Gene: Kdm8

Name
lysine (K)-specific demethylase 8
MGI ID
MGI:1924285
Synonyms
Jmjd5 3110005O21Rik
Viability
Homozygous - Lethal Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased body weight Kdm8tm1a(EUCOMM)Wtsi HET postnatal 1.01×10-07
preweaning lethality, incomplete penetrance Kdm8tm1a(EUCOMM)Wtsi HOM n/a 0.00
increased circulating potassium level Kdm8tm1a(EUCOMM)Wtsi HET postnatal 4.45×10-07
increased B cell number Kdm8tm1a(EUCOMM)Wtsi HET postnatal 8.24×10-05
abnormal response to tactile stimuli Kdm8tm1a(EUCOMM)Wtsi HET postnatal 1.86×10-07
abnormal glucose homeostasis Kdm8tm1a(EUCOMM)Wtsi HET postnatal 2.18×10-06
abnormal iris pigmentation Kdm8tm1a(EUCOMM)Wtsi HET postnatal 2.79×10-05
increased circulating HDL cholesterol level Kdm8tm1b(EUCOMM)Wtsi HET postnatal 1.44×10-05
preweaning lethality, complete penetrance Kdm8tm1b(EUCOMM)Wtsi HOM n/a 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584) N/A
Aorta 4 No N/A
Bone 4 No N/A
Brain 4 No  (4/4)  Wholemount images
Brainstem 4 No  (4/4)  Wholemount images
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (4/4)  Wholemount images
Cerebellum 4 No  (4/4)  Wholemount images
Cerebral cortex 4 No  (4/4)  Wholemount images
Esophagus 4 No  (7/415) N/A
Eye 4 No N/A
Gall bladder 4 No N/A
Heart 4 No N/A
Hippocampus 4 No  (4/4)  Wholemount images
Hypothalamus 4 No  (4/4)  Wholemount images
Kidney 4 No  (18/584)  (4/4)  Wholemount images
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (3/4)  Wholemount images
Oral epithelium 4 No N/A
Ovary 4 No  (1/584) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/584) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No  (4/4)  Wholemount images
Peyer's patch 4 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584) N/A
Skeletal muscle 4 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No  (4/4)  Wholemount images
Spleen 4 No  (2/584) N/A
Stomach 4 No  (12/584) N/A
Striatum 4 No  (4/4)  Wholemount images
Testis 4 No  (2/584)  (2/4)  Wholemount images
Thymus 4 No N/A
Thyroid gland 4 No  (15/584) N/A
Trachea 4 No  (4/4)  Wholemount images
Uterus 4 No N/A
Vascular system 4 No N/A
White adipose tissue 4 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (1/2) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/2) N/A
Eye 2  (1/485)  (1/2) N/A
Foot 2  (1/485)  (1/2) N/A
Forebrain 2  (1/485)  (1/2) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (1/2) N/A
Heart 2  (1/485)  (1/2) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485)  (1/2) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (1/2) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485)  (1/2) N/A
Tail 2  (1/485)  (1/2) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
44 Images
Echo: M-Mode Images
68 Images
Adult LacZ: LacZ Images Wholemount
9 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
X-ray: XRay Images Dorso Ventral
60 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
29 Images
X-ray: XRay Images Forepaw
15 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Embryo LacZ: LacZ images wholemount
4 Images
X-ray: XRay Images Hind Leg and Hip
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Kdm8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Kdm8tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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