Sec24a | SEC24 homolog A, COPII coat complex component

GeneMGI:1924621Synonyms: 9430090N21Rik

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Skeleton

16 No significant impact

5 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

decreased body weight3 supporting datasetsSec24atm1a(KOMP)WtsihomozygoteEarly adult8.17x10-7 
increased circulating alanine transaminase level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult1.21x10-12 
decreased circulating cholesterol level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult3.62x10-10 
decreased circulating HDL cholesterol level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult1.08x10-9 
increased bone mineral density1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult3.34x10-5 
increased lactate dehydrogenase level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult2.08x10-5 
increased blood urea nitrogen level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult1.84x10-5 
decreased circulating LDL cholesterol level1 supporting datasetSec24atm1a(KOMP)WtsihomozygoteEarly adult3.23x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sec24atm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sec24atm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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