Sla2 | Src-like-adaptor 2

GeneMGI:1925049Synonyms: SLAP-2, A930009E21Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased NK cell number1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult4.15x10-5 
decreased body weight1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult7.51x10-9 
abnormal skin morphology1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased circulating HDL cholesterol level1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult2.56x10-6 
increased circulating cholesterol level1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult1.66x10-6 
increased circulating total protein level1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult1.05x10-6 
abnormal cranium morphology1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult2.9x10-7 
enhanced cued conditioning behavior1 supporting datasetSla2em1(IMPC)CcpczhomozygoteEarly adult3.99x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sla2em1(IMPC)CcpczExon Deletionmouse
Sla2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Sla2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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