Oplah | 5-oxoprolinase (ATP-hydrolysing)

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

12 No significant impact

7 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:140Adult tissues
0Embryo tissues

Phenotypes

decreased circulating unsaturated transferrin level1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult7.15x10-5 
abnormal lens morphology1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult8.53x10-10 
decreased heart rate1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult5.07x10-8 
increased startle reflex1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult3.24x10-6 
cataract1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult4.09x10-10 
decreased red blood cell distribution width1 supporting datasetOplahtm1b(KOMP)WtsihomozygoteEarly adult3.57x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Oplahtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Oplahtm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Oplahtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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