Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
RNA binding motif protein 12
Synonyms:
9430070C08Rik,  SWAN,  5730420G12Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rbm12 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rbm12 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Schizophrenia 19
OMIM:617629

The table below shows human diseases predicted to be associated to Rbm12 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Frontal Encephalocele
Spina bifida, Encephalocele, Hydrocephalus ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Acalvaria
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Schisis Association
Anencephaly, Spina bifida, Encephalocele ORPHA:63862
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Chiari Malformation Type Ii
Myelomeningocele, Spina bifida, Cervical myelopathy, Hydrocephalus OMIM:207950
Caudal Duplication
Spina bifida, Myelomeningocele ORPHA:1756
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Postnatal growth retardation, Cervical spina bifida, Growth delay OMIM:600122
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Camptodactyly Syndrome, Guadalajara Type 1
Short stature, Spina bifida, Intrauterine growth retardation ORPHA:1327
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Cerebrocostomandibular Syndrome
Myelomeningocele, Intrauterine growth retardation, Hydranencephaly, Short stature, Spina bifida, ... ORPHA:1393
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Fountain Syndrome
Short stature, Spina bifida, Spina bifida occulta ORPHA:3219
Czeizel-Losonci Syndrome
Spina bifida occulta, Spina bifida, Myelomeningocele, Hydrocephalus ORPHA:2437
Iniencephaly
Myelomeningocele, Rhizomelia, Anencephaly, Spinal dysraphism, Spina bifida, Hydrocephalus, Holopr... ORPHA:63259
Pelvis-Shoulder Dysplasia
Hydranencephaly, Short stature, Mesomelic/rhizomelic limb shortening, Spina bifida, Hydrocephalus... ORPHA:2839
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
Vacterl With Hydrocephalus
Intrauterine growth retardation, Spina bifida, Hydrocephalus, Aqueductal stenosis, Arrhinencephaly ORPHA:3412
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Posterior Meningocele
Occipital meningocele, Lipomyelomeningocele, Neural tube defect, Hydrocephalus, Meningocele ORPHA:268810
Trisomy 18
Intrauterine growth retardation, Anencephaly, Growth delay, Short stature, Spina bifida, Holopros... ORPHA:3380
Lumbar Syndrome
Spina bifida, Myelomeningocele ORPHA:83628
Trisomy 20P
Umbilical hernia, Spina bifida ORPHA:261318
Mosaic Trisomy 9
Spina bifida, Intrauterine growth retardation ORPHA:99776
Neu-Laxova Syndrome
Spina bifida, Intrauterine growth retardation ORPHA:2671
Pagod Syndrome
Short stature, Spina bifida, Meningocele, Encephalocele ORPHA:991
Nail-Patella Syndrome
Short stature, Spina bifida OMIM:161200
Limb Body Wall Complex
Short umbilical cord, Myelomeningocele, Anencephaly, Spina bifida, Hydrocephalus, Spina bifida oc... ORPHA:2369
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Cloacal Exstrophy
Spina bifida, Myelomeningocele ORPHA:93929
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Fibular Hemimelia
Spina bifida ORPHA:93323
Hallermann-Streiff Syndrome
Proportionate short stature, Spina bifida OMIM:234100
22Q11.2 Deletion Syndrome
Occipital myelomeningocele, Intrauterine growth retardation, Short stature, Spina bifida, Hydroce... ORPHA:567
Jacobsen Syndrome
Short stature, Growth delay, Spina bifida, Intrauterine growth retardation ORPHA:2308
Basal Cell Nevus Syndrome
Spina bifida, Hydrocephalus OMIM:109400
Neurofibromatosis, Type I
Short stature, Spina bifida, Aqueductal stenosis, Hydrocephalus OMIM:162200
Fanconi Anemia
Intrauterine growth retardation, Growth delay, Short stature, Spina bifida, Hydrocephalus, Umbili... ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Short stature, Spina bifida OMIM:274000
Campomelic Dysplasia
Neonatal short-limb short stature, Spinal dysraphism, Spina bifida, Hydrocephalus, Disproportiona... OMIM:114290
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Short stature, Spina bifida ORPHA:508498
Neu-Laxova Syndrome 1
Short umbilical cord, Intrauterine growth retardation, Hydranencephaly, Spina bifida, Small placenta OMIM:256520
Aicardi Syndrome
Postnatal growth retardation, Spina bifida OMIM:304050
Koolen-De Vries Syndrome Due To A Point Mutation
Postnatal growth retardation, Spina bifida, Hydrocephalus ORPHA:363965
17Q21.31 Microdeletion Syndrome
Postnatal growth retardation, Spina bifida, Hydrocephalus ORPHA:363958
Vater/Vacterl Association
Intrauterine growth retardation, Occipital encephalocele, Patent urachus, Spina bifida, Postnatal... OMIM:192350
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Split Cord Malformation
Myelomeningocele, Cervical spina bifida, Lipomyelomeningocele, Hydrocephalus, Meningocele ORPHA:573278
Exstrophy-Epispadias Complex
Spina bifida, Hydrocephalus ORPHA:322
Schizophrenia 19
OMIM:617629

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rbm12

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rbm12.

No publications found that use IMPC mice or data for Rbm12.

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MGI Allele Allele Type Produced
Rbm12tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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