Gene Summary

Name:
C-type lectin domain family 16, member A
Synonyms:
4932416N17Rik,  curt

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased exploration in new environment Clec16aem1(IMPC)J HET Early adult 3.32×10-05
preweaning lethality, complete penetrance Clec16aem1(IMPC)J HOM   Early adult 0.00
abnormal auditory brainstem response Clec16aem1(IMPC)J HET   Early adult 5.68×10-05
improved glucose tolerance Clec16aem1(IMPC)J HET Early adult 7.67×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Electrocardiogram (ECG)

Waveform Image

16 Images

Eye Morphology

Images Ophthalmoscopy

1 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Clec16a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Clec16a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Wolfram-Like Syndrome, Autosomal Dominant
Glucose intolerance, Impaired glucose tolerance, Hearing impairment, Anxiety, Diabetes mellitus, ... OMIM:614296
Type 1 Diabetes Mellitus 2
Diabetes mellitus, Type I diabetes mellitus OMIM:125852
Maturity-Onset Diabetes Of The Young, Type 14
Maturity-onset diabetes of the young, Diabetes mellitus OMIM:616511
Type 1 Diabetes Mellitus 15
Diabetes mellitus, Type I diabetes mellitus OMIM:601666
Deafness, Autosomal Recessive 9
Absent brainstem auditory responses, Sensorineural hearing impairment OMIM:601071
Auditory Neuropathy, Autosomal Dominant, 1
Abnormal auditory evoked potentials, Sensorineural hearing impairment OMIM:609129
Charcot-Marie-Tooth Disease, Type 4B1
Decreased motor nerve conduction velocity, Abnormal auditory evoked potentials, Facial palsy OMIM:601382
Ravine Syndrome
Atrophy/Degeneration affecting the brainstem, Failure to thrive, Abnormal auditory evoked potenti... ORPHA:99852
Abcd Syndrome
Hearing impairment, Abnormal auditory evoked potentials, Aganglionic megacolon OMIM:600501
Insulinomatosis And Diabetes Mellitus
Impaired glucose tolerance, Diabetes mellitus, Hyperinsulinemic hypoglycemia, Glucose intolerance OMIM:147630
Optic Atrophy 8
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Prolonged somatosensory ev... OMIM:616648
Obesity Due To Sim1 Deficiency
Hyperinsulinemia, Glucose intolerance, Postural hypotension with compensatory tachycardia, Abnorm... ORPHA:369873
Autosomal Recessive Spastic Paraplegia Type 44
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Abnormal motor evoked pote... ORPHA:320401
Arthrogryposis, Distal, Type 2A
Camptodactyly, Abnormal auditory evoked potentials, Small for gestational age, Wrist flexion cont... OMIM:193700
Neurodevelopmental Disorder With Hypotonia, Neuropathy, And Deafness
Absent brainstem auditory responses, Sensorineural hearing impairment, EEG abnormality, Facial palsy OMIM:617519
Acrocraniofacial Dysostosis
Conductive hearing impairment, Short 1st metacarpal, Abnormality of the outer ear, Metatarsus add... OMIM:201050
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy
Progressive sensorineural hearing impairment, Ptosis, Abnormal auditory evoked potentials, Optic ... OMIM:125250
Charcot-Marie-Tooth Disease, Type 4D
Talipes cavus equinovarus, Hearing impairment, Abnormal auditory evoked potentials, Decreased ner... OMIM:601455
Charcot-Marie-Tooth Disease, Type 4C
Decreased motor nerve conduction velocity, Abnormal cranial nerve morphology, Prolonged brainstem... OMIM:601596
Autosomal Dominant Optic Atrophy Plus Syndrome
Temporal optic disc pallor, Absent brainstem auditory responses, Sensorineural hearing impairment... ORPHA:1215
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities
Absent extraocular muscles, Abnormal auditory evoked potentials, Sensorineural hearing impairment... OMIM:109120
Mohr-Tranebjaerg Syndrome
Mental deterioration, Dementia, Absent brainstem auditory responses, Sensorineural hearing impair... ORPHA:52368
Trisomy 10P
Low voltage EEG, Abnormal hip joint morphology, Camptodactyly, Abnormal auditory evoked potential... ORPHA:171929
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis
Irregular epiphyses, Cerebral atrophy, Synophrys, Brain atrophy, Cerebellar atrophy, Abnormal aud... OMIM:619260
Late-Infantile/Juvenile Krabbe Disease
Prolonged brainstem auditory evoked potentials, EEG with persistent abnormal rhythmic activity, E... ORPHA:206443
Mend Syndrome
Overlapping fingers, Hand polydactyly, Overlapping toe, Upslanted palpebral fissure, 2-3 toe synd... ORPHA:401973
Adult Krabbe Disease
Progressive neurologic deterioration, Prolonged brainstem auditory evoked potentials, EEG abnorma... ORPHA:206448
Charcot-Marie-Tooth Disease Type 1F
Hand muscle weakness, Flexion contracture of finger, Scapular winging, Cervical spinal cord atrop... ORPHA:101085
Infantile Krabbe Disease
Progressive neurologic deterioration, Prolonged brainstem auditory evoked potentials, Psychomotor... ORPHA:206436
Chronic Bilirubin Encephalopathy
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Conjunctival icterus, Abno... ORPHA:529808
Acute Bilirubin Encephalopathy
Abnormal auditory evoked potentials, Sensorineural hearing impairment, Conjunctival icterus, Abno... ORPHA:529799
Cerebrotendinous Xanthomatosis
Abnormality of tibia morphology, Abnormality of finger, Abnormal eyelid morphology, Global brain ... ORPHA:909
Adult-Onset Autosomal Dominant Leukodystrophy
Autonomic bladder dysfunction, Orthostatic hypotension, Dementia, Abnormal autonomic nervous syst... ORPHA:99027
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Vestibular areflexia, Absent brainstem auditory responses, Diffuse cerebral atrophy, Cerebellar h... ORPHA:3240
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Hypoplasia of the semicircular canal, White eyebrow, Long-segment aganglionic megacolon, Abnormal... OMIM:609136
Cockayne Syndrome B
Square pelvis bone, Hypoplastic pelvis, Decreased nerve conduction velocity, Cerebral atrophy, Hy... OMIM:133540
Cockayne Syndrome Type 1
Macrotia, Conjunctivitis, Hearing impairment, Absent brainstem auditory responses, Failure to thr... ORPHA:90321
Cockayne Syndrome A
Square pelvis bone, Hypoplastic pelvis, Cerebral atrophy, Hypoplastic iliac wing, Abnormality of ... OMIM:216400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Clec16a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Clec16a.

No publications found that use IMPC mice or data for Clec16a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Clec16aem1(IMPC)J Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter