Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
protein phosphatase 1, regulatory subunit 3G
Synonyms:
1600032L17Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ppp1r3g mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ppp1r3g by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Type II diabetes mellitus, Polyphagia, Hyperinsulinemia, Obesity, Child... ORPHA:71529
Obesity Due To Prohormone Convertase I Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Hyperinsulinemia, Cholestasis, Obesity, ... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Increased adipose tissue, Polyphagia, Failure to thrive, Hyperinsulinemia, Cholestasis, Obesity, ... ORPHA:71526
Hyperinsulinism Due To Hnf1A Deficiency
Hepatomegaly, Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Small for gestat... ORPHA:324575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hepatomegaly, Fasting hypoglycemia, Hypoketotic hypoglycemia, Maternal diabetes, Polyphagia, Hype... ORPHA:276580
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Hyperinsulinemia, Polyphagia ORPHA:329249
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hepatomegaly, Fasting hypoglycemia, Hypoketotic hypoglycemia, Polyphagia, Focal pancreatic islet ... ORPHA:276575
Body Mass Index Quantitative Trait Locus 20
Obesity, Hyperinsulinemia, Polyphagia OMIM:618406
Obesity Due To Sim1 Deficiency
Obesity, Glucose intolerance, Hyperinsulinemia, Polyphagia ORPHA:369873
Hyperinsulinism Due To Ucp2 Deficiency
Hepatomegaly, Hypoketotic hypoglycemia, Polyphagia, Hyperinsulinemic hypoglycemia, Large for gest... ORPHA:276556
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity, Hypoglycemic seizures, Cholestasis, Polyphagia OMIM:609734
Type 1 Diabetes Mellitus
Hyperglycemia, Polyphagia, Diabetes mellitus, Polydipsia OMIM:222100
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Diabetes mellitus, Polyphagia OMIM:614963
Temple Syndrome
Type II diabetes mellitus, Small for gestational age, Polyphagia, Recurrent hypoglycemia, Obesity ORPHA:254516
Macrosomia Adiposa Congenita
Obesity, Polyphagia, Large for gestational age OMIM:248100
Insulinoma
Abnormality of the pancreatic islet cells, Polyphagia, Hyperinsulinemic hypoglycemia, Fasting hyp... ORPHA:97279
Renal Glucosuria
Polydipsia, Polyphagia, Glycosuria OMIM:233100
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia, Hyperglycemia, Truncal obesity, Obesity OMIM:615986
Obesity, Hyperphagia, And Developmental Delay
Obesity, Polyphagia OMIM:613886
Leptin Deficiency Or Dysfunction
Obesity, Abnormal eating behavior, Polyphagia OMIM:614962
Bardet-Biedl Syndrome 22
Obesity, Polyphagia, Large for gestational age OMIM:617119
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia, Neonatal hypoglycemia OMIM:606407
Hypotonia-Cystinuria Syndrome
Failure to thrive, Polyphagia ORPHA:163690
Prader-Willi Syndrome Due To Imprinting Mutation
Obesity, Polyphagia ORPHA:177910
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Obesity Due To Congenital Leptin Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia ORPHA:179494
Lipodystrophy, Congenital Generalized, Type 1
Hepatomegaly, Umbilical hernia, Polyphagia, Insulin-resistant diabetes mellitus at puberty, Reduc... OMIM:608594
6Q16 Microdeletion Syndrome
Obesity, Polyphagia ORPHA:171829
Schaaf-Yang Syndrome
Failure to thrive in infancy, Polyphagia, Arthrogryposis multiplex congenita, Flexion contracture... OMIM:615547
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Obesity, Polyphagia ORPHA:411515
Lipodystrophy, Congenital Generalized, Type 2
Hepatomegaly, Umbilical hernia, Polyphagia, Insulin-resistant diabetes mellitus at puberty, Reduc... OMIM:269700
Huntington Disease
Polyphagia, Decreased body mass index, Weight loss, Choking episodes, Oral-pharyngeal dysphagia ORPHA:399
Graves Disease, Susceptibility To, 1
Weight loss, Polyphagia OMIM:275000
Pick Disease Of Brain
Polyphagia OMIM:172700
Cebalid Syndrome
Congenital diaphragmatic hernia, Polyphagia OMIM:618774
Frontotemporal Dementia
Polyphagia OMIM:600274
Pediatric-Onset Graves Disease
Hepatomegaly, Polydipsia, Polyphagia, Failure to thrive, Splenomegaly, Elevated hepatic transamin... ORPHA:525731
Man1B1-Cdg
Polyphagia, Truncal obesity ORPHA:397941
Secondary Short Bowel Syndrome
Failure to thrive, Weight loss, Cholestasis, Polyphagia ORPHA:95427
Sim1-Related Prader-Willi-Like Syndrome
Type II diabetes mellitus, Polyphagia, Failure to thrive, Abdominal obesity, Obesity ORPHA:398079
X-Linked Acrogigantism
Fasting hyperinsulinemia, Increased body mass index, Polyphagia, Abnormal oral glucose tolerance ORPHA:300373
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Polyphagia, Small for gestational age, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:98754
Magel2-Related Prader-Willi-Like Syndrome
Type II diabetes mellitus, Polyphagia, Failure to thrive, Abdominal obesity, Flexion contracture,... ORPHA:398069
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Polyphagia, Small for gestational age, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:98793
Prader-Willi Syndrome
Failure to thrive in infancy, Type II diabetes mellitus, Polyphagia, Abdominal obesity, Obesity, ... OMIM:176270
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Polyphagia, Small for gestational age, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Polyphagia, Small for gestational age, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:177901
2Q23.1 Microdeletion Syndrome
Polyphagia ORPHA:228402
Luscan-Lumish Syndrome
Obesity, Polyphagia OMIM:616831
Paternal Uniparental Disomy Of Chromosome 1
Obesity, Abnormal dental enamel morphology, Polyphagia ORPHA:251004
Prader-Willi-Like Syndrome
Polyphagia, Small for gestational age, Failure to thrive, Bulimia, Diabetes mellitus, Obesity ORPHA:398073
Trisomy 18P
Polyphagia ORPHA:1715
Craniopharyngioma
Obesity, Type II diabetes mellitus, Polyphagia ORPHA:54595
Prader-Willi Syndrome
Failure to thrive, Abdominal obesity, Diabetes mellitus, Polyphagia ORPHA:739
Intellectual Developmental Disorder, Autosomal Dominant 1
Polyphagia OMIM:156200
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Polyphagia, Hyperglycemia, Cyanosis, Elevated hepatic transaminase, Obesity ORPHA:293987
Angelman Syndrome
Obesity, Dysphagia, Polyphagia ORPHA:72
7Q11.23 Microduplication Syndrome
Congenital diaphragmatic hernia, Polyphagia, Inguinal hernia, Obesity ORPHA:96121
Chromosome 22Q13 Duplication Syndrome
Polyphagia OMIM:615538
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia ORPHA:251028
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Adnp Syndrome
Polyphagia, Inguinal hernia, Truncal obesity, Oral-pharyngeal dysphagia, Umbilical hernia ORPHA:404448
Gangliocytoma
Polyphagia ORPHA:251937
Pseudohypoparathyroidism Type 1C
Obesity, Enamel hypoplasia, Polyphagia ORPHA:79444
1P36 Deletion Syndrome
Abnormality of the spleen, Dysphagia, Polyphagia, Annular pancreas, Failure to thrive, Abnormalit... ORPHA:1606
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Polyphagia OMIM:607485
Pseudohypoparathyroidism Type 1A
Obesity, Enamel hypoplasia, Polyphagia ORPHA:79443
Alström Syndrome
Hepatomegaly, Type II diabetes mellitus, Hepatic fibrosis, Polyphagia, Insulin resistance, Dorsoc... ORPHA:64
Early-Onset Schizophrenia
Polyphagia ORPHA:96369
Chromosome 1P36 Deletion Syndrome, Distal
Dysphagia, Polyphagia, Camptodactyly of finger, Camptodactyly, Obesity OMIM:607872

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ppp1r3g

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ppp1r3g.

No publications found that use IMPC mice or data for Ppp1r3g.

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