Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

RNA binding motif protein 12
5730420G12Rik,  SWAN,  9430070C08Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rbm12 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Rbm12 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Schizophrenia 19

The table below shows human diseases predicted to be associated to Rbm12 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Frontal Encephalocele
Spina bifida, Hydrocephalus ORPHA:1931
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Cervical spina bifida, Sirenomelia, Spinal dysraphism, Anencephaly, Myelomeningocele ORPHA:63260
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Nevus Comedonicus Syndrome
Spina bifida, Spina bifida occulta ORPHA:64754
Caudal Duplication
Spina bifida, Myelomeningocele ORPHA:1756
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Growth delay, Cervical spina bifida, Postnatal growth retardation OMIM:600122
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Schisis Association
Spina bifida, Anencephaly ORPHA:63862
Camptodactyly Syndrome, Guadalajara Type 1
Intrauterine growth retardation, Spina bifida, Short stature ORPHA:1327
Chiari Malformation Type Ii
Spina bifida, Myelomeningocele, Hydrocephalus OMIM:207950
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Spina bifida, Sirenomelia ORPHA:3169
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Cerebrocostomandibular Syndrome
Spina bifida, Meningocele, Hydranencephaly, Short stature, Intrauterine growth retardation, Myelo... ORPHA:1393
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Fountain Syndrome
Spina bifida, Short stature, Spina bifida occulta ORPHA:3219
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Czeizel-Losonci Syndrome
Spina bifida, Myelomeningocele, Hydrocephalus, Spina bifida occulta ORPHA:2437
Posterior Meningocele
Neural tube defect, Meningocele, Occipital meningocele, Lipomyelomeningocele, Hydrocephalus ORPHA:268810
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Pelvis-Shoulder Dysplasia
Spina bifida, Mesomelic/rhizomelic limb shortening, Hydranencephaly, Short stature, Neonatal shor... ORPHA:2839
Spina bifida, Holoprosencephaly, Rhizomelia, Spinal dysraphism, Anencephaly, Myelomeningocele, Hy... ORPHA:63259
Vacterl With Hydrocephalus
Spina bifida, Arrhinencephaly, Aqueductal stenosis, Intrauterine growth retardation, Hydrocephalus ORPHA:3412
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Trisomy 18
Spina bifida, Holoprosencephaly, Growth delay, Anencephaly, Short stature, Intrauterine growth re... ORPHA:3380
Lumbar Syndrome
Spina bifida, Myelomeningocele ORPHA:83628
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Mosaic Trisomy 9
Intrauterine growth retardation, Spina bifida ORPHA:99776
Hallermann-Streiff Syndrome
Spina bifida, Proportionate short stature OMIM:234100
Neu-Laxova Syndrome
Intrauterine growth retardation, Spina bifida ORPHA:2671
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Nail-Patella Syndrome
Spina bifida, Short stature OMIM:161200
Cloacal Exstrophy
Spina bifida, Myelomeningocele ORPHA:93929
Fibular Hemimelia
Spina bifida ORPHA:93323
Pagod Syndrome
Meningocele, Spina bifida, Short stature ORPHA:991
Jacobsen Syndrome
Intrauterine growth retardation, Spina bifida, Short stature, Growth delay ORPHA:2308
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Basal Cell Nevus Syndrome
Spina bifida, Hydrocephalus OMIM:109400
Limb Body Wall Complex
Spina bifida, Short umbilical cord, Anencephaly, Spina bifida occulta, Myelomeningocele, Hydrocep... ORPHA:2369
22Q11.2 Deletion Syndrome
Spina bifida, Arrhinencephaly, Umbilical hernia, Meningocele, Short stature, Intrauterine growth ... ORPHA:567
Neurofibromatosis, Type I
Short stature, Spina bifida, Hydrocephalus, Aqueductal stenosis OMIM:162200
Fanconi Anemia
Spina bifida, Growth delay, Umbilical hernia, Short stature, Intrauterine growth retardation, Hyd... ORPHA:84
Thrombocytopenia-Absent Radius Syndrome
Spina bifida, Short stature OMIM:274000
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida, Short stature ORPHA:508498
Neu-Laxova Syndrome 1
Spina bifida, Short umbilical cord, Hydranencephaly, Intrauterine growth retardation, Small placenta OMIM:256520
Aicardi Syndrome
Spina bifida, Postnatal growth retardation OMIM:304050
Koolen-De Vries Syndrome Due To A Point Mutation
Spina bifida, Hydrocephalus, Postnatal growth retardation ORPHA:363965
17Q21.31 Microdeletion Syndrome
Spina bifida, Hydrocephalus, Postnatal growth retardation ORPHA:363958
Alobar Holoprosencephaly
Growth delay, Hydrocephalus, Short stature, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Growth delay, Hydrocephalus, Short stature, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Growth delay, Hydrocephalus, Short stature, Neural tube defect ORPHA:93924
Semilobar Holoprosencephaly
Growth delay, Hydrocephalus, Short stature, Neural tube defect ORPHA:220386
Schinzel-Giedion Syndrome
Umbilical hernia, Neural tube defect ORPHA:798
Vater/Vacterl Association
Intrauterine growth retardation, Spina bifida, Patent urachus, Postnatal growth retardation OMIM:192350
Split Cord Malformation
Cervical spina bifida, Meningocele, Lipomyelomeningocele, Myelomeningocele, Hydrocephalus ORPHA:573278
Exstrophy-Epispadias Complex
Spina bifida, Hydrocephalus ORPHA:322
Schizophrenia 19


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rbm12

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rbm12.

No publications found that use IMPC mice or data for Rbm12.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Rbm12tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter