Usp38 | ubiquitin specific peptidase 38

GeneMGI:1922091Synonyms: 4631402N15Rik, 4833420O05Rik

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

4 Not tested

Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

decreased lean body mass2 supporting datasetsUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult1.95x10-15 
decreased prepulse inhibition3 supporting datasetsUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult3.97x10-6 
persistence of hyaloid vascular system1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult2x10-5 
increased total body fat amount2 supporting datasetsUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult2.26x10-14 
thrombocytopenia1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult1.33x10-7 
decreased exploration in new environment1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult2x10-5 
abnormal bone structure1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult5.55x10-7 
increased mean corpuscular volume1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult6.26x10-5 
decreased circulating creatinine level1 supporting datasetUsp38tm1b(EUCOMM)HmguhomozygoteEarly adult1.74x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Usp38tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Usp38tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Usp38tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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