Gene Summary

Name:
yippee like 2
Synonyms:
E130113K08Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged urinary bladder Ypel2em1(IMPC)Tcp HOM Early adult 0.00
decreased prepulse inhibition Ypel2em1(IMPC)Tcp HOM Early adult 1.71×10-05
abnormal eye morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00
abnormal tooth morphology Ypel2em1(IMPC)Tcp HOM Early adult 2.82×10-06
prolonged QT interval Ypel2em1(IMPC)Tcp HOM Early adult 2.47×10-06
decreased body length Ypel2em1(IMPC)Tcp HOM Early adult 4.50×10-05
abnormal sternum morphology Ypel2em1(IMPC)Tcp HOM Early adult 0.00

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Eye Morphology

Images Slit Lamp

21 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Eye Morphology

Images Ophthalmoscopy

47 Images

Gross Pathology and Tissue Collection

Images

9 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Ypel2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ypel2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Jervell And Lange-Nielsen Syndrome 1
Prolonged QT interval, Prolonged QTc interval, Sudden cardiac death, Syncope, Torsade de pointes OMIM:220400
Long Qt Syndrome 2
Prolonged QT interval, Prolonged QTc interval, Cardiac arrest, Notched T wave, Ventricular fibril... OMIM:613688
Long Qt Syndrome 13
Congestive heart failure, Reduced left ventricular ejection fraction, Prolonged QTc interval, Syn... OMIM:613485
Long Qt Syndrome 10
Prolonged QT interval, Atrial fibrillation, T-wave alternans, Atrioventricular block, Sudden card... OMIM:611819
Long Qt Syndrome 6
Prolonged QT interval, Prolonged QTc interval, Cardiac arrest, Ventricular fibrillation, Sudden c... OMIM:613693
Long Qt Syndrome 14
2:1 atrioventricular block, Prolonged QT interval, Prolonged QTc interval, T-wave alternans, Card... OMIM:616247
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3
Polymorphic ventricular tachycardia, Prolonged QT interval, Paroxysmal ventricular tachycardia, P... OMIM:614021
Atrial Fibrillation, Familial, 9
Paroxysmal atrial fibrillation, Prolonged QTc interval, Permanent atrial fibrillation, Syncope, P... OMIM:613980
Long Qt Syndrome 1
Prolonged QT interval, Prolonged QTc interval, Ventricular fibrillation, Sudden cardiac death, Sy... OMIM:192500
Atrial Fibrillation, Familial, 3
Paroxysmal atrial fibrillation, Prolonged QTc interval, Atrial fibrillation, Permanent atrial fib... OMIM:607554
Long Qt Syndrome 11
Syncope, Prolonged QTc interval OMIM:611820
Brugada Syndrome 9
Presyncope, ST segment elevation, Prolonged QT interval, Palpitations OMIM:616399
Long Qt Syndrome 9
Abnormal U wave, Prolonged QT interval, Cardiac arrest, Sinus bradycardia, Ventricular arrhythmia... OMIM:611818
Andersen-Tawil Syndrome
Clinodactyly of the 5th toe, Prolonged QT interval, Polymorphic ventricular tachycardia, Prominen... ORPHA:37553
Regional Odontodysplasia
Yellow-brown discoloration of the teeth, Eruption failure, Abnormality of primary teeth, Short de... ORPHA:83450
Cardiac Arrhythmia Syndrome, With Or Without Skeletal Muscle Weakness
Polymorphic ventricular tachycardia, Prolonged QT interval, Cardiac arrest, Premature ventricular... OMIM:615441
Andersen Cardiodysrhythmic Periodic Paralysis
Short mandibular rami, Clinodactyly of the 5th toe, Prolonged QT interval, Prominent U wave, Dent... OMIM:170390
Jervell And Lange-Nielsen Syndrome 2
Prolonged QT interval, Premature ventricular contraction, Sudden cardiac death, Syncope, Torsade ... OMIM:612347
Sick Sinus Syndrome 1
Sick sinus syndrome, Prolonged QT interval, Ventricular escape rhythm, Sinus bradycardia, Atriove... OMIM:608567
Progressive Familial Heart Block, Type Ib
Left anterior fascicular block, Prolonged QT interval, Bradycardia, Syncope, Right bundle branch ... OMIM:604559
Long Qt Syndrome 8
Prolonged QTc interval, Ventricular fibrillation, Sinus bradycardia, Syndactyly, Syncope, Aborted... OMIM:618447
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Congestive heart failure, Atrial flutter, Left anterior fascicular block, Atrial fibrillation, Pr... OMIM:616117
Long Qt Syndrome 16
Prolonged QTc interval, T-wave alternans, Second degree atrioventricular block, Bradycardia OMIM:618782
Cardiac Arrhythmia, Ankyrin-B-Related
Prolonged QT interval, Atrial fibrillation, Sinus bradycardia, Syncope, Sudden cardiac death OMIM:600919
Cardiomyopathy, Dilated, 1D
Congestive heart failure, Prolonged QT interval, Reduced left ventricular ejection fraction, Inco... OMIM:601494
Myofibrillar Myopathy 10
Sandal gap, Prolonged QTc interval, Mandibular prognathia, Increased QRS voltage, Flexion contrac... OMIM:619040
Long Qt Syndrome 5
Torsade de pointes, Prolonged QTc interval, Ventricular fibrillation, Sinus bradycardia, Syncope,... OMIM:613695
Long Qt Syndrome 12
Prolonged QTc interval, Ventricular fibrillation, Syncope, Torsade de pointes OMIM:612955
Long Qt Syndrome 15
2:1 atrioventricular block, Polymorphic ventricular tachycardia, Ventricular bigeminy, Bradycardi... OMIM:616249
Sick Sinus Syndrome 2
Paroxysmal atrial fibrillation, Sick sinus syndrome, Aortic regurgitation, Atrial fibrillation, P... OMIM:163800
Atrial Fibrillation, Familial, 7
Paroxysmal atrial fibrillation, Prolonged QTc interval, Permanent atrial fibrillation, Premature ... OMIM:612240
Sick Sinus Syndrome 4
Paroxysmal atrial fibrillation, Abnormal QRS complex, Syncope, Chronotropic incompetence, Abnorma... OMIM:619464
Cardiomyopathy, Familial Hypertrophic, 27
Congestive heart failure, Prolonged QT interval, Concentric hypertrophic cardiomyopathy, Cardiac ... OMIM:618052
Amelogenesis Imperfecta
Fragile teeth, Widely spaced teeth, Abnormal permanent molar morphology, Yellow-brown discolorati... ORPHA:88661
Long Qt Syndrome 3
Torsade de pointes, Prolonged QTc interval, Ventricular flutter, Ventricular fibrillation, Syncop... OMIM:603830
Cardiomyopathy, Familial Hypertrophic, 26
Congestive heart failure, Left anterior fascicular block, Left bundle branch block, Atrial fibril... OMIM:617047
Tako-Tsubo Cardiomyopathy
Prolonged QT interval, Bradycardia, Palpitations, Low-output congestive heart failure, Mildly red... ORPHA:66529
Romano-Ward Syndrome
Torsade de pointes, Prolonged QTc interval, Sinus bradycardia, Ventricular arrhythmia, Syncope, S... ORPHA:101016
Timothy Syndrome
Prolonged QT interval, Bradycardia, Microdontia, Pulmonary arterial hypertension, Atrioventricula... OMIM:601005
Dentin Dysplasia, Type I
Oligodontia, Short dental root, Microdontia, Enamel hypoplasia, Periapical bone loss, Pulp oblite... OMIM:125400
Congenital Heart Block
Congestive heart failure, Bradycardia, Prolonged QTc interval, Gallop rhythm, Abnormal heart valv... ORPHA:60041
Familial Short Qt Syndrome
Bradycardia, Atrial fibrillation, Syncope, Ventricular fibrillation, Ventricular arrhythmia, Shor... ORPHA:51083
Metaphyseal Chondrodysplasia, Spahr Type
Abnormal metaphysis morphology, Bowing of the long bones, Abnormality of the dentition, Carious t... ORPHA:2501
Jervell And Lange-Nielsen Syndrome
Prolonged QTc interval, Ventricular fibrillation, Arrhythmia, Syncope, Torsade de pointes ORPHA:90647
Brugada Syndrome 3
J wave, Atrial fibrillation, Shortened QT interval, Ventricular arrhythmia, Syncope, Sudden cardi... OMIM:611875
3-Methylglutaconic Aciduria, Type V
3-Methylglutaconic aciduria, Congestive heart failure, Prolonged QT interval, Hypospadias, Noncom... OMIM:610198
Dental Ankylosis
Abnormal dental enamel morphology, Mandibular prognathia, Clinodactyly of the 5th finger, Tooth a... ORPHA:1077
Short Qt Syndrome 1
Paroxysmal atrial fibrillation, Cardiac arrest, Shortened QT interval, Syncope, Palpitations, Sud... OMIM:609620
Oligodontia
Short dental root, Microdontia, Eclabion, Agenesis of maxillary lateral incisor, Taurodontia, Age... ORPHA:99798
Sinoatrial Node Dysfunction And Deafness
Abnormal QRS complex, Syncope, Increased heart rate variability, Bradycardia OMIM:614896
Cirrhotic Cardiomyopathy
Elevated pulmonary artery pressure, Congestive heart failure, Fourth heart sound, Hepatomegaly, P... ORPHA:57777
Dentinogenesis Imperfecta
Fragile teeth, Grayish enamel, Yellow-brown discoloration of the teeth, Selective tooth agenesis,... ORPHA:49042
Amelogenesis Imperfecta, Type Ij
Amelogenesis imperfecta, Widely spaced teeth, Increased overbite, Abnormal dentin morphology, Car... OMIM:617297
Short Qt Syndrome 7
Cardiac arrest, Ventricular fibrillation, Shortened QT interval, Syncope, Sudden cardiac death OMIM:620231
Incessant Infant Ventricular Tachycardia
Congestive heart failure, Wolff-Parkinson-White syndrome, Histiocytoid cardiomyopathy, Supraventr... ORPHA:45453
Neonatal Lupus Erythematosus
Hepatomegaly, Prolonged QT interval, Heart block, Splenomegaly, Arrhythmia, Atrioventricular bloc... ORPHA:398124
Short Qt Syndrome 2
Bradycardia, Atrial fibrillation, Ventricular fibrillation, Shortened QT interval, Syncope, Sudde... OMIM:609621
Pseudohypoparathyroidism Type 1B
Low urinary cyclic AMP response to PTH administration, Prolonged QT interval, Delayed eruption of... ORPHA:94089
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:204700
Brugada Syndrome
Sick sinus syndrome, Paroxysmal ventricular tachycardia, ST segment elevation, Trifascicular bloc... ORPHA:130
Amelogenesis Imperfecta, Type Ia
Amelogenesis imperfecta, Enamel hypoplasia, Generalized microdontia, Dental enamel pits, Taurodontia OMIM:104530
Florid Cemento-Osseous Dysplasia
Supernumerary tooth, Atrophy of alveolar ridges, Oral ulcer, Abnormality of primary teeth, Abnorm... ORPHA:83451
Otodental Dysplasia
Agenesis of premolar, Delayed eruption of teeth, Enamel hypoplasia, Long philtrum, Tooth ankylosi... OMIM:166750
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Prolonged QT interval, Arrhythmia ORPHA:2151
Familial Hyperaldosteronism Type Iii
Prolonged QT interval, Hypercalciuria, Hypertension, Epistaxis, Intracranial hemorrhage, Left ven... ORPHA:251274
Atrial Fibrillation, Familial, 11
Atrial fibrillation, Prolonged QRS complex, Reduced left ventricular ejection fraction, Prolonged... OMIM:614049
Idiopathic Neonatal Atrial Flutter
Abnormal atrioventricular conduction, Abnormal QRS complex, Reduced left ventricular ejection fra... ORPHA:45452
Dentinogenesis Imperfecta, Shields Type Iii
Anterior open-bite malocclusion, Periapical bone loss, Dentinogenesis imperfecta, Dental enamel p... OMIM:125500
Pyle Disease
Genu valgum, Delayed eruption of teeth, Mandibular prognathia, Hypoplastic frontal sinuses, Persi... OMIM:265900
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 14
Prolonged QT interval OMIM:615351
Acquired Aneurysmal Subarachnoid Hemorrhage
Congestive heart failure, Ischemic stroke, Prolonged QTc interval, Hypertension, Cerebral ischemi... ORPHA:90065
Dentin Dysplasia, Type Ii
Dentinogenesis imperfecta limited to primary teeth, Pulp calcification, Thistle tube shaped pulp OMIM:125420
Amelogenesis Imperfecta, Type Ic
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:204650
Amelogenesis Imperfecta, Type Ih
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:616221
Amelogenesis Imperfecta, Type Iiia
Amelogenesis imperfecta, Dental malocclusion, Anterior open-bite malocclusion OMIM:130900
Neurodevelopmental Disorder With Hypotonia, Language Delay, And Skeletal Defects With Or Without Seizures
Thin vermilion border, 2-3 toe cutaneous syndactyly, Prolonged QT interval, Narrow mouth, Camptod... OMIM:620029
Wolff-Parkinson-White Syndrome
Paroxysmal atrial fibrillation, Wolff-Parkinson-White syndrome, Atrial flutter, Syncope, Ventricu... OMIM:194200
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis
Amelogenesis imperfecta, Genu valgum, Small epiphyses, Mandibular prognathia, Short long bone, Hi... OMIM:618363
Pseudohypoparathyroidism Type 2
Prolonged QT interval ORPHA:94090
Autoimmune Hypoparathyroidism
Abnormal left ventricular function, Ventricular arrhythmia, Calcium nephrolithiasis, Prolonged QT... ORPHA:36913
Atrial Standstill
Sick sinus syndrome, Congestive heart failure, Ischemic stroke, Reduced left ventricular ejection... ORPHA:1344
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Prolonged QT interval, Ventricular fibrillation, Atrioventricular block, Arrhythmia... ORPHA:26793
Short Qt Syndrome 3
Tachycardia, Palpitations, Shortened QT interval OMIM:609622
Brugada Syndrome 4
Syncope, Shortened QT interval, Atrial fibrillation OMIM:611876
Rett Syndrome
Prolonged QTc interval, Abnormality of the dentition, Short foot, Abnormal T-wave OMIM:312750
Arrhythmogenic Right Ventricular Dysplasia, Familial, 5
Presyncope, Congestive heart failure, Right ventricular cardiomyopathy, Palpitations, Premature v... OMIM:604400
Simpson-Golabi-Behmel Syndrome
Ureteral duplication, Prolonged QT interval, Hypoplasia of penis, Cardiomyopathy, Broad thumb, Wi... ORPHA:373
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
Right ventricular cardiomyopathy, Ventricular arrhythmia, Ventricular tachycardia, Prolonged QRS ... OMIM:611528
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:612529
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:618386
Cardiomyopathy, Familial Hypertrophic, 6
Congestive heart failure, Wolff-Parkinson-White syndrome, Left bundle branch block, Atrial fibril... OMIM:600858
Muscular Dystrophy, Becker Type
Cardiomyopathy, Abnormal EKG, Arrhythmia OMIM:300376
Nathalie Syndrome
Abnormal EKG OMIM:255990
Otodental Syndrome
Agenesis of premolar, Abnormality of canine, Delayed eruption of teeth, Periodontitis, Abnormal d... ORPHA:2791
Muscular Dystrophy, Cardiac Type
Cardiomyopathy, Carnosinuria, Abnormal EKG OMIM:309930
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Carious teeth OMIM:615887
Cardiomyopathy, Familial Hypertrophic, 8
Congestive heart failure, Reduced left ventricular ejection fraction, Palpitations, Restrictive c... OMIM:608751
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Epsilon wave, Right ventricular cardiomyopathy, Palpitations, Right bundle branch block, Prematur... OMIM:610193
Amelogenesis Imperfecta, Type If
Amelogenesis imperfecta, Enamel hypoplasia, Dental enamel pits, Abnormality of dental color OMIM:616270
Cerebral Creatine Deficiency Syndrome 1
Mandibular prognathia, Elevated urinary creatine/creatinine ratio, Prolonged QT interval, Malar f... OMIM:300352
Epidermolysis Bullosa, Junctional 1A, Intermediate
Enamel hypoplasia, Camptodactyly of finger, Carious teeth, Hypodontia, Oral mucosal blisters OMIM:226650
Pseudohypoparathyroidism Type 1C
Short 4th metacarpal, Low urinary cyclic AMP response to PTH administration, Prolonged QT interva... ORPHA:79444
Lipodystrophy, Congenital Generalized, Type 4
Hepatomegaly, Prolonged QT interval, Bradycardia, Atrial fibrillation, Splenomegaly, Tachycardia OMIM:613327
Cocaine Intoxication
Acute kidney injury, Ischemic stroke, Myocardial infarction, Hematuria, Prolonged QT interval, Ta... ORPHA:90068
Cardiomyopathy, Familial Hypertrophic, 10
Systolic anterior motion of the mitral valve, Left bundle branch block, Palpitations, Supraventri... OMIM:608758
Amelogenesis Imperfecta, Type Ie
Amelogenesis imperfecta, Enamel hypoplasia, Anterior open-bite malocclusion, Abnormal dentin morp... OMIM:301200
Multifocal Atrial Tachycardia
Atrial flutter, Tachycardia, Atrial fibrillation, Effort-induced polymorphic ventricular tachycar... ORPHA:3282
Amelogenesis Imperfecta, Type Iv
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Enamel hypoplasia, Taurodontia OMIM:104510
Ethylene Glycol Poisoning
Congestive heart failure, Renal tubular epithelial necrosis, Shock, Hematuria, Prolonged QT inter... ORPHA:31826
17Q24.2 Microdeletion Syndrome
Prolonged QT interval, Short philtrum, Tooth malposition, Upper limb undergrowth, Vesicoureteral ... ORPHA:529962
Dilated Cardiomyopathy With Ataxia
3-Methylglutaconic aciduria, Prolonged QT interval, Hypoplasia of penis, Dilated cardiomyopathy, ... ORPHA:66634
Drug-Induced Lupus Erythematosus
Prolonged QTc interval, Pericarditis, Hematuria ORPHA:231111
Pseudohypoparathyroidism Type 1A
Short 4th metacarpal, Low urinary cyclic AMP response to PTH administration, Prolonged QT interva... ORPHA:79443
Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome
Arrhythmia, Prolonged QT interval, Abnormal EKG, Ketonuria ORPHA:480864
Gitelman Syndrome
Polyuria, Prolonged QT interval, Hypocalciuria, Renal potassium wasting, Hypotension, Enuresis, N... OMIM:263800
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration
Prolonged QTc interval, Myoglobinuria, Cardiac arrest, Hypertrophic cardiomyopathy, Ventricular f... OMIM:616878
Cleidocranial Dysplasia
Glossoptosis, Sinusitis, Abnormal epiphysis morphology, Abnormal metacarpal morphology, Abnormali... ORPHA:1452
Hypophosphatemic Rickets, Autosomal Recessive, 2
Genu valgum, Medullary nephrocalcinosis, Pulmonic stenosis, Hypoplasia of teeth, Carious teeth, H... OMIM:613312
Brugada Syndrome 7
Paroxysmal atrial fibrillation, Atrial flutter, ST segment elevation, Permanent atrial fibrillati... OMIM:613120
Amelo-Onycho-Hypohidrotic Syndrome
Advanced eruption of teeth, Delayed eruption of teeth, Yellow-brown discoloration of the teeth, A... ORPHA:1028
Cardiomyopathy, Dilated, 1Nn
Congestive heart failure, Reduced left ventricular ejection fraction, Abnormal ST segment, Ventri... OMIM:615916
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Dicarboxylic aciduria, Prolonged QT interval, Myoglobinuria, Hypertrophic cardiomyopathy, Dilated... ORPHA:71212
Gitelman Syndrome
Urinary incontinence, Prolonged QT interval, Renal tubular acidosis, Renal potassium wasting, Pro... ORPHA:358
Attrv122I Amyloidosis
Abnormal atrioventricular conduction, Congestive heart failure, Reduced left ventricular ejection... ORPHA:85451
Cardiomyopathy, Familial Hypertrophic, 13
Left anterior fascicular block, Concentric hypertrophic cardiomyopathy, Reduced left ventricular ... OMIM:613243
Thyrotoxic Periodic Paralysis
Prolonged QT interval, Decreased urinary potassium, Ventricular fibrillation, Palpitations, Urina... ORPHA:79102
45,X/46,Xy Mixed Gonadal Dysgenesis
Epispadias, Short 4th metacarpal, Penoscrotal hypospadias, Short metatarsal, Hypospadias, Prolong... ORPHA:1772
Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Epsilon wave, Right ventricular cardiomyopathy, Palpitations, Cardiac arrest, Premature ventricul... OMIM:609040
Craniometadiaphyseal Dysplasia
Genu valgum, Flared metaphysis, Dental crowding, Mandibular prognathia, High palate, Microdontia,... OMIM:269300
Pycnodysostosis
Narrow palate, Absent frontal sinuses, Narrow iliac wing, Osteolytic defects of the distal phalan... OMIM:265800
Turner Syndrome Due To Structural X Chromosome Anomalies
Retrognathia, Prolonged QT interval, Ectopic kidney, Hypertension, Abnormal forearm bone morpholo... ORPHA:99413
Turner Syndrome
Retrognathia, Prolonged QT interval, Ectopic kidney, Hypertension, Abnormal forearm bone morpholo... ORPHA:881
Mosaic Monosomy X
Retrognathia, Prolonged QT interval, Ectopic kidney, Hypertension, Abnormal forearm bone morpholo... ORPHA:99228
Monosomy X
Retrognathia, Prolonged QT interval, Ectopic kidney, Hypertension, Abnormal forearm bone morpholo... ORPHA:99226
Coronary Arterial Fistula
Congestive heart failure, Tachycardia, Angina pectoris, Elevated jugular venous pressure, Syncope... ORPHA:2041
Atrial Septal Defect, Ostium Primum Type
Third heart sound, Left ventricular hypertrophy, Right-to-left shunt, Pulmonary arterial hyperten... ORPHA:99106
Wild Type Attr Amyloidosis
Congestive heart failure, Hepatomegaly, Renal insufficiency, Bradycardia, Atrial fibrillation, Hy... ORPHA:330001
Congenital Left Ventricular Aneurysm
Congestive heart failure, Abnormal T-wave, Arrhythmia, Abnormal ST segment ORPHA:1055
Orofaciodigital Syndrome Iii
Supernumerary tooth, Postaxial hand polydactyly, Microdontia, Short sternum, Bifid uvula, Tongue ... OMIM:258850
Tropical Endomyocardial Fibrosis
P pulmonale, Abnormal ST segment, Splenomegaly, Prolonged QRS complex, Cardiomegaly, Pulmonary ve... ORPHA:75565
Exercise-Induced Malignant Hyperthermia
Acute kidney injury, Prolonged QT interval, Sinus tachycardia, Abnormal pulse pressure, Hypotensi... ORPHA:466650
Cardiogenic Shock
Congestive heart failure, Hepatomegaly, Abnormal left ventricular function, Low-output congestive... ORPHA:97292
Complete Atrioventricular Septal Defect
Elevated pulmonary artery pressure, Congestive heart failure, Hepatomegaly, Third heart sound, Ta... ORPHA:1329
Multiple Synostoses Syndrome 1
Radial deviation of finger, Proximal/middle symphalangism of 5th toe, Dislocated radial head, Sho... OMIM:186500
Pulmonic Stenosis, Atrial Septal Defect, And Unique Electrocardiographic Abnormalities
Pulmonic stenosis, Abnormal EKG OMIM:178650
Dysosteosclerosis
Diaphyseal undertubulation, Abnormal metaphyseal trabeculation, Flared metaphysis, Delayed erupti... OMIM:224300
Peripartum Cardiomyopathy
Myocarditis, Congestive heart failure, Left ventricular systolic dysfunction, Left bundle branch ... ORPHA:563
Brugada Syndrome 6
ST segment elevation, Cardiac arrest, Ventricular fibrillation OMIM:613119
Cardiomyopathy, Familial Restrictive, 3
Reduced left ventricular ejection fraction, Abnormal ST segment, Restrictive cardiomyopathy, Hypo... OMIM:612422
Brugada Syndrome 8
Ventricular tachycardia, Right bundle branch block, ST segment elevation OMIM:613123
Dpagt1-Cdg
Hepatomegaly, Prolonged QT interval, Camptodactyly, Arachnodactyly, Intracranial hemorrhage, Clin... ORPHA:86309
Brugada Syndrome 5
ST segment elevation, Ventricular fibrillation, Bundle branch block OMIM:612838
Atrial Fibrillation, Familial, 14
Paroxysmal atrial fibrillation, ST segment elevation, Hypertension, Prolonged PR interval OMIM:615378
Orofaciodigital Syndrome Type 2
Cone-shaped epiphyses of the phalanges of the hand, Abnormal oral frenulum morphology, Tongue nod... ORPHA:2751
Enamel-Renal Syndrome
Amelogenesis imperfecta, Delayed eruption of teeth, Yellow-brown discoloration of the teeth, Abno... ORPHA:1031
Familial Osteodysplasia, Anderson Type
Aplasia/hypoplasia of the femur, Abnormal zygomatic bone morphology, Clinodactyly of the 5th fing... ORPHA:2769
Amelogenesis Imperfecta, Type Ig
Amelogenesis imperfecta, Polyuria, Gingival fibromatosis, Impaired renal concentrating ability, D... OMIM:204690
Early-Onset Cerebellar Ataxia With Retained Tendon Reflexes
Abnormal EKG ORPHA:1177
Hyperparathyroidism-Jaw Tumor Syndrome
Mandibular pain, Hypercalciuria, Renal hamartoma, Nephrolithiasis, Renal cyst, Nephrocalcinosis, ... ORPHA:99880
Cerebrocostomandibular Syndrome
Anomalous rib insertion to vertebrae, Ectopic kidney, Glossoptosis, Short humerus, Long philtrum,... OMIM:117650
Hypotrichosis And Recurrent Skin Vesicles
Abnormality of the dentition, Angular cheilitis, Abnormal EKG OMIM:613102
Parathyroid Carcinoma
Mandibular pain, Hypercalciuria, Renal hamartoma, Nephrolithiasis, Renal cyst, Nephrocalcinosis, ... ORPHA:143
Al Amyloidosis
Gastrointestinal hemorrhage, Hepatomegaly, Abnormal salivary gland morphology, Hypertrophic cardi... ORPHA:85443
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Congenital Aortic Valve Stenosis
Reduced left ventricular ejection fraction, Angina pectoris, Abnormal pulse pressure, Aortic valv... ORPHA:3093
Congenital Sialidosis Type 2
Polydactyly, Hepatomegaly, Gingival overgrowth, Protruding tongue, Hepatosplenomegaly, Abnormal E... ORPHA:93400
Coffin-Lowry Syndrome
Narrow palate, Thick lower lip vermilion, Widely spaced teeth, Bifid sternum, Hyperextensibility ... OMIM:303600
Congenitally Uncorrected Transposition Of The Great Arteries
Abnormal QRS complex, Congestive heart failure, Hepatomegaly, Abnormality of blood circulation, T... ORPHA:860
Dextrocardia
Abnormal rib morphology, Abnormality of the ureter, Congenital hip dislocation, T-wave inversion,... ORPHA:1666
Cerebellar-Facial-Dental Syndrome
Abnormal T-wave, Slender long bone, Micrognathia, Macrodontia of permanent maxillary central inci... ORPHA:444072
Muscular Dystrophy, Duchenne Type
Congestive heart failure, Cardiomyopathy, Arrhythmia, Dilated cardiomyopathy, Abnormal EKG OMIM:310200
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Hypertension, Epistaxis, Increased urinary potassium, Intracranial hemorrhage, Palpitations, Abno... ORPHA:231625
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Reduced left ventricular ejection fraction, Pollakisuria, Right bundle branch block, Right ventri... ORPHA:268
Multiple Endocrine Neoplasia Type 1
Hematemesis, Melena, Gingival fibromatosis, Hypercalciuria, Hypertension, Nephrolithiasis, Shorte... ORPHA:652
Dopamine Beta-Hydroxylase Deficiency
Orthostatic hypotension, Orthostatic syncope, Elevated urinary dopamine level, Nocturia, Syncope,... ORPHA:230
Friedreich Ataxia
Congestive heart failure, Abnormal EKG, Hypertrophic cardiomyopathy OMIM:229300
Ulbright-Hodes Syndrome
Hypoplasia of the radius, Fibular aplasia, Thin vermilion border, Polycystic kidney dysplasia, Th... ORPHA:3404
Cardiac Diverticulum
Congestive heart failure, Angina pectoris, Tricuspid stenosis, Premature ventricular contraction,... ORPHA:1686
Craniorachischisis
Bifid sternum ORPHA:63260
Noonan Syndrome
Thick lower lip vermilion, Clinodactyly of the 5th finger, Hepatomegaly, High palate, Hypertrophi... ORPHA:648
Absence Of The Pulmonary Artery
Congestive heart failure, Atrial flutter, Reduced left ventricular ejection fraction, Tachycardia... ORPHA:980
Chronic Thromboembolic Pulmonary Hypertension
Congestive heart failure, Increased pulmonary vascular resistance, Right bundle branch block, Pul... ORPHA:70591
African Trypanosomiasis
Myocarditis, Congestive heart failure, Hepatomegaly, Urinary incontinence, Third degree atriovent... ORPHA:3385
Friedreich Ataxia 2
Congestive heart failure, Hammertoe, Concentric hypertrophic cardiomyopathy, Abnormal EKG OMIM:601992

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ypel2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ypel2.

No publications found that use IMPC mice or data for Ypel2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ypel2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ypel2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ypel2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ypel2em1(IMPC)Tcp Exon Deletion Mice

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