Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
DEAD box helicase 10
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ddx10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ddx10 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
17Q21.31 Microduplication Syndrome
Short philtrum, Short nose, High palate, Abnormality of the dentition, Failure to thrive, Microce... ORPHA:217340
Palant Cleft Palate Syndrome
Contracture of the proximal interphalangeal joint of the 4th finger, Contracture of the proximal ... OMIM:260150
Diabetes Insipidus, Neurohypophyseal
Osteopenia, Long philtrum, Short nose, Wide nose OMIM:125700
Cleft Palate-Short Stature-Vertebral Anomalies Syndrome
Thin upper lip vermilion, Anteverted nares, Short nose, Cleft palate ORPHA:2015
Mental Retardation, X-Linked 91
High palate, Short nose, Macrodontia, Obesity OMIM:300577
Cortical Blindness, Retardation, And Postaxial Polydactyly
Long philtrum, Short nose OMIM:218010
Adenylosuccinate Lyase Deficiency
Long philtrum, Short nose, Smooth philtrum, Thin upper lip vermilion, Microcephaly, Anteverted nares ORPHA:46
Rhiny
Thin vermilion border, Anteverted nares, Short nose OMIM:180360
Weaver-Williams Syndrome
Microcephaly, Narrow mouth, Decreased body weight, Cleft palate ORPHA:3448
Congenital Heart Defect-Round Face-Developmental Delay Syndrome
Narrow mouth, Short nose, Depressed nasal ridge, Abnormal oral cavity morphology, Anteverted nares ORPHA:1355
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2
Short nose, Pneumonia, High palate, Anteverted nares, Chronic bronchitis, Depressed nasal bridge OMIM:614069
Bainbridge-Ropers Syndrome
Short nose, Dental crowding, High palate, Everted lower lip vermilion, Wide mouth, Failure to thr... OMIM:615485
Mental Retardation With Language Impairment And With Or Without Autistic Features
Short nose, Drooling, Open mouth, Failure to thrive in infancy, Broad nasal tip, Macrocephaly, Ob... OMIM:613670
Intellectual Developmental Disorder, X-Linked 30
Drooling, Open mouth, Short nose, High palate, Thin upper lip vermilion, Microcephaly, Anteverted... OMIM:300558
Non-Distal Trisomy 10Q
Convex nasal ridge, Short nose, Joint hyperflexibility, Everted lower lip vermilion, High palate,... ORPHA:1695
Developmental And Epileptic Encephalopathy 73
Short nose, Flexion contracture, Failure to thrive, Microcephaly, Narrow nasal bridge OMIM:618379
Burn-Mckeown Syndrome
Short nose, Abnormal palate morphology, Bilateral choanal atresia, Wide nasal bridge, Prominent n... ORPHA:1200
Macrocephaly-Spastic Paraplegia-Dysmorphism Syndrome
Short philtrum, Short nose, Everted lower lip vermilion, Wide mouth, Thin upper lip vermilion, Tr... ORPHA:2429
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Short nose, Downturned corners of mouth, Open mouth, Everted lower lip vermilion, Failure to thri... OMIM:617865
Fetal Valproate Spectrum Disorder
Long philtrum, Thin vermilion border, Short nose, Narrow mouth, Downturned corners of mouth, Depr... ORPHA:1906
Lethal Osteosclerotic Bone Dysplasia
Median cleft lip and palate, Gingival fibromatosis, Short nose, Gingival overgrowth, Depressed na... ORPHA:1832
Simpson-Golabi-Behmel Syndrome, Type 2
Short nose, Recurrent upper respiratory tract infections, Deep philtrum, Wide mouth, Pneumonia, T... OMIM:300209
Clark-Baraitser Syndrome
Long philtrum, Short nose, Downturned corners of mouth, Wide mouth, Obesity, High palate, Depress... OMIM:617752
Fatty Acyl-Coa Reductase 1 Deficiency
Long philtrum, Short nose, Smooth philtrum, Thin upper lip vermilion, Progressive microcephaly, D... ORPHA:438178
Achondrogenesis
Long philtrum, Short nose, Abnormal enchondral ossification, Aplasia/Hypoplasia of the lungs, Abn... ORPHA:932
14Q11.2 Microdeletion Syndrome
Long philtrum, Narrow mouth, Short nose, High palate, Everted lower lip vermilion, Deep philtrum,... ORPHA:261120
Macrocephaly/Autism Syndrome
Postnatal macrocephaly, Long philtrum, Biparietal narrowing, Short nose, Obesity, Depressed nasal... OMIM:605309
Chromosome 3Q29 Duplication Syndrome
Bulbous nose, Short nose, Wide nasal bridge, Macrocephaly, Microcephaly, Obesity OMIM:611936
Lowry-Maclean Syndrome
Convex nasal ridge, Delayed eruption of teeth, Craniosynostosis, Cleft palate, Microcephaly OMIM:600252
Larsen-Like Osseous Dysplasia-Short Stature Syndrome
Reduced bone mineral density, Thin vermilion border, Narrow mouth, Short nose ORPHA:2370
Ring Chromosome 8 Syndrome
Abnormal palate morphology, Anteverted nares, Short nose ORPHA:1450
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly
Short nose, Dental crowding, High palate, Thick vermilion border, Hypodontia, Microcephaly OMIM:617061
Chondrodysplasia Punctata 1, X-Linked Recessive
Epiphyseal stippling, Short nose, Anosmia, Microcephaly, Short nasal septum, Depressed nasal bridge OMIM:302950
Temple Syndrome
Joint hypermobility, Short philtrum, Overweight, Flexion contracture, Truncal obesity, Relative m... OMIM:616222
Maxillonasal Dysplasia
Open bite, Short nose, Depressed nasal ridge, Short columella, Abnormality of the nares, Tooth ag... ORPHA:1248
Pierpont Syndrome
Thin vermilion border, Short nose, Everted lower lip vermilion, Long upper lip, Smooth philtrum, ... OMIM:602342
Combined Oxidative Phosphorylation Deficiency 25
Long philtrum, Short nose, Wide nasal bridge, Anteverted nares, Depressed nasal bridge OMIM:616430
Maxillonasal Dysplasia, Binder Type
Dental malocclusion, Short nose, Short columella, Depressed nasal bridge OMIM:155050
Cortical Blindness-Intellectual Disability-Polydactyly Syndrome
Long philtrum, Short nose, Abnormal palate morphology, Cachexia, Recurrent respiratory infections ORPHA:1389
Adducted Thumbs Syndrome
Arthrogryposis multiplex congenita, Craniosynostosis, High palate, Cleft palate, Microcephaly, Hi... OMIM:201550
Chondrodysplasia With Joint Dislocations, Gpapp Type
Narrow mouth, Short nose, Wide nasal bridge, Cleft palate, Coronal craniosynostosis OMIM:614078
Tetrasomy 12P
Long philtrum, Delayed eruption of teeth, Abnormal soft palate morphology, Downturned corners of ... ORPHA:884
Chung-Jansen Syndrome
Joint hypermobility, Thin vermilion border, Long philtrum, Short philtrum, Short nose, High palat... OMIM:617991
Congenital Laryngomalacia
Laryngomalacia, Non-midline cleft lip, Cleft palate ORPHA:2373
Al-Raqad Syndrome
Narrow mouth, Joint laxity, Short nose, Thin upper lip vermilion, Microcephaly OMIM:616459
Intellectual Developmental Disorder, X-Linked 98
Short philtrum, Short nose, Underdeveloped nasal alae, Open mouth, Secondary microcephaly, Failur... OMIM:300912
Arthrogryposis, Distal, Type 1C
Pursed lips, Camptodactyly of finger, Thin vermilion border, Narrow mouth, Camptodactyly of toe, ... OMIM:619110
Hyperphosphatasia With Mental Retardation Syndrome 3
Short nose, Tented upper lip vermilion, Wide nasal bridge, Cleft palate, Broad nasal tip, Microce... OMIM:614207
Mitochondrial Myopathy And Sideroblastic Anemia
Microcephaly, High palate, Long philtrum, Short nose ORPHA:2598
Robinow Syndrome, Autosomal Recessive 2
Long philtrum, Broad nasal tip, Short nose, Camptodactyly, Abnormality of the dentition, Wide nas... OMIM:618529
Robinow Syndrome, Autosomal Dominant 2
Long philtrum, Short nose, Dental crowding, Abnormality of the dentition, Thin upper lip vermilio... OMIM:616331
Intellectual Disability-Hypoplastic Corpus Callosum-Preauricular Tag Syndrome
Camptodactyly of finger, Narrow mouth, Short nose, Abnormal palate morphology, Recurrent pneumoni... ORPHA:1495
Meckel Syndrome, Type 8
Short nose, Cleft palate, Cleft upper lip, Depressed nasal ridge, Microcephaly OMIM:613885
Achondrogenesis Type 1A
Long philtrum, Short nose, Abnormal enchondral ossification, Recurrent fractures, Aplasia/Hypopla... ORPHA:93299
Acromicric Dysplasia
Long philtrum, Narrow mouth, Bulbous nose, Short nose, Joint stiffness, Thick lower lip vermilion... ORPHA:969
9q subtelomeric deletion syndrome
Protruding tongue, Microcephaly, Anteverted nares, Short nose DECIPHER:52
Pallister-Hall-Like Syndrome
Short nose, Microglossia, Pulmonary hypoplasia, Cleft palate, Macrocephaly, Median cleft lip, Dep... OMIM:241800
Achondrogenesis Type 1B
Long philtrum, Short nose, Abnormal enchondral ossification, Aplasia/Hypoplasia of the lungs, Mac... ORPHA:93298
Catifa Syndrome
Long philtrum, Delayed eruption of teeth, Tooth malposition, Anteverted nares, Camptodactyly, Cle... OMIM:618761
Perlman Syndrome
Short nose, Open mouth, Smooth philtrum, Wide nasal bridge, Broad alveolar ridges, Macrocephaly, ... ORPHA:2849
Mental Retardation, Autosomal Dominant 20
Short philtrum, Short nose, Downturned corners of mouth, Anteverted nares, Depressed nasal bridge OMIM:613443
Jaberi-Elahi Syndrome
Joint hypermobility, Short nose, Abnormality of the dentition, Triangular mouth, Joint stiffness,... OMIM:617988
Marshall-Smith Syndrome
Craniosynostosis, Short nose, Open mouth, Joint hyperflexibility, Choanal atresia, Reduced bone m... ORPHA:561
Baker-Gordon Syndrome
Short nose, Joint laxity, Smooth philtrum, Prominent nasal tip, Thin upper lip vermilion OMIM:618218
Edinburgh Malformation Syndrome
Thin vermilion border, Narrow mouth, Downturned corners of mouth, Short nose, Choanal atresia, Jo... ORPHA:1895
Absent Eyebrows And Eyelashes With Mental Retardation
Microcephaly, Convex nasal ridge, Short nose OMIM:200130
17P13.3 Microduplication Syndrome
High palate, Narrow mouth, Short nose, Wide nose ORPHA:217385
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 3
Osteoporosis, Long philtrum, Short nose, Downturned corners of mouth, Open mouth, High palate, De... OMIM:615398
Melanocytic Nevus Syndrome, Congenital
Narrow nasal ridge, Long philtrum, Short nose, Open mouth, Everted lower lip vermilion, Deep phil... OMIM:137550
Leukodystrophy, Hypomyelinating, 10
Long philtrum, Bulbous nose, Anteverted nares, Short nose, Smooth philtrum, Thick vermilion borde... OMIM:616420
Peho-Like Syndrome
Progressive microcephaly, Short nose, Open mouth OMIM:617507
Methylmalonate Semialdehyde Dehydrogenase Deficiency
Long philtrum, Bulbous nose, Short nose, High palate, Tented upper lip vermilion, Microcephaly, D... OMIM:614105
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome
Prominent nasolabial fold, Short nose, Downturned corners of mouth, Open mouth, Recurrent upper r... ORPHA:391372
Spinocerebellar Ataxia-Dysmorphism Syndrome
Short nose, Downturned corners of mouth, Joint hyperflexibility, Thick vermilion border, Reduced ... ORPHA:1185
Potocki-Shaffer Syndrome
Short philtrum, Short nose, Underdeveloped nasal alae, Downturned corners of mouth, Wide nasal br... OMIM:601224
Desmosterolosis
Arthrogryposis multiplex congenita, Gingival fibromatosis, Short nose, Generalized osteosclerosis... OMIM:602398
Spondyloepiphyseal Dysplasia, Nishimura Type
Recurrent respiratory infections, Osteoarthritis, Short nose, Delayed epiphyseal ossification OMIM:618618
Craniosynostosis-Hydrocephalus-Arnold-Chiari Malformation Type I-Radioulnar Synostosis Syndrome
Long philtrum, Thin vermilion border, Craniosynostosis, Radioulnar synostosis, Short nose, Short ... ORPHA:171839
Helsmoortel-Van Der Aa Syndrome
Long philtrum, Advanced eruption of teeth, Joint laxity, Short nose, Everted lower lip vermilion,... OMIM:615873
Craniofacial-Deafness-Hand Syndrome
Camptodactyly of finger, Narrow mouth, Short nose, Depressed nasal ridge, Aplasia/Hypoplasia invo... ORPHA:1529
Arthrogryposis, Distal, Type 2A
Pursed lips, Restricted neck movement due to contractures, Narrow mouth, Underdeveloped nasal ala... OMIM:193700
Congenital Muscular Dystrophy With Intellectual Disability And Severe Epilepsy
Short nose, Deep philtrum, Dental malocclusion, Thin upper lip vermilion, Failure to thrive, High... ORPHA:329178
Chromosome 6Q11-Q14 Deletion Syndrome
Long philtrum, Short nose, Thin upper lip vermilion, Broad nasal tip, High palate OMIM:613544
Fetal Alcohol Syndrome
Biparietal narrowing, Short nose, Smooth philtrum, Non-midline cleft lip, Thin upper lip vermilio... ORPHA:1915
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Short nose, Anteverted nares, Pleural effusion, Flexion contracture, Wide nasal bridge, Unilatera... OMIM:616897
14Q24.1Q24.3 Microdeletion Syndrome
Long philtrum, Joint laxity, Short nose, Intestinal malrotation, Smooth philtrum, Wide nasal brid... ORPHA:401935
Chromosome 4Q32.1-Q32.2 Triplication Syndrome
Short philtrum, Short nose, Aganglionic megacolon, Wide nasal bridge, Macrocephaly OMIM:613603
Pontocerebellar Hypoplasia, Type 10
Short nose, Underdeveloped nasal alae, High palate, Wide nasal bridge, Thin upper lip vermilion, ... OMIM:615803
Congenital Disorder Of Glycosylation, Type Iu
Short nose, High palate, Congenital contracture, Thin upper lip vermilion, Secondary microcephaly OMIM:615042
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Bulbous nose, Decreased body weight, Wide nasal bridge, Cleft upper lip, Cleft palate, Bifid uvul... OMIM:300958
Chromosome 14Q11-Q22 Deletion Syndrome
Long philtrum, Narrow mouth, Short nose, High palate, Failure to thrive, Microcephaly, Wide nose,... OMIM:613457
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Osteoporosis, Anosmia, Hyposmia, Cleft lip, Cleft palate OMIM:614838
Spondyloepiphyseal Dysplasia, Nishimura Type
Long philtrum, Abnormal bone ossification, Short nose, Downturned corners of mouth, Increased bon... ORPHA:163649
Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome
Long philtrum, Oligodontia, Short philtrum, Joint laxity, Narrow mouth, Hypoplasia of teeth, Down... ORPHA:391408
Facial Paresis, Hereditary Congenital, 3
Short nose, Downturned corners of mouth, Smooth philtrum, Anteverted nares, Depressed nasal bridge OMIM:614744
Verheij Syndrome
Long philtrum, Short nose, Wide nasal bridge, Vertebral fusion, Thin upper lip vermilion, Microce... OMIM:615583
Stickler Syndrome Type 1
Long philtrum, Short nose, Joint hyperflexibility, Cleft palate, Osteoarthritis ORPHA:90653
Ohdo Syndrome
Long philtrum, Thin vermilion border, Hypoplasia of teeth, Joint laxity, Narrow mouth, Short nose... OMIM:249620
Chromosome 16P12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb
Bulbous nose, Open mouth, Short nose, Camptodactyly, Thin upper lip vermilion, High palate OMIM:613604
Cerebrooculonasal Syndrome
Craniosynostosis, Narrow palate, Short nose, Downturned corners of mouth, Anteverted nares, Solit... OMIM:605627
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Macroglossia, Short nose, Bronchiectasis, Pneumonia, Protruding tongue, Failure to thrive, Sinusi... OMIM:242860
Microcephaly-Capillary Malformation Syndrome
Short nose, Small for gestational age, Failure to thrive, Cleft palate, Progressive microcephaly,... OMIM:614261
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14
Joint hypermobility, Short philtrum, Narrow mouth, Obesity, Truncal obesity, Small for gestationa... ORPHA:96184
Lowry-Maclean Syndrome
Osteoporosis, Convex nasal ridge, Delayed eruption of primary teeth, Craniosynostosis, Talon cusp... ORPHA:2409
Intellectual Disability-Brachydactyly-Pierre Robin Syndrome
Oligodontia, Agenesis of central incisor, Bulbous nose, Underdeveloped nasal alae, Short nose, Ab... ORPHA:364577
Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies 1
Slender nose, Short nose, Smooth philtrum, Wide mouth, Thin upper lip vermilion, Microcephaly OMIM:615419
Camptodactyly Syndrome, Guadalajara Type 1
Open bite, Camptodactyly of finger, Narrow mouth, Downturned corners of mouth, Short nose, High p... ORPHA:1327
Acrocephalopolydactyly
Abnormality of the mouth, Short nose, Depressed nasal ridge ORPHA:221054
Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies
Long philtrum, Short nose, Unilambdoid synostosis, Wide nasal bridge, Broad philtrum, Anteverted ... OMIM:618577
Coffin-Siris Syndrome 9
Abnormality of the columella, Short philtrum, Short nose, Open mouth, Underdeveloped nasal alae, ... OMIM:615866
Miller-Dieker Syndrome
Abnormality of upper lip, Anteverted nares, Short nose ORPHA:531
Pontocerebellar Hypoplasia, Type 2E
Osteoporosis, Short nose, Flexion contracture, Secondary microcephaly, Failure to thrive, Microce... OMIM:615851
Baraitser-Winter Syndrome 1
Long philtrum, Short nose, Wide mouth, Wide nasal bridge, Oral cleft, Thin upper lip vermilion, C... OMIM:243310
Teebi Hypertelorism Syndrome
Long philtrum, Craniosynostosis, Short nose, Dental crowding, Natal tooth, Wide nasal bridge, Dep... OMIM:145420
Tetrasomy 18P
Long philtrum, Thin vermilion border, Narrow mouth, Short nose, Microcephaly ORPHA:3307
Craniosynostosis, Herrmann-Opitz Type
Convex nasal ridge, Craniosynostosis, Short nose, Aplasia/Hypoplasia of the lungs, Cleft palate ORPHA:2145
Distal Trisomy 18Q
Camptodactyly of finger, Carious teeth, Short nose, Abnormality of dental morphology, Choanal atr... ORPHA:1716
Smith-Kingsmore Syndrome
Long philtrum, Short nose, Open mouth, Wide mouth, Smooth philtrum, Thin upper lip vermilion, Mac... OMIM:616638
Intellectual Developmental Disorder, X-Linked 21
Joint hypermobility, Short nose, Open mouth, Dental crowding, Tented upper lip vermilion OMIM:300143
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Narrow mouth, Dental crowding, Increased susceptibility to fractures, High palate, Wide nose, Lon... ORPHA:251028
Pituitary Hormone Deficiency, Combined, 1
Macroglossia, Anteverted nares, Short nose, Depressed nasal bridge OMIM:613038
Non-Distal Trisomy 13Q
Long philtrum, Thin vermilion border, Short nose, Everted lower lip vermilion, Abnormality of the... ORPHA:1702
Congenital Disorder Of Glycosylation, Type Il
Long philtrum, Short nose, Wide mouth, Failure to thrive, Microcephaly, Depressed nasal bridge OMIM:608776
Neurodevelopmental Disorder With Microcephaly, Seizures, And Cortical Atrophy
Progressive microcephaly, Short nose, Depressed nasal bridge OMIM:617802
Gms Syndrome
Microcephaly, Short philtrum, Short nose, Depressed nasal bridge OMIM:138770
Congenital Disorder Of Glycosylation With Defective Fucosylation 1
Short nose, High palate, Flexion contracture, Wide nasal bridge, Failure to thrive, Osteopenia, M... OMIM:618005
3Q29 Microdeletion Syndrome
Short philtrum, Short nose, Dental crowding, Joint hyperflexibility, High palate, Everted lower l... ORPHA:65286
Nablus Mask-Like Facial Syndrome
Long philtrum, Craniosynostosis, Narrow mouth, Short nose, Camptodactyly, High palate, Smooth phi... OMIM:608156
Bartsocas-Papas Syndrome
Narrow mouth, Underdeveloped nasal alae, Synostosis of joints, Short nose, Cleft palate, Microcep... ORPHA:1234
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1
Epiphyseal stippling, Joint hemorrhage, Short nose, Epistaxis OMIM:277450
Noonan Syndrome-Like Disorder With Loose Anagen Hair
Thin vermilion border, Carious teeth, Short nose, Deep philtrum, Abnormal palate morphology, Thic... ORPHA:2701
Early-Onset Epileptic Encephalopathy And Intellectual Disability Due To Grin2A Mutation
Small for gestational age, Primary microcephaly, Secondary microcephaly, Short nose ORPHA:289266
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3
Microcephaly, Short nose, Depressed nasal bridge OMIM:616910
Spondyloepimetaphyseal Dysplasia, Faden-Alkuraya Type
Craniosynostosis, Short nose, Thick vermilion border, Tented upper lip vermilion, Osteopenia, Mic... OMIM:616723
Foxg1 Syndrome Due To 14Q12 Microdeletion
Macroglossia, Bulbous nose, Short nose, Excessive salivation, Everted lower lip vermilion, Smooth... ORPHA:261144
Vitamin K Antagonist Embryofetopathy
Macroglossia, Epiphyseal stippling, Short nose, Choanal atresia, Anteverted nares, Depressed nasa... ORPHA:1914
Tetraploidy
Radial club hand, Short philtrum, Convex nasal ridge, Biparietal narrowing, Aplasia/Hypoplasia of... ORPHA:3305
Antley-Bixler Syndrome
Camptodactyly of finger, Long philtrum, Craniosynostosis, Narrow mouth, Short nose, Recurrent fra... ORPHA:83
Disorder Of Sex Development-Intellectual Disability Syndrome
Short philtrum, Thin vermilion border, Short nose, Downturned corners of mouth, Reduced bone mine... ORPHA:2983
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Bulbous nose, Downturned corners of mouth, Open mouth, Short nose, Tented upper lip vermilion, Th... OMIM:618430
Rnf13-Related Severe Early-Onset Epileptic Encephalopathy
Joint hypermobility, Finger joint hypermobility, Short nose, Flexion contracture, Hyperextensibil... ORPHA:544503
Cutis Laxa, Autosomal Recessive, Type Iia
Joint hypermobility, Carious teeth, Long philtrum, Narrow mouth, Anteverted nares, Short nose, Fa... OMIM:219200
Hamel Cerebro-Palato-Cardiac Syndrome
Narrow mouth, Bulbous nose, Wide nasal bridge, Cleft palate, Microcephaly ORPHA:93946
Glutamine Deficiency, Congenital
Thin vermilion border, Short nose, Camptodactyly, Flexion contracture, Wide nasal bridge, Antever... OMIM:610015
Linear Skin Defects With Multiple Congenital Anomalies 2
Microcephaly, Long philtrum, Short nose OMIM:300887
Intellectual Developmental Disorder With Microcephaly And Pontine And Cerebellar Hypoplasia
Long philtrum, Short nose, High palate, Decreased body weight, Wide nasal bridge, Broad nasal tip... OMIM:300749
C Syndrome
Fused sternal ossification centers, Short nose, Anteverted nares, Wide mouth, Wide nasal bridge, ... OMIM:211750
3Q29 Microduplication Syndrome
Craniosynostosis, Biparietal narrowing, Camptodactyly of toe, High palate, Deep philtrum, Abnorma... ORPHA:251038
Desmosterolosis
Anomalous pulmonary venous return, Narrow mouth, Short nose, Abnormality of the nose, Intestinal ... ORPHA:35107
Peho Syndrome
Arthrogryposis multiplex congenita, Biparietal narrowing, Abnormality of upper lip, Open mouth, S... ORPHA:2836
Pfeiffer Syndrome
Humeroradial synostosis, Short nose, Choanal stenosis, Dental crowding, Elbow ankylosis, Choanal ... OMIM:101600
Microcephaly 26, Primary, Autosomal Dominant
Long philtrum, Short nose, Wide nasal bridge, Protruding tongue, Gingival overgrowth, Recurrent p... OMIM:619179
Down Syndrome
Macroglossia, Narrow palate, Narrow mouth, Downturned corners of mouth, Joint laxity, Open mouth,... ORPHA:870
Diamond-Blackfan Anemia 8
Short nose, Thick upper lip vermilion, Wide nasal bridge OMIM:612563
Developmental And Epileptic Encephalopathy 75
Short philtrum, Short nose, Open mouth, Wide nasal bridge, Secondary microcephaly, Anteverted nares OMIM:618437
Smith-Magenis Syndrome
Delayed eruption of primary teeth, Short philtrum, Short nose, Open mouth, Taurodontia, Tented up... ORPHA:819
Pectus Excavatum-Macrocephaly-Dysplastic Nails Syndrome
Macrocephaly, Short nose, Depressed nasal bridge ORPHA:2835
Chromosome 16P13.3 Duplication Syndrome
Short nose, Camptodactyly, Bulbous nose OMIM:613458
Congenital Heart Defects And Skeletal Malformations Syndrome
Carious teeth, Short nose, Dental crowding, Camptodactyly, Intestinal malrotation, Anal atresia, ... OMIM:617602
Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Macrocephaly, Short nose, Decreased skull ossification, Depressed nasal ridge OMIM:300863
Spondylometaphyseal Dysplasia With Corneal Dystrophy
Coarse metaphyseal trabecularization, Anteverted nares, Short nose, Depressed nasal bridge OMIM:618961
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Choanal atresia, Tooth agenesis, Cleft palate, High palate, Aplasia/Hypoplasia involving the nose... ORPHA:1135
Carey-Fineman-Ziter Syndrome
Long philtrum, Thin vermilion border, Short nose, Anteverted nares, Pierre-Robin sequence, Abnorm... ORPHA:1358
Orofaciodigital Syndrome Ix
Accessory oral frenulum, Broad nasal tip, Camptodactyly, Abnormality of the dentition, Hypoplasia... OMIM:258865
Microphthalmia With Limb Anomalies
Fused fourth and fifth metacarpals, Short nose, Deep philtrum, Flared nostrils, Camptodactyly of ... OMIM:206920
Microform Holoprosencephaly
Short philtrum, Short nose, Choanal atresia, Midnasal stenosis, Tented upper lip vermilion, Oral ... ORPHA:280200
Desbuquois Dysplasia 1
Osteoporosis, Long philtrum, Advanced tarsal ossification, Joint laxity, Narrow mouth, Short nose... OMIM:251450
Codas Syndrome
Delayed eruption of teeth, Abnormal dental enamel morphology, Short nose, Abnormality of dental m... ORPHA:1458
Fetal Trimethadione Syndrome
Microcephaly, High palate, Short nose, Depressed nasal bridge ORPHA:1913
Spinocerebellar Ataxia With Dysmorphism
Thick lower lip vermilion, Anteverted nares, Short nose, Downturned corners of mouth OMIM:271270
Encephalopathy Due To Sulfite Oxidase Deficiency
Microcephaly, Long philtrum, Thick vermilion border, Short nose ORPHA:833
Raine Syndrome
Enamel hypoplasia, Arthrogryposis multiplex congenita, Narrow mouth, Choanal stenosis, Short nose... OMIM:259775
Chromosome 19Q13.11 Deletion Syndrome, Distal
Thin vermilion border, Carious teeth, Short philtrum, Short nose, Underdeveloped nasal alae, Hypo... OMIM:613026
Van Der Woude Syndrome 1
Hypodontia, Cleft upper lip, Cleft palate, Bifid uvula, Lower lip pit OMIM:119300
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Macrocephaly, Short nose, Depressed nasal bridge OMIM:614732
Pterygium Colli, Isolated
Short nose OMIM:177990
Cebalid Syndrome
Short nose, Depressed nasal ridge, High palate, Anteverted nares, Depressed nasal bridge OMIM:618774
Ehlers-Danlos Syndrome, Musculocontractural Type, 2
Long philtrum, Narrow mouth, Short nose, Dental crowding, Camptodactyly, High palate OMIM:615539
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Camptodactyly of finger, Cleft palate, Bifid uvula, Microcephaly, Submucous cleft hard palate ORPHA:2521
Fetal Hydantoin Syndrome
Short nose, Everted lower lip vermilion, Wide mouth, Cleft palate, Microcephaly, Depressed nasal ... ORPHA:1912
Meier-Gorlin Syndrome 6
Short nose, Underdeveloped nasal alae, Depressed nasal ridge, Emphysema, Thick vermilion border, ... OMIM:616835
Nabais Sa-De Vries Syndrome, Type 1
Bulbous nose, Short nose, Smooth philtrum, Primary microcephaly, Prominent nasal bridge, Depresse... OMIM:618828
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Short nose, Deep philtrum, Small for gestational age, Anteverted nares, Wide nose, Depressed nasa... OMIM:613320
Agenesis Of The Corpus Callosum With Peripheral Neuropathy
Respiratory tract infection, Short nose, Flexion contracture, Wide nasal bridge, High palate OMIM:218000
Hypomandibular Faciocranial Dysostosis
Craniosynostosis, Narrow mouth, Choanal stenosis, Short nose, Laryngeal hypoplasia, Aplasia/Hypop... ORPHA:1790
Hyperphosphatasia With Mental Retardation Syndrome 2
Broad nasal tip, Short nose, Anal stenosis, Aganglionic megacolon, Tented upper lip vermilion, Wi... OMIM:614749
Johanson-Blizzard Syndrome
Delayed eruption of teeth, Oligodontia, Short nose, Underdeveloped nasal alae, Abnormality of the... ORPHA:2315
Short Stature, Facial Dysmorphism, And Skeletal Anomalies With Or Without Cardiac Anomalies 1
Long philtrum, Short nose, Dental crowding, Pierre-Robin sequence, Everted lower lip vermilion, T... OMIM:617877
5Q14.3 Microdeletion Syndrome
Short philtrum, Anteverted nares, Short nose, Open mouth ORPHA:228384
Faciocardiorenal Syndrome
Narrow mouth, Underdeveloped nasal alae, Smooth philtrum, Hypodontia, Wide nasal bridge, Failure ... ORPHA:1973
Acrodysostosis
Open bite, Delayed eruption of teeth, Epiphyseal stippling, Short nose, Open mouth, Wide nasal br... ORPHA:950
Frontofacionasal Dysplasia
Short nose, Depressed nasal ridge, Choanal atresia, Non-midline cleft lip, Cleft palate, Bifid na... ORPHA:1791
16P13.11 Microdeletion Syndrome
Camptodactyly of finger, Short nose, Anteverted nares, Wide mouth, Smooth philtrum, Thin upper li... ORPHA:261236
Hyperphosphatasia With Mental Retardation Syndrome 1
Short philtrum, Broad nasal tip, Downturned corners of mouth, Short nose, Delayed ossification of... OMIM:239300
Schisis Association
Unilateral cleft lip, Anal atresia, Small for gestational age, Cleft palate, Microcephaly, Trache... ORPHA:63862
Cleft Lip/Palate
Agenesis of lateral incisor, Oral cleft, Peg-shaped maxillary lateral incisors, Abnormality of de... ORPHA:199306
Developmental Delay With Or Without Dysmorphic Facies And Autism
Short philtrum, Bulbous nose, Laryngotracheomalacia, Anteverted nares, Short nose, Wide mouth, Sm... OMIM:618454
Neurodevelopmental Disorder With Brain Anomalies, Seizures, And Scoliosis
Joint hypermobility, Short nose, Downturned corners of mouth, Long nose, Wide mouth, Smooth philt... OMIM:618590
Otopalatodigital Syndrome Type 2
Camptodactyly of finger, Oligodontia, Tarsal synostosis, Narrow mouth, Short nose, Synostosis of ... ORPHA:90652
8P23.1 Microdeletion Syndrome
Thin vermilion border, Biparietal narrowing, Short nose, Weight loss, Wide nasal bridge, Pulmonar... ORPHA:251071
Developmental Delay-Facial Dysmorphism Syndrome Due To Med13L Deficiency
Macroglossia, Bulbous nose, Downturned corners of mouth, Open mouth, Short nose, Camptodactyly, W... ORPHA:369891
Craniofacial-Deafness-Hand Syndrome
Short nose OMIM:122880
Temtamy Preaxial Brachydactyly Syndrome
Oligodontia, Talon cusp, Tarsal synostosis, Narrow mouth, Tooth malposition, Short nose, Abnormal... ORPHA:363417
X-Linked Intellectual Disability, Cantagrel Type
Short philtrum, Short nose, Tented upper lip vermilion ORPHA:85277
Microphthalmia-Microtia-Fetal Akinesia Syndrome
Camptodactyly of finger, Duodenal stenosis, Limitation of joint mobility, Short nose ORPHA:2547
Odontochondrodysplasia
Delayed eruption of teeth, Short nose, Joint hyperflexibility, Dentinogenesis imperfecta, Depress... ORPHA:166272
Femoral-Facial Syndrome
Long philtrum, Radioulnar synostosis, Short nose, Oral cleft, Thin upper lip vermilion, Cleft palate ORPHA:1988
Craniofaciofrontodigital Syndrome
Joint hypermobility, Long philtrum, Short nose, Abnormality of the dentition, Macrocephaly, Denta... OMIM:114620
Aarskog-Scott Syndrome
Joint laxity, Short nose, Curved linear dimple below the lower lip, Hypodontia, Wide nasal bridge... OMIM:305400
Mental Retardation, Autosomal Dominant 1
Bulbous nose, Downturned corners of mouth, Open mouth, Short nose, Wide mouth, Thin upper lip ver... OMIM:156200
Marshall-Smith Syndrome
Short philtrum, Short nose, Choanal stenosis, Choanal atresia, Decreased body weight, Irregular d... OMIM:602535
Autosomal Recessive Omodysplasia
Long philtrum, Craniosynostosis, Short nose, Anteverted nares, Depressed nasal bridge ORPHA:93329
Trisomy 8Q
Camptodactyly of finger, Bone cyst, Everted lower lip vermilion, Non-midline cleft lip, Wide nasa... ORPHA:1752
Toluene Embryopathy
Thin vermilion border, Biparietal narrowing, Short nose, Smooth philtrum, Microcephaly ORPHA:1920
Achondrogenesis, Type Ia
Abnormal hand bone ossification, Short nose, Decreased skull ossification, Unossified vertebral b... OMIM:200600
Distal Trisomy 5Q
Long philtrum, Thin vermilion border, Craniosynostosis, Carious teeth, Narrow mouth, Short nose, ... ORPHA:96097
Opsismodysplasia
Short nose, Abnormally ossified vertebrae, Joint stiffness, Macrocephaly, Recurrent respiratory i... ORPHA:2746
Gomez-Lopez-Hernandez Syndrome
Thin vermilion border, Craniosynostosis, Short nose, Smooth philtrum, High palate, Anteverted nares OMIM:601853
Acrodysostosis 2 With Or Without Hormone Resistance
Obesity, Anteverted nares, Short nose, Depressed nasal bridge OMIM:614613
Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction
Contractures of the interphalangeal joint of the thumb, Short nose, Bulbous nose, Aganglionic meg... OMIM:613870
Severe X-Linked Intellectual Disability, Gustavson Type
Short nose, Recurrent upper respiratory tract infections, Small for gestational age, Microcephaly... ORPHA:3078
Intellectual Disability-Strabismus Syndrome
Narrow nasal ridge, Short nose, Congenital finger flexion contractures, High palate, Wide mouth, ... ORPHA:363528
Even-Plus Syndrome
Short nose, Hypodontia, Anal atresia, Bifid nasal tip, High palate, Depressed nasal ridge OMIM:616854
Trisomy 12P
Short nose, Downturned corners of mouth, Everted lower lip vermilion, Wide nasal bridge, Anal atr... ORPHA:1699
Microlissencephaly-Micromelia Syndrome
Secondary microcephaly, Long philtrum, Short nose, Failure to thrive ORPHA:50810
Ruvalcaba Syndrome
Convex nasal ridge, Thin vermilion border, Narrow mouth, Short nose, Dental crowding, Synostosis ... ORPHA:3121
Mandibulofacial Dysostosis, Guion-Almeida Type
Short nose, Anteverted nares, Deep philtrum, Choanal atresia, Esophageal atresia, Cleft palate, M... OMIM:610536
Brain Malformations With Or Without Urinary Tract Defects
Short nose, Narrow mouth, Thin upper lip vermilion, Macrocephaly, Anteverted nares OMIM:613735
Corpus Callosum, Agenesis Of, With Facial Anomalies And Robin Sequence
Short nose, Downturned corners of mouth, Laryngeal hypoplasia, Pierre-Robin sequence, Abnormality... OMIM:217980
Orofaciodigital Syndrome Type 4
Choanal atresia, Oral cleft, Rectovaginal fistula, High, narrow palate, Wide nose, Median cleft l... ORPHA:2753
Spondyloepimetaphyseal Dysplasia, Sponastrime Type
Limited elbow extension, Bulbous nose, Laryngotracheomalacia, Short nose, Delayed ossification of... OMIM:271510
Neurodevelopmental Disorder With Hypotonia, Facial Dysmorphism, And Brain Abnormalities
Long philtrum, Short nose, Flexion contracture, Low hanging columella, Thick vermilion border, Te... OMIM:619383
Miller-Dieker Lissencephaly Syndrome
Delayed eruption of teeth, Short nose, Camptodactyly, Thick upper lip vermilion, Wide nasal bridg... OMIM:247200
Marshall Syndrome
Long philtrum, Short nose, Anteverted nares, Hypoplastic frontal sinuses, Thick upper lip vermili... ORPHA:560
Pde4D Haploinsufficiency Syndrome
Long philtrum, Abnormal dental enamel morphology, Short philtrum, Joint laxity, Short nose, Promi... ORPHA:439822
20Q11.2 Microduplication Syndrome
Limited elbow extension, Tented philtrum, Short nose, Tented upper lip vermilion, Wide nasal brid... ORPHA:363659
Prolidase Deficiency
Short nose, Concave nasal ridge, Failure to thrive, Recurrent pneumonia, High palate, Depressed n... OMIM:170100
Robinow Syndrome, Autosomal Dominant 3
Long philtrum, Agenesis of permanent teeth, Downturned corners of mouth, Short nose, Camptodactyl... OMIM:616894
Donnai-Barrow Syndrome
Macrocephaly, Intestinal malrotation, Short nose, Depressed nasal bridge ORPHA:2143
Tetrasomy 5P
Long philtrum, Short nose, Wide nasal bridge, Pulmonary hypoplasia, Failure to thrive, Macrocepha... ORPHA:3309
3C Syndrome
Short nose, Intestinal malrotation, Wide nasal bridge, Oral cleft, Ectopic anus, Anal atresia, Cl... ORPHA:7
Distal Monosomy 10Q
Craniosynostosis, Short nose, High palate, Smooth philtrum, Wide nasal bridge, Thin upper lip ver... ORPHA:96148
Cardiofaciocutaneous Syndrome 1
Open bite, Bulbous nose, Open mouth, Short nose, Deep philtrum, High palate, Abnormality of the d... OMIM:115150
Bone Fragility With Contractures, Arterial Rupture, And Deafness
Long philtrum, Short nose, Downturned corners of mouth, Pathologic fracture, Osteopenia, Elbow fl... OMIM:612394
Autosomal Recessive Cutis Laxa Type 2, Classic Type
Long philtrum, Carious teeth, Prominent nasolabial fold, Short nose, Anteverted nares, Generalize... ORPHA:357074
Warburg Micro Syndrome 3
Narrow palate, Short nose, Downturned corners of mouth, Flexion contracture, Secondary microcepha... OMIM:614222
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1
Long philtrum, Thin vermilion border, Short nose, Open mouth, Anal stenosis, Anal atresia, Pulmon... OMIM:614080
Dermotrichic Syndrome
Aganglionic megacolon, Short nose, Depressed nasal bridge ORPHA:99688
Peho Syndrome
Tented upper lip vermilion, Progressive microcephaly, Short nose, Open mouth OMIM:260565
Mandibulofacial Dysostosis-Microcephaly Syndrome
Secondary microcephaly, Short nose, Accessory oral frenulum, Cleft palate ORPHA:79113
Waardenburg Syndrome Type 1
Short nose, Underdeveloped nasal alae, Aganglionic megacolon, Tented upper lip vermilion, Wide na... ORPHA:894
Diaphanospondylodysostosis
Short nose, Depressed nasal ridge, Tracheomalacia, Absent in utero rib ossification, Absent in ut... OMIM:608022
Neurodevelopmental Disorder With Cataracts, Poor Growth, And Dysmorphic Facies
Long philtrum, Bulbous nose, Downturned corners of mouth, Short nose, Deep philtrum, Wide nasal b... OMIM:618571
Lathosterolosis
Long philtrum, Biparietal narrowing, Bulbous nose, Downturned corners of mouth, Short nose, High ... ORPHA:46059
Pfeiffer Syndrome Type 2
Short nose, Intestinal malrotation, Choanal atresia, Tracheomalacia, Laryngomalacia, Anal atresia... ORPHA:93259
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Biparietal narrowing, Short nose, Underdeveloped nasal alae, Glossoptosis, Anteverted nares ORPHA:2031
Axial Spondylometaphyseal Dysplasia
Anteverted nares, Short nose ORPHA:168549
Otopalatodigital Syndrome, Type I
Limited elbow extension, Narrow mouth, Short nose, Synostosis of carpal bones, Capitate-hamate fu... OMIM:311300
Prominent Glabella-Microcephaly-Hypogenitalism Syndrome
Camptodactyly of finger, Short nose, Underdeveloped nasal alae, Microcephaly, Prominent nasal bridge ORPHA:2083
Oculodentodigital Dysplasia
Camptodactyly of finger, Carious teeth, Abnormal dental enamel morphology, Thin anteverted nares,... ORPHA:2710
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Short nose, Anosmia, Abnormality of the nares, Thin upper lip vermilion, Joint stiffness ORPHA:1295
Gaucher Disease, Perinatal Lethal
Arthrogryposis multiplex congenita, Narrow mouth, Open mouth, Short nose, Everted lower lip vermi... OMIM:608013
Craniodigital-Intellectual Disability Syndrome
Short nose, Narrow nasal bridge ORPHA:1514
1P21.3 Microdeletion Syndrome
Joint hypermobility, Short nose, Wide mouth, Broad nasal tip, Macrocephaly, Obesity ORPHA:293948
Autosomal Dominant Omodysplasia
Long philtrum, Short nose, Depressed nasal bridge ORPHA:93328
Acrocallosal Syndrome
Long philtrum, Thin vermilion border, Short philtrum, Hypoplasia of teeth, Open mouth, Short nose... OMIM:200990
Adenylosuccinase Deficiency
Long philtrum, Short nose, Smooth philtrum, Wide mouth, Thin upper lip vermilion, Microcephaly, A... OMIM:103050
Mosaic Variegated Aneuploidy Syndrome 2
Abnormal lung lobation, Craniosynostosis, Narrow mouth, Bulbous nose, Short nose, Duodenal atresi... OMIM:614114
16P11.2P12.2 Microdeletion Syndrome
Camptodactyly of finger, Bulbous nose, Open mouth, Absent nasal bridge, Short nose, Oral cleft, L... ORPHA:261211
Alkuraya-Kucinskas Syndrome
Arthrogryposis multiplex congenita, Short nose, Camptodactyly, Macrocephaly, High palate, Antever... OMIM:617822
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To 10P11.21P12.31 Microdeletion
Bulbous nose, Short nose, Choanal atresia, Absent cupid's bow, Celiac disease, Depressed nasal br... ORPHA:284169
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Long philtrum, Short nose, Dental crowding, Secondary microcephaly, Abnormality of the dentition,... ORPHA:476126
Craniofaciofrontodigital Syndrome
Long philtrum, Short nose, Thick vermilion border, Wide nasal bridge, Tooth agenesis, Anteverted ... ORPHA:363705
16P12.1P12.3 Triplication Syndrome
Long philtrum, Thin vermilion border, Bulbous nose, Short nose, Wide mouth, Failure to thrive, Hi... ORPHA:485405
Kleefstra Syndrome
Delayed eruption of teeth, Macroglossia, Advanced eruption of teeth, Short nose, Downturned corne... ORPHA:261494
Rhombencephalosynapsis
Narrow mouth, Short nose, Aganglionic megacolon, Esophageal atresia, Anal atresia, Macrocephaly, ... ORPHA:59315
Cerebrofaciothoracic Dysplasia
Short nose, Wide mouth, Cleft upper lip, Cleft palate, Macrocephaly, Broad philtrum, Wide nose ORPHA:1394
Ctcf-Related Neurodevelopmental Disorder
Thin vermilion border, Craniosynostosis, Narrow mouth, Small for gestational age, Long philtrum, ... ORPHA:363611
Trisomy 20P
Camptodactyly of finger, Thin vermilion border, Short philtrum, Short nose, Downturned corners of... ORPHA:261318
Mietens Syndrome
Short nose, Elbow ankylosis, Wide nasal bridge, Joint stiffness, Microcephaly, Wide nose ORPHA:2557
Kleefstra Syndrome Due To 9Q34 Microdeletion
Macroglossia, Short nose, Downturned corners of mouth, Everted lower lip vermilion, Protruding to... ORPHA:96147
Cenani-Lenz Syndrome
Convex nasal ridge, Abnormal dental enamel morphology, Short philtrum, Radioulnar synostosis, Sho... ORPHA:3258
Pfeiffer Syndrome Type 1
High palate, Bicoronal synostosis, Short nose, Depressed nasal bridge ORPHA:93258
19P13.13 Microdeletion Syndrome
Macroglossia, Narrow mouth, Short nose, Smooth philtrum, Thin upper lip vermilion, Macrocephaly, ... ORPHA:357001
Pfeiffer Syndrome Type 3
Short nose, Intestinal malrotation, Choanal atresia, Tracheomalacia, Laryngomalacia, Anal atresia... ORPHA:93260
Brachytelephalangic Chondrodysplasia Punctata
Epiphyseal stippling, Abnormal ossification involving the femoral head and neck, Epiphyseal stipp... ORPHA:79345
Distal Monosomy 9P
Short nose, Abnormality of the dentition, Wide nasal bridge, Cleft palate, High, narrow palate ORPHA:1642
Rhizomelic Dysplasia, Patterson-Lowry Type
Short nose, Wide nose, Depressed nasal ridge ORPHA:2831
Robinow Syndrome
Dental crowding, Oral cleft, Triangular mouth, Small for gestational age, Depressed nasal bridge,... ORPHA:97360
Micro Syndrome
Short philtrum, Short nose, High palate, Wide nasal bridge, Joint stiffness, Microcephaly, Anteve... ORPHA:2510
Stuve-Wiedemann Syndrome
Osteoporosis, Pursed lips, Abnormal dental enamel morphology, Wide nasal base, Short nose, Pulmon... OMIM:601559
Prader-Willi Syndrome Due To Translocation
Carious teeth, Broad nasal tip, Downturned corners of mouth, Short nose, Everted lower lip vermil... ORPHA:177907
Chops Syndrome
Short nose, Downturned corners of mouth, Laryngomalacia, Aspiration pneumonia, Tracheal stenosis,... OMIM:616368
Kaufman Oculocerebrofacial Syndrome
Carious teeth, Narrow mouth, Anteverted nares, Short nose, Diastema, Intestinal malrotation, Smoo... OMIM:244450
Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5Q31.3 Microdeletion
Short nose, Deep philtrum, Tented upper lip vermilion, Aspiration pneumonia, Recurrent pneumonia,... ORPHA:314655
Baller-Gerold Syndrome
Narrow mouth, Short nose, Failure to thrive in infancy, Anal atresia, Cleft palate, High palate, ... ORPHA:1225
Acrofacial Dysostosis, Catania Type
Carious teeth, Short nose, Abnormal palate morphology, Smooth philtrum, Abnormality of the dentit... ORPHA:1786
Osteoglophonic Dysplasia
Long philtrum, Craniosynostosis, Abnormal nasopharynx morphology, Short nose, Nasal congestion, I... OMIM:166250
Van Der Woude Syndrome
Abnormal salivary gland morphology, Lip pit, Hypodontia, Cleft upper lip, Cleft palate, Lower lip... ORPHA:888
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Long philtrum, Short nose, Smooth philtrum, Tented upper lip vermilion, Cessation of head growth,... OMIM:617527
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal
Meckel diverticulum, Long philtrum, Short nose, Failure to thrive, Anteverted nares, Depressed na... OMIM:602613
Craniofacial Dysmorphism, Skeletal Anomalies, And Mental Retardation Syndrome
Joint hypermobility, Craniosynostosis, Short nose, Large for gestational age, Gingival overgrowth... OMIM:213980
Congenital Disorder Of Glycosylation, Type Iie
Narrow mouth, Short nose, Thick vermilion border, Smooth philtrum, Protruding tongue, Failure to ... OMIM:608779
Zttk Syndrome
Joint hypermobility, Thin vermilion border, Craniosynostosis, Short philtrum, Narrow mouth, Downt... OMIM:617140
X-Linked Cerebral-Cerebellar-Coloboma Syndrome
Meckel diverticulum, Short nose, Thick nasal alae ORPHA:163961
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Long philtrum, Contracture of the proximal interphalangeal joint of the 4th toe, Short nose, Thin... ORPHA:457279
Mandibuloacral Dysplasia With Type B Lipodystrophy
Osteolytic defects of the distal phalanges of the hand, Acroosteolysis of distal phalanges (feet)... ORPHA:90154
Holoprosencephaly 7
Median cleft lip and palate, Absent nasal septal cartilage, Depressed nasal tip, Short nose, Flat... OMIM:610828
Geleophysic Dysplasia 1
Camptodactyly of finger, Long philtrum, Short nose, Smooth philtrum, Wide mouth, Wrist flexion co... OMIM:231050
Plaa-Associated Neurodevelopmental Disorder
Long philtrum, Short nose, Smooth philtrum, Tented upper lip vermilion, Failure to thrive, High p... ORPHA:521426
Holoprosencephaly 3
Short columella, Abnormality of the nose, Single naris, Solitary median maxillary central incisor... OMIM:142945
Craniosynostosis 4
Macrocephaly, Short nose, Pansynostosis, Lambdoidal craniosynostosis OMIM:600775
Marshall Syndrome
Long philtrum, Absent frontal sinuses, Short nose, Pierre-Robin sequence, Thick upper lip vermili... OMIM:154780
Trisomy 10P
Thin vermilion border, Flexion contracture of thumb, Short nose, Camptodactyly, Abnormality of th... ORPHA:171929
Spinocerebellar Ataxia 42, Early-Onset, Severe, With Neurodevelopmental Deficits
Microcephaly, Short nose OMIM:618087
Oculocerebral Hypopigmentation Syndrome, Cross Type
Narrow mouth, Short nose, Abnormal palate morphology, Microcephaly, Microdontia, Anteverted nares... ORPHA:2719
C Syndrome
Long philtrum, Thin vermilion border, Biparietal narrowing, Short nose, Anteverted nares, Smooth ... ORPHA:1308
Stickler Syndrome
Open bite, Long philtrum, Abnormal dental enamel morphology, Macroglossia, Slender build, Short n... ORPHA:828
Warburg Micro Syndrome 2
Short nose, Flexion contracture, Secondary microcephaly, Microcephaly, Prominent nasal bridge OMIM:614225
Neurodevelopmental Disorder With Dysmorphic Facies, Impaired Speech, And Hypotonia
Short nose, Underdeveloped nasal alae, Dental crowding, Thick vermilion border, Decreased body we... OMIM:619005
Witteveen-Kolk Syndrome
Thin vermilion border, Joint laxity, Open mouth, Narrow mouth, Underdeveloped nasal alae, Small f... OMIM:613406
Musculocontractural Ehlers-Danlos Syndrome
Long philtrum, Arthrogryposis multiplex congenita, Craniosynostosis, Malrotation of small bowel, ... ORPHA:2953
Lathosterolosis
Osteoporosis, Long philtrum, Thin vermilion border, Short nose, High palate, Thick upper lip verm... OMIM:607330
Intellectual Developmental Disorder, X-Linked, Syndromic, Turner Type
Long philtrum, Oligodontia, Craniosynostosis, Short philtrum, Narrow mouth, Bulbous nose, Short n... OMIM:309590
Monosomy 9Q22.3
Long philtrum, Delayed eruption of teeth, Narrow mouth, Odontogenic keratocysts of the jaw, Short... ORPHA:77301
Mosaic Variegated Aneuploidy Syndrome 1
Long philtrum, Short nose, Triangular mouth, Small for gestational age, Cleft palate, Microcephal... OMIM:257300
Bannayan-Riley-Ruvalcaba Syndrome
Long philtrum, Narrow palate, Short nose, Joint hyperflexibility, Intestinal polyposis, Cachexia,... ORPHA:109
Ectodermal Dysplasia-Intellectual Disability-Central Nervous System Malformation Syndrome
Abnormal dental enamel morphology, Short nose, Cleft palate, Macrocephaly, Microdontia, Depressed... ORPHA:1812
Opsismodysplasia
Long philtrum, Short nose, Macrocephaly, Anteverted nares, Recurrent respiratory infections, Depr... OMIM:258480
Fibrochondrogenesis 2
Anteverted nares, Short nose OMIM:614524
X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type
Short nose, Short philtrum, Wide mouth, Depressed nasal ridge ORPHA:163966
Autosomal Recessive Robinow Syndrome
Open bite, Downturned corners of mouth, Oral cleft, Exaggerated cupid's bow, Depressed nasal brid... ORPHA:1507
Donnai-Barrow Syndrome
Short nose, Intestinal malrotation, Broad nasal tip, Macrocephaly, Depressed nasal bridge OMIM:222448
Rothmund-Thomson Syndrome, Type 2
Osteoporosis, Delayed eruption of teeth, Agenesis of permanent teeth, Hypoplasia of teeth, Short ... OMIM:268400
Progressive Spondyloepimetaphyseal Dysplasia-Short Stature-Short Fourth Metatarsals-Intellectual Disability Syndrome
Limited elbow extension, Craniosynostosis, Hyperextensible hand joints, Short nose, Abnormality o... ORPHA:457395
Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked
Macroglossia, Absent frontal sinuses, Short nose, Protruding tongue, U-Shaped upper lip vermilion... OMIM:301040
Fibrochondrogenesis 1
Long philtrum, Narrow mouth, Short nose, Camptodactyly, Joint contracture of the hand, Cleft pala... OMIM:228520
Jacobsen Syndrome
Short nose, Flexion contracture, U-Shaped upper lip vermilion, Failure to thrive, Macrocephaly, M... OMIM:147791
Robinow Syndrome, Autosomal Recessive 1
Long philtrum, Macroglossia, Short nose, Dental crowding, Wide nasal bridge, Vertebral fusion, Th... OMIM:268310
Faciodigitogenital Syndrome, Autosomal Recessive
Prominent nasal bridge, Hyperextensible hand joints, Narrow palate, Short nose, Camptodactyly, De... OMIM:227330
Trichothiodystrophy 4, Nonphotosensitive
Microcephaly, Anteverted nares, Hypoplasia of teeth, Short nose OMIM:234050
Harel-Yoon Syndrome
Short nose OMIM:617183
Autosomal Recessive Faciodigitogenital Syndrome
Open bite, Long philtrum, Short nose, Joint hyperflexibility, Everted lower lip vermilion, Deep p... ORPHA:1974
Trisomy 18
Camptodactyly of finger, Narrow palate, Narrow mouth, Short nose, Choanal atresia, Esophageal atr... ORPHA:3380
Blomstrand Lethal Chondrodysplasia
Long philtrum, Short nose, Synostosis of joints, Natal tooth, Increased bone mineral density, Pro... ORPHA:50945
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Long philtrum, Recurrent pneumonia, Craniosynostosis, Narrow mouth, Open mouth, Drooling, Bulbous... ORPHA:508533
Autosomal Dominant Robinow Syndrome
Open bite, Camptodactyly of finger, Oligodontia, Long philtrum, Median cleft lip and palate, Shor... ORPHA:3107
Robinow Syndrome, Autosomal Dominant 1
Long philtrum, Macroglossia, Delayed eruption of teeth, Narrow palate, Short nose, Downturned cor... OMIM:180700
Khan-Khan-Katsanis Syndrome
Short nose, Flexion contracture, Tented upper lip vermilion, Triangular mouth, Failure to thrive,... OMIM:618460
Toriello-Lacassie-Droste Syndrome
Short nose, Laryngeal hypoplasia, Aganglionic megacolon, Failure to thrive, Macrocephaly, Antever... ORPHA:3339
Weiss-Kruszka Syndrome
Exaggerated cupid's bow, Broad philtrum, Anteverted nares, Short nose OMIM:618619
Dysmorphism-Short Stature-Deafness-Disorder Of Sex Development Syndrome
Short nose, Submucous cleft soft palate, Wide nasal bridge, Cleft soft palate, Microcephaly, Ante... ORPHA:2282
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Osteoporosis, Joint hypermobility, Carious teeth, Craniosynostosis, Long philtrum, Radioulnar syn... ORPHA:536467
Coffin-Siris Syndrome
Wide nasal base, Delayed eruption of teeth, Joint laxity, Short nose, Recurrent upper respiratory... ORPHA:1465
Wiedemann-Steiner Syndrome
Long philtrum, Short nose, Wide nasal bridge, Thin upper lip vermilion, Hyperextensibility at elb... ORPHA:319182
Cleft Palate With Or Without Ankyloglossia, X-Linked
Bifid uvula, Ankyloglossia, Cleft palate OMIM:303400
Cardiofaciocutaneous Syndrome
Long philtrum, Biparietal narrowing, Short nose, Failure to thrive in infancy, Depressed nasal br... ORPHA:1340
Brachycephaly, Deafness, Cataract, Microstomia, And Mental Retardation
Long philtrum, Narrow mouth, Short nose, Camptodactyly, Thin upper lip vermilion, Cleft palate, D... OMIM:601353
Subaortic Stenosis--Short Stature Syndrome
Narrow mouth, Short nose, Diastema, Wide nasal bridge, Short upper lip, Anteverted nares OMIM:271960
Molybdenum Cofactor Deficiency, Complementation Group B
Long philtrum, Short nose, Thick vermilion border, Macrocephaly, Microcephaly OMIM:252160
Monosomy 9P
Long philtrum, Narrow mouth, Anteverted nares, Short nose, Choanal atresia, Abnormality of the de... ORPHA:261112
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies
Convex nasal ridge, Short nose, Downturned corners of mouth, Flexion contracture, Intestinal malr... OMIM:619321
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked
Short nose, Taurodontia, Underdeveloped nasal alae, Everted lower lip vermilion, Thick vermilion ... OMIM:305100
Sponastrime Dysplasia
Limited elbow extension, Recurrent pneumonia, Joint laxity, Hypoplasia of the nasal bone, General... ORPHA:93357
Menke-Hennekam Syndrome 1
Joint hypermobility, Long philtrum, Short philtrum, Agenesis of permanent teeth, Underdeveloped n... OMIM:618332
Aymé-Gripp Syndrome
Long philtrum, Oligodontia, Craniosynostosis, Radioulnar synostosis, Narrow mouth, Short nose, Ca... ORPHA:1272
Frontofacionasal Dysplasia
Short nose, Underdeveloped nasal alae, Midline defect of the nose, Oral cleft, Cleft upper lip, B... OMIM:229400
Dend Syndrome
Long philtrum, Anteverted nares, Short nose, Downturned corners of mouth ORPHA:79134
Pallister-Hall Syndrome
Abnormal lung lobation, Bifid epiglottis, Short nose, Natal tooth, Choanal atresia, Laryngeal cle... OMIM:146510
Trisomy 8P
Abnormal lung lobation, Thin vermilion border, Malrotation of small bowel, Short nose, Recurrent ... ORPHA:264450
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome
Narrow mouth, Short nose, Anal stenosis, Rectovestibular fistula, Flexion contracture of toe, Per... ORPHA:280633
Schinzel-Giedion Midface Retraction Syndrome
Increased density of long bones, Macroglossia, Abnormal nasopharynx morphology, Choanal stenosis,... OMIM:269150
Okamoto Syndrome
Open bite, Joint hypermobility, Short nose, Downturned corners of mouth, Open mouth, Anal stenosi... ORPHA:2729
Geleophysic Dysplasia 2
Long philtrum, Short nose, Smooth philtrum, Thin upper lip vermilion, Joint stiffness, Limitation... OMIM:614185
Omodysplasia 1
Limited elbow extension, Long philtrum, Short nose, Limited knee extension, Limited elbow flexion... OMIM:258315
Fontaine Progeroid Syndrome
Oligodontia, Craniosynostosis, Narrow mouth, Small for gestational age, High, narrow palate, Depr... OMIM:612289
Ayme-Gripp Syndrome
Long philtrum, Radioulnar synostosis, Narrow mouth, Short nose, Camptodactyly, Smooth philtrum, A... OMIM:601088
Schinzel-Giedion Syndrome
Choanal stenosis, Camptodactyly, Failure to thrive in infancy, High palate, Sclerosis of skull ba... ORPHA:798
Arachnodactyly-Abnormal Ossification-Intellectual Disability Syndrome
Aplasia/Hypoplasia of the Epiglottis, Short nose ORPHA:1129
Atelosteogenesis, Type I
Short nose, Laryngeal stenosis, Cleft palate, Fused cervical vertebrae, Depressed nasal bridge OMIM:108720
Cataract, Aberrant Oral Frenula, And Growth Retardation
Anteverted nares, Short nose, Accessory oral frenulum OMIM:115645
Spondylocarpotarsal Synostosis Syndrome
Enamel hypoplasia, Limited elbow extension, Failure of eruption of permanent teeth, Tarsal synost... OMIM:272460
Arterial Tortuosity Syndrome
Median cleft lip and palate, Hiatus hernia, Craniosynostosis, Esophagitis, Short nose, Joint hype... ORPHA:3342
Camptodactyly Syndrome, Guadalajara, Type I
Narrow mouth, Downturned corners of mouth, Short nose, High palate, Absent ethmoidal sinuses, Cam... OMIM:211910
Molybdenum Cofactor Deficiency, Complementation Group A
Long philtrum, Short nose, Thick vermilion border, Macrocephaly, Microcephaly OMIM:252150
Ocular Anomalies-Axonal Neuropathy-Developmental Delay Syndrome
Short nose ORPHA:496790
Acrocephalopolydactylous Dysplasia
Craniosynostosis, Short nose, Hypoplastic colon, Hypoplasia of the small intestine, Pulmonary hyp... OMIM:200995
Deeah Syndrome
Long philtrum, Short philtrum, Narrow palate, Narrow mouth, Short nose, Decreased body weight, Pr... OMIM:619004
Jacobsen Syndrome
Long philtrum, Short nose, Abnormal palate morphology, Intestinal malrotation, Smooth philtrum, W... ORPHA:2308
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency
Craniosynostosis, Tarsal synostosis, Narrow mouth, Choanal stenosis, Bulbous nose, Camptodactyly,... ORPHA:95699
Noonan Syndrome 3
Left unilambdoid synostosis, Short nose, Sagittal craniosynostosis, Hypoplastic nasal bridge, Hig... OMIM:609942
Neurodegeneration With Brain Iron Accumulation 2A
Short nose OMIM:256600
Ring Chromosome 7 Syndrome
Thin vermilion border, Short philtrum, Narrow naris, Narrow mouth, Anteverted nares, Short nose, ... ORPHA:1449
Aspartylglucosaminuria
Macroglossia, Carious teeth, Short nose, Abnormality of the dentition, Abnormal cortical bone mor... ORPHA:93
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
Long philtrum, Macroglossia, Short nose, Downturned corners of mouth, High palate, Tracheomalacia... ORPHA:444077
Phocomelia, Schinzel Type
Humeroradial synostosis, Short nose, Anal atresia, Cleft palate, High, narrow palate, Tracheoesop... ORPHA:2879
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Short philtrum, Short nose, Downturned corners of mouth, Dental crowding, Camptodactyly, Choanal ... OMIM:301044
Spondylodysplastic Ehlers-Danlos Syndrome
Joint hypermobility, Long philtrum, Radioulnar synostosis, Narrow mouth, Generalized joint laxity... ORPHA:536471
Simpson-Golabi-Behmel Syndrome
Camptodactyly of finger, Macroglossia, Short nose, Wide mouth, Wide nasal bridge, Vertebral fusio... ORPHA:373
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Joint hypermobility, Thin vermilion border, Hyperextensible hand joints, Short philtrum, Unilater... ORPHA:500150
Renal And Mullerian Duct Hypoplasia
Short nose OMIM:266810
Cornelia De Lange Syndrome
Long philtrum, Thin vermilion border, Delayed eruption of teeth, Radioulnar synostosis, Downturne... ORPHA:199
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Progressive flexion contractures, Joint laxity, Short nose, Smooth philtrum, Prominent nasal tip,... ORPHA:522077
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Short nose, Underdeveloped nasal alae, Failure to thrive in infancy, Small for gestational age, S... ORPHA:268261
Craniosynostosis-Mental Retardation Syndrome Of Lin And Gettig
Long philtrum, Thin vermilion border, Craniosynostosis, Multiple small bowel atresias, Short nose... OMIM:218649
Specc1L-Related Hypertelorism Syndrome
Long philtrum, Thin vermilion border, Short nose, Everted lower lip vermilion, Wide nasal bridge,... ORPHA:1519
Simpson-Golabi-Behmel Syndrome, Type 1
Meckel diverticulum, Abnormal lung lobation, Macroglossia, Two carpal ossification centers presen... OMIM:312870
Facial Dysmorphism With Multiple Malformations
Narrow mouth, Downturned corners of mouth, Bulbous nose, Short nose, Wide nasal bridge, Rectovagi... OMIM:227255
Genitourinary And/Or Brain Malformation Syndrome
Long philtrum, Short nose, Aplasia of the nasal bone, Jejunal atresia, Joint stiffness, Macroceph... OMIM:618820
Williams Syndrome
Open bite, Carious teeth, Abnormal dental enamel morphology, Joint laxity, Peripheral pulmonary a... ORPHA:904
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type
Epiphyseal stippling, Tracheal calcification, Short nose, Abnormal calcification of the carpal bo... OMIM:271665
Femoral-Facial Syndrome
Long philtrum, Humeroradial synostosis, Radioulnar synostosis, Underdeveloped nasal alae, Short n... OMIM:134780
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Macroglossia, Short nose, Flexion contracture, Thick vermilion border, Joint stiffness, Recurrent... ORPHA:505248
Bartsocas-Papas Syndrome 1
Arthrogryposis multiplex congenita, Short nose, Underdeveloped nasal alae, Anal stenosis, Flexion... OMIM:263650
Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia
Thin vermilion border, Craniosynostosis, Short nose, Wide nasal bridge, U-Shaped upper lip vermil... OMIM:609945
Peroxisome Biogenesis Disorder 4B
Macrocephaly, Short nose OMIM:614863
Williams-Beuren Syndrome
Joint laxity, Open mouth, Peripheral pulmonary artery stenosis, Failure to thrive in infancy, Col... OMIM:194050
Acromesomelic Dysplasia, Maroteaux Type
Limited elbow extension, Joint laxity, Short nose OMIM:602875
Pallister-Hall Syndrome
Bifid epiglottis, Short nose, Depressed nasal ridge, Recurrent upper and lower respiratory tract ... ORPHA:672
Peters Plus Syndrome
Long philtrum, Short nose, Short columella, Abnormal pulmonary vein morphology, Intestinal fistul... ORPHA:709
Pallister-Killian Syndrome
Long philtrum, Macroglossia, Delayed eruption of teeth, Short nose, Anal stenosis, Everted lower ... OMIM:601803
Penile Agenesis
Short nose, Rectal fistula, Anal atresia, Pulmonary hypoplasia, Bilateral lung agenesis, Tracheoe... ORPHA:49

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ddx10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ddx10.

No publications found that use IMPC mice or data for Ddx10.

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