Gene Summary

Name:
ribonuclease, RNase A family, 10 (non-active)
Synonyms:
4930474F22Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Rnase10tm1a(EUCOMM)Hmgu HOM Early adult 3.35×10-05
decreased circulating triglyceride level Rnase10tm1a(EUCOMM)Hmgu HOM Early adult 9.65×10-05
decreased CD4-positive, alpha beta T cell number Rnase10tm1a(EUCOMM)Hmgu HOM   Early adult 2.19×10-05
increased lean body mass Rnase10tm1a(EUCOMM)Hmgu HOM Early adult 1.38×10-06
decreased locomotor activity Rnase10tm1a(EUCOMM)Hmgu HOM   Early adult 6.54×10-05
decreased CD8-positive, alpha-beta T cell number Rnase10tm1a(EUCOMM)Hmgu HOM   Early adult 3.07×10-05
increased total body fat amount Rnase10tm1a(EUCOMM)Hmgu HOM Early adult 2.85×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rnase10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rnase10 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 15A
Decreased proportion of memory B cells, Decreased proportion of CD4-positive helper T cells, Decr... OMIM:618204
Immunodeficiency 17
Failure to thrive, Autoimmune hemolytic anemia, Decreased proportion of CD8-positive T cells OMIM:615607
Combined Immunodeficiency, X-Linked
Decreased proportion of CD4-positive helper T cells, Decreased proportion of CD8-positive T cells OMIM:312863
Wiskott-Aldrich Syndrome 2
Thrombocytopenia, Decreased proportion of CD8-positive T cells OMIM:614493
Cd8 Deficiency, Familial
Absence of CD8-positive T cells OMIM:608957
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Failure to thrive in infancy, Small for gestational age, Decreased proportion of CD4-positive hel... OMIM:617241
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Eosinophilia, T lymphocytopenia, Decreased proportion of CD3-positive T cells, Hepatosplenomegaly... ORPHA:169154
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Pancytopenia, Decreased helper T cell proportion, Hypersplenism, Splenomegaly OMIM:183350
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
Decreased helper T cell proportion, T lymphocytopenia OMIM:601705
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased proportion of CD4-positive helper T cells, Decreased proportion of CD8-positive T cells OMIM:611926
Progressive Multifocal Leukoencephalopathy
Gait ataxia, Abnormal proportion of CD4-positive T cells, Dysmetria, Decreased proportion of CD8-... ORPHA:217260
Combined Immunodeficiency Due To Zap70 Deficiency
Eosinophilia, Hepatosplenomegaly, Autoimmune thrombocytopenia, Autoimmune hemolytic anemia, Failu... ORPHA:911
Immunodeficiency 22
Panniculitis, Failure to thrive, Decreased proportion of CD4-positive helper T cells OMIM:615758
Immunodeficiency 13
T lymphocytopenia, Decreased CD4:CD8 ratio, Decreased proportion of CD4-positive helper T cells, ... OMIM:615518
Selective Igm Deficiency
Cellulitis, Decreased proportion of CD8-positive T cells, Decreased proportion of CD3-positive T ... ORPHA:331235
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
T lymphocytopenia, Craniosynostosis, Hypereosinophilia, Inability to walk, Decreased proportion o... ORPHA:508533
Immunodeficiency 85 And Autoimmunity
T lymphocytopenia, Decreased proportion of memory B cells, Failure to thrive in infancy, Decrease... OMIM:619510
Wiskott-Aldrich Syndrome
Eosinophilia, Autoimmune hemolytic anemia, Absent microvilli on the surface of peripheral blood l... OMIM:301000
Pgm3-Cdg
Eosinophilia, T lymphocytopenia, Leukopenia, Decreased proportion of CD3-positive T cells, Cutane... ORPHA:443811
Aregenerative Anemia
Pancytopenia, Decreased proportion of CD4-positive helper T cells, Abnormal proportion of CD8-pos... ORPHA:101096
Autoimmune Lymphoproliferative Syndrome
Eosinophilia, Coombs-positive hemolytic anemia, Autoimmune hemolytic anemia, Autoimmune thrombocy... ORPHA:3261
Bloom Syndrome
Small for gestational age, Acute myeloid leukemia, Abnormal proportion of CD8-positive T cells, A... ORPHA:125

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rnase10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rnase10.

No publications found that use IMPC mice or data for Rnase10.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rnase10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rnase10tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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