Gene: Kdm8

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal response to tactile stimuli Kdm8tm1a(EUCOMM)Wtsi HET Early adult 1.86×10-07
abnormal glucose homeostasis Kdm8tm1a(EUCOMM)Wtsi HET Early adult 2.18×10-06
increased B cell number Kdm8tm1a(EUCOMM)Wtsi HET Early adult 8.24×10-05
preweaning lethality, incomplete penetrance Kdm8tm1a(EUCOMM)Wtsi HOM Early adult 0.00
prenatal lethality Kdm8tm1a(EUCOMM)Wtsi HOM E18.5 0.00
embryonic lethality prior to tooth bud stage Kdm8tm1b(EUCOMM)Wtsi HOM E12.5 0.00
abnormal iris pigmentation Kdm8tm1a(EUCOMM)Wtsi HET Early adult 2.79×10-05
abnormal coat/ hair morphology Kdm8tm1a(EUCOMM)Wtsi HET Early adult 2.79×10-05
increased circulating potassium level Kdm8tm1a(EUCOMM)Wtsi HET Early adult 3.05×10-07
mammalian phenotype Kdm8tm1a(EUCOMM)Wtsi HET Early adult 2.79×10-05
preweaning lethality, complete penetrance Kdm8tm1b(EUCOMM)Wtsi HOM Early adult 0.00
abnormal behavior Kdm8tm1b(EUCOMM)Wtsi HET Early adult 1.31×10-05
increased circulating HDL cholesterol level Kdm8tm1b(EUCOMM)Wtsi HET Early adult 1.44×10-05
increased body weight Kdm8tm1a(EUCOMM)Wtsi HET Early adult 3.55×10-06

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584) N/A
Aorta 4 No N/A
Bone 4 No N/A
Brain 4 No  (4/4)  Wholemount images
Brainstem 4 No  (4/4)  Wholemount images
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (4/4)  Wholemount images
Cerebellum 4 No  (4/4)  Wholemount images
Cerebral cortex 4 No  (4/4)  Wholemount images
Esophagus 4 No  (7/415) N/A
Eye 4 No N/A
Gall bladder 4 No N/A
Heart 4 No N/A
Hippocampus 4 No  (4/4)  Wholemount images
Hypothalamus 4 No  (4/4)  Wholemount images
Kidney 4 No  (18/584)  (4/4)  Wholemount images
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (3/4)  Wholemount images
Oral epithelium 4 No N/A
Ovary 4 No  (1/584) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/584) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No  (4/4)  Wholemount images
Peyer's patch 4 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584) N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No  (4/4)  Wholemount images
Spleen 4 No  (2/584) N/A
Stomach 4 No  (12/584) N/A
Striatum 4 No  (4/4)  Wholemount images
Testis 4 No  (2/584)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (15/584) N/A
Trachea 4 No  (4/4)  Wholemount images
Uterus 4 No N/A
Vascular system 4 No N/A
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (2/2) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/2) N/A
Eye 2  (1/504)  (2/2) N/A
Foot 2  (1/504)  (1/2) N/A
Forebrain 2  (1/504)  (2/2) N/A
Forelimb 2  (1/504)  (1/2) N/A
Hand 2  (1/503)  (1/2) N/A
Head 2  (5/504)  (2/2) N/A
Heart 2  (1/504)  (1/2) N/A
Hindbrain 2  (6/504)  (1/2) N/A
Hindlimb 2  (1/503)  (1/2) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500)  (1/2) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504)  (2/2) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504)  (1/2) N/A
Tail 2  (1/504)  (1/2) N/A
Tail somite 2  (1/504)  (1/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
9 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Whole Body Dorso Ventral
60 Images
X-ray: XRay Images Whole Body Lateral Orientation
44 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
29 Images
Echo: M-Mode Images
68 Images
Embryo LacZ: LacZ images wholemount
4 Images
X-ray: XRay Images Hind Leg and Hip
1 Images
X-ray: XRay Images Forepaw
15 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Kdm8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Kdm8tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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