EKG, T-wave inversion, Congenital hip dislocation, Abnormality of the ureter, Abnormal r... ORPHA:1666
Congenitally Uncorrected Transposition Of The Great Arteries
Left ventricular outflow tract obstruction, Cardiac shunt, Heart murmur, Abnormality of blood cir... ORPHA:860
Cerebellar-Facial-Dental Syndrome
Abnormal T-wave, Dental malocclusion, Tapered finger, Long philtrum, Macrodontia of permanent max... ORPHA:444072
Muscular Dystrophy, Duchenne Type
Abnormal EKG, Dilated cardiomyopathy, Congestive heart failure, Arrhythmia, Cardiomyopathy OMIM:310200
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Abnormal T-wave, Intracranial hemorrhage, Hypertension, Increased urinary potassium, Epistaxis, P... ORPHA:231625
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Right bundle branch block, Pollakisuria, Reduced left ventricular ejection fraction, Abnormal EKG... ORPHA:268
Multiple Endocrine Neoplasia Type 1
Gingival fibromatosis, Hypertension, Hematemesis, Shortened QT interval, Nephrolithiasis, Hyperca... ORPHA:652
Dopamine Beta-Hydroxylase Deficiency
Abnormal EKG, Syncope, Nocturia, Elevated urinary dopamine, Orthostatic hypotension, Orthostatic ... ORPHA:230
Ulbright-Hodes Syndrome
Short sternum, High palate, Humeroradial synostosis, Short ribs, Short metacarpal, Hypoplasia of ... ORPHA:3404
Friedreich Ataxia
Hypertrophic cardiomyopathy, Congestive heart failure, Abnormal EKG OMIM:229300
Cardiac Diverticulum
Abnormal EKG, Mitral stenosis, Syncope, Left ventricular hypertrophy, Angina pectoris, Congestive... ORPHA:1686
Craniorachischisis
Bifid sternum ORPHA:63260
Absence Of The Pulmonary Artery
Pulmonary arterial hypertension, Systolic heart murmur, Reduced left ventricular ejection fractio... ORPHA:980
Chronic Thromboembolic Pulmonary Hypertension
Pulmonary arterial hypertension, Pulmonary embolism, Abnormal T-wave, Right bundle branch block, ... ORPHA:70591
African Trypanosomiasis
Urinary incontinence, Second degree atrioventricular block, Third degree atrioventricular block, ... ORPHA:3385
Friedreich Ataxia 2
Abnormal EKG, Congestive heart failure, Concentric hypertrophic cardiomyopathy, Hammertoe OMIM:601992

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ypel2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ypel2.

No publications found that use IMPC mice or data for Ypel2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Ypel2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ypel2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ypel2em1(IMPC)Tcp Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter