Cyld | CYLD lysine 63 deubiquitinase

GeneMGI:1921506Synonyms: 2010013M14Rik, 2900009M21Rik, +2 more

Physiological systems

16 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological

13 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity8 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.43x10-11 
increased basophil cell number2 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.96x10-35 
decreased exploration in new environment1 supporting datasetCyldem2(IMPC)MarchomozygoteEarly adult8.32x10-6 
increased grip strength1 supporting datasetCyldem2(IMPC)MarchomozygoteEarly adult5.97x10-9 
increased eosinophil cell number2 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.35x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cyldem2(IMPC)MarcDeletionmouse
Cyldtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)ES Cell
Cyldtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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