Gene: Cyrib

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
edema Fam49btm1b(KOMP)Wtsi HOM E15.5 0.00
male infertility Fam49btm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating sodium level Fam49btm1b(KOMP)Wtsi HET Early adult 5.94×10-05
decreased body length Fam49btm1b(KOMP)Wtsi HET Early adult 9.86×10-05
preweaning lethality, incomplete penetrance Fam49btm1b(KOMP)Wtsi HOM Early adult 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 1  (1/61) N/A
Brain 2  (6/504) N/A
Central nervous system ganglion 1  (1/70) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505) N/A
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Gut 1  (1/56)  (1/2) N/A
Hand 2  (1/503) N/A
Head 2  (5/504) N/A
Heart 2  (1/504)  (1/3) N/A
Hindbrain 2  (6/504) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 1  (1/70) N/A
Oral cavity 2  (1/504) N/A
1  (7/37)  (1/2) N/A
Skeleton 1  (1/70) N/A
Skin 2  (1/504) N/A
Spinal cord 1  (1/69) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A
Trachea 1  (1/56) N/A
Urinary system 1  (1/56) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
13 Images
X-ray: XRay Images Skull Lateral Orientation
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
Eye Morphology: Images Ophthalmoscopy
30 Images
Gross Pathology and Tissue Collection
14 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
13 Images
Histopathology
5 Images
Combined SHIRPA and Dysmorphology
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Brain - process of degenerative change Fam49btm1b(KOMP)Wtsi HET Early adult
Eye with optic nerve - developmental and structural abnormality Fam49btm1b(KOMP)Wtsi HET Early adult
Eye with optic nerve - developmental and structural abnormality Fam49btm1b(KOMP)Wtsi HOM Early adult
Spleen - hyperplasia Fam49btm1b(KOMP)Wtsi HET Early adult
Brain - MPATH diagnostic term hydrocephalus Fam49btm1b(KOMP)Wtsi HET Early adult
Spleen - hyperplasia Fam49btm1b(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cyribtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cyribtm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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