Gene Summary

Name:
coagulation factor XIII, A1 subunit
Synonyms:
1200014I03Rik,  Factor XIIIA

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Blood  Section images heterozygote 50% (1 of 2)
Bone marrow  Section images heterozygote 100% (2 of 2)
Brown adipose tissue  Section images heterozygote 100% (2 of 2)
Cecum  Section images heterozygote 100% (2 of 2)
Cerebellum  Section images heterozygote 50% (1 of 2)
Colon  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Esophagus  Section images heterozygote 100% (2 of 2)
Eye  Section images heterozygote 50% (1 of 2)
Gonadal fat pad  Section images heterozygote 50% (1 of 2)
Harderian gland  Section images heterozygote 50% (1 of 2)
Ileum  Section images heterozygote 100% (2 of 2)
Jejunum  Section images heterozygote 100% (2 of 2)
Lung  Section images heterozygote 50% (1 of 2)
Mesenteric lymph node  Section images heterozygote 50% (1 of 2)
Midbrain  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Penis  Section images heterozygote 50% (1 of 2)
Prostate gland  Section images heterozygote 50% (1 of 2)
Quadriceps  Section images heterozygote 50% (1 of 2)
Skin  Section images heterozygote 100% (2 of 2)
Spleen  Section images heterozygote 100% (2 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Thymus  Section images heterozygote 100% (2 of 2)
Tongue  Section images heterozygote 100% (2 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Trigeminal V nerve  Section images heterozygote 50% (1 of 2)
Urinary bladder  Section images heterozygote 50% (1 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Vas deferens  Section images heterozygote 50% (1 of 2)
Vesicular gland  Section images heterozygote 50% (1 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote Not available
Brainstem N/A heterozygote Not available
Cartilage tissue N/A heterozygote Not available
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote Not available
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote Not available
Parotid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Small intestine N/A heterozygote Not available
Spinal cord N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote Not available
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.7% (4 of 573)
aorta 0.18% (1 of 571)
blood 0.0%
bone marrow 0.0%
brain 0.53% (3 of 570)
brainstem 0.35% (2 of 564)
brown adipose tissue 0.0%
cartilage tissue 0.18% (1 of 569)
cecum 3.33% (12 of 360)
cerebellum 0.53% (3 of 565)
cerebral cortex 0.35% (2 of 565)
chest bone Unavailable
colon 9.6% (12 of 125)
diaphragm 0.0%
duodenum 1.63% (2 of 123)
epididymis 13.08% (17 of 130)
esophagus 1.8% (7 of 389)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.0%
heart 0.35% (2 of 566)
hindlimb 0.0%
hippocampus 0.53% (3 of 571)
hypothalamus 0.36% (2 of 560)
ileum 9.68% (12 of 124)
jejunum 4.84% (6 of 124)
kidney 3.72% (21 of 565)
large intestine 1.78% (10 of 561)
liver 0.0%
lower urinary tract 0.0%
lung 0.35% (2 of 577)
lymph node 0.18% (1 of 566)
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.0%
midbrain 0.0%
olfactory lobe 0.18% (1 of 553)
ovary 0.18% (1 of 566)
oviduct 0.0%
pancreas 0.89% (5 of 559)
parathyroid gland 0.18% (1 of 546)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.35% (2 of 574)
peyers patch 0.0%
pituitary gland 0.18% (1 of 570)
prostate gland 1.77% (10 of 564)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.18% (1 of 563)
small intestine 1.59% (9 of 565)
spinal cord 0.53% (3 of 566)
spleen 0.53% (3 of 566)
stomach 2.12% (12 of 565)
stomach pyloric region 0.0%
striatum 0.53% (3 of 567)
sublingual gland 0.0%
submandibular gland 1.56% (2 of 128)
testis 1.05% (6 of 572)
thymus 0.18% (1 of 567)
thyroid gland 2.84% (16 of 563)
tongue 3.25% (4 of 123)
trachea 0.53% (3 of 562)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vagina 0.0%
vas deferens 4.03% (15 of 372)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Hind Leg and Hip

8 Images

Adult LacZ

LacZ Images Section

92 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Lateral Orientation

8 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

8 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

8 Images

Human diseases caused by F13a1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to F13a1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Thrombophilia Due To Thrombin Defect
Pulmonary embolism OMIM:188050
Congenital Factor Xiii Deficiency
Cerebral hemorrhage, Ecchymosis, Menorrhagia, Recurrent spontaneous abortion, Gingival bleeding, ... ORPHA:331
Factor Xiii, A Subunit, Deficiency Of
Ecchymosis, Intracranial hemorrhage, Joint hemorrhage, Epistaxis, Spontaneous hematomas, Abnormal... OMIM:613225

The table below shows human diseases predicted to be associated to F13a1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Von Willebrand Disease, X-Linked Form
Abnormal bleeding, Prolonged bleeding time OMIM:314560
Tatsumi Factor Deficiency
Abnormal bleeding, Prolonged bleeding time OMIM:272650
Glanzmann Thrombasthenia 2
Menorrhagia, Impaired epinephrine-induced platelet aggregation, Impaired clot retraction, Epistax... OMIM:619267
Athrombia, Essential
Abnormal bleeding, Prolonged bleeding time, Impaired platelet aggregation, Impaired platelet adhe... OMIM:209050
Congenital Factor X Deficiency
Menorrhagia, Subarachnoid hemorrhage, Gingival bleeding, Post-partum hemorrhage, Prolonged prothr... ORPHA:328
Glanzmann Thrombasthenia
Ecchymosis, Menorrhagia, Gingival bleeding, Spontaneous, recurrent epistaxis, Impaired ristocetin... ORPHA:849
Glanzmann Thrombasthenia 1
Menorrhagia, Intracranial hemorrhage, Gingival bleeding, Impaired clot retraction, Epistaxis, Dec... OMIM:273800
Bleeding Disorder, Platelet-Type, 11
Ecchymosis, Menorrhagia, Epistaxis, Prolonged bleeding time, Bruising susceptibility OMIM:614201
Bleeding Disorder, Platelet-Type, 18
Epistaxis, Impaired platelet aggregation, Prolonged bleeding time OMIM:615888
Pseudo-Von Willebrand Disease
Prolonged bleeding time OMIM:177820
Bernard-Soulier Syndrome
Menorrhagia, Gingival bleeding, Epistaxis, Impaired ristocetin-induced platelet aggregation, Gast... OMIM:231200
Congenital Alpha2-Antiplasmin Deficiency
Intracranial hemorrhage, Gingival bleeding, Joint hemorrhage, Persistent bleeding after trauma, A... ORPHA:79
Alpha-2-Plasmin Inhibitor Deficiency
Hemothorax, Joint hemorrhage, Persistent bleeding after trauma, Bruising susceptibility OMIM:262850
Bleeding Disorder, Platelet-Type, 14
Ecchymosis, Bruising susceptibility, Epistaxis, Prolonged bleeding time OMIM:614158
Congenital Plasminogen Activator Inhibitor Type 1 Deficiency
Menorrhagia, Intracranial hemorrhage, Epidural hemorrhage, Post-partum hemorrhage, Joint hemorrha... ORPHA:465
Factor V Deficiency
Menorrhagia, Prolonged prothrombin time, Epistaxis, Prolonged bleeding time, Abnormal bleeding, B... OMIM:227400
Prothrombin Deficiency, Congenital
Ecchymosis, Menorrhagia, Gingival bleeding, Prolonged prothrombin time, Joint hemorrhage, Epistax... OMIM:613679
Von Willebrand Disease, Type 3
Menorrhagia, Joint hemorrhage, Epistaxis, Prolonged bleeding time, Abnormal bleeding, Prolonged b... OMIM:277480
Pulmonary Arteriovenous Malformation
Hypoxemia, Telangiectasia, Ischemic stroke, Palpitations, Epistaxis, Pulmonary arterial hypertens... ORPHA:2038
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Menorrhagia, Epistaxis, Myocardial infarction, Prolonged bleeding time, Abnormal bleeding, Bruisi... OMIM:155100
Hemophilia B
Intracranial hemorrhage, Joint hemorrhage, Spontaneous, recurrent epistaxis, Menometrorrhagia, Ce... ORPHA:98879
Platelet Glycoprotein Iv Deficiency
Abnormal bleeding, Prolonged bleeding time OMIM:608404
Pulmonary Capillary Hemangiomatosis
Right ventricular failure, Hypoxemia, Pulmonary capillary hemangiomatosis, Interlobular septal th... ORPHA:199241
Von Willebrand Disease, Type 1
Menorrhagia, Joint hemorrhage, Epistaxis, Gastrointestinal hemorrhage, Prolonged bleeding time, P... OMIM:193400
Slc35A1-Cdg
Hypoxemia, Pneumonia, Pulmonary hemorrhage, Subcutaneous hemorrhage, Respiratory distress, Prolon... ORPHA:238459
Gray Platelet Syndrome
Menorrhagia, Impaired thrombin-induced platelet aggregation, Epistaxis, Impaired collagen-induced... OMIM:139090
Sebastian syndrome
Epistaxis, Prolonged bleeding time OMIM:605249
Platelet Disorder, Undefined
Abnormal bleeding, Prolonged bleeding time, Impaired platelet aggregation OMIM:173420
Macrothrombocytopenia and progressive sensorineural deafness
Abnormal bleeding, Prolonged bleeding time, Bruising susceptibility OMIM:600208
Thrombocytopenia With Beta-Thalassemia, X-Linked
Petechiae, Epistaxis, Splenomegaly, Prolonged bleeding time, Bruising susceptibility OMIM:314050
Hermansky-Pudlak Syndrome 5
Menorrhagia, Epistaxis, Prolonged bleeding time, Abnormal bleeding, Bruising susceptibility OMIM:614074
Klippel-Trénaunay Syndrome
Hepatomegaly, Respiratory insufficiency, Abnormality of the menstrual cycle, Gastrointestinal hem... ORPHA:90308
Bleeding Disorder, Platelet-Type, 17
Ecchymosis, Petechiae, Epistaxis, Gastrointestinal hemorrhage, Prolonged bleeding time, Abnormal ... OMIM:187900
Crimean-Congo Hemorrhagic Fever
Myocarditis, Subdural hemorrhage, Melena, Splenomegaly, Acute pancreatitis, Diffuse alveolar hemo... ORPHA:99827
Congenital Factor Ii Deficiency
Menorrhagia, Intracranial hemorrhage, Prolonged bleeding following procedure, Post-partum hemorrh... ORPHA:325
Antithrombin Iii Deficiency
Pulmonary embolism, Arterial occlusion OMIM:613118
Myh9-Related Disease
Menorrhagia, Spontaneous, recurrent epistaxis, Myocardial infarction, Prolonged bleeding time, Br... ORPHA:182050
Fechtner syndrome
Abnormal bleeding, Menorrhagia, Prolonged bleeding time, Bruising susceptibility OMIM:153640
Congenital Factor Vii Deficiency
Menorrhagia, Intracranial hemorrhage, Gingival bleeding, Post-partum hemorrhage, Prolonged prothr... ORPHA:327
Blue Rubber Bleb Nevus
Prolonged bleeding time, Intestinal bleeding ORPHA:1059
Thrombocytopenia, Paris-Trousseau Type
Abnormal bleeding, Prolonged bleeding time OMIM:188025
Telangiectasia, Hereditary Hemorrhagic, Type 1
Spontaneous, recurrent epistaxis, Melena, Pulmonary arteriovenous malformation, Exertional dyspne... OMIM:187300
Aplasia Cutis Congenita
Prolonged bleeding time ORPHA:1114
Hermansky-Pudlak Syndrome 6
Epistaxis, Recurrent upper respiratory tract infections, Prolonged bleeding time, Impaired ADP-in... OMIM:614075
Neurofibromatosis-Noonan Syndrome
Hypertrophic cardiomyopathy, Prolonged bleeding time, Pulmonic stenosis ORPHA:638
Factor X Deficiency
Menorrhagia, Intracranial hemorrhage, Gingival bleeding, Prolonged prothrombin time, Joint hemorr... OMIM:227600
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Bruising susceptibility, Epistaxis, Impaired platelet aggregation, Prolonged bleeding time OMIM:601399
Storage Pool Platelet Disease
Abnormal bleeding, Prolonged bleeding time OMIM:185050
Combined Deficiency Of Factor V And Factor Viii
Menorrhagia, Intracranial hemorrhage, Gingival bleeding, Prolonged prothrombin time, Joint hemorr... ORPHA:35909
Thrombophilia Due To Thrombin Defect
Pulmonary embolism OMIM:188050
Hermansky-Pudlak Syndrome 1
Gingival bleeding, Epistaxis, Cardiomyopathy, Prolonged bleeding time, Pulmonary fibrosis, Restri... OMIM:203300
Deafness-Lymphedema-Leukemia Syndrome
Hepatomegaly, Intracranial hemorrhage, Splenomegaly, Prolonged bleeding time, Respiratory failure... ORPHA:3226
+173470 integrin, beta-3
Menorrhagia, Intracranial hemorrhage, Gingival bleeding, Epistaxis, Decreased platelet glycoprote... OMIM:173470
Essential Thrombocythemia
Myocardial infarction, Prolonged bleeding time, Transient ischemic attack, Splenomegaly ORPHA:3318
Thrombophilia Due To Protein C Deficiency, Autosomal Recessive
Vitreous hemorrhage, Purpura, Pulmonary embolism OMIM:612304
Mixed Connective Tissue Disease
Myocarditis, Hepatomegaly, Pericarditis, Pleuritis, Pulmonary arterial hypertension, Splenomegaly... ORPHA:809
Platelet Aggregation, Spontaneous
Abnormal platelet function, Spontaneous platelet aggregation OMIM:173400
Ehlers-Danlos Syndrome, Vascular Type
Ecchymosis, Pneumothorax, Pulmonary bleb, Arterial rupture, Pulmonary bulla, Recurrent intrapulmo... OMIM:130050
Long Qt Syndrome 13
Syncope, Hypertension, Prolonged QT interval, Atrial fibrillation, Atrioventricular block, Tachyc... OMIM:613485
Wiskott-Aldrich Syndrome
Sinusitis, Abnormal platelet function, Petechiae, Abnormality of the menstrual cycle, Recurrent i... ORPHA:906
Acquired Von Willebrand Syndrome
Menorrhagia, Intracranial hemorrhage, Mitral regurgitation, Prolonged prothrombin time, Joint hem... ORPHA:99147
Bleeding Disorder, Platelet-Type, 12
Menorrhagia, Joint hemorrhage, Epistaxis, Intestinal bleeding, Impaired platelet aggregation, Bru... OMIM:605735
Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency
Recurrent spontaneous abortion, Spontaneous abortion, Pulmonary embolism ORPHA:82
Pseudoxanthoma Elasticum-Like Disorder With Multiple Coagulation Factor Deficiency
Prolonged prothrombin time, Epistaxis, Abnormal bleeding OMIM:610842
Thrombophilia Due To Protein S Deficiency, Autosomal Recessive
Cerebral hemorrhage, Purpura, Pulmonary embolism OMIM:614514
Macs Syndrome
Prolonged bleeding time, Hypergonadotropic hypogonadism, Bruising susceptibility, Bronchiectasis OMIM:613075
Dentinogenesis Imperfecta
Prolonged bleeding time, Bruising susceptibility ORPHA:49042
Congenital Fibrinogen Deficiency
Splenic rupture, Gingival bleeding, Prolonged prothrombin time, Tachycardia, Subcutaneous hemorrh... ORPHA:335
Acquired Purpura Fulminans
Shock, Intracranial hemorrhage, Macular purpura, Prolonged prothrombin time, Internal hemorrhage ORPHA:49566
Multiple Osteochondromas
Hemothorax, Pneumothorax ORPHA:321
Wiskott-Aldrich Syndrome, Autosomal Dominant
Sinusitis, Gingival bleeding, Pneumonia, Epistaxis, Recurrent lower respiratory tract infections,... OMIM:600903
Pulmonary Hypertension, Primary, 4
Elevated pulmonary artery pressure, Pulmonary arterial hypertension, Increased pulmonary vascular... OMIM:615344
Wiskott-Aldrich Syndrome
Gingival bleeding, Petechiae, Epistaxis, Melena, Recurrent lower respiratory tract infections, La... OMIM:301000
Pulmonary Hypertension, Primary, 3
Dyspnea, Elevated pulmonary artery pressure, Pulmonary arterial hypertension, Increased pulmonary... OMIM:615343
Hermansky-Pudlak Syndrome 2
Hepatomegaly, Splenomegaly, Hepatosplenomegaly, Prolonged bleeding time, Recurrent pneumonia, Pul... OMIM:608233
Hepatoportal Sclerosis
Hepatocellular carcinoma, Prolonged prothrombin time, Nodular regenerative hyperplasia of liver, ... ORPHA:64743
Congenital Factor Xiii Deficiency
Cerebral hemorrhage, Ecchymosis, Menorrhagia, Recurrent spontaneous abortion, Gingival bleeding, ... ORPHA:331
Cardiogenic Shock
Right ventricular failure, Hypoxemia, Crackles, Mitral regurgitation, Low pulse pressure, Elevate... ORPHA:97292
Dermatosparaxis Ehlers-Danlos Syndrome
Prolonged bleeding time ORPHA:1901
Complete Atrioventricular Septal Defect
Right ventricular failure, Left-to-right shunt, Wheezing, Crackles, Third heart sound, Abnormal E... ORPHA:1329
Infantile Liver Failure Syndrome 2
Prolonged prothrombin time, Cardiomyopathy, Jaundice OMIM:616483
Relapsing Fever
Prolonged prothrombin time, Epistaxis, Tachycardia, Cough, Abnormal bleeding, Hypotension, Jaundice ORPHA:91547
Monosomy 13Q34
Prolonged prothrombin time, Epistaxis, Metrorrhagia, Pulmonic stenosis, Hepatic steatosis, Hemato... ORPHA:96168
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Dilated cardiomyopathy, Hepatomegaly, Respiratory insufficiency, Prolonged prothrombin time, Cirr... ORPHA:367
Factor Xiii, A Subunit, Deficiency Of
Ecchymosis, Intracranial hemorrhage, Joint hemorrhage, Epistaxis, Spontaneous hematomas, Abnormal... OMIM:613225
Acyl-Coa Dehydrogenase 9 Deficiency
Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Prolonged prothrombin time, Hepatic steatosi... ORPHA:99901
Infantile Liver Failure Syndrome 3
Hepatomegaly, Prolonged prothrombin time, Splenomegaly, Hepatic steatosis, Cholestasis, Hepatic b... OMIM:618641
Congenital Disorder Of Glycosylation, Type It
Dilated cardiomyopathy, Hepatomegaly, Increased hepatic glycogen content, Prolonged prothrombin t... OMIM:614921
Noonan Syndrome 9
Prolonged prothrombin time, Pulmonic stenosis OMIM:616559
Pulmonary Hypertension, Primary, 2
Pulmonary arterial hypertension, Increased pulmonary vascular resistance OMIM:615342
Hellp Syndrome
Cerebral hemorrhage, Prolonged prothrombin time, Pulmonary edema, Internal hemorrhage, Pleural ef... ORPHA:244242
Cholestasis, Progressive Familial Intrahepatic, 5
Prolonged prothrombin time, Pleural effusion, Cirrhosis, Jaundice OMIM:617049
Cog8-Cdg
Prolonged prothrombin time, Spontaneous hematomas ORPHA:95428
Sialuria
Hepatomegaly, Prolonged prothrombin time, Cholelithiasis, Upper airway obstruction, Hepatosplenom... ORPHA:3166
Classical Ehlers-Danlos Syndrome
Ecchymosis, Mitral regurgitation, Orthostatic hypotension, Arterial rupture, Prolonged bleeding t... ORPHA:287
Congenital Bile Acid Synthesis Defect Type 2
Abnormality of the intrahepatic bile duct, Hepatomegaly, Giant cell hepatitis, Prolonged prothrom... ORPHA:79303
S-Adenosylhomocysteine Hydrolase Deficiency
Hepatocellular carcinoma, Prolonged prothrombin time, Cardiomyopathy, Abnormality of the liver, R... ORPHA:88618
Congenital Disorder Of Glycosylation, Type Ia
Hepatomegaly, Hepatic fibrosis, Prolonged prothrombin time, Cardiomyopathy, Hepatic steatosis, Pr... OMIM:212065
Yellow Fever
Shock, Reduced ejection fraction, Prolonged prothrombin time, Hematemesis, Bradycardia, Excessive... ORPHA:99829
Combined Oxidative Phosphorylation Deficiency 37
Hypertrophic cardiomyopathy, Respiratory insufficiency, Prolonged prothrombin time, Bile duct pro... OMIM:618329
Acute Liver Failure
Shock, Intracranial hemorrhage, Hepatocellular necrosis, Abnormal respiratory system physiology, ... ORPHA:90062
Isolated Biliary Atresia
Hepatomegaly, Acholic stools, Prolonged prothrombin time, Bile duct proliferation, Atretic gallbl... ORPHA:30391
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Prolonged QT interval, Prolonged prothrombin... ORPHA:71212
Marburg Hemorrhagic Fever
Shock, Pericarditis, Petechiae, Prolonged prothrombin time, Subconjunctival hemorrhage, Tachycard... ORPHA:99826
Primary Sclerosing Cholangitis
Spider hemangioma, Hepatomegaly, Neoplasm of the gallbladder, Cholangiocarcinoma, Hepatic fibrosi... ORPHA:171
3-Hydroxy-3-Methylglutaric Aciduria
Dilated cardiomyopathy, Hepatomegaly, Prolonged prothrombin time, Tachypnea, Lipid accumulation i... ORPHA:20
Kasabach-Merritt Syndrome
Hypopnea, Petechiae, Prolonged prothrombin time, Respiratory distress, Purpura, Hyperhidrosis, He... ORPHA:2330
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Prolonged prothrombin time, Intraventricular hemorrhage OMIM:619055
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypertrophic cardiomyopathy, Hepatomegaly, Prolonged prothrombin time, Micronodular cirrhosis, Sp... ORPHA:309854
Shwachman-Diamond Syndrome 2
Prolonged prothrombin time, Exocrine pancreatic insufficiency, Hyperechogenic pancreas, Hepatomegaly OMIM:617941
Hemophagocytic Lymphohistiocytosis, Familial, 1
Prolonged prothrombin time, Jaundice, Hepatomegaly, Splenomegaly OMIM:267700
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hepatomegaly, Prolonged prothrombin time, Splenomegaly, Hepatosplenomegaly, Jaundice OMIM:603553
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Hepatomegaly, Prolonged prothrombin time, Hepatic steatosis, Gastrointestinal hemorrhage, Hepatos... ORPHA:247598
Celiac Disease, Susceptibility To, 1
Prolonged prothrombin time, Infertility OMIM:212750
Abetalipoproteinemia
Hepatomegaly, Hepatic fibrosis, Prolonged prothrombin time, Abnormal bleeding, Cirrhosis, Hepatic... ORPHA:14
Alg12-Cdg
Prolonged prothrombin time, Chronic rhinitis, Recurrent pneumonia, Recurrent pharyngitis, Recurre... ORPHA:79324
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Hepatomegaly, Microvesicular hepatic steatosis, Obstructive sleep apnea, Prolonged prothrombin ti... ORPHA:404454
Congenital Disorder Of Glycosylation, Type Iiw
Hepatomegaly, Increased hepatic echogenicity, Prolonged prothrombin time, Bile duct proliferation... OMIM:619525

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for F13a1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to F13a1.

No publications found that use IMPC mice or data for F13a1.

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MGI Allele Allele Type Produced
F13a1tm388122(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
F13a1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
F13a1em1H Point Mutation Mice
F13a1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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