The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| preweaning lethality, complete penetrance | Bcl7atm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
| abnormal embryo size | Bcl7atm1b(EUCOMM)Wtsi | HOM | E18.5 | 0.00 | ||
| unresponsive to tactile stimuli | Bcl7atm1b(EUCOMM)Wtsi | HET | E18.5 | 0.00 | ||
| unresponsive to tactile stimuli | Bcl7atm1b(EUCOMM)Wtsi | HOM | E18.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Heart atrium | N/A | heterozygote | 100% (2 of 2) |
| Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
| Brain | N/A | heterozygote | 100% (2 of 2) |
| Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
| Cranium | N/A | heterozygote | 100% (2 of 2) |
| Dorsal root ganglion | N/A | heterozygote | 100% (2 of 2) |
| Ear | N/A | heterozygote | 100% (2 of 2) |
| Embryo | N/A | heterozygote | 100% (2 of 2) |
| Outer ear | N/A | heterozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | 100% (2 of 2) |
| Femur pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Footplate | N/A | heterozygote | 100% (2 of 2) |
| Forearm | N/A | heterozygote | 100% (2 of 2) |
| Forebrain | N/A | heterozygote | 100% (2 of 2) |
| Forelimb | N/A | heterozygote | 100% (2 of 2) |
| Fronto-nasal process | N/A | heterozygote | 100% (2 of 2) |
| Gut | N/A | heterozygote | 100% (2 of 2) |
| Handplate | N/A | heterozygote | 100% (2 of 2) |
| Head mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Head | N/A | heterozygote | 100% (2 of 2) |
| Heart ventricle | N/A | heterozygote | 100% (2 of 2) |
| Heart | N/A | heterozygote | 100% (2 of 2) |
| Hindbrain | N/A | heterozygote | 100% (2 of 2) |
| Hindlimb | N/A | heterozygote | 100% (2 of 2) |
| Humerus pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Inner ear | N/A | heterozygote | 100% (2 of 2) |
| Intestine | N/A | heterozygote | 100% (2 of 2) |
| Liver | N/A | heterozygote | 100% (2 of 2) |
| Lower leg | N/A | heterozygote | 100% (2 of 2) |
| Lung | N/A | heterozygote | 100% (2 of 2) |
| Mandibular process | N/A | heterozygote | 100% (2 of 2) |
| Maxillary process | N/A | heterozygote | 100% (2 of 2) |
| Mesonephros of female | N/A | heterozygote | 50% (1 of 2) |
| Mesonephros of male | N/A | heterozygote | 50% (1 of 2) |
| Metanephros | N/A | heterozygote | 100% (2 of 2) |
| Midbrain | N/A | heterozygote | 100% (2 of 2) |
| Nasal septum | N/A | heterozygote | 100% (2 of 2) |
| Nose | N/A | heterozygote | 100% (2 of 2) |
| Notochord | N/A | heterozygote | 100% (2 of 2) |
| Oral cavity | N/A | heterozygote | 100% (2 of 2) |
| Outflow tract | N/A | heterozygote | 100% (2 of 2) |
| Pancreas | N/A | heterozygote | 100% (2 of 2) |
| N/A | heterozygote | 100% (2 of 2) | |
| Pharynx | N/A | heterozygote | 100% (2 of 2) |
| Radius-ulna pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Rib pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Skeleton | N/A | heterozygote | 100% (2 of 2) |
| Skin | N/A | heterozygote | 100% (2 of 2) |
| Spinal cord | N/A | heterozygote | 100% (2 of 2) |
| Stomach | N/A | heterozygote | 100% (2 of 2) |
| Tail somite | N/A | heterozygote | 100% (2 of 2) |
| Tail | N/A | heterozygote | 100% (2 of 2) |
| Thoracic vertebral cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Tongue | N/A | heterozygote | 100% (2 of 2) |
| Trachea | N/A | heterozygote | 100% (2 of 2) |
| Trunk mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Umbilical artery embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Umbilical vein embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Upper arm | N/A | heterozygote | 100% (2 of 2) |
| Upper leg | N/A | heterozygote | 100% (2 of 2) |
| Urinary system | N/A | heterozygote | 100% (2 of 2) |
| Vibrissa | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| atrium | Ambiguous |
| axial skeleton | Ambiguous |
| brain | 0.0% |
| central nervous system ganglion | Ambiguous |
| cranium | Ambiguous |
| dorsal root ganglion | Ambiguous |
| ear | 0.0% |
| embryo | 0.0% |
| external ear | Ambiguous |
| eye | 0.0% |
| femur pre-cartilage condensation | Ambiguous |
| footplate | 0.0% |
| forearm | Ambiguous |
| forebrain | 0.0% |
| forelimb | 0.0% |
| fronto-nasal process | Ambiguous |
| gut | Ambiguous |
| handplate | 0.0% |
| head | 0.0% |
| head mesenchyme | Ambiguous |
| heart | 0.0% |
| heart ventricle | Ambiguous |
| hindbrain | 0.0% |
| hindlimb | 0.0% |
| humerus pre-cartilage condensation | Ambiguous |
| inner ear | Ambiguous |
| intestine | Ambiguous |
| liver | 0.0% |
| lower leg | Ambiguous |
| lung | 0.0% |
| mandibular process | 0.0% |
| maxillary process | 0.0% |
| mesonephros of female | Ambiguous |
| mesonephros of male | Ambiguous |
| metanephros | Ambiguous |
| midbrain | 0.0% |
| nasal septum | Ambiguous |
| nose | Ambiguous |
| notochord | Ambiguous |
| oral cavity | 0.0% |
| outflow tract | Ambiguous |
| pancreas | Ambiguous |
| pericardium | Ambiguous |
| pharynx | Ambiguous |
| radius-ulna pre cartilage condensation | Ambiguous |
| rib pre-cartilage condensation | Ambiguous |
| skeleton | Ambiguous |
| skin | 0.0% |
| spinal cord | Ambiguous |
| stomach | Ambiguous |
| tail | 0.0% |
| tail somite group | 0.0% |
| thoracic vertebral cartilage condensation | Ambiguous |
| tongue | Ambiguous |
| trachea | Ambiguous |
| trunk mesenchyme | Ambiguous |
| umbilical artery embryonic part | Ambiguous |
| umbilical vein embryonic part | Ambiguous |
| upper arm | Ambiguous |
| upper leg | Ambiguous |
| urinary system | Ambiguous |
| vibrissa | Ambiguous |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| MGI Allele | Allele Type | Produced |
|---|---|---|
| Bcl7atm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
| Bcl7atm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
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