Gene Summary

Name:
prune homolog 2
Synonyms:
A230083H22Rik,  A330102H22Rik,  6330414G02Rik,  Olfaxin

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

Human diseases caused by Prune2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prune2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Anosmia For Isobutyric Acid
Partial anosmia OMIM:207000
Anosmia For Butyl Mercaptan
Anosmia OMIM:270350
Isovaleric Acid, Inability To Smell
Anosmia OMIM:243450
Anosmia, Isolated Congenital, X-Linked
Anosmia OMIM:301700
Anosmia, Isolated Congenital
Anosmia OMIM:107200
Leber Congenital Amaurosis 10
Hyposmia OMIM:611755
Musk, Inability To Smell
Anosmia OMIM:254150
Freesia Flowers, Inability To Smell
Specific anosmia OMIM:229250
Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Anosmia OMIM:614839
Body Mass Index Quantitative Trait Locus 19
Hyposmia, Anosmia OMIM:617885
Aural Atresia, Congenital
Hyposmia OMIM:607842
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia
Hyposmia OMIM:615271
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Anosmia OMIM:614842
Thumb Agenesis, Short Stature, And Immunodeficiency
Anosmia OMIM:274190
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia
Hyposmia, Anosmia OMIM:615267
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia
Anosmia OMIM:614858
Dermoid Cysts, Familial Frontonasal
Nasal congestion, Deviated nasal septum, Anosmia, Wide nasal bridge OMIM:600679
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia
Hyposmia, Anosmia OMIM:614897
Apnea, Obstructive Sleep
Anosmia OMIM:107650
Bardet-Biedl Syndrome 19
Hyposmia OMIM:615996
Brachytelephalangy With Characteristic Facies And Kallmann Syndrome
Depressed nasal bridge, Anosmia OMIM:113480
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Anosmia OMIM:612370
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Hyposmia, Anosmia OMIM:614838
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia
Anosmia OMIM:616030
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia
Hyposmia, Anosmia OMIM:612702
Indifference To Pain, Congenital, Autosomal Recessive
Hyposmia, Anosmia OMIM:243000
Chondrodysplasia Punctata 1, X-Linked Recessive
Short nasal septum, Depressed nasal bridge, Anosmia, Short nose OMIM:302950
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Abnormality of the sense of smell, Aplasia/Hypoplasia involving the nose, Choanal atresia ORPHA:1135
Neuropathy, Hereditary Sensory And Autonomic, Adult-Onset, With Anosmia
Hyposmia, Anosmia OMIM:608720
Leukoencephalopathy With Dystonia And Motor Neuropathy
Hyposmia OMIM:613724
Peroxisome Biogenesis Disorder 9B
Anosmia OMIM:614879
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Anosmia OMIM:610628
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Hyposmia, Anosmia, Choanal atresia OMIM:147950
Hypogonadotropic Hypogonadism 25 With Anosmia
Anosmia OMIM:618841
Blepharophimosis-Ptosis-Esotropia-Syndactyly-Short Stature Syndrome
Anosmia ORPHA:2057
Blepharophimosis With Ptosis, Syndactyly, And Short Stature
Anosmia, Wide nasal bridge OMIM:210745
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Anosmia OMIM:614837
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Anosmia OMIM:244200
Solitary Median Maxillary Central Incisor
Pyriform aperture stenosis, Anosmia, Midnasal stenosis, Choanal atresia, Abnormal nasopharynx mor... OMIM:147250
Gorlin Syndrome
Abnormality of the sense of smell, Wide nasal bridge ORPHA:377
Ventricular Extrasystoles With Syncopal Episodes-Perodactyly-Robin Sequence Syndrome
Abnormality of the sense of smell ORPHA:3201
Marcus-Gunn Syndrome
Abnormality of the sense of smell, Choanal atresia ORPHA:91412
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Anosmia, Abnormality of the nares, Short nose ORPHA:1295
Huntington Disease
Abnormality of the sense of smell ORPHA:399
Hyperostosis Cranialis Interna
Hyposmia OMIM:144755
Parkinson Disease 8, Autosomal Dominant
Hyposmia OMIM:607060
Bardet-Biedl Syndrome 17
Hyposmia, Anosmia OMIM:615994
Johnson Neuroectodermal Syndrome
Anosmia, Bulbous nose, Choanal atresia ORPHA:2316
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Anosmia OMIM:614841
Refsum Disease, Classic
Anosmia OMIM:266500
Johnson Neuroectodermal Syndrome
Choanal stenosis, Anosmia OMIM:147770
Kufor-Rakeb Syndrome
Hyposmia, Anosmia OMIM:606693
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Hyposmia, Anosmia OMIM:308700
Hydrolethalus
Abnormality of the sense of smell ORPHA:2189
Ciliary Dyskinesia, Primary, 1
Anosmia, Nasal polyposis, Chronic rhinitis, Recurrent bronchitis OMIM:244400
Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy
Anosmia OMIM:601152
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia
Abnormality of the sense of smell OMIM:228300
Refsum Disease
Anosmia ORPHA:773
8Q21.11 Microdeletion Syndrome
Wide nose, Abnormality of the sense of smell, Underdeveloped nasal alae ORPHA:284160
Kallmann Syndrome With Spastic Paraplegia
Anosmia OMIM:308750
Ichthyosis And Male Hypogonadism
Anosmia OMIM:308200
Congenital Hypothyroidism
Anosmia, Depressed nasal ridge ORPHA:442
Campomelic Dysplasia
Abnormality of the sense of smell, Depressed nasal bridge ORPHA:140
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Single naris, Anosmia, Absent nares, Hyposmia ORPHA:2250
Acro-Renal-Mandibular Syndrome
Abnormality of the sense of smell ORPHA:958
Kallmann Syndrome
Hyposmia, Anosmia ORPHA:478
Young-Onset Parkinson Disease
Hyposmia ORPHA:2828
Kallmann Syndrome-Heart Disease Syndrome
Total anosmia, Partial anosmia ORPHA:2326
Septo-Optic Dysplasia Spectrum
Anosmia ORPHA:3157
Holoprosencephaly
Absent nares, Anosmia, Depressed nasal ridge, Aplasia/Hypoplasia involving the nose, Choanal atre... ORPHA:2162
8P11.2 Deletion Syndrome
Depressed nasal bridge, Anosmia ORPHA:251066
Moebius Syndrome
Abnormality of the sense of smell ORPHA:570
Waardenburg Syndrome, Type 4C
Anosmia OMIM:613266
Waardenburg Syndrome, Type 2E
Anosmia OMIM:611584
Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Anosmia OMIM:619718
Hereditary Late-Onset Parkinson Disease
Hyposmia ORPHA:411602
Superficial Siderosis
Anosmia, Partial anosmia ORPHA:247245
Bosma Arhinia Microphthalmia Syndrome
Anosmia, Aplasia of the nose, Choanal atresia OMIM:603457
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Anosmia OMIM:609136
Meningioma
Abnormality of the sense of smell ORPHA:2495
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Hyposmia OMIM:618653
Amoebiasis Due To Free-Living Amoebae
Hyposmia ORPHA:68
Leopard Syndrome 1
Hyposmia, Depressed nasal ridge OMIM:151100
Occipital Horn Syndrome
Abnormality of the sense of smell ORPHA:198
Charge Syndrome
Depressed nasal bridge, Anosmia, Choanal atresia ORPHA:138
Lacrimoauriculodentodigital Syndrome
Anosmia, Choanal atresia ORPHA:2363
Charge Syndrome
Anosmia, Choanal atresia OMIM:214800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prune2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prune2.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Prune2tm1e(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Prune2tm1e(KOMP)Wtsi PMC6671969

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MGI Allele Allele Type Produced
Prune2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Prune2tm1e(KOMP)Wtsi Targeted, non-conditional allele Mice, ES Cells

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