Dnaaf2 | dynein, axonemal assembly factor 2

GeneMGI:1923566Synonyms: kintoun, 1110034A24Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

increased circulating sodium level1 supporting datasetDnaaf2tm1.1(KOMP)VlcgheterozygoteEarly adult6.26x10-9 
increased circulating total protein level1 supporting datasetDnaaf2tm1.1(KOMP)VlcgheterozygoteEarly adult5.8x10-6 
preweaning lethality, complete penetrance1 supporting datasetDnaaf2tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetDnaaf2tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal sleep behavior1 supporting datasetDnaaf2tm1.1(KOMP)VlcgheterozygoteEarly adult8.83x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dnaaf2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Dnaaf2tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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