Spidr | scaffolding protein involved in DNA repair
Physiological systems
16 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Reproductive system Adipose tissue Growth/size/body region Vision/eye Skeleton
11 No significant impact
8 Not tested
Data collections
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
decreased bone mineral density | 1 supporting dataset | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.62x10-9 | ||
decreased bone mineral content | 2 supporting datasets | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.5x10-10 | ||
increased total body fat amount | 2 supporting datasets | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.89x10-8 | ||
female infertility | 1 supporting dataset | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
abnormal eye posterior chamber depth | 1 supporting dataset | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.23x10-6 | ||
decreased lean body mass | 2 supporting datasets | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.62x10-6 | ||
male infertility | 1 supporting dataset | Spidrtm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Spidr.
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Spidrtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Spidrtm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Spidrtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
Spidrtm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Spidrtm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
Spidrtm3a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |