Chic2 | cysteine-rich hydrophobic domain 2

GeneMGI:1921527Synonyms: 4930502K01Rik, 1700081B18Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

10 No significant impact

3 Not tested

Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

abnormal coat/hair pigmentation1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adult1.54x10-8 
enlarged spleen1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
increased circulating amylase level1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adult9.85x10-10 
enlarged ovary1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
preweaning lethality, incomplete penetrance1 supporting datasetChic2tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adult1.59x10-5 
iris synechia1 supporting datasetChic2tm1b(EUCOMM)WtsiheterozygoteEarly adult1.61x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a100% (2/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a100% (2/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Chic2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Chic2tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Chic2tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Chic2tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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