Gene Summary

Name:
divergent protein kinase domain 2B
Synonyms:
4930578C19Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
increased freezing behavior Dipk2bem1(IMPC)Mbp HOM   Early adult 3.22×10-06
enlarged lymph nodes Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
hydrometra Dipk2bem1(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Dipk2bem1(IMPC)Mbp HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

48 Images

X-ray

XRay Images Whole Body Lateral Orientation

16 Images

Human diseases caused by Dipk2b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dipk2b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Severe Primary Trimethylaminuria
Negative affectivity, Low self esteem, Aggressive behavior, Depression, Emotional lability, Anxiety ORPHA:468726
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Kerion Celsi
Lymphadenopathy ORPHA:499
Apolipoprotein A-I Deficiency
Lymphadenopathy, Splenomegaly ORPHA:425
Immunodeficiency 75
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Splenomegaly OMIM:608971
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
T-Cell Receptor-Alpha/Beta Deficiency
Lymphadenopathy OMIM:615387
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Splenomegaly OMIM:618495
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus, Genital ulcers OMIM:602450
Mast Cell Sarcoma
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:66661
Pandas
Claustrophobia, Depression, Agoraphobia, Separation insecurity, Emotional lability, Impulsivity, ... ORPHA:66624
Immunodeficiency With Hyper-Igm, Type 5
Epididymitis, Lymphadenopathy OMIM:608106
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the ovary, Abnormality of the lymph nodes ORPHA:543
Autoinflammation With Episodic Fever And Lymphadenopathy
Recurrent tonsillitis, Lymphadenopathy, Splenomegaly OMIM:618852
Alpha-Heavy Chain Disease
Premature ovarian insufficiency, Lymphadenopathy, Splenomegaly ORPHA:100025
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Ovarian Dysgenesis 2
Gonadal hypoplasia, Abnormality of the uterus, Hypergonadotropic hypogonadism, Hypoplasia of the ... OMIM:300510
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Follicular Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:545
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Testicular Regression Syndrome
Abnormal morphology of female internal genitalia, Ambiguous genitalia, Absent testis, Abnormality... ORPHA:983
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy OMIM:615895
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Candidiasis, Familial, 2
Lymphadenopathy OMIM:212050
46,Xy Sex Reversal 3
Ambiguous genitalia, Exaggerated rugosity of the labia majora, Sex reversal, Hypoplasia of the ut... OMIM:612965
Mu-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100024
Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:98293
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Immunodeficiency 72 With Autoinflammation
Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Premature Ovarian Failure 3
Hypoplasia of the uterus, Premature ovarian insufficiency OMIM:608996
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
46,Xx Ovotesticular Disorder Of Sex Development
Abnormal morphology of female internal genitalia, Cryptorchidism, Abnormality of the uterus, Ambi... ORPHA:2138
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Leydig Cell Hypoplasia
Cryptorchidism, Hyoplasia of the Leydig cells, Male hypogonadism, Ambiguous genitalia, Aplasia of... ORPHA:755
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:613101
46,Xy Sex Reversal 11
Urogenital sinus anomaly, Vanishing testis, Abnormal internal genitalia, Gonadal dysgenesis with ... OMIM:273250
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Immunodeficiency 64
Splenomegaly, Mediastinal lymphadenopathy, Hepatosplenomegaly, Lymphadenopathy, Cervical lymphade... OMIM:618534
Autoimmune Lymphoproliferative Syndrome, Type Iii
Generalized lymphadenopathy, Follicular hyperplasia, Splenomegaly, Mediastinal lymphadenopathy, H... OMIM:615559
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Lcat Deficiency
Lymphadenopathy, Splenomegaly ORPHA:650
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Diethylstilbestrol Syndrome
Cryptorchidism, Abnormality of the uterus, Abnormal reproductive system morphology, Abnormal test... ORPHA:1916
Immunodeficiency, Common Variable, 2
Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:240500
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly OMIM:300853
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormality of the lymph nodes, Abnormal testis morphology ORPHA:54251
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Hypogonadotropic hypogonadism, Hypoplasia of the uterus OMIM:614842
Immunodeficiency 27A
Enlarged mesenteric lymph node, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:209950
Rhabdoid Tumor
Irritability, Lymphadenopathy ORPHA:69077
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Premature Ovarian Failure 7
Clitoral hypertrophy, Gonadal dysgenesis, Hypoplasia of the uterus, Premature ovarian insufficiency OMIM:612964
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Cryptorchidism, Azoospermia, Hypoplasia of the uterus, Hypogonadotropic hypogonadism, Decreased t... OMIM:614837
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Desmoplastic Small Round Cell Tumor
Mediastinal lymphadenopathy, Ovarian neoplasm, Lymphadenopathy, Testicular neoplasm ORPHA:83469
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Lymphadenopathy ORPHA:2221
Ovarian Dysgenesis 6
Hypoplasia of the uterus OMIM:618078
Ovarian Dysgenesis 7
Hypoplasia of the uterus OMIM:618117
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Male hypogonadism, Abnormal vagina morphology, Gonadoblastoma, Hypoplasia of the uterus, Streak o... ORPHA:168563
Schnitzler Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37748
Complete Androgen Insensitivity Syndrome
Abnormal morphology of female internal genitalia, Blind vagina, Bilateral cryptorchidism, Aplasia... ORPHA:99429
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
46,Xy Sex Reversal 7
Gonadoblastoma, Sex reversal, Hypoplasia of the fallopian tube, Hypoplasia of the uterus, Streak ... OMIM:233420
Partial Androgen Insensitivity Syndrome
Ambiguous genitalia, Blind vagina, Azoospermia, Aplasia of the ovary, Urogenital sinus anomaly, B... ORPHA:90797
Indolent Systemic Mastocytosis
Lymphadenopathy, Splenomegaly ORPHA:98848
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Classic Hodgkin Lymphoma
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:391
Tularemia
Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy, Lymphadenopathy, Cervica... ORPHA:3392
Ovarian Dysgenesis 5
Hypoplasia of the uterus OMIM:617690
Perrault Syndrome 6
Premature ovarian insufficiency, Hypoplasia of the uterus, Streak ovary OMIM:617565
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Roifman Syndrome
Hypogonadotropic hypogonadism, Hepatosplenomegaly, Lymphadenopathy ORPHA:353298
Testicular Agenesis
Urethrovaginal fistula, Ambiguous genitalia, Urogenital sinus anomaly, Absent testis, Vanishing t... ORPHA:325124
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Mullerian Aplasia And Hyperandrogenism
Aplasia of the uterus, Aplasia/Hypoplasia of the fallopian tube, Aplasia of the vagina OMIM:158330
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Lymphoproliferative Syndrome 2
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:615122
46,Xx Sex Reversal 2
Ovotestis, Azoospermia, Bifid scrotum, Sex reversal, Scrotal hypoplasia, Hypoplasia of the uterus... OMIM:278850
Ras-Associated Autoimmune Leukoproliferative Disorder
Follicular hyperplasia, Splenomegaly OMIM:614470
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Aregenerative Anemia
Depression, Bone marrow hypocellularity, Lymphadenopathy, Emotional lability ORPHA:101096
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Cryptorchidism, Hypoplasia of the uterus, Hypogonadotropic hypogonadism, Decreased testicular siz... OMIM:614841
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Hepatosplenomegaly, Abnormality of the lymph nodes, Lymphadenopathy ORPHA:911
Omenn Syndrome
Hypoplasia of the thymus, Lymphadenopathy, Splenomegaly OMIM:603554
Roifman Syndrome
Lymphadenopathy, Splenomegaly OMIM:616651
Agammaglobulinemia, X-Linked
Prostatitis, Lymph node hypoplasia, Epididymitis OMIM:300755
Normosmic Congenital Hypogonadotropic Hypogonadism
Cryptorchidism, Male hypogonadism, Azoospermia, Depression, Non-obstructive azoospermia, Hypoplas... ORPHA:432
Premature Ovarian Failure 6
Premature ovarian insufficiency, Hypoplasia of the uterus, Streak ovary OMIM:612310
Nephroblastoma
Lymphadenopathy ORPHA:654
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Premature Ovarian Failure 18
Premature ovarian insufficiency, Hypoplasia of the uterus, Hypoplasia of the ovary OMIM:619203
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:3226
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy OMIM:618935
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:601859
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy ORPHA:69126
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Mayer-Rokitansky-Kuster-Hauser Syndrome
Hypoplasia of the uterus, Aplasia of the vagina OMIM:277000
Leishmaniasis
Lymphadenopathy, Splenomegaly ORPHA:507
Niemann-Pick Disease, Type A
Irritability, Lymphadenopathy, Splenomegaly OMIM:257200
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Boutonneuse Fever
Lymphadenopathy, Cervical lymphadenopathy ORPHA:83313
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:603909
Renal And Mullerian Duct Hypoplasia
Hydrocele testis, Aplasia of the uterus, Anteriorly displaced urethral meatus OMIM:266810
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Griscelli Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:381
Sézary Syndrome
Lymphadenopathy, Splenomegaly ORPHA:3162
Lymphatic Filariasis
Hydrocele testis, Epididymitis, Urethral obstruction, Abnormality of the scrotum, Lymphadenitis, ... ORPHA:2035
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Kaposi Sarcoma
Abnormality of the spleen, Generalized lymphadenopathy ORPHA:33276
Lig4 Syndrome
Cryptorchidism, Lymphadenopathy, Hypoplasia of penis ORPHA:99812
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Splenomegaly OMIM:613179
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Cyclic Neutropenia
Recurrent tonsillitis, Lymphadenopathy, Cervical lymphadenopathy ORPHA:2686
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Primary Myelofibrosis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:824
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Autoimmune Lymphoproliferative Syndrome, Type V
Lymphadenopathy, Splenomegaly OMIM:616100
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Lumbar Syndrome
Cryptorchidism, Bifid uterus, Ambiguous genitalia, Bifid scrotum, Hypoplastic labia majora, Hypos... ORPHA:83628
Cinca Syndrome
Lymphadenopathy, Splenomegaly ORPHA:1451
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Ovarian cyst, Male hypogonadism, Blind vagina, Ambiguous genitalia, male, Bifid scrotum, Bilatera... ORPHA:90793
Thymic Neuroendocrine Tumor
Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy, Neoplasm of the thymus ORPHA:97289
Omenn Syndrome
Lymphadenopathy, Splenomegaly ORPHA:39041
Felty Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:47612
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Hypersplenism, Lymphadenopathy ORPHA:98850
Immunodeficiency With Hyper-Igm, Type 1
Absence of lymph node germinal center, Enlarged tonsils, Splenomegaly OMIM:308230
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly ORPHA:36412
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Adult-Onset Still Disease
Bone marrow hypocellularity, Generalized lymphadenopathy, Splenomegaly ORPHA:829
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Familial Pancreatic Carcinoma
Hepatosplenomegaly, Lymphadenopathy, Ovarian carcinoma ORPHA:1333
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Cryptorchidism, Midshaft hypospadias, Urogenital sinus anomaly, Ambiguous genitalia, male, Abnorm... ORPHA:168558
Legionnaires Disease
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:549
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Cryptorchidism, Midshaft hypospadias, Urogenital sinus anomaly, Ambiguous genitalia, male, Abnorm... ORPHA:289548
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Hemophagocytic Lymphohistiocytosis, Familial, 1
Irritability, Lymphadenopathy, Splenomegaly OMIM:267700
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Hepatosplenomegaly, Enlarged tonsils, Lymphadenopathy OMIM:606367
Mixed Connective Tissue Disease
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:809
Thymoma
Neoplasm of the thymus, Lymphadenopathy ORPHA:99867
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy ORPHA:343
Castleman Disease
Mediastinal lymphadenopathy, Generalized lymphadenopathy, Follicular hyperplasia, Lymphadenopathy ORPHA:160
Hydatidiform Mole
Enlarged uterus ORPHA:99927
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hepatosplenomegaly, Irritability, Lymphadenopathy, Splenomegaly OMIM:603553
Townes-Brocks Syndrome 2
Hypospadias, Bifid uterus, Rectovaginal fistula OMIM:617466
H Syndrome
Azoospermia, Decreased testicular size, Hypogonadism, Hepatosplenomegaly, Micropenis, Lymphadenop... ORPHA:168569
Lassa Fever
Lymphadenopathy ORPHA:99824
Graft Versus Host Disease
Hepatosplenomegaly, Irritability, Lymphadenopathy ORPHA:39812
Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Aplasia of the vagina, Aplasia of the uterus, Uterus didelphys, Septate vagina OMIM:146255
Cardiac-Urogenital Syndrome
Cryptorchidism, Ambiguous genitalia, Accessory spleen, Bifid scrotum, Micropenis, Aplasia of the ... OMIM:618280
Immunodeficiency, Common Variable, 8, With Autoimmunity
Generalized lymphadenopathy, Lymphadenopathy, Splenomegaly OMIM:614700
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Lymphadenitis, Hepatosplenomegaly, Generalized lymphadenopathy OMIM:618986
Histiocytosis-Lymphadenopathy Plus Syndrome
Azoospermia, Hypergonadotropic hypogonadism, Splenomegaly, Hepatosplenomegaly, Micropenis, Lympha... OMIM:602782
Hyper-Igd Syndrome
Lymphadenitis, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:260920
Periodic Fever, Familial, Autosomal Dominant
Cervical lymphadenopathy OMIM:142680
Mevalonic Aciduria
Hepatosplenomegaly, Fluctuating splenomegaly, Lymphadenopathy OMIM:610377
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233710
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Long penis, Clitoral hypertrophy, Precocious puberty in males, Hypoplasia of the uterus, Hypoplas... OMIM:202010
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Mayer-Rokitansky-Küster-Hauser Syndrome
Hypoplasia of the vagina, Aplasia of the uterus ORPHA:3109
Proteasome-Associated Autoinflammatory Syndrome 3
Lymphadenopathy, Splenomegaly OMIM:617591
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Acute Monoblastic/Monocytic Leukemia
Cervical lymphadenopathy ORPHA:514
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:306400
Poems Syndrome
Hypogonadism, Lymphadenopathy ORPHA:2905
Lymphangioleiomyomatosis
Pulmonary lymphangiomyomatosis, Abnormal morphology of female internal genitalia, Abnormality of ... ORPHA:538
Carney Triad
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Drug Rash With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Chediak-Higashi Syndrome
Lymphadenopathy, Splenomegaly OMIM:214500
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Absence of lymph node germinal center, Hepatosplenomegaly ORPHA:79124
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus ORPHA:2736
Oeis Complex
Cryptorchidism, Bifid uterus, Ambiguous genitalia, male, Ambiguous genitalia, female, Rectovagina... OMIM:258040
Farber Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:333
Chikungunya
Depression, Diminished motivation, Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
Kikuchi-Fujimoto Disease
Generalized lymphadenopathy, Splenomegaly, Abnormality of the lymph nodes, Lymphadenopathy, Cervi... ORPHA:50918
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Vaginal atresia, Aplasia of the uterus, Uterus didelphys, Septate vagina ORPHA:2237
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Ambiguous genitalia, Urogenital sinus anomaly, Long penis, Premature pubarche, Decreased testicul... ORPHA:90794
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Urethral atresia, Aplasia of the vagina, Aplasia of the uterus, Absent external genitalia OMIM:271520
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly ORPHA:98849
Waldenström Macroglobulinemia
Lymphadenopathy, Splenomegaly ORPHA:33226
Coccidioidomycosis
Abnormal sperm morphology, Abnormality of the male genitalia, Abnormality of the female genitalia... ORPHA:228123
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Hypersplenism, Splenomegaly, Bone marrow hypocellularity, ... ORPHA:3261
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Neuroendocrine Tumor Of The Colon
Chronic noninfectious lymphadenopathy ORPHA:100080
Spondylocostal Dysostosis-Anal Atresia-Genitourinary Malformation Syndrome
Urethral atresia, Cryptorchidism, Absent external genitalia, Persistent cloaca, Aplasia of the ut... ORPHA:94095
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Cherubism
Submandibular lymph node enlargement OMIM:118400
Multiple Endocrine Neoplasia Type 2
Cervical neoplasm, Anxiety, Cervical lymphadenopathy ORPHA:653
Q Fever
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:781
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Hepatosplenomegaly, Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly OMIM:615688
Tangier Disease
Chronic noninfectious lymphadenopathy, Orange discolored tonsils, Hepatosplenomegaly ORPHA:31150
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy ORPHA:331235
Pontocerebellar Hypoplasia Type 7
Cryptorchidism, Ambiguous genitalia, Microphallus, Absent penis, Abnormal scrotal rugation, Clito... ORPHA:284339
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Hepatosplenomegaly, Lymphadenopathy ORPHA:85408
Primary Sjögren Syndrome
Vaginal dryness, Anxiety, Lymphadenopathy, Depression ORPHA:289390
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Malakoplakia
Orchitis, Follicular hyperplasia, Prostate neoplasm ORPHA:556
Neuroendocrine Tumor Of The Rectum
Chronic noninfectious lymphadenopathy ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Chronic noninfectious lymphadenopathy ORPHA:100082
Chromosome 17Q12 Deletion Syndrome
Cryptorchidism, Ovarian cyst, Unicornuate uterus, Urethral stenosis, Aplasia of the uterus, Aplas... OMIM:614527
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy OMIM:607944
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100086
Hennekam Syndrome
Lymphangioma, Pulmonary lymphangiectasia, Lymphadenopathy, Splenomegaly ORPHA:2136
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Orchitis, Lymphadenopathy, Splenomegaly ORPHA:32960
X-Linked Lymphoproliferative Disease
Enlarged tonsils, Splenomegaly, Hepatosplenomegaly, Bone marrow hypocellularity, Lymphadenopathy,... ORPHA:2442
Chédiak-Higashi Syndrome
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:167
Multiple Myeloma
Lymphadenopathy, Splenomegaly ORPHA:29073
Riddle Syndrome
Generalized lymphadenopathy, Emotional lability ORPHA:420741
Familial Mediterranean Fever
Orchitis, Lymphadenopathy, Splenomegaly ORPHA:342
Thrombocytopenia-Absent Radius Syndrome
Hepatosplenomegaly, Aplasia of the uterus OMIM:274000
Brucellosis
Epididymitis, Depression, Orchitis, Hypersplenism, Splenomegaly, Lymphadenopathy ORPHA:1304
Phocomelia, Schinzel Type
Cryptorchidism, Aplasia of the uterus, Hypoplasia of penis ORPHA:2879
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Behçet Disease
Irritability, Orchitis, Lymphadenopathy, Splenomegaly ORPHA:117
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
African Trypanosomiasis
Aggressive behavior, Apathy, Irritability, Anxiety, Splenomegaly, Hepatosplenomegaly, Lymphadenop... ORPHA:3385
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Bifid uterus, Abnormal reproductive system morphology ORPHA:1521
Igg4-Related Kidney Disease
Lymphadenitis, Prostatitis, Urethritis, Lymphadenopathy ORPHA:449395
Igg4-Related Submandibular Gland Disease
Prostatitis, Lymphadenopathy ORPHA:449432
Neuroendocrine Neoplasm Of Appendix
Chronic noninfectious lymphadenopathy, Ovarian neoplasm ORPHA:100079
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Aplasia of the uterus, Aplasia of the vagina ORPHA:457284
Hydrolethalus Syndrome 1
Hypospadias, Bifid uterus, Accessory spleen, Abnormal vagina morphology OMIM:236680
Rubinstein-Taybi Syndrome 1
Self-mutilation, Cryptorchidism, Bifid uterus, Shawl scrotum, Agoraphobia, Impulsivity, Papillary... OMIM:180849
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Plague
Depression, Lymphadenitis, Anxiety, Splenomegaly, Enlarged mesenteric lymph node ORPHA:707
Exstrophy-Epispadias Complex
Cryptorchidism, Bifid uterus, Bifid scrotum, Penoscrotal transposition, Cystocele, Absent penis, ... ORPHA:322
Igg4-Related Ophthalmic Disease
Prostatitis, Orchitis, Lymphadenopathy ORPHA:449563
Proteasome-Associated Autoinflammatory Syndrome 1
Epididymitis, Lymphadenopathy, Splenomegaly OMIM:256040
Sarcoidosis
Abnormal reproductive system morphology, Abnormality of the lymph nodes, Lymphadenopathy ORPHA:797
Townes-Brocks Syndrome 1
Cryptorchidism, Bifid uterus, Bifid scrotum, Urethral valve, Rectovaginal fistula, Hypospadias, R... OMIM:107480
Okamoto Syndrome
Bifid uterus, Splenomegaly ORPHA:2729
Autosomal Recessive Malignant Osteopetrosis
Lymphadenopathy, Splenomegaly ORPHA:667
Limb-Mammary Syndrome
Aplasia of the uterus, Aplasia of the ovary ORPHA:69085
Coffin-Siris Syndrome 1
Cryptorchidism, Aggressive behavior, Clitoral hypertrophy, Hypospadias, Aplasia of the uterus OMIM:135900
Wolf-Hirschhorn Syndrome
Cryptorchidism, Accessory spleen, Hypospadias, Precocious puberty, Aplasia of the uterus OMIM:194190
Norrie Disease
Cryptorchidism, Self-injurious behavior, Uterine rupture, Irritability, Anxiety ORPHA:649
Sarcoidosis, Susceptibility To, 1
Mediastinal lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:181000
Kawasaki Disease
Irritability, Cervical lymphadenopathy ORPHA:2331
Ehlers-Danlos Syndrome, Vascular Type
Cryptorchidism, Uterine rupture, Cystocele, Cervical insufficiency, Uterine prolapse OMIM:130050
Neu-Laxova Syndrome 1
Cryptorchidism, Bifid uterus OMIM:256520
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Cryptorchidism, Scrotal hypoplasia, Hypospadias, Anteriorly displaced genitalia, Aplasia of the u... OMIM:276820
Blau Syndrome
Lymphadenopathy, Splenomegaly ORPHA:90340
Leptospirosis
Lymphadenopathy ORPHA:509
Loeys-Dietz Syndrome
Uterine rupture ORPHA:60030
Vascular Ehlers-Danlos Syndrome
Cryptorchidism, Uterine rupture, Cystocele, Hypospadias, Uterine prolapse ORPHA:286
Pallister-Killian Syndrome
Cryptorchidism, Small scrotum, Hypoplastic labia majora, Aplasia of the upper vagina, Hypospadias... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dipk2b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dipk2b.

No publications found that use IMPC mice or data for Dipk2b.

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MGI Allele Allele Type Produced
Dipk2btm378701(L1L2_Bact_P) Targeting vectors
Dipk2bem1(IMPC)Mbp Exon Deletion Mice, Tissue

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