Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

forkhead box P4
2310007G05Rik,  1200010K03Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Foxp4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxp4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Microhydranencephaly, X-Linked
Holoprosencephaly OMIM:306990
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Frontal Encephalocele
Encephalocele, Hydrocephalus, Spina bifida ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Hydrocephalus, Holoprosencephaly OMIM:617967
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Holoprosencephaly 5
Syntelencephaly, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosenceph... OMIM:609637
Delpire-Mcneill Syndrome
Ventricular septal defect, Tracheoesophageal fistula, Dysphagia OMIM:619083
Laryngotracheoesophageal Cleft Type 4
Tracheal stenosis, Abnormal cardiac septum morphology, Tracheoesophageal fistula, Intestinal atresia ORPHA:93941
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Vissers-Bodmer Syndrome
Holoprosencephaly OMIM:619033
Congenital Alveolar Capillary Dysplasia
Bicuspid aortic valve, Ventricular septal defect, Aganglionic megacolon, Intestinal malrotation, ... ORPHA:210122
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Atrial Septal Defect 2
Aortic regurgitation, Ventricular septal defect, Dextrocardia, Patent ductus arteriosus, Mitral r... OMIM:607941
Tracheoesophageal Fistula With Or Without Esophageal Atresia
Esophageal atresia, Tracheoesophageal fistula OMIM:189960
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
17Q12 Microduplication Syndrome
Atrial septal defect, Tracheoesophageal fistula, Cleft palate ORPHA:261272
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Dextrocardia, Esophageal atresia, Tracheoesophageal fistula, Transposition of the great arteries,... OMIM:314390
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Caudal Duplication
Myelomeningocele, Spinal cord lesion, Spina bifida ORPHA:1756
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Chiari Malformation Type Ii
Spina bifida, Myelomeningocele, Hydrocephalus, Cervical myelopathy, Syringomyelia OMIM:207950
Ossification Of The Posterior Longitudinal Ligament Of Spine
Spinal cord compression, Myelopathy OMIM:602475
Methimazole Embryofetopathy
Esophageal atresia, Ventricular septal defect, Tracheoesophageal fistula ORPHA:1923
Schisis Association
Encephalocele, Anencephaly, Spina bifida ORPHA:63862
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly ORPHA:2182
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Holoprosencephaly OMIM:600674
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holoprosencephaly ORPHA:1908
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Anterior encephalocele OMIM:601357
Hartsfield Syndrome
Encephalocele, Lobar holoprosencephaly ORPHA:2117
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Distal Deletion 13Q
Encephalocele, Anencephaly, Holoprosencephaly ORPHA:1590
Joubert Syndrome 15
Exencephaly OMIM:614464
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Holoprosencephaly ORPHA:2570
Congenital Contractural Arachnodactyly
Intestinal malrotation, Tracheoesophageal fistula, Mitral valve prolapse, High palate, Duodenal a... ORPHA:115
Ciliary Dyskinesia, Primary, 39
Double outlet right ventricle, Bronchiectasis, Dextrocardia OMIM:618254
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Congenital Herpes Simplex Virus Infection
Hydranencephaly ORPHA:293
Atrioventricular Septal Defect, Susceptibility To, 2
Atrioventricular canal defect, Dextrocardia OMIM:606217
Congenital Tracheomalacia
Ventricular septal defect, Bronchomalacia, Tracheomalacia, Cardiomegaly, Anomalous tracheal carti... ORPHA:95430
Thanatophoric Dysplasia Type 2
Encephalocele, Hydrocephalus, Holoprosencephaly ORPHA:93274
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Esophageal atresia, Patent ductus arteriosus, Ventricular septal defect, Tracheoesophageal fistula ORPHA:77298
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Hydrocephalus, Myelomeningocele, Anencephaly OMIM:182940
Martinez-Frias Syndrome
Intestinal hypoplasia, Jejunal atresia, Intestinal malrotation, Tracheoesophageal fistula, Duoden... OMIM:601346
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Holoprosencephaly ORPHA:83463
Hereditary Mucoepithelial Dysplasia
Anorectal anomaly, Tracheoesophageal fistula, Furrowed tongue ORPHA:1839
Ring Chromosome 21 Syndrome
Holoprosencephaly ORPHA:1445
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Distal Monosomy 7Q36
Holoprosencephaly ORPHA:1636
Spina bifida, Sirenomelia ORPHA:3169
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Esophageal atresia, Muscular ventricular septal defect, Submucous cleft hard palate, Tracheoesoph... OMIM:619227
Fanconi Anemia, Complementation Group B
Ventricular septal defect, Esophageal atresia, Patent ductus arteriosus, Tracheoesophageal fistul... OMIM:300514
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Thoraco-Abdominal Enteric Duplication
Intestinal malrotation, Abnormal tricuspid valve morphology, Dextrocardia, Duodenal stenosis ORPHA:1759
Methylmalonic Aciduria And Homocystinuria, Cblf Type
Dextrocardia, Patent ductus arteriosus, Tracheoesophageal fistula, High palate, Atrial septal def... OMIM:277380
Encephalocele, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dysraphism, Syr... ORPHA:63259
Congenital Tracheal Stenosis
Ventricular septal defect, Abnormal bronchus morphology, Abnormal stomach morphology, Patent duct... ORPHA:141127
Czeizel-Losonci Syndrome
Tracheoesophageal fistula, High palate, Dextrocardia ORPHA:2437
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:3376
Anaplastic Thyroid Carcinoma
Laryngotracheal stenosis, Tracheoesophageal fistula, Dysphagia ORPHA:142
Congenital Pseudoarthrosis Of The Clavicle
Situs inversus totalis, Dextrocardia ORPHA:66630
Infantile Myofibromatosis
Intestinal obstruction, Abnormal intestine morphology, Tracheoesophageal fistula ORPHA:2591
Congenitally Corrected Transposition Of The Great Arteries
Wolff-Parkinson-White syndrome, Atrial situs ambiguous, First degree atrioventricular block, Hear... ORPHA:216694
Thakker-Donnai Syndrome
Ventricular septal defect, Tracheoesophageal fistula, Rectovaginal fistula, Transposition of the ... ORPHA:1780
Lambotte Syndrome
Semilobar holoprosencephaly OMIM:245552
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Bicuspid aortic valve, Parachute mitral valve, Neonatal death, Atrial septal defect, Atrioventric... OMIM:265380
Vacterl/Vater Association
Anorectal anomaly, Tracheoesophageal fistula, Cleft palate, Abnormal cardiac septum morphology, T... ORPHA:887
Axial Mesodermal Dysplasia Spectrum
Anorectal anomaly, Tracheoesophageal fistula, Gastroesophageal reflux, Abnormal intestine morphol... ORPHA:1834
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Phosphoribosylaminoimidazole Carboxylase Deficiency
Neonatal death, Esophageal atresia, Tracheoesophageal fistula OMIM:619859
Esophageal Atresia
Barrett esophagus, Ventricular septal defect, Intestinal malrotation, Pyloric stenosis, Gastroint... ORPHA:1199
Acces Syndrome
Tracheoesophageal fistula OMIM:619959
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility
Situs inversus totalis, Dextrocardia OMIM:618948
Total Anomalous Pulmonary Venous Return 1
Pulmonary arterial hypertension, Total anomalous pulmonary venous return, Dextrocardia OMIM:106700
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Microgastria-Limb Reduction Defect Syndrome
Intestinal malrotation, Hiatus hernia, Esophageal atresia, Rectal atresia, Tracheoesophageal fist... ORPHA:2538
Esophageal atresia, Aganglionic megacolon, Tracheoesophageal fistula, Anal atresia ORPHA:59315
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Ciliary Dyskinesia, Primary, 17
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:614679
Ciliary Dyskinesia, Primary, 7
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:611884
Monosomy 18P
Holoprosencephaly ORPHA:1598
Heterotaxy, Visceral, 6, Autosomal
Dextrocardia, Situs inversus totalis, Double outlet right ventricle, Hypoplastic left heart, Tran... OMIM:614779
Toxic Epidermal Necrolysis
Gastrointestinal hemorrhage, Sudden cardiac death, Malabsorption, Intestinal perforation, Tracheo... ORPHA:537
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly ORPHA:250999
Intellectual Disability-Myopathy-Short Stature-Endocrine Defect Syndrome
Tracheoesophageal fistula ORPHA:3068
Opitz Gbbb Syndrome
Ventricular septal defect, Tracheomalacia, Patent ductus arteriosus, Tracheoesophageal fistula, C... ORPHA:2745
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Feingold Syndrome 1
Ventricular septal defect, Tricuspid stenosis, Jejunal atresia, Esophageal atresia, Patent ductus... OMIM:164280
Acrodysplasia Scoliosis
Spina bifida occulta ORPHA:2956
Heterotaxy, Visceral, 7, Autosomal
Dextrocardia, Mitral atresia, Intestinal malrotation, Situs inversus totalis, Common atrium, Hypo... OMIM:616749
Ciliary Dyskinesia, Primary, 37
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:617577
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Septo-Optic Dysplasia Spectrum
Esophageal atresia, Tracheoesophageal fistula, Cleft palate ORPHA:3157
Heterotaxy, Visceral, 2, Autosomal
Dextrocardia, Intestinal malrotation, Situs inversus totalis, Atrioventricular canal defect, Left... OMIM:605376
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly ORPHA:2163
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Short Stature-Wormian Bones-Dextrocardia Syndrome
Patent ductus arteriosus, High palate, Dextrocardia, Anal atresia ORPHA:2863
Ciliary Dyskinesia, Primary, 38
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:618063
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Solitary Median Maxillary Central Incisor
Holoprosencephaly OMIM:147250
Chronic Granulomatous Disease
Pyloric stenosis, Tracheoesophageal fistula, Malabsorption ORPHA:379
Mycophenolate Mofetil Embryopathy
Tracheomalacia, Ventricular septal defect, Tracheoesophageal fistula ORPHA:268249
Arachnoid Cyst
Encephalocele, Spinal cord compression, Spinal arachnoid cyst, Hydrocephalus, Abnormal spinal men... ORPHA:2356
Sacral Defect With Anterior Meningocele
Myeloschisis, Tethered cord, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract, Hy... OMIM:600145
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Van Esch-O'Driscoll Syndrome
Ventricular septal defect, Esophageal atresia, Tracheoesophageal fistula, Atrial septal defect, P... OMIM:301030
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:253800
Pseudotrisomy 13 Syndrome
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:264480
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Meningocele, Spina bifida ORPHA:1393
Cardiac Diverticulum
Bicuspid aortic valve, Bicuspid pulmonary valve, Ventricular tachycardia, Atrial septal defect, P... ORPHA:1686
Diabetic Embryopathy
Hydrocephalus, Spinal dysraphism ORPHA:1926
Acro-Renal-Mandibular Syndrome
Tracheoesophageal fistula, High palate, Aplasia/Hypoplasia of the tongue ORPHA:958
Right Atrial Isomerism
Right atrial isomerism, Ventricular septal defect, Dextrocardia, Situs inversus totalis, Complete... OMIM:208530
Fanconi Anemia, Complementation Group D2
Esophageal atresia, Patent ductus arteriosus, Tracheoesophageal fistula, Abnormal heart morphology OMIM:227646
Ciliary Dyskinesia, Primary, 25
Situs inversus totalis, Bronchiectasis, Gastroesophageal reflux, Dextrocardia OMIM:615482
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly OMIM:612530
Ciliary Dyskinesia, Primary, 2
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:606763
Fanconi Anemia
Meckel diverticulum, Aganglionic megacolon, Aplasia/Hypoplasia of the uvula, Patent ductus arteri... ORPHA:84
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Ciliary Dyskinesia, Primary, 30
Situs inversus totalis, Bronchiectasis, Ventricular septal defect, Dextrocardia OMIM:616037
Renal Agenesis, Bilateral
Abnormal intestine morphology, Tracheoesophageal fistula, Cleft palate ORPHA:1848
Meckel Syndrome 14
Occipital encephalocele, Holoprosencephaly OMIM:619879
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi
Tethered cord, Spinal dysraphism OMIM:612918
Wildervanck Syndrome
Meningocele ORPHA:3456
49,Xxxxy Syndrome
Holoprosencephaly ORPHA:96264
Heterotaxy, Visceral, 8, Autosomal
Atrial situs inversus, Atrial situs ambiguous, Ventricular septal defect, Dextrocardia, Hypoplast... OMIM:617205
Pancreatic Agenesis-Holoprosencephaly Syndrome
Holoprosencephaly, Semilobar holoprosencephaly ORPHA:556955
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
46,Xx Difference Of Sex Development-Anorectal Anomalies Syndrome
Tracheoesophageal fistula, Intestinal malrotation, Anal atresia ORPHA:2973
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Abnormal EKG, Dextrocardia, Intestinal malrotation, Situs inversus totalis, Abnormal heart morpho... ORPHA:1666
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Tethered cord, Spinal dysraphism OMIM:617660
Short-Rib Thoracic Dysplasia 12
Neonatal death, Hydrocephalus, Anencephaly, Holoprosencephaly OMIM:269860
Heterotaxy, Visceral, 4, Autosomal
Ventricular septal defect, Dextrocardia, Complete atrioventricular canal defect, Dextrotransposit... OMIM:613751
Trisomy 18
Anencephaly, Holoprosencephaly, Spina bifida ORPHA:3380
Isolated Posterior Meningocele
Tethered cord, Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Hydromyelia,... ORPHA:268810
Dyskeratosis Congenita
Esophageal stenosis, Telangiectasia of the skin, Malabsorption, Anorectal anomaly, Tracheoesophag... ORPHA:1775
Holoprosencephaly-Postaxial Polydactyly Syndrome
Encephalocele, Umbilical hernia, Hydrocephalus, Holoprosencephaly ORPHA:2166
Microform Holoprosencephaly
Holoprosencephaly ORPHA:280200
Vacterl With Hydrocephalus
Esophageal atresia, Tracheoesophageal fistula, Anal atresia ORPHA:3412
Holoprosencephaly 14
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly, Alobar holoprosencephaly OMIM:619895
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
16P13.11 Microdeletion Syndrome
Holoprosencephaly ORPHA:261236
Chromosome 17P13.1 Deletion Syndrome
Umbilical hernia, Hydrocephalus, Spina bifida OMIM:613776
Fanconi Anemia, Complementation Group L
Esophageal atresia, Anal atresia, Tracheoesophageal fistula, Cleft palate OMIM:614083
Scimitar Syndrome
Left-to-right shunt, Ventricular septal defect, Dextrocardia, Mitral atresia, Heart block, Conges... ORPHA:185
Encephalocele, Hydrocephalus, Spinal cord tumor, Spinal dysraphism, Branchial anomaly, Holoprosen... ORPHA:2162
Congenital Heart Defects, Multiple Types, 8, With Or Without Heterotaxy
Ventricular septal defect, Dextrocardia, Intestinal malrotation, Patent ductus arteriosus, Partia... OMIM:619657
Williams Syndrome
Bicuspid aortic valve, Myocardial infarction, Cardiomegaly, Rectal prolapse, Gastroesophageal ref... ORPHA:904
Phakomatosis Pigmentokeratotica
Spina bifida ORPHA:2874
Ciliary Dyskinesia, Primary, 22
Situs inversus totalis, Bronchiectasis, Dextrocardia OMIM:615444
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Treacher-Collins Syndrome
Patent ductus arteriosus, Tracheoesophageal fistula, Cleft palate, Glossoptosis, High palate, Rec... ORPHA:861
Heterotaxy, Visceral, 10, Autosomal, With Male Infertility
Situs inversus totalis, Dextrocardia OMIM:619607
Limb Body Wall Complex
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Abnormal spinal cord m... ORPHA:2369
Trisomy 20P
Umbilical hernia, Spina bifida ORPHA:261318
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Meningocele, Anencephaly OMIM:611134
Penile Agenesis
Ventricular septal defect, Rectal fistula, Anorectal anomaly, Tracheoesophageal fistula, Atrial s... ORPHA:49
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2
Spinal dysraphism OMIM:603546
Phocomelia, Schinzel Type
High, narrow palate, Anal atresia, Tracheoesophageal fistula, Cleft palate ORPHA:2879
Hydrocephalus, Holoprosencephaly OMIM:612651
Halperin-Birk Syndrome
Umbilical hernia, Semilobar holoprosencephaly OMIM:618651
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Lobar holoprosencephaly OMIM:614701
Poland Syndrome
Dextrocardia OMIM:173800
Developmental And Epileptic Encephalopathy 66
Atrial septal defect, Ventricular septal defect, Dextrocardia OMIM:618067
Vater/Vacterl Association
Ventricular septal defect, Esophageal atresia, Patent ductus arteriosus, Tracheoesophageal fistul... OMIM:192350
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Cardiac-Urogenital Syndrome
Cor triatrium sinister, Tachycardia, Ventricular septal defect, Dextrocardia, Coronary sinus enla... OMIM:618280
Charge Syndrome
Abnormal soft palate morphology, Patent ductus arteriosus, Tracheoesophageal fistula, Cleft palat... ORPHA:138
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Meckel Syndrome, Type 2
Encephalocele, Meningocele, Anencephaly OMIM:603194
Nail-Patella Syndrome
Spina bifida OMIM:161200
Pagod Syndrome
Encephalocele, Meningocele, Spina bifida ORPHA:991
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Exencephaly ORPHA:2211
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Charge Syndrome
Anal stenosis, Overriding aorta, Ventricular septal defect, Secundum atrial septal defect, Esopha... OMIM:214800
Pallister-Hall Syndrome
Neonatal death, Holoprosencephaly OMIM:146510
Primary Pulmonary Hypoplasia
Secundum atrial septal defect, Dextrocardia, Cleft palate, Abnormal tracheal morphology ORPHA:2257
Ulnar Hemimelia
Spinal dysraphism ORPHA:93320
Fibular Hemimelia
Spina bifida ORPHA:93323
Proximal 16P11.2 Microdeletion Syndrome
Dextrocardia, Pyloric stenosis, Cleft palate, Abnormal heart morphology, Abnormal aortic valve mo... ORPHA:261197
Jacobsen Syndrome
Hydrocephalus, Holoprosencephaly OMIM:147791
Heterotaxy, Visceral, 1, X-Linked
Cardiomegaly, Dextrotransposition of the great arteries, Atrial septal defect, Atrioventricular c... OMIM:306955
Neurofibromatosis, Type I
Aqueductal stenosis, Hydrocephalus, Spina bifida OMIM:162200
Basal Cell Nevus Syndrome 1
Hydrocephalus, Spina bifida OMIM:109400
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Heterotaxy, Visceral, 5, Autosomal
Atrial reentry tachycardia, Right atrial isomerism, Ventricular septal defect, Dextrocardia, Inte... OMIM:270100
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Neonatal death, Semilobar holoprosencephaly, Lobar holoprosencephaly OMIM:618500
Heterotaxy, Visceral, 12, Autosomal
Ventricular septal defect, Dextrocardia, Situs inversus totalis, Common atrium, Patent ductus art... OMIM:619702
Split Cord Malformation
Tethered cord, Cervical spina bifida, Myelomeningocele, Lipomyelomeningocele, Meningocele, Hydroc... ORPHA:573278
Townes-Brocks Syndrome 1
Anal stenosis, Rectoperineal fistula, Ventricular septal defect, Tracheoesophageal fistula, Recto... OMIM:107480
Hartsfield Syndrome
Semilobar holoprosencephaly, Lobar holoprosencephaly, Alobar holoprosencephaly OMIM:615465
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Situs inversus totalis, Hypertension, Dextrocardia OMIM:613095
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Meacham Syndrome
Bicuspid aortic valve, Ventricular septal defect, Dextrocardia, Patent ductus arteriosus, Partial... OMIM:608978
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome
Atrioventricular canal defect, Tricuspid regurgitation, High palate, Dextrocardia OMIM:618929
Johanson-Blizzard Syndrome
Dextrocardia, Malabsorption, Anteriorly placed anus, Abnormal cardiac septum morphology, Anal atr... ORPHA:2315
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Meckel Syndrome
Encephalocele, Hydrocephalus, Anencephaly, Lobar holoprosencephaly ORPHA:564
Ciliary Dyskinesia, Primary, 20
Atrial situs inversus, Ventricular septal defect, Dextrocardia, Situs inversus totalis, Double ou... OMIM:615067
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly ORPHA:1052
Marden-Walker Syndrome
Dextrocardia, High, narrow palate, Pyloric stenosis, Cleft palate, Zollinger-Ellison syndrome, Hi... OMIM:248700
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Monosomy 13Q14
Holoprosencephaly ORPHA:1587
Spondylocostal Dysostosis 4, Autosomal Recessive
Situs inversus totalis, Anal stenosis, Ectopic anus, Dextrocardia OMIM:613686
Chromosome 13Q14 Deletion Syndrome
Umbilical hernia, Holoprosencephaly OMIM:613884
Holoprosencephaly 9
Hydrocephalus, Holoprosencephaly OMIM:610829
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Tethered cord, Spina bifida OMIM:619480
Holoprosencephaly 13, X-Linked
Semilobar holoprosencephaly, Alobar holoprosencephaly OMIM:301043
Bardet-Biedl Syndrome 17
Situs inversus totalis, Dextrocardia OMIM:615994
Smith-Lemli-Opitz Syndrome
Holoprosencephaly ORPHA:818
Aicardi Syndrome
Spina bifida OMIM:304050
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Holoprosencephaly 2
Semilobar holoprosencephaly, Holoprosencephaly, Alobar holoprosencephaly OMIM:157170
Neu-Laxova Syndrome 1
Hydranencephaly, Spina bifida, Stillbirth, Short umbilical cord, Small placenta, Neonatal death OMIM:256520
Campomelic Dysplasia
Hydrocephalus, Spina bifida, Spinal dysraphism OMIM:114290
Thrombocytopenia-Absent Radius Syndrome
Syringomyelia, Spina bifida OMIM:274000
22Q11.2 Deletion Syndrome
Spina bifida, Hydrocephalus, Meningocele, Occipital myelomeningocele, Umbilical hernia ORPHA:567
Koolen-De Vries Syndrome Due To A Point Mutation
Hydrocephalus, Spina bifida, Dural ectasia ORPHA:363965
17Q21.31 Microdeletion Syndrome
Hydrocephalus, Spina bifida, Dural ectasia ORPHA:363958
Jacobsen Syndrome
Spina bifida ORPHA:2308
Thoracoabdominal Syndrome
Patent ductus arteriosus, Transposition of the great arteries, Cleft palate, Ectopia cordis OMIM:313850
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Lobar holoprosencephaly ORPHA:468631
Smith-Lemli-Opitz Syndrome
Hydrocephalus, Holoprosencephaly OMIM:270400
Orofaciodigital Syndrome Xiv
Occipital encephalocele, Holoprosencephaly OMIM:615948
Holoprosencephaly 1
Ethmocephaly, Alobar holoprosencephaly OMIM:236100
Joubert Syndrome With Ocular Defect
Aganglionic megacolon, Dextrocardia, Cleft palate ORPHA:220493
Ring Chromosome 7 Syndrome
Holoprosencephaly ORPHA:1449
Chromosome 15Q25 Deletion Syndrome
Ventricular septal defect, Dextrocardia, Cleft palate, Coronary artery fistula, Abnormal cardiac ... OMIM:614294
Congenital Total Pulmonary Venous Return Anomaly
Atrial situs ambiguous, Cardiomegaly, Mixed total anomalous pulmonary venous connection, Atrial s... ORPHA:99125
8P Inverted Duplication/Deletion Syndrome
High, narrow palate, Tetralogy of Fallot, Dextrocardia, Abnormal heart morphology ORPHA:96092
Proboscis Lateralis
Holoprosencephaly ORPHA:141099
Rubinstein-Taybi Syndrome 1
Spina bifida occulta, Spina bifida OMIM:180849
Cartilage-Hair Hypoplasia
Spinal dysraphism ORPHA:175
Distal Duplication 5Q
Ventricular septal defect, Dextrocardia ORPHA:96097
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Semilobar holoprosencephaly OMIM:301044
Otopalatodigital Syndrome, Type Ii
Umbilical hernia, Hydrocephalus, Stillbirth, Spina bifida OMIM:304120
Knobloch Syndrome
Pyloric stenosis, Patent ductus arteriosus, Dextrocardia ORPHA:1571
Marden-Walker Syndrome
Ventricular septal defect, Dextrocardia, Situs inversus totalis, Pyloric stenosis, Submucous clef... ORPHA:2461
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly ORPHA:95494
Ellis Van Creveld Syndrome
Ventricular septal defect, Dextrocardia, Abnormal heart valve morphology, Situs inversus totalis,... ORPHA:289
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Pallister-Hall Syndrome
Umbilical hernia, Holoprosencephaly ORPHA:672
Constricting Bands, Congenital
Ectopia cordis, Cleft palate OMIM:217100
Biliary, Renal, Neurologic, And Skeletal Syndrome
Secundum atrial septal defect, Primum atrial septal defect, Inlet ventricular septal defect, Gast... OMIM:619534
Neurooculorenal Syndrome
Dextrocardia, Intestinal malrotation, Mitral valve prolapse, Anteriorly placed anus, Tetralogy of... OMIM:620305
Kyphoscoliotic Ehlers-Danlos Syndrome
Bicuspid aortic valve, Dextrocardia, Cerebral hemorrhage, Subdural hemorrhage, Arterial rupture, ... ORPHA:536545
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Large placenta, Spinal dysraphism ORPHA:96334
Catel-Manzke Syndrome
Overriding aorta, Ventricular septal defect, Dextrocardia, Cleft palate, Glossoptosis, High palat... OMIM:616145
Tetrasomy 9P
Pericarditis, Dextrocardia, Raynaud phenomenon, Cleft palate, Abnormal cardiac septum morphology,... ORPHA:3310
Microphthalmia, Syndromic 2
Ventricular septal defect, Dextrocardia, Patent ductus arteriosus, Submucous cleft hard palate, D... OMIM:300166
Carpenter Syndrome 2
Tricuspid regurgitation, Dextrocardia, Situs inversus totalis, High, narrow palate, Patent ductus... OMIM:614976
Restrictive Dermopathy
Dextrocardia, Patent ductus arteriosus, Submucous cleft hard palate, Transposition of the great a... ORPHA:1662
Floating-Harbor Syndrome
Celiac disease, Tetralogy of Fallot, Gastroesophageal reflux, Atrial septal defect, Mesocardia ORPHA:2044
Floating-Harbor Syndrome
Atrial septal defect, Mesocardia, Celiac disease OMIM:136140
Poland Syndrome
Atrial septal defect, Dextrocardia ORPHA:2911


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxp4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxp4.

No publications found that use IMPC mice or data for Foxp4.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Foxp4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Foxp4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Foxp4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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