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Gene: Jade2 MGI:1924151

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Gene Summary

Name:
jade family PHD finger 2
Synonyms:
1200017K05Rik,  Phf15

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged urinary bladder Jade2em1(IMPC)Tcp HOM Early adult 0.00
small spleen Jade2em1(IMPC)Tcp HOM Early adult 0.00
abnormal sternum morphology Jade2em1(IMPC)Tcp HOM Early adult 0.00
decreased bone mineral density Jade2em1(IMPC)Tcp HOM   Early adult 3.12×10-07
abnormal seminal vesicle morphology Jade2em1(IMPC)Tcp HOM Early adult 0.00
decreased fasting circulating glucose level Jade2em1(IMPC)Tcp HOM Early adult 1.74×10-06
decreased prepulse inhibition Jade2em1(IMPC)Tcp HOM Early adult 3.36×10-06
decreased bone mineral content Jade2em1(IMPC)Tcp HOM   Early adult 1.72×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Ophthalmoscopy

69 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Gross Pathology and Tissue Collection

Images

9 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Jade2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Jade2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hip Dysplasia, Beukes Type
Abnormality of the epiphysis of the femoral head, Abnormal ossification involving the femoral hea... ORPHA:2114
Gracile Bone Dysplasia
Asplenia, Flared metaphysis, Hypoplastic spleen, Thin ribs, Slender long bone, Micropenis, Decrea... OMIM:602361
Mirage Syndrome
Hypergonadotropic hypogonadism, Hypospadias, Rocker bottom foot, Hypoglycemia, Cryptorchidism, Ra... OMIM:617053
Bent Bone Dysplasia Syndrome 2
Osteopenia, Hepatomegaly, Bowed humerus, Hypoplastic iliac wing, Short tibia, Ulnar bowing, Femor... OMIM:620076
Lissencephaly Syndrome, Norman-Roberts Type
Hypoplastic spleen, Rocker bottom foot, Adducted thumb ORPHA:89844
Dysosteosclerosis
Osteopenia, Sclerosis of hand bone, Sclerotic scapulae, Abnormal metaphyseal trabeculation, Flare... OMIM:224300
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Impaired lymphocyte transformation with phytohemagglutinin, T lymphocytopenia, B lymphocytopenia,... OMIM:619313
Stormorken Syndrome
Howell-Jolly bodies, Asplenia, Anemia, Hematuria, Hypoplastic spleen, Thrombocytopenia OMIM:185070
Schinzel-Giedion Midface Retraction Syndrome
Small scrotum, Increased density of long bones, Tibial bowing, Hypoplasia of first ribs, Hepatobl... OMIM:269150
Microphthalmia, Syndromic 9
Cryptorchidism, Multilobulated spleen, Renal hypoplasia, Horseshoe kidney, Hypoplasia of the uter... OMIM:601186
Pearson Syndrome
Decreased response to growth hormone stimulation test, Renal cyst, Abnormality of the liver, Neut... ORPHA:699
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Ulbright-Hodes Syndrome
Abnormal penis morphology, Short humerus, Short metacarpal, Abnormal external genitalia, Enlarged... ORPHA:3404
Craniorachischisis
Bifid sternum ORPHA:63260
Coffin-Lowry Syndrome
Hyperextensibility of the finger joints, Short metacarpal, Bifid sternum, Tapered finger, Coxa va... OMIM:303600

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Jade2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Jade2.

No publications found that use IMPC mice or data for Jade2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Jade2tm33789(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Jade2em1(IMPC)Tcp Exon Deletion Mice
Jade2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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