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Gene: Ankrd36 MGI:1923639

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Gene Summary

Name:
ankyrin repeat domain 36
Synonyms:
GC3,  1700008J08Rik,  1700012M14Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Ankrd36em1(IMPC)Tcp HOM Early adult 0.00
abnormal sternum morphology Ankrd36em1(IMPC)Tcp HOM Early adult 0.00
preweaning lethality, incomplete penetrance Ankrd36em1(IMPC)Tcp HOM Early adult 0.00
enlarged stomach Ankrd36em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

90 Images

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Eye Morphology

Images Ophthalmoscopy

94 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Gross Pathology and Tissue Collection

Images

9 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Human diseases caused by Ankrd36 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ankrd36 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Necrotizing Encephalomyelopathy, Subacute, Of Leigh, Adult
Foot acroosteolysis, Gastric hypertrophy, Metatarsal periosteal thickening, Metacarpal periosteal... OMIM:161700
Polyposis of gastric fundus without polyposis coli
Multiple gastric polyps, Abnormal gastric mucosa morphology OMIM:175505
Pyloric Atresia
Congenital pyloric atresia OMIM:265950
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
Absence of intrinsic factor OMIM:243320
Chronic Intestinal Pseudoobstruction
Intestinal malrotation, Abnormal intestine morphology, Pyloric stenosis ORPHA:2978
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Congenital pyloric atresia, Neonatal death OMIM:612138
Serrated Polyposis Syndrome
Biliary tract neoplasm, Neoplasm of the large intestine, Gastric diverticulum, Adenomatous coloni... ORPHA:157798
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Congenital pyloric atresia, Esophageal stenosis, Neonatal death OMIM:619817
Alpha-1-Antitrypsin Deficiency
Gastric varix, Hepatocellular carcinoma OMIM:613490
Nk-Cell Enteropathy
Hematochezia, Colonic diverticula, Gastroesophageal reflux, Stercoral ulcer, Abnormal gastric muc... ORPHA:263665
Microgastria-Limb Reduction Defect Syndrome
Esophagitis, Perineal fistula, Abnormal metacarpal morphology, Rectal atresia, Abnormal morpholog... ORPHA:2538
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Ménétrier Disease
Gastrointestinal hemorrhage, Gastroesophageal reflux, Stomach cancer, Abnormal gastric mucosa mor... ORPHA:2494
Intrinsic Factor Deficiency
Absence of intrinsic factor OMIM:261000
Syndromic Recessive X-Linked Ichthyosis
Abnormal stomach morphology ORPHA:281090
Oculogastrointestinal Muscular Dystrophy
Spontaneous esophageal perforation, Abnormality of the gastrointestinal tract, Intestinal pseudo-... ORPHA:1876
Craniorachischisis
Bifid sternum, Anal atresia ORPHA:63260
Bronchogenic Cyst
Abnormal stomach morphology, Abnormal esophagus morphology, Dysphagia ORPHA:2357
Systemic Sclerosis
Barrett esophagus, Intestinal bleeding, Finger swelling, Abnormal phalangeal joint morphology of ... ORPHA:90291
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 8
Gastric varix, Clubbing, Esophageal varix OMIM:620367
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Gastric varix, Esophageal varix, Hepatocellular carcinoma ORPHA:64743
Congenital Tracheal Stenosis
Meckel diverticulum, Duodenal stenosis, Abnormal stomach morphology, Abnormal gastrointestinal tr... ORPHA:141127
Metachromatic Leukodystrophy
Abnormal stomach morphology, Neoplasm of the gallbladder, Abnormal duodenum morphology, Intussusc... ORPHA:512
Coffin-Lowry Syndrome
Narrow palate, Bifid sternum, Rectal prolapse, Tapered finger, Drumstick terminal phalanges, Narr... OMIM:303600
Viss Syndrome
Genu valgum, Cleft soft palate, Contracture of the proximal interphalangeal joint of the 2nd toe,... OMIM:619472
Hardikar Syndrome
Intestinal malrotation, Cleft soft palate, Bilateral cleft palate, Unilateral cleft palate, Gastr... OMIM:301068

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ankrd36

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ankrd36.

No publications found that use IMPC mice or data for Ankrd36.

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MGI Allele Allele Type Produced
Ankrd36tm215(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ankrd36tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ankrd36em1(IMPC)Tcp Exon Deletion Mice
Ankrd36tm214(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ankrd36tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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