Gene: Actr5

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal hindbrain development Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
increased bone mineral content Actr5tm2b(EUCOMM)Wtsi HET postnatal 7.80×10-05
abnormal embryo turning Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
embryonic growth retardation Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Actr5tm2b(EUCOMM)Wtsi HOM n/a 0.00
abnormal forebrain development Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
abnormal embryo size Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
abnormal midbrain development Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Actr5tm2b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00
hyperactivity Actr5tm2b(EUCOMM)Wtsi HET postnatal 1.41×10-05
increased bone mineral density Actr5tm2b(EUCOMM)Wtsi HET postnatal 2.77×10-07

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cecum 2 No  (12/383) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47)  (2/2) N/A
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 2  (6/485)  (2/2) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Cranium 2  (1/46)  (2/2) N/A
Dorsal root ganglion 2  (1/47)  (2/2) N/A
Ear 2  (1/485)  (2/2) N/A
Embryo 2  (1/485)  (2/2) N/A
Outer ear 2  (1/47)  (2/2) N/A
Eye 2  (1/485)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/46)  (2/2) N/A
Foot 2  (1/485)  (2/2) N/A
Forearm 2  (1/282)  (2/2) N/A
Forebrain 2  (1/485)  (2/2) N/A
Forelimb 2  (1/485)  (2/2) N/A
Fronto-nasal process 2  (1/48)  (2/2) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 2  (1/485)  (2/2) N/A
Head 2  (5/485)  (2/2) N/A
Head mesenchyme 2  (1/47)  (2/2) N/A
Heart 2  (1/485)  (2/2) N/A
Heart ventricle 2  (1/47)  (2/2) N/A
Hindbrain 2  (6/485)  (2/2) N/A
Hindlimb 2  (1/485)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/46)  (2/2) N/A
Inner ear 2  (1/46)  (2/2) N/A
Intestine 2  (1/47)  (2/2) N/A
Liver 2  (1/485)  (2/2) N/A
Lower leg 2  (1/282)  (2/2) N/A
Lung 2  (1/485)  (2/2) N/A
Mandibular process 2  (1/485)  (2/2) N/A
Maxillary process 2  (1/485)  (2/2) N/A
Mesonephros of female 2  (1/46)  (1/2) N/A
Mesonephros of male 2  (1/46)  (1/2) N/A
Metanephros 2  (1/46)  (2/2) N/A
Midbrain 2  (1/485)  (2/2) N/A
Nasal septum 2  (1/47)  (2/2) N/A
Nose 2  (1/51)  (2/2) N/A
Notochord 2  (1/47)  (2/2) N/A
Oral cavity 2  (1/485)  (2/2) N/A
Outflow tract 2  (1/47)  (2/2) N/A
Pancreas 2  (1/46)  (2/2) N/A
Pericardium 2  (1/46)  (2/2) N/A
Pharynx 2  (1/46)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/46)  (2/2) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 2  (1/485)  (2/2) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Stomach 2  (1/46)  (2/2) N/A
Tail 2  (1/485)  (2/2) N/A
Tail somite 2  (1/485)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/46)  (2/2) N/A
Tongue 2  (1/46)  (2/2) N/A
Trachea 2  (1/50)  (2/2) N/A
Trunk mesenchyme 2  (1/47)  (2/2) N/A
Umbilical artery embryonic part 2  (1/47)  (2/2) N/A
Umbilical vein embryonic part 2  (1/47)  (2/2) N/A
Upper arm 2  (1/282)  (2/2) N/A
Upper leg 2  (1/282)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A
Vibrissa 2  (1/47)  (2/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
6 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Actr5tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Actr5tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Actr5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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