Chic2 | cysteine-rich hydrophobic domain 2
Physiological systems
21 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system
10 No significant impact
3 Not tested
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
abnormal coat/hair pigmentation | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.54x10-8 | ||
enlarged spleen | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
increased circulating amylase level | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.85x10-10 | ||
enlarged ovary | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
enlarged heart | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
increased circulating alanine transaminase level | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.59x10-5 | ||
iris synechia | 1 supporting dataset | Chic2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.61x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Chic2.
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Chic2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
Chic2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Chic2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Chic2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |