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Gene: Miga2 MGI:1922035

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Gene Summary

Name:
mitoguardin 2
Synonyms:
Fam73b,  R74766,  5730472N09Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cranium morphology Miga2tm1a(KOMP)Wtsi HOM Early adult 5.71×10-09
decreased hematocrit Miga2tm1a(KOMP)Wtsi HOM Early adult 3.61×10-05
decreased body weight Miga2tm1a(KOMP)Wtsi HOM Early adult 7.33×10-19
decreased body length Miga2tm1a(KOMP)Wtsi HOM Early adult 1.91×10-08
decreased bone mineral density Miga2tm1a(KOMP)Wtsi HOM Early adult 5.81×10-07
decreased erythrocyte cell number Miga2tm1a(KOMP)Wtsi HOM Early adult 5.42×10-05
decreased total body fat amount Miga2tm1a(KOMP)Wtsi HOM Early adult 1.95×10-13
abnormal maxilla morphology Miga2tm1a(KOMP)Wtsi HOM Early adult 6.00×10-05
decreased lean body mass Miga2tm1a(KOMP)Wtsi HOM Early adult 3.43×10-07
decreased bone mineral content Miga2tm1a(KOMP)Wtsi HOM Early adult 6.44×10-11
abnormal tooth morphology Miga2tm1a(KOMP)Wtsi HOM Early adult 8.73×10-09
decreased hemoglobin content Miga2tm1a(KOMP)Wtsi HOM Early adult 5.36×10-06
abnormal snout morphology Miga2tm1a(KOMP)Wtsi HOM Early adult 2.25×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote Not available
Blood vessel N/A heterozygote 0.0% (0 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 100% (2 of 2)
Cartilage tissue N/A heterozygote 100% (2 of 2)
Cerebellum N/A heterozygote Not available
Cerebral cortex N/A heterozygote Not available
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Heart N/A heterozygote 100% (2 of 2)
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 100% (2 of 2)
Liver N/A heterozygote 100% (2 of 2)
Lower urinary tract N/A heterozygote 100% (2 of 2)
Lung N/A heterozygote 100% (2 of 2)
Lymph node N/A heterozygote 100% (2 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 100% (2 of 2)
Olfactory lobe N/A heterozygote Not available
Ovary N/A heterozygote 50% (1 of 2)
Oviduct N/A heterozygote 50% (1 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote Not available
Peripheral nervous system N/A heterozygote 100% (2 of 2)
Peyer's patch N/A heterozygote Ambiguous
Pituitary gland N/A heterozygote Not available
Prostate gland N/A heterozygote 0.0% (0 of 2)
Skeletal muscle tissue N/A heterozygote 100% (2 of 2)
Skin N/A heterozygote 100% (2 of 2)
Small intestine N/A heterozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (2 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 100% (2 of 2)
Striatum N/A heterozygote Not available
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote Not available
Trachea N/A heterozygote 100% (2 of 2)
Uterus N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote 100% (2 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood vessel
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
oesophagus
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyer's patch
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle tissue
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Histopathology

Images

28 Images

View images

Human diseases caused by Miga2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Miga2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hemoglobin D Disease
Increased HbA2 hemoglobin, Decreased mean corpuscular hemoglobin concentration, HbS hemoglobin, A... ORPHA:90039
Congenital Amegakaryocytic Thrombocytopenia
Thrombocytopenia, Decreased skull ossification, Abnormal hemoglobin, Anemia ORPHA:3319
Regional Odontodysplasia
Dental enamel pits, Abnormality of dental color, Gingivitis, Eruption failure, Abnormal dental pu... ORPHA:83450
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Anemia, Splenomegaly, Persistence of hemoglobin F, Abnormal bone structure ORPHA:46532
Florid Cemento-Osseous Dysplasia
Abnormal trabecular bone morphology, Jaw swelling, Multiple bony cystic lesions, Mandibular osteo... ORPHA:83451
Hemoglobin E-Beta-Thalassemia Syndrome
Abnormal hemoglobin, Anemia ORPHA:231249
Hemoglobin-Delta locus
Imbalanced hemoglobin synthesis, Anemia OMIM:142000
Lipodystrophy, Generalized, With Mental Retardation, Deafness, Short Stature, And Slender Bones
Osteopenia, Small for gestational age, Hypoplasia of the maxilla, Congenital generalized lipodyst... OMIM:608154
Thalassemia, Beta+, Silent Allele
Reduced beta/alpha synthesis ratio OMIM:187550
Amelogenesis Imperfecta
Abnormality of dental color, Fragile teeth, Hypomature dental enamel, Enamel hypomineralization, ... ORPHA:88661
Fetal Hemoglobin Quantitative Trait Locus 1
Persistence of hemoglobin F OMIM:141749
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
Anemia, Splenomegaly, Abnormal hemoglobin, Thrombocytopenia ORPHA:231393
Dentinogenesis Imperfecta
Generalized hypoplasia of dental enamel, Odontodysplasia, Pulp obliteration, Selective tooth agen... ORPHA:49042
Hemoglobin H Disease
Splenomegaly, Hemolytic anemia, Reduced alpha/beta synthesis ratio, HbH hemoglobin OMIM:613978
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
Microcytic anemia, Micrognathia, Flexion contracture, Wide nasal bridge, Retrognathia, High palat... ORPHA:98791
Hemoglobin E Disease
Drug-sensitive hemolytic anemia, Abnormal hemoglobin, Anemia of inadequate production, Splenomega... ORPHA:2133
Multicentric Carpotarsal Osteolysis Syndrome
Osteopenia, Congenital diaphragmatic hernia, Micrognathia, Hypoplasia of the maxilla, Osteolysis ... OMIM:166300
Beta-Thalassemia, Dominant Inclusion Body Type
Increased HbA2 hemoglobin, Decreased mean corpuscular hemoglobin concentration, Erythrocyte inclu... OMIM:603902
Diamond-Blackfan Anemia 6
Macrocytic anemia, Micrognathia, Cleft upper lip, Retrognathia, Cleft palate, Persistence of hemo... OMIM:612561
Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly
Hypoplasia of the maxilla, Premature loss of teeth, Thin vermilion border, Short philtrum, Osteop... OMIM:156510
Osteopetrosis, Autosomal Recessive 2
Mandibular prognathia, Pancytopenia, Osteomyelitis, Extramedullary hematopoiesis, Recurrent fract... OMIM:259710
Methemoglobinemia, Beta Type
Methemoglobinemia OMIM:617971
Methemoglobinemia, Alpha Type
Methemoglobinemia OMIM:617973
Intellectual Developmental Disorder, Autosomal Recessive 68
Hypoplasia of the maxilla, Small for gestational age, Wide nasal bridge OMIM:618302
Autosomal Recessive Distal Osteolysis Syndrome
Hypoplasia of the maxilla, Osteolysis, Abnormality of the dentition ORPHA:2776
Sickle Cell Anemia
Hemolytic anemia, Reticulocytosis, Osteomyelitis, Microcytic anemia, Abnormality of the spleen, L... ORPHA:232
X-Linked Intellectual Disability, Sutherland-Haan Type
Mandibular prognathia, Hypoplasia of the maxilla, Small for gestational age, Decreased body weight ORPHA:93950
Pycnodysostosis
Joint laxity, Obtuse angle of mandible, Increased bone mineral density, Delayed eruption of prima... ORPHA:763
Maxillonasal Dysplasia
Mandibular prognathia, Hypoplasia of the maxilla, Open bite, Cleft palate, Tooth agenesis, Microd... ORPHA:1248
Aarskog-Scott Syndrome
Delayed eruption of teeth, Inguinal hernia, Camptodactyly of finger, Cleft upper lip, Hypoplasia ... ORPHA:915
Hemoglobin C-Beta-Thalassemia Syndrome
Splenomegaly, Abnormal hemoglobin, Anemia, Microcytic anemia ORPHA:231242
Acetophenetidin Sensitivity
Hemolytic anemia, Methemoglobinemia OMIM:200300
Frontonasal Dysplasia 1
Frontal cutaneous lipoma, Pericallosal lipoma, Median cleft lip, Hypoplasia of the maxilla, Hypop... OMIM:136760
Oligodontia
Orofacial cleft, Oligodontia, Agenesis of mandibular premolar, Widely spaced teeth, Microdontia, ... ORPHA:99798
Bone Marrow Failure Syndrome 6
Osteopenia, Squamous cell carcinoma of the tongue, Persistence of hemoglobin F, Increased mean co... OMIM:618849
Dislocation Of The Hip-Dysmorphism Syndrome
Prominence of the premaxilla, Inguinal hernia, Wide nasal bridge, Joint hyperflexibility, Narrow ... ORPHA:2412
Cleft Lip/Palate
Agenesis of lateral incisor, Bilateral cleft palate, Hypoplasia of the maxilla, Velopharyngeal in... ORPHA:199306
Delta-Beta-Thalassemia
Abnormal hemoglobin, Anemia, Microcytic anemia ORPHA:231237
Split-Hand/Foot Malformation 3
Microretrognathia, Hypoplasia of the maxilla, Narrow mouth, Cleft palate, High palate, Camptodactyly OMIM:246560
Cohen Syndrome
Small for gestational age, Micrognathia, Hypoplasia of the maxilla, High, narrow palate, Leukopen... OMIM:216550
Bone Marrow Failure Syndrome 3
Acute myeloid leukemia, Pancytopenia, Aplastic anemia, Micrognathia, Thrombocytopenia, Oral ulcer... OMIM:617052
Lowry-Maclean Syndrome
Osteopenia, Inguinal hernia, Congenital diaphragmatic hernia, Craniosynostosis, Micrognathia, Hyp... ORPHA:2409
Hemifacial Hyperplasia
Hypoplasia of the maxilla, Dental malocclusion OMIM:133900
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Osteopenia, Anemia of inadequate production, Carious teeth, Splenomegaly, Calvarial hyperostosis,... OMIM:612714
Dental Anomalies And Short Stature
Mandibular prognathia, Hypoplasia of the maxilla, Oligodontia, Widely spaced teeth, Microdontia, ... OMIM:601216
Beta-Thalassemia
Abnormal hemoglobin, Microcytic anemia, Splenomegaly, Reduced bone mineral density, Anemia, Throm... ORPHA:848
Stickler Syndrome Type 1
Hypoplasia of the maxilla, Osteoarthritis, Cleft palate, Joint hyperflexibility, Long philtrum, S... ORPHA:90653
Temtamy Preaxial Brachydactyly Syndrome
Proximal radio-ulnar synostosis, Abnormal spaced incisors, Tarsal synostosis, Micrognathia, Hypop... ORPHA:363417
Craniofacial-Deafness-Hand Syndrome
Hypoplasia of the maxilla, Short nose, Camptodactyly of finger, Narrow mouth ORPHA:1529
Melanocytic Nevus Syndrome, Congenital
Prominence of the premaxilla, Deep philtrum, Everted lower lip vermilion, Long philtrum, Short no... OMIM:137550
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome
Mandibular prognathia, Hypoplasia of the maxilla, Obesity, Crowded maxillary incisors ORPHA:397973
Polycythemia Vera
Splenomegaly, Leukocytosis, Increased hemoglobin, Increased red blood cell mass, Increased hemato... OMIM:263300
Anemia, Congenital Dyserythropoietic, Type Iv
Decreased hemoglobin concentration, Hemolytic anemia, Circulating nucleated red blood cells, Reti... OMIM:613673
Intellectual Developmental Disorder, Autosomal Dominant 70
Mandibular prognathia, Micrognathia, Hypoplasia of the maxilla, Wide nasal bridge, Retrognathia, ... OMIM:620157
X-Linked Intellectual Disability, Porteous Type
Mandibular prognathia, Hypoplasia of the maxilla, Short philtrum, Decreased body weight ORPHA:93945
Cyanosis, Transient Neonatal
Reticulocytosis, Methemoglobinemia, Anemia OMIM:613977
Alpha-Thalassemia
Hemolytic anemia, Abnormal hemoglobin, Microcytic anemia, Hypersplenism, Splenomegaly, Anemia ORPHA:846
20P12.3 Microdeletion Syndrome
Hypoplasia of the maxilla, Wide nasal bridge, Narrow mouth, Malar flattening, Long philtrum ORPHA:261295
Osteopetrosis, Autosomal Recessive 1
Increased bone mineral density, Osteomyelitis, Pancytopenia, Craniosynostosis, Carious teeth, Thr... OMIM:259700
Mandibulofacial Dysostosis With Alopecia
Dental crowding, Delayed eruption of primary teeth, Micrognathia, Hypoplasia of the maxilla, Tris... OMIM:616367
Diamond-Blackfan Anemia 14 With Mandibulofacial Dysostosis
Macrocytic anemia, Micrognathia, Cleft palate, Persistence of hemoglobin F, Increased mean corpus... OMIM:300946
Oculodentodigital Dysplasia, Autosomal Recessive
Delayed eruption of teeth, Dental crowding, Micrognathia, Long nose, Hypoplasia of the maxilla, D... OMIM:257850
Lujan-Fryns Syndrome
Dental crowding, Camptodactyly of finger, Micrognathia, Hypoplasia of the maxilla, Abnormality of... ORPHA:776
Alpha-Thalassemia-Myelodysplastic Syndrome
Microcytic anemia, Splenomegaly, Acute leukemia, Neutropenia, HbH hemoglobin, Thrombocytopenia ORPHA:231401
Malan Syndrome
Mandibular prognathia, Hyperplasia of the premaxilla, Gingival overgrowth, Everted lower lip verm... OMIM:614753
Intellectual Developmental Disorder, X-Linked, Syndromic 14
Mandibular prognathia, Hypoplasia of the maxilla, High palate, Slender build OMIM:300676
Hypophosphatasia, Adult
Premature loss of permanent teeth, Recurrent fractures, Osteomalacia, Premature loss of primary t... OMIM:146300
Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Reticulocytosis, HbS hemoglobin, Asplenia, Splenomegaly, Splenic infarction, Hypochromic microcyt... ORPHA:251380
Hereditary Methemoglobinemia
Methemoglobinemia, Lip discoloration, Small for gestational age ORPHA:621
Dominant Beta-Thalassemia
Extramedullary hematopoiesis, Failure to thrive in infancy, Decreased mean corpuscular hemoglobin... ORPHA:231226
Otodental Syndrome
Delayed eruption of teeth, Abnormal dental enamel morphology, Agenesis of premolar, Carious teeth... ORPHA:2791
Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin
Dental crowding, Persistence of primary teeth, Overweight, Hiatus hernia, Persistence of hemoglob... OMIM:619769
Recon Progeroid Syndrome
Joint laxity, Smooth philtrum, Prominence of the premaxilla, Dental crowding, Anemia, Delayed eru... OMIM:620370
Pde4D Haploinsufficiency Syndrome
Joint laxity, Mandibular prognathia, Thin upper lip vermilion, Abnormal dental enamel morphology,... ORPHA:439822
Dysostosis, Stanescu Type
Increased bone mineral density, Abnormal dental enamel morphology, Abnormality of the dentition, ... ORPHA:1798
Beta-Thalassemia Major
Extramedullary hematopoiesis, Failure to thrive in infancy, Decreased mean corpuscular hemoglobin... ORPHA:231214
Erythrocytosis, Familial, 2
Increased red blood cell mass, Failure to thrive, Increased hematocrit, Increased hemoglobin OMIM:263400
Aarskog-Scott Syndrome
Joint laxity, Hyperextensibility of the finger joints, Inguinal hernia, Cleft upper lip, Hypoplas... OMIM:305400
Cleidocranial Dysplasia 2
Osteopenia, Delayed eruption of primary teeth, Hypoplasia of the maxilla, Supernumerary tooth, De... OMIM:620099
Cortical Dysplasia, Complex, With Other Brain Malformations 15
Hypoplasia of the maxilla, Thin upper lip vermilion, Smooth philtrum, Widely-spaced incisors OMIM:618737
Craniolenticulosutural Dysplasia
Delayed eruption of teeth, Hypoplasia of the maxilla, Carious teeth, Hypoplasia of teeth, Wide mo... ORPHA:50814
Treacher-Collins Syndrome
Abnormal dental morphology, Abnormal dental enamel morphology, Micrognathia, Hypoplasia of the ma... ORPHA:861
Carpenter Syndrome 1
Omphalocele, Sagittal craniosynostosis, Micrognathia, Hypoplasia of the maxilla, Persistence of p... OMIM:201000
Intellectual Developmental Disorder With Persistence Of Fetal Hemoglobin
Thin upper lip vermilion, Micrognathia, Persistence of hemoglobin F, Everted lower lip vermilion,... OMIM:617101
Agenesis Of The Corpus Callosum With Peripheral Neuropathy
Hypoplasia of the maxilla, Flexion contracture, Wide nasal bridge, High palate, Short nose OMIM:218000
Acrodysostosis
Mandibular prognathia, Delayed eruption of teeth, Hypoplasia of the maxilla, Open bite, Wide nasa... ORPHA:950
Erythrocytosis, Familial, 8
Splenomegaly, Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:222800
8Q22.1 Microdeletion Syndrome
Camptodactyly of finger, Craniosynostosis, Abnormality of the dentition, Hypoplasia of the maxill... ORPHA:178303
Erythrocytosis, Familial, 1
Increased red blood cell mass, Splenomegaly, Increased hematocrit, Increased hemoglobin OMIM:133100
Peroxisome Biogenesis Disorder 12A (Zellweger)
Prominence of the premaxilla, Abnormal cortical bone morphology, Wide nasal bridge, Decreased bod... OMIM:614886
Erythrocytosis, Familial, 4
Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:611783
Premature Aging Syndrome, Penttinen Type
Delayed eruption of teeth, Failure to thrive, Lipoatrophy, Recurrent fractures, Micrognathia, Hyp... OMIM:601812
Spondylospinal Thoracic Dysostosis
Hypoplasia of the maxilla, Arthrogryposis multiplex congenita, Micrognathia OMIM:601809
Hypomandibular Faciocranial Dysostosis
Pursed lips, Micrognathia, Hypoplasia of the maxilla, Aglossia, Malar flattening, Coronal cranios... OMIM:241310
Beta-Thalassemia Intermedia
Osteopenia, Increased HbA2 hemoglobin, Extramedullary hematopoiesis, Anemia of inadequate product... ORPHA:231222
Erythrocytosis, Familial, 3
Increased red blood cell mass, Increased hematocrit, Increased hemoglobin OMIM:609820
Erythrocytosis, Familial, 5
Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:617907
Camurati-Engelmann Disease
Reduced subcutaneous adipose tissue, Mandibular prognathia, Increased bone mineral density, Cario... OMIM:131300
Kdm5C-Related Syndromic X-Linked Intellectual Disability
Hypoplasia of the maxilla, High palate, Camptodactyly of finger ORPHA:85279
Microcephaly-Capillary Malformation Syndrome
Small for gestational age, Hypoplasia of the maxilla, Cleft palate, Short nose, Failure to thrive OMIM:614261
Cohen Syndrome
Failure to thrive in infancy, Aplasia/Hypoplasia of the tongue, Macrodontia, Micrognathia, Hypopl... ORPHA:193
Axenfeld-Rieger Syndrome, Type 2
Mandibular prognathia, Inguinal hernia, Hypoplasia of the maxilla, Wide nasal bridge, Short philt... OMIM:601499
Alpha-Thalassemia Myelodysplasia Syndrome
Reduced alpha/beta synthesis ratio, HbH hemoglobin, Hypochromic microcytic anemia OMIM:300448
Marshall Syndrome
Micrognathia, Hypoplasia of the maxilla, Abnormality of the dentition, Osteoarthritis, Hypoplasti... ORPHA:560
Pycr2-Related Microcephaly-Progressive Leukoencephalopathy
Smooth philtrum, Hypoplasia of the maxilla, Flexion contracture, Hyperextensibility at wrists, Th... ORPHA:481152
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Carious teeth, Enamel hypomineralization, Anterior open-bite malocclusion, Yellow-brown discolora... OMIM:204700
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Mandibular prognathia, Thin upper lip vermilion, Micrognathia, Hypoplasia of the maxilla, Diastem... OMIM:300534
Multicentric Osteolysis, Nodulosis, And Arthropathy
Osteopenia, Hip contracture, Delayed eruption of teeth, Interphalangeal joint contracture of fing... OMIM:259600
Van Maldergem Syndrome 1
Osteopenia, Joint laxity, Irregular dentition, Tented upper lip vermilion, Micrognathia, Hypoplas... OMIM:601390
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Joint laxity, Hyperextensibility of the finger joints, Thin upper lip vermilion, Dental crowding,... OMIM:309520
Erythrocytosis, Familial, 6
Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:617980
Andersen Cardiodysrhythmic Periodic Paralysis
Joint laxity, Thin upper lip vermilion, Dental crowding, Short mandibular rami, Micrognathia, Hyp... OMIM:170390
Geroderma Osteodysplasticum
Osteopenia, Hyperextensibility of the finger joints, Mandibular prognathia, Recurrent fractures, ... OMIM:231070
Pfeiffer Syndrome
Mandibular prognathia, Dental crowding, Hypoplasia of the maxilla, Humeroradial synostosis, Coron... OMIM:101600
Mandibulofacial Dysostosis-Microcephaly Syndrome
Accessory oral frenulum, Micrognathia, Hypoplasia of the maxilla, Cleft palate, Malar flattening,... ORPHA:79113
Coffin-Lowry Syndrome
Delayed eruption of teeth, Craniofacial hyperostosis, Abnormal dental morphology, Hypoplasia of t... ORPHA:192
Van Maldergem Syndrome 2
Osteopenia, Joint laxity, Inguinal hernia, Tented upper lip vermilion, Irregular dentition, Micro... OMIM:615546
Rothmund-Thomson Syndrome
Osteopenia, Abnormal trabecular bone morphology, Delayed eruption of teeth, Small for gestational... ORPHA:2909
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Mandibular prognathia, U-Shaped upper lip vermilion, Malar flattening, Protruding tongue, Absent ... OMIM:301040
Spastic Paraplegia 16, X-Linked
Hypoplasia of the maxilla OMIM:300266
Kagami-Ogata Syndrome
Omphalocele, Inguinal hernia, Micrognathia, Hypoplasia of the maxilla, Splenomegaly, Flexion cont... OMIM:608149
Crouzon Syndrome
Hypoplasia of the maxilla, Narrow palate, Multiple suture craniosynostosis ORPHA:207
Andersen-Tawil Syndrome
Joint laxity, Thin upper lip vermilion, Abnormality of dental color, Dental crowding, Micrognathi... ORPHA:37553
Shwachman-Diamond Syndrome 1
Acute myeloid leukemia, Pancytopenia, Small for gestational age, Thrombocytopenia, Persistence of... OMIM:260400
Nasopalpebral Lipoma-Coloboma Syndrome
Hypoplasia of the maxilla, Lipomas of eyelids, Wide nasal bridge OMIM:167730
Erythrocytosis, Familial, 7
Increased hematocrit, Polycythemia OMIM:617981
Keipert Syndrome
Hypoplasia of the maxilla, Tented upper lip vermilion, Exaggerated cupid's bow ORPHA:2662
Diamond-Blackfan Anemia
Acute myeloid leukemia, Small for gestational age, Cleft soft palate, Pure red cell aplasia, Micr... ORPHA:124
Osteoglophonic Dysplasia
Osteopenia, Mandibular prognathia, Inguinal hernia, Delayed eruption of teeth, Camptodactyly of f... OMIM:166250
Dyskeratosis Congenita
Recurrent fractures, Abnormality of neutrophils, Abnormality of the dentition, Hypoplasia of the ... ORPHA:1775
Primary Familial Polycythemia
Polycythemia, Abnormal hemoglobin ORPHA:90042
Rapp-Hodgkin Syndrome
Conical tooth, Hypoplasia of the maxilla, Carious teeth, Cleft upper lip, Velopharyngeal insuffic... OMIM:129400
Distal Limb Deficiencies-Micrognathia Syndrome
Microretrognathia, Tarsal synostosis, Hypoplasia of the maxilla, Cleft palate, High palate, Narro... ORPHA:1307
Acrodysostosis 1 With Or Without Hormone Resistance
Mandibular prognathia, Delayed eruption of teeth, Small for gestational age, Hypoplasia of the ma... OMIM:101800
Nager Syndrome
Micrognathia, Hypoplasia of the maxilla, Joint stiffness, Non-midline cleft lip, Cleft palate, Wi... ORPHA:245
Hb Bart'S Hydrops Fetalis
Splenomegaly, Abnormal hemoglobin, Anemia ORPHA:163596
Crouzon Syndrome-Acanthosis Nigricans Syndrome
Hypoplasia of the maxilla, Malar flattening, Abnormal palate morphology ORPHA:93262
Jackson-Weiss Syndrome
Mandibular prognathia, Hypoplasia of the maxilla, Abnormal palate morphology ORPHA:1540
Shprintzen-Goldberg Craniosynostosis Syndrome
Osteopenia, Joint laxity, Inguinal hernia, Craniosynostosis, Micrognathia, Hypoplasia of the maxi... OMIM:182212
Nablus Mask-Like Facial Syndrome
Thin upper lip vermilion, Craniosynostosis, Abnormality of the dentition, Hypoplasia of the maxil... OMIM:608156
Lead Poisoning
Delayed eruption of teeth, Small for gestational age, Cranial hyperostosis, Imbalanced hemoglobin... ORPHA:330015
Shprintzen-Goldberg Syndrome
Osteopenia, Inguinal hernia, Camptodactyly of finger, Craniosynostosis, Joint stiffness, Microgna... ORPHA:2462
Pseudohermaphroditism, Female, With Skeletal Anomalies
Hypoplasia of the maxilla, Short mandibular condyles OMIM:264270
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate
Selective tooth agenesis, Conical tooth, Hypoplasia of the maxilla, Cleft upper lip, Wide nasal b... OMIM:106260
Marshall-Smith Syndrome
Omphalocele, Microretrognathia, Prominence of the premaxilla, Decreased hip abduction, Large ster... OMIM:602535
Cardioacrofacial Dysplasia 1
Accessory oral frenulum, Conical tooth, Hypoplasia of the maxilla, Diastema, Short philtrum OMIM:619142
Axenfeld-Rieger Syndrome
Hypoplasia of the maxilla, Wide nasal bridge, Everted lower lip vermilion, Hypodontia, Microdontia ORPHA:782
Angelman Syndrome
Mandibular prognathia, Protruding tongue, Hypoplasia of the maxilla, Obesity, Wide mouth, Macrogl... OMIM:105830
Cerebrofacioarticular Syndrome
Osteopenia, Irregular dentition, Micrognathia, Hypoplasia of the maxilla, Narrow mouth, Wide nasa... ORPHA:314679
3Mc Syndrome 2
Prominence of the premaxilla, Craniosynostosis, Limited elbow movement, Cleft upper lip, Wide nas... OMIM:265050
Crouzon Syndrome
Mandibular prognathia, Dental crowding, Sagittal craniosynostosis, Hypoplasia of the maxilla, Hig... OMIM:123500
Diamond-Blackfan Anemia 3
Persistence of hemoglobin F, Macrocytic anemia, Increased mean corpuscular volume, Reticulocytopenia OMIM:610629
Craniofacial Dysmorphism, Skeletal Anomalies, And Impaired Intellectual Development Syndrome 1
Hyperextensibility of the finger joints, Vertebral fusion, Inguinal hernia, Craniosynostosis, Lar... OMIM:213980
Stickler Syndrome
Abnormal dental enamel morphology, Cachexia, Micrognathia, Hypoplasia of the maxilla, Cleft upper... ORPHA:828
Gorlin-Chaudhry-Moss Syndrome
Abnormality of the dentition, Hypoplasia of the maxilla, Oligodontia, Umbilical hernia, Coronal c... ORPHA:2095
Martsolf Syndrome 1
Joint laxity, Inguinal hernia, Micrognathia, Hypoplasia of the maxilla, High palate, Short philtr... OMIM:212720
Meier-Gorlin Syndrome 4
Micrognathia, Hypoplasia of the maxilla, Thick lower lip vermilion, Narrow mouth, Failure to thrive OMIM:613804
Brachytelephalangic Chondrodysplasia Punctata
Calcaneal epiphyseal stippling, Hypoplasia of the maxilla, Abnormal ossification involving the fe... ORPHA:79345
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Tented upper lip vermilion, Abnormal hemoglobin, Joint stiffness, Abnormality of the dentition, F... ORPHA:847
Distal Xq28 Microduplication Syndrome
Short lingual frenulum, Dental crowding, Hypoplasia of the maxilla, Thick lower lip vermilion, Hi... ORPHA:293939
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
Methemoglobinemia, Polycythemia OMIM:250800
Dehydrated Hereditary Stomatocytosis
Hemolytic anemia, Reticulocytosis, Macrocytic anemia, Anemia of inadequate production, Splenomega... ORPHA:3202
Tempi Syndrome
Increased hematocrit, Polycythemia ORPHA:284227
Greenberg Dysplasia
Recurrent fractures, Micrognathia, Multiple prenatal fractures, Costal cartilage calcification, P... OMIM:215140
Mohr Syndrome
Median cleft lip, Accessory oral frenulum, Micrognathia, Hypoplasia of the maxilla, Cleft palate,... OMIM:252100
Myhre Syndrome
Mandibular prognathia, Craniofacial hyperostosis, Inguinal hernia, Femoral hernia, Joint stiffnes... ORPHA:2588
Atelosteogenesis, Type Iii
Hypoplasia of the maxilla, Malar flattening, Cleft palate, Micrognathia OMIM:108721
Cowden Syndrome 1
Micrognathia, Hypoplasia of the maxilla, Furrowed tongue, High palate, Narrow mouth, Lymphopenia,... OMIM:158350
Ptosis-Upper Ocular Movement Limitation-Absence Of Lacrimal Punctum Syndrome
Microretrognathia, Hypoplasia of the maxilla, Thick vermilion border, Long philtrum ORPHA:228396
Thymoma
Aplastic anemia, Pure red cell aplasia, Imbalanced hemoglobin synthesis, Weight loss, Rheumatoid ... ORPHA:99867
Ear-Patella-Short Stature Syndrome
Camptodactyly of finger, Craniosynostosis, Micrognathia, Hypoplasia of the maxilla, High, narrow ... ORPHA:2554
Barber-Say Syndrome
Mandibular prognathia, Delayed eruption of teeth, Lipodystrophy, Micrognathia, Hypoplasia of the ... OMIM:209885
Meier-Gorlin Syndrome 1
Joint laxity, Failure to thrive, Absent sternal ossification, Small for gestational age, Microgna... OMIM:224690
Elsahy-Waters Syndrome
Mandibular prognathia, Delayed eruption of teeth, Thin upper lip vermilion, Hypoplasia of the max... OMIM:211380
Hypohidrotic Ectodermal Dysplasia
Sinusitis, Abnormal dental morphology, Abnormality of the dentition, Hypoplasia of the maxilla, T... ORPHA:238468
Acrofacial Dysostosis, Cincinnati Type
Micrognathia, Hypoplasia of the maxilla, Cleft palate, Decreased body weight, Retrognathia, Aplas... OMIM:616462
Diamond-Blackfan Anemia 1
Macrocytic anemia, Congenital hypoplastic anemia, Micrognathia, Cleft upper lip, Reticulocytopeni... OMIM:105650
Meier-Gorlin Syndrome 5
Micrognathia, Hypoplasia of the maxilla, Submucous cleft hard palate, Thick vermilion border, Lon... OMIM:613805
Cleft Velum
Hypoplasia of the maxilla, Velopharyngeal insufficiency, Cleft soft palate ORPHA:99772
Cowden Syndrome 5
Micrognathia, Hypoplasia of the maxilla, Furrowed tongue, High palate, Narrow mouth, Subcutaneous... OMIM:615108
Meier-Gorlin Syndrome 3
Microretrognathia, Absent sternal ossification, Micrognathia, Hypoplasia of the maxilla, Thick ve... OMIM:613803
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities
Hypoplasia of the maxilla, Malar flattening OMIM:109120
Beta-Thalassemia
Reduced beta/alpha synthesis ratio, Hypochromic microcytic anemia OMIM:613985
Alpha-Thalassemia
Reduced alpha/beta synthesis ratio, Hypochromic microcytic anemia OMIM:604131
Branchioskeletogenital Syndrome
Mandibular prognathia, Unilateral cleft palate, Craniosynostosis, Abnormality of the dentition, H... ORPHA:1299
Cowden Syndrome 6
Micrognathia, Hypoplasia of the maxilla, Furrowed tongue, High palate, Narrow mouth, Subcutaneous... OMIM:615109
Van Den Ende-Gupta Syndrome
Dental crowding, Craniosynostosis, Micrognathia, Hypoplasia of the maxilla, High, narrow palate, ... OMIM:600920
Microphthalmia With Limb Anomalies
Failure to thrive, Macrodontia, Tarsal synostosis, Hypoplasia of the premaxilla, Micrognathia, Hy... ORPHA:1106
X-Linked Intellectual Disability-Limb Spasticity-Retinal Dystrophy-Diabetes Insipidus Syndrome
Severe failure to thrive, HbH hemoglobin ORPHA:423479
Zttk Syndrome
Craniosynostosis, Abnormality of the dentition, Hypoplasia of the maxilla, Flexion contracture, S... OMIM:617140
Rubinstein-Taybi Syndrome 1
Dental crowding, Micrognathia, Hypoplasia of the maxilla, High, narrow palate, Flexion contractur... OMIM:180849
Apert Syndrome
Mandibular prognathia, Delayed eruption of teeth, Hypoplasia of the maxilla, Cervical C5/C6 verte... ORPHA:87
Frontorhiny
Pericallosal lipoma, Camptodactyly of finger, Hypoplasia of the maxilla, Hypoplastic frontal sinu... ORPHA:391474
Intellectual Disability-Dysmorphism-Hypogonadism-Diabetes Mellitus Syndrome
Eunuchoid habitus, Hypoplasia of the maxilla, Mandibular prognathia ORPHA:3044
Gaisböck Syndrome
Overweight, Splenomegaly, Increased mean corpuscular hemoglobin concentration, Obesity, Gout, Inc... ORPHA:90041
Distal Deletion 19P
Vaginal hernia, Hypoplasia of the maxilla, Cleft palate, Joint hyperflexibility, Umbilical hernia... ORPHA:96129
Nasopalpebral Lipoma-Coloboma Syndrome
Hypoplasia of the maxilla, Multiple lipomas, Lipomas of eyelids ORPHA:2399
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked
Everted upper lip vermilion, Abnormal oral mucosa morphology, Conical tooth, Hypoplasia of the ma... OMIM:305100
Saethre-Chotzen Syndrome
Proximal radio-ulnar synostosis, Craniosynostosis, Hypoplasia of the maxilla, Open bite, Narrow p... ORPHA:794
Acquired Methemoglobinemia
Methemoglobinemia ORPHA:464453
Cutis Laxa, Autosomal Recessive, Type Iic
Joint laxity, Reduced subcutaneous adipose tissue, Mandibular prognathia, Dental crowding, Hypopl... OMIM:617402
Craniofacial-Deafness-Hand Syndrome
Hypoplasia of the maxilla, Malar flattening, Short nose OMIM:122880
Myhre Syndrome
Mandibular prognathia, Vertebral fusion, Thin upper lip vermilion, Small for gestational age, Joi... OMIM:139210
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Mandibular prognathia, Tented upper lip vermilion, Large for gestational age, Micrognathia, Hypop... ORPHA:96334
Weill-Marchesani Syndrome 1
Joint stiffness, Hypoplasia of the maxilla, Narrow palate, Tooth malposition, Thin bony cortex OMIM:277600
Weill-Marchesani Syndrome 2
Joint stiffness, Hypoplasia of the maxilla, Elbow flexion contracture, Narrow palate, High palate... OMIM:608328
Goldberg-Shprintzen Syndrome
Hypoplasia of the maxilla, Wide nasal bridge, Oligodontia, Short philtrum, Thick vermilion border... OMIM:609460
7Q31 Microdeletion Syndrome
Hypoplasia of the maxilla, Wide mouth, Long philtrum ORPHA:251061
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Mandibular prognathia, Inguinal hernia, Camptodactyly of finger, Hypoplasia of the maxilla, High,... ORPHA:1101
Holoprosencephaly 9
Hypoplasia of the premaxilla, Cleft upper lip, Hypoplasia of the maxilla, Agenesis of incisor, De... OMIM:610829
Aicardi Syndrome
Prominence of the premaxilla, Block vertebrae, Hiatus hernia, Cleft upper lip, Cleft palate, Mult... ORPHA:50
Methemoglobinemia And Ambiguous Genitalia
Methemoglobinemia OMIM:250790
Bartsocas-Papas Syndrome 1
Omphalocele, Inguinal hernia, Micrognathia, Hypoplasia of the maxilla, Cleft upper lip, Flexion c... OMIM:263650
Singleton-Merten Syndrome 1
Osteopenia, Thin upper lip vermilion, Hypoplasia of the maxilla, Carious teeth, Short dental root... OMIM:182250
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Pericallosal lipoma, Camptodactyly of finger, Hypoplasia of the maxilla, Wide nasal bridge, Cleft... ORPHA:306542
Aicardi Syndrome
Prominence of the premaxilla, Block vertebrae, Cleft upper lip, Hiatus hernia, Cleft palate, Lipoma OMIM:304050
Primrose Syndrome
Hip contracture, Joint hypermobility, Hypoplasia of the maxilla, Flexion contracture, Osteoporosi... OMIM:259050
Craniosynostosis And Dental Anomalies
Mandibular prognathia, Delayed eruption of teeth, Dental crowding, Sagittal craniosynostosis, Hyp... OMIM:614188
Ablepharon Macrostomia Syndrome
Omphalocele, Camptodactyly of finger, Hypoplasia of the maxilla, Wide mouth, Thin vermilion borde... ORPHA:920
Peters-Plus Syndrome
Joint laxity, Thin upper lip vermilion, Short lingual frenulum, Bilateral cleft lip, Craniosynost... OMIM:261540
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Smooth philtrum, Failure to thrive in infancy, Sagittal craniosynostosis, Submucous cleft soft pa... ORPHA:500150
Cutis Laxa, Autosomal Recessive, Type Ib
Prominence of the premaxilla, Inguinal hernia, Congenital diaphragmatic hernia, Micrognathia, Hig... OMIM:614437
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Inguinal hernia, Absence of Stensen duct, Selective tooth agenesis, Cleft upper lip, Hypoplasia o... OMIM:129900
Saethre-Chotzen Syndrome
Long nose, Hypoplasia of the maxilla, Cleft of chin, Narrow palate, Cleft palate, Radioulnar syno... OMIM:101400
Floating-Harbor Syndrome
Small for gestational age, Persistence of primary teeth, Long nose, Hypoplasia of the maxilla, Ca... ORPHA:2044
Axenfeld-Rieger Syndrome, Type 1
Thin upper lip vermilion, Hypoplasia of the maxilla, Wide nasal bridge, Oligodontia, Short philtr... OMIM:180500
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Absence of Stensen duct, Selective tooth agenesis, Cleft upper lip, Hypoplasia of the maxilla, Ca... OMIM:604292
Spondyloepimetaphyseal Dysplasia, X-Linked
Joint laxity, Hypoplasia of the maxilla, Limited elbow extension, Delayed ossification of carpal ... OMIM:300106
Craniofacial Microsomia 1
Block vertebrae, Micrognathia, Hypoplasia of the maxilla, Cleft upper lip, Cleft palate, Wide mou... OMIM:164210
Holoprosencephaly 2
Aplasia of the premaxilla, Submucous cleft hard palate, Bilateral cleft lip and palate, Solitary ... OMIM:157170

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Liver - lipid deposition Miga2tm1a(KOMP)Wtsi HOM Early adult
Sternum - hypoplasia Miga2tm1a(KOMP)Wtsi HOM Early adult
Sternum - MPATH diagnostic term osteopenia Miga2tm1a(KOMP)Wtsi HOM Early adult
Testes - process of degenerative change Miga2tm1a(KOMP)Wtsi HOM Early adult
Liver - MPATH diagnostic term steatosis Miga2tm1a(KOMP)Wtsi HOM Early adult
Femur - MPATH diagnostic term osteopenia Miga2tm1a(KOMP)Wtsi HOM Early adult
Kidney - process of degenerative change Miga2tm1a(KOMP)Wtsi HOM Early adult
Kidney - MPATH diagnostic term glomerulonephritis Miga2tm1a(KOMP)Wtsi HOM Early adult
Tibia - hypoplasia Miga2tm1a(KOMP)Wtsi HOM Early adult
Femur - hypoplasia Miga2tm1a(KOMP)Wtsi HOM Early adult
Tibia - MPATH diagnostic term osteopenia Miga2tm1a(KOMP)Wtsi HOM Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Miga2.

There are 9 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway. Cell death & disease (November 2023) Miga2tm1a(KOMP)Wtsi PMC10682431
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior. Cell (October 2019) Miga2tm1c(KOMP)Wtsi Miga2tm1a(KOMP)Wtsi 31675497
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability. Nature communications (November 2017) Miga2tm1c(KOMP)Wtsi Miga2tm1a(KOMP)Wtsi PMC5703766
Mitochondrial Function Regulated by Mitoguardin-1/2 Is Crucial for Ovarian Endocrine Functions and Ovulation. Endocrinology (November 2017) Miga2tm1a(KOMP)Wtsi 28938432
Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions. Oncotarget (January 2016) Miga2tm1c(KOMP)Wtsi Miga2tm1a(KOMP)Wtsi PMC4811450
Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Molecular cell (December 2015) Miga2tm1a(KOMP)Wtsi 26711011
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Miga2tm1a(KOMP)Wtsi PMC4631787
MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (December 2014) Miga2tm1a(KOMP)Wtsi 25526730
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS genetics (August 2012) Miga2tm1a(KOMP)Wtsi PMC3410859

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Miga2tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Miga2tm357788(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Miga2tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Miga2tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Miga2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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