Gene Summary

Name:
sperm tail PG rich repeat containing 4
Synonyms:
1700011E24Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal duodenum morphology Stpg4em1(IMPC)Rbrc HOM Late adult 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Pathology and Tissue Collection

Images

11 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

4 Images

Gross Pathology and Tissue Collection

Images

1 Images

Eye Morphology

Images Ophthalmoscopy

1 Images

Human diseases caused by Stpg4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Stpg4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Epilepsy With Bilateral Occipital Calcifications
Celiac disease OMIM:226810
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Duodenal Atresia
Duodenal atresia OMIM:223400
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Jejunal Atresia
Jejunal atresia OMIM:243600
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Duodenal Ulcer, Hyperpepsinogenemic I
Duodenal ulcer OMIM:126850
Diarrhea 11, Malabsorptive, Congenital
Villous atrophy OMIM:618662
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Pancreatic Lipase Deficiency
Steatorrhea, Fat malabsorption OMIM:614338
Tremor-Nystagmus-Duodenal Ulcer Syndrome
Duodenal ulcer ORPHA:3350
Duodenal Ulcer Due To Antral G-Cell Hyperfunction
Duodenal ulcer OMIM:126840
Inflammatory Bowel Disease (Crohn Disease) 30
Protein-losing enteropathy, Esophagitis, Pancolitis, Ileitis, Abnormal intestine morphology, Gast... OMIM:619079
Diarrhea 9
Villous atrophy OMIM:618168
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Fat malabsorption, Jejunoileal ulceration, Small bowel diverticula OMIM:221400
Bile Acid Malabsorption, Primary, 1
Steatorrhea, Increased fecal bile acid, Fat malabsorption OMIM:613291
Diarrhea 5, With Tufting Enteropathy, Congenital
Villous atrophy, Crypt hyperplasia OMIM:613217
Annular Pancreas
High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
High intestinal obstruction, Duodenal stenosis OMIM:167750
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Volvulus, Intestinal pseudo-obstruction, Intestinal m... OMIM:619350
Chronic Intestinal Pseudoobstruction
Intestinal malrotation, Abnormal intestine morphology, Pyloric stenosis ORPHA:2978
Diarrhea 2, With Microvillus Atrophy, With Or Without Cholestasis
Abnormal intestine morphology, Villous atrophy OMIM:251850
Martinez-Frias Syndrome
Intestinal malrotation, Jejunal atresia, Tracheoesophageal fistula, Intestinal hypoplasia, Duoden... OMIM:601346
Nk-Cell Enteropathy
Hematochezia, Colonic diverticula, Gastroesophageal reflux, Stercoral ulcer, Abnormal gastric muc... ORPHA:263665
Intussusception
Intussusception OMIM:147710
Congenital Short Bowel Syndrome
Congenital shortened small intestine, Decreased intestinal transit time, Intestinal malrotation, ... OMIM:615237
Diarrhea 7, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Villous atrophy OMIM:615863
Duodenal Atresia
Duodenal atresia ORPHA:1203
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Intestinal atresia, Duodenal atresia ORPHA:3405
Tremor, Nystagmus, And Duodenal Ulcer
Duodenal ulcer OMIM:190310
Chronic Diarrhea Due To Glucoamylase Deficiency
Abnormal small intestinal mucosa morphology, Decreased small intestinal mucosa lactase level ORPHA:103907
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Hematochezia, Ileal atresia, Colonic atresia, Intestinal malrotation, Intestinal obstruction, Jej... OMIM:243150
Diarrhea 12, With Microvillus Atrophy
Villous atrophy, Microvillus inclusions, Microvillar PAS-positive secretory granules OMIM:619445
Mitchell-Riley Syndrome
Meckel diverticulum, Anteriorly placed anus, Intestinal malrotation, Jejunal atresia, Acholic sto... OMIM:615710
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intestinal polyposis, Intussusception OMIM:175510
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility
Intestinal malrotation, Duodenal atresia OMIM:619608
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Hematochezia, Duodenal polyposis, Multiple gastric polyps, Small intestinal polyposis, Adenomatou... ORPHA:329971
Mirror Polydactyly-Vertebral Segmentation-Limbs Defects Syndrome
Duodenal atresia ORPHA:3004
Hypercholanemia, Familial 1
Steatorrhea, Fat malabsorption OMIM:607748
Secondary Short Bowel Syndrome
Volvulus, Villous atrophy, Abnormal small intestine morphology, Aganglionic megacolon, Small inte... ORPHA:95427
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Duodenal ulcer, Gastric ulcer, Esophageal ulceration OMIM:618372
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Protein-losing enteropathy OMIM:619063
Congenital Contractural Arachnodactyly
Intestinal malrotation, High palate, Tracheoesophageal fistula, Duodenal atresia ORPHA:115
Attenuated Familial Adenomatous Polyposis
Duodenal polyposis, Large intestinal polyposis, Adenomatous colonic polyposis, Adenocarcinoma of ... ORPHA:220460
Alpha-Heavy Chain Disease
Abnormal small intestine morphology ORPHA:100025
Vascular Hyalinosis
Protein-losing enteropathy, Hematochezia OMIM:277175
Pancreatic Colipase Deficiency
Steatorrhea, Fat malabsorption ORPHA:309108
Colonic Atresia
Peptic ulcer, Colonic atresia, Duodenal stenosis ORPHA:1198
Agammaglobulinemia 4, Autosomal Recessive
Protein-losing enteropathy OMIM:613502
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal malrotation, Congenital shortened small intestine, Intestinal pseudo-obstruction, Pylo... OMIM:300048
Congenital Enterocyte Heparan Sulfate Deficiency
Protein-losing enteropathy, Hematochezia ORPHA:103910
Fanconi Anemia, Complementation Group W
Duodenal atresia OMIM:617784
Congenital Tufting Enteropathy
Abnormal large intestinal mucosa morphology, Villous atrophy, Abnormal small intestinal mucosa mo... ORPHA:92050
Chylomicron Retention Disease
Steatorrhea, Accumulation of lipid droplets in small-bowel enterocytes OMIM:246700
Mungan Syndrome
Barrett esophagus, Megaduodenum, Hypoperistalsis, Intestinal pseudo-obstruction OMIM:611376
Eosinophilic Gastroenteritis
Protein-losing enteropathy, Hematochezia, Abnormality of the gastrointestinal tract, Steatorrhea,... ORPHA:2070
Familial Adenomatous Polyposis 4
Duodenal polyposis, Gastric adenocarcinoma, Adenomatous colonic polyposis OMIM:617100
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Tracheoesophageal fistula, Esophageal atresia, Duodenal atresia, Submucous cleft hard palate OMIM:619227
Deafness-Small Bowel Diverticulosis-Neuropathy Syndrome
Steatorrhea, Duodenal ulcer ORPHA:3217
Esophageal Atresia
Barrett esophagus, Gastrointestinal carcinoma, Gastroesophageal reflux, Intestinal malrotation, E... ORPHA:1199
Fryns Syndrome
Gastroesophageal reflux, Intestinal malrotation, Aganglionic megacolon, Ectopic anus, Anal atresi... ORPHA:2059
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis OMIM:614328
Fanconi Anemia, Complementation Group B
Tracheoesophageal fistula, Esophageal atresia, Duodenal atresia OMIM:300514
Alg1-Cdg
Protein-losing enteropathy, Abnormality of the gastrointestinal tract ORPHA:79327
Feingold Syndrome
Esophageal atresia, Duodenal atresia ORPHA:1305
Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections
Colonic diverticula, Gastroesophageal reflux, Gastric ulcer, Esophageal furrows, Odynophagia, Eos... OMIM:147060
Alg6-Cdg
Protein-losing enteropathy, Macroglossia ORPHA:79320
Congenital Disorder Of Glycosylation, Type Ib
Steatorrhea, Protein-losing enteropathy, Villous atrophy OMIM:602579
Intellectual Developmental Disorder, Autosomal Dominant 53
Intestinal malrotation, Gastrointestinal dysmotility, Duodenal atresia OMIM:617798
Congenital Tracheal Stenosis
Meckel diverticulum, Duodenal stenosis, Abnormal stomach morphology, Abnormal gastrointestinal tr... ORPHA:141127
Microvillus Inclusion Disease
Villous atrophy, Abnormal small intestinal villus morphology ORPHA:2290
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Protein-losing enteropathy OMIM:618154
Stromme Syndrome
Intestinal malrotation, Duodenal atresia, Cleft palate, Jejunal atresia OMIM:243605
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Protein-losing enteropathy, Hematochezia, Gastrointestinal carcinoma, Xerostomia, Glossitis, Hama... OMIM:175500
Visceral Myopathy 1
Microcolon, Intestinal pseudo-obstruction, Megaduodenum, Thinning of outer muscular layer of smal... OMIM:155310
Down Syndrome
Narrow palate, Macroglossia, Gastroesophageal reflux, Protruding tongue, Aganglionic megacolon, C... ORPHA:870
Feingold Syndrome Type 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Anal atresia, Duodenal atresia ORPHA:391641
Mpi-Cdg
Protein-losing enteropathy, Gastrointestinal hemorrhage ORPHA:79319
Refractory Celiac Disease
Protein-losing enteropathy, Villous atrophy, Jejunitis ORPHA:398063
Microform Holoprosencephaly
Duodenal atresia, Cleft palate ORPHA:280200
Systemic Sclerosis
Barrett esophagus, Intestinal bleeding, Abnormal large intestine morphology, Gastroesophageal ref... ORPHA:90291
Juvenile Polyposis Of Infancy
High, narrow palate, Protein-losing enteropathy, Intestinal bleeding, Gastrointestinal hemorrhage... ORPHA:79076
Feingold Syndrome 1
Jejunal atresia, Tracheoesophageal fistula, Esophageal atresia, Gastrointestinal atresia, High pa... OMIM:164280
Plasminogen Deficiency, Type I
Duodenal ulcer OMIM:217090
Mosaic Variegated Aneuploidy Syndrome 2
Duodenal atresia OMIM:614114
Mosaic Variegated Aneuploidy Syndrome
Stomach cancer, Intestinal polyposis, Duodenal atresia, Cleft palate, Colon cancer ORPHA:1052
Fryns Syndrome
Meckel diverticulum, Intestinal malrotation, Aganglionic megacolon, Esophageal atresia, Anal atre... OMIM:229850
Cog8-Cdg
Protein-losing enteropathy ORPHA:95428
Mosaic Variegated Aneuploidy Syndrome 1
Duodenal atresia, Cleft palate OMIM:257300
Congenital Disorder Of Glycosylation, Type Ih
Protein-losing enteropathy OMIM:608104
Cat Eye Syndrome
Anal stenosis, Meckel diverticulum, Volvulus, Intestinal malrotation, Rectal fistula, Rectal atre... OMIM:115470
Fanconi Anemia, Complementation Group F
Duodenal atresia OMIM:603467
Zollinger-Ellison Syndrome
Hematochezia, Gastrointestinal hemorrhage, Peptic ulcer, Esophagitis, Intestinal obstruction, Zol... ORPHA:913
Pericardial And Diaphragmatic Defect
Intestinal malrotation, Meckel diverticulum, Abnormal gastrointestinal tract morphology ORPHA:2847
Focal Dermal Hypoplasia
Gastroesophageal reflux, Duodenal atresia ORPHA:2092
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Congenital shortened small intestine, Meckel diverticulum, Intestinal malrotation, Tracheoesophag... OMIM:265380
Miller-Dieker Lissencephaly Syndrome
Duodenal atresia, Cleft palate OMIM:247200
Jacobsen Syndrome
Intestinal malrotation, Ectopic anus, Abnormality of the anus, Duodenal atresia, Pyloric stenosis ORPHA:2308
Apc-Related Attenuated Familial Adenomatous Polyposis
Gastrointestinal carcinoma, Duodenal adenocarcinoma, Duodenal polyposis, Multiple gastric polyps,... ORPHA:247806
Dyrk1A-Related Intellectual Disability Syndrome
Gastroesophageal reflux, Duodenal atresia, Pyloric stenosis ORPHA:464306
Juvenile Polyposis Syndrome
Rectocele, Gastrointestinal hemorrhage, Protein-losing enteropathy, Hematochezia, Colon cancer, S... ORPHA:2929
Distal Deletion 12Q
High, narrow palate, Microglossia, Esophageal atresia, Duodenal atresia, Pyloric stenosis ORPHA:96149
Holoprosencephaly 13, X-Linked
Gastroesophageal reflux, Median cleft palate, Submucous cleft hard palate, Duodenal atresia, Clef... OMIM:301043
Gardner Syndrome
Gastrointestinal carcinoma, Adenomatous colonic polyposis, Ampulla of Vater carcinoma, Duodenal p... ORPHA:79665
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Gastroesophageal reflux, Duodenal atresia ORPHA:464311
Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart
Furrowed tongue, High palate, Gastroesophageal reflux, Duodenal atresia OMIM:616975
Menke-Hennekam Syndrome 2
Duodenal ulcer OMIM:618333
Scedosporiosis
Abnormal jejunum morphology ORPHA:449280
Familial Adenomatous Polyposis 1
Duodenal adenocarcinoma, Duodenal polyposis, Multiple gastric polyps, Hepatoblastoma, Adenomatous... OMIM:175100
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Duodenal atresia ORPHA:468631
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Protein-losing enteropathy, Narrow palate, Rectal prolapse, Intestinal lymphangiectasia OMIM:235510
Oculoskeletodental Syndrome
Protein-losing enteropathy, Macroglossia OMIM:618440
Immunodeficiency 31C
Protein-losing enteropathy, Villous atrophy, Gastrointestinal eosinophilia, Intussusception OMIM:614162
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Protein-losing enteropathy, High palate, Cleft palate OMIM:235255
Familial Adenomatous Polyposis
Adenomatous colonic polyposis, Stomach cancer, Duodenal adenocarcinoma, Duodenal polyposis, Multi... ORPHA:733
Heterotaxy, Visceral, 1, X-Linked
Posteriorly placed anus, Anal atresia, Duodenal atresia OMIM:306955
Iniencephaly
Anal atresia, Duodenal atresia ORPHA:63259
Hypoplasminogenemia
Duodenal ulcer ORPHA:722
Metachromatic Leukodystrophy
Abnormal stomach morphology, Neoplasm of the gallbladder, Abnormal duodenum morphology, Intussusc... ORPHA:512
Immunodeficiency 82 With Systemic Inflammation
Anoperineal fistula, Villous atrophy, Crohn's disease, Gastritis, Colitis, Duodenal ulcer OMIM:619381
Heterotaxy, Visceral, 5, Autosomal
Intestinal malrotation, Duodenal atresia OMIM:270100
Familial Adenomatous Polyposis Due To 5Q22.2 Microdeletion
Intestinal bleeding, Duodenal polyposis, Hepatoblastoma, Adenomatous colonic polyposis, Desmoid t... ORPHA:261584
Spondyloocular Syndrome
Duodenal ulcer OMIM:605822
Diets-Jongmans Syndrome
Duodenal atresia OMIM:618846
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Protein-losing enteropathy, High palate ORPHA:1655
Townes-Brocks Syndrome 1
Anal stenosis, Gastroesophageal reflux, Tracheoesophageal fistula, Rectoperineal fistula, Anal at... OMIM:107480
Multiple Endocrine Neoplasia Type 1
Peptic ulcer, Gastroesophageal reflux, Zollinger-Ellison syndrome, Hematemesis, Melena, Intestina... ORPHA:652
Coffin-Siris Syndrome 1
Intestinal malrotation, High palate, Duodenal ulcer, Gastric ulcer, Cleft palate, Intussusception OMIM:135900
Whim Syndrome
Abnormal small intestine morphology, Parotitis ORPHA:51636
Diarrhea 10, Protein-Losing Enteropathy Type
Protein-losing enteropathy, Hematochezia OMIM:618183
Tarp Syndrome
Glossoptosis, Abnormal duodenum morphology, Tongue nodules, Cleft palate ORPHA:2886
Charge Syndrome
Anal stenosis, Tracheoesophageal fistula, Esophageal atresia, Anal atresia, Dysphagia, Duodenal a... OMIM:214800
Autosomal Recessive Polycystic Kidney Disease
Protein-losing enteropathy, Gastrointestinal hemorrhage, Hepatoblastoma, Cholangiocarcinoma, Fat ... ORPHA:731
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Intestinal malrotation, Hiatus hernia, Abnormal duodenum morphology, High palate, Cleft palate OMIM:601776
Fraser Syndrome 1
Abnormal small intestine morphology, Abnormality of the anus, Cleft palate OMIM:219000
Liver Disease, Severe Congenital
Protein-losing enteropathy, Chronic gastritis OMIM:619991

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stpg4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stpg4.

No publications found that use IMPC mice or data for Stpg4.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Stpg4em1(IMPC)Rbrc Intra-exon deletion Mice
Stpg4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Stpg4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Stpg4tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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