Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

forkhead box P4
2310007G05Rik,  1200010K03Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Foxp4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxp4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydrocephalus, Hydranencephaly, Holoprosencephaly OMIM:617967
Hydrocephalus, Spina bifida, Holoprosencephaly ORPHA:945
Microhydranencephaly, X-Linked
Holoprosencephaly OMIM:306990
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Frontal Encephalocele
Hydrocephalus, Spina bifida, Encephalocele ORPHA:1931
Holoprosencephaly 5
Hydrocephalus, Alobar holoprosencephaly, Holoprosencephaly, Syntelencephaly, Semilobar holoprosen... OMIM:609637
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Delpire-Mcneill Syndrome
Ventricular septal defect, Tracheoesophageal fistula, Dysphagia OMIM:619083
Laryngotracheoesophageal Cleft Type 4
Abnormal cardiac septum morphology, Tracheoesophageal fistula, Tracheal stenosis, Intestinal atresia ORPHA:93941
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Congenital Alveolar Capillary Dysplasia
Pulmonary valve atresia, Bicuspid aortic valve, Anal atresia, Atrial septal defect, Aortic valve ... ORPHA:210122
Vissers-Bodmer Syndrome
Holoprosencephaly OMIM:619033
Atrial Septal Defect 2
Atrial septal defect, Atrioventricular canal defect, Pulmonic stenosis, Mitral regurgitation, Ven... OMIM:607941
Tracheoesophageal Fistula With Or Without Esophageal Atresia
Tracheoesophageal fistula, Esophageal atresia OMIM:189960
17Q12 Microduplication Syndrome
Tracheoesophageal fistula, Atrial septal defect, Cleft palate ORPHA:261272
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Ossification Of The Posterior Longitudinal Ligament Of Spine
Myelopathy, Spinal cord compression OMIM:602475
Methimazole Embryofetopathy
Ventricular septal defect, Tracheoesophageal fistula, Esophageal atresia ORPHA:1923
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Anal atresia, Tracheoesophageal fistula, Transposition of the great arteries, Atrioventricular ca... OMIM:314390
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Hydrocephalus, Aqueductal stenosis, Holoprosencephaly ORPHA:2182
Distal Monosomy 13Q
Encephalocele, Anencephaly, Holoprosencephaly ORPHA:1590
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Holoprosencephaly ORPHA:2570
Holoprosencephaly OMIM:600674
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Anterior encephalocele, Holoprosencephaly OMIM:601357
Nevus Comedonicus Syndrome
Spina bifida, Spina bifida occulta ORPHA:64754
Neural Tube Defects, Susceptibility To
Myelomeningocele, Hydrocephalus, Anencephaly, Spina bifida occulta OMIM:182940
Caudal Duplication
Myelomeningocele, Spina bifida, Spinal cord lesion ORPHA:1756
Schisis Association
Encephalocele, Spina bifida, Anencephaly ORPHA:63862
Aminopterin/Methotrexate Embryofetopathy
Hydrocephalus, Holoprosencephaly, Anencephaly, Spinal dysraphism, Meningocele, Encephalocele ORPHA:1908
Chiari Malformation Type Ii
Myelomeningocele, Hydrocephalus, Syringomyelia, Spina bifida, Cervical myelopathy OMIM:207950
Hartsfield Syndrome
Encephalocele, Lobar holoprosencephaly ORPHA:2117
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Congenital Herpes Simplex Virus Infection
Hydranencephaly ORPHA:293
Congenital Contractural Arachnodactyly
High palate, Duodenal atresia, Intestinal malrotation, Tracheoesophageal fistula, Mitral valve pr... ORPHA:115
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Ciliary Dyskinesia, Primary, 39
Double outlet right ventricle, Dextrocardia, Bronchiectasis OMIM:618254
Atrioventricular Septal Defect, Susceptibility To, 2
Dextrocardia, Atrioventricular canal defect OMIM:606217
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Congenital Tracheomalacia
Atrial septal defect, Gastroesophageal reflux, Tracheomalacia, Single ventricle, Tracheoesophagea... ORPHA:95430
Holoprosencephaly, Recurrent Infections, And Monocytosis
Holoprosencephaly OMIM:610680
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Ventricular septal defect, Tracheoesophageal fistula, Esophageal atresia, Patent ductus arteriosus ORPHA:77298
Thanatophoric Dysplasia Type 2
Hydrocephalus, Holoprosencephaly, Encephalocele ORPHA:93274
Congenital Hypothyroidism
Abnormal pericardium morphology, Macroglossia, Tracheoesophageal fistula, Arrhythmia, Hypotension... ORPHA:442
Martinez-Frias Syndrome
Duodenal atresia, Intestinal malrotation, Tracheoesophageal fistula, Intestinal hypoplasia, Jejun... OMIM:601346
Ring Chromosome 21 Syndrome
Holoprosencephaly ORPHA:1445
Hereditary Mucoepithelial Dysplasia
Anorectal anomaly, Tracheoesophageal fistula, Furrowed tongue ORPHA:1839
Distal Monosomy 7Q36
Holoprosencephaly ORPHA:1636
Holoprosencephaly ORPHA:83463
Heterotaxy, Visceral, 2, Autosomal
Double outlet right ventricle, Atrioventricular canal defect, Intestinal malrotation, Situs inver... OMIM:605376
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Duodenal atresia, Muscular ventricular septal defect, Tracheoesophageal fistula, Esophageal atres... OMIM:619227
Fanconi Anemia, Complementation Group B
Duodenal atresia, Tracheoesophageal fistula, Ventricular septal defect, Patent ductus arteriosus,... OMIM:300514
Congenital Tracheal Stenosis
Anal atresia, Duodenal atresia, Hypoplastic left heart, Abnormal stomach morphology, Abnormal tra... ORPHA:141127
Myelomeningocele, Hydrocephalus, Holoprosencephaly, Anencephaly, Spinal dysraphism, Encephalocele... ORPHA:63259
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
Congenital Pseudoarthrosis Of The Clavicle
Situs inversus totalis, Dextrocardia ORPHA:66630
Thakker-Donnai Syndrome
Anal atresia, Tracheoesophageal fistula, Tetralogy of Fallot, Ventricular septal defect, Transpos... ORPHA:1780
Thoraco-Abdominal Enteric Duplication
Intestinal malrotation, Dextrocardia, Abnormal tricuspid valve morphology, Duodenal stenosis ORPHA:1759
Czeizel-Losonci Syndrome
High palate, Dextrocardia, Tracheoesophageal fistula ORPHA:2437
Lambotte Syndrome
Semilobar holoprosencephaly OMIM:245552
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Cleft palate, Atrioventricular canal defect, Tracheoesophageal fistula, Ventricular septal defect... OMIM:265380
Anaplastic Thyroid Carcinoma
Dysphagia, Tracheoesophageal fistula, Laryngotracheal stenosis ORPHA:142
Split-Hand With Obstructive Uropathy, Spina Bifida, And Diaphragmatic Defects
Myelomeningocele, Hydrocephalus, Spina bifida occulta OMIM:183802
Infantile Myofibromatosis
Intestinal obstruction, Tracheoesophageal fistula, Abnormal intestine morphology ORPHA:2591
Vacterl/Vater Association
Abnormal cardiac septum morphology, Anal atresia, Cleft palate, Tracheoesophageal fistula, Trache... ORPHA:887
Ciliary Dyskinesia, Primary, 25
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:615482
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:3376
Congenitally Corrected Transposition Of The Great Arteries
Mobitz I atrioventricular block, Heart murmur, Ventricular septal defect, Sick sinus syndrome, Ab... ORPHA:216694
Spina bifida, Sirenomelia ORPHA:3169
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Axial Mesodermal Dysplasia Spectrum
Anal atresia, Gastroesophageal reflux, Morphological abnormality of the gastrointestinal tract, T... ORPHA:1834
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Cervical spina bifida OMIM:600122
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Phosphoribosylaminoimidazole Carboxylase Deficiency
Tracheoesophageal fistula, Esophageal atresia, Neonatal death OMIM:619859
Acces Syndrome
Tracheoesophageal fistula OMIM:619959
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility
Situs inversus totalis, Dextrocardia OMIM:618948
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Esophageal Atresia
Laryngotracheomalacia, Gastrointestinal carcinoma, Duodenal atresia, Gastroesophageal reflux, Cle... ORPHA:1199
Total Anomalous Pulmonary Venous Return 1
Dextrocardia, Total anomalous pulmonary venous return, Pulmonary arterial hypertension OMIM:106700
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Tracheoesophageal fistula, Anal atresia, Esophageal atresia, Aganglionic megacolon ORPHA:59315
Monosomy 18P
Holoprosencephaly ORPHA:1598
Microgastria-Limb Reduction Defect Syndrome
Anal atresia, Atrial septal defect, Hiatus hernia, Gastroesophageal reflux, Intestinal malrotatio... ORPHA:2538
Ciliary Dyskinesia, Primary, 7
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:611884
Heterotaxy, Visceral, 6, Autosomal
Double outlet right ventricle, Hypoplastic left heart, Unbalanced atrioventricular canal defect, ... OMIM:614779
Dextrocardia With Unusual Facies And Microphthalmia
Dextrocardia, Cleft palate OMIM:221950
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Ciliary Dyskinesia, Primary, 38
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:618063
Congenital Vertical Talus
Myelomeningocele ORPHA:178382
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly ORPHA:250999
Ciliary Dyskinesia, Primary, 20
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:615067
Toxic Epidermal Necrolysis
Malabsorption, Tracheoesophageal fistula, Sudden cardiac death, Abnormal myocardium morphology, D... ORPHA:537
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly ORPHA:2163
Intellectual Disability-Myopathy-Short Stature-Endocrine Defect Syndrome
Tracheoesophageal fistula ORPHA:3068
Ciliary Dyskinesia, Primary, 37
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:617577
Opitz Gbbb Syndrome
High palate, Anal atresia, Ectopic anus, Atrial septal defect, Cleft palate, Tracheomalacia, Trac... ORPHA:2745
Ciliary Dyskinesia, Primary, 17
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:614679
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Short Stature-Wormian Bones-Dextrocardia Syndrome
High palate, Dextrocardia, Anal atresia, Patent ductus arteriosus ORPHA:2863
Subependymal Nodular Heterotopia
Myelomeningocele, Occipital encephalocele, Nasofrontal encephalocele, Meningocele ORPHA:101030
Solitary Median Maxillary Central Incisor
Holoprosencephaly OMIM:147250
Chronic Granulomatous Disease
Pyloric stenosis, Tracheoesophageal fistula, Malabsorption ORPHA:379
Septo-Optic Dysplasia Spectrum
Tracheoesophageal fistula, Esophageal atresia, Cleft palate ORPHA:3157
Heterotaxy, Visceral, 7, Autosomal
Abnormal cardiac septum morphology, Atrial septal defect, Atrioventricular canal defect, Intestin... OMIM:616749
Wildervanck Syndrome
Meningocele ORPHA:3456
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
49,Xxxxy Syndrome
Arrhinencephaly, Holoprosencephaly ORPHA:96264
Arachnoid Cyst
Hydrocephalus, Holoprosencephaly, Abnormal spinal meningeal morphology, Spinal cord compression, ... ORPHA:2356
Mycophenolate Mofetil Embryopathy
Ventricular septal defect, Tracheoesophageal fistula, Tracheomalacia ORPHA:268249
Fountain Syndrome
Spina bifida, Spina bifida occulta ORPHA:3219
Humero-Radial Synostosis
Meningocele ORPHA:3265
Pseudotrisomy 13 Syndrome
Hydrocephalus, Holoprosencephaly, Encephalocele OMIM:264480
Right Atrial Isomerism
Atrial septal defect, Pulmonic stenosis, Single ventricle, Right atrial isomerism, Tetralogy of F... OMIM:208530
Van Esch-O'Driscoll Syndrome
Pulmonary valve atresia, Atrial septal defect, Tracheoesophageal fistula, Bifid uvula, Ventricula... OMIM:301030
Cardiac Diverticulum
Tricuspid atresia, Angina pectoris, Tricuspid stenosis, Ventricular septal defect, Abnormal heart... ORPHA:1686
Feingold Syndrome 1
High palate, Duodenal atresia, Tracheoesophageal fistula, Patent ductus arteriosus, Esophageal at... OMIM:164280
Posterior Meningocele
Occipital meningocele, Hydrocephalus, Tethered cord, Neural tube defect, Meningocele, Lipomyelome... ORPHA:268810
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Ciliary Dyskinesia, Primary, 30
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:616037
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly OMIM:612530
Fanconi Anemia, Complementation Group D2
Tracheoesophageal fistula, Esophageal atresia, Patent ductus arteriosus, Abnormal heart morphology OMIM:227646
Acro-Renal-Mandibular Syndrome
High palate, Tracheoesophageal fistula, Aplasia/Hypoplasia of the tongue ORPHA:958
Holoprosencephaly 7
Hydrocephalus, Alobar holoprosencephaly, Holoprosencephaly, Semilobar holoprosencephaly OMIM:610828
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Anencephaly, Meningocele OMIM:611134
Ciliary Dyskinesia, Primary, 2
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:606763
Fanconi Anemia
High palate, Abnormal cardiac septum morphology, Anal atresia, Atrial septal defect, Cleft palate... ORPHA:84
Renal Agenesis, Bilateral
Tracheoesophageal fistula, Abnormal intestine morphology, Cleft palate ORPHA:1848
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Hydrocephalus, Holoprosencephaly, Encephalocele OMIM:253800
Cerebrocostomandibular Syndrome
Myelomeningocele, Spina bifida, Hydranencephaly, Meningocele ORPHA:1393
Myelomeningocele ORPHA:66637
Pelvis-Shoulder Dysplasia
Hydrocephalus, Spina bifida, Hydranencephaly ORPHA:2839
Meckel Syndrome, Type 2
Encephalocele, Anencephaly, Meningocele OMIM:603194
Meckel Syndrome 14
Occipital encephalocele, Holoprosencephaly OMIM:619879
46,Xx Disorder Of Sex Development-Anorectal Anomalies Syndrome
Intestinal malrotation, Anal atresia, Tracheoesophageal fistula ORPHA:2973
Intestinal malrotation, Situs inversus totalis, Dextrocardia, T-wave inversion, Abnormal EKG, Mec... ORPHA:1666
Diabetic Embryopathy
Spinal dysraphism, Hydrocephalus ORPHA:1926
Heterotaxy, Visceral, 4, Autosomal
Atrioventricular canal defect, Dextrotransposition of the great arteries, Ventricular septal defe... OMIM:613751
Heterotaxy, Visceral, 8, Autosomal
Double outlet right ventricle, Hypoplastic left heart, Atrial situs inversus, Unbalanced atrioven... OMIM:617205
Trisomy 18
Spina bifida, Anencephaly, Holoprosencephaly ORPHA:3380
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi
Spinal dysraphism, Tethered cord OMIM:612918
Microform Holoprosencephaly
Holoprosencephaly ORPHA:280200
Hydrocephalus, Holoprosencephaly OMIM:612651
Short-Rib Thoracic Dysplasia 12
Hydrocephalus, Anencephaly, Neonatal death, Holoprosencephaly OMIM:269860
Pancreatic Agenesis-Holoprosencephaly Syndrome
Semilobar holoprosencephaly, Holoprosencephaly ORPHA:556955
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
16P13.11 Microdeletion Syndrome
Holoprosencephaly ORPHA:261236
Lumbar Syndrome
Myelomeningocele, Spina bifida ORPHA:83628
Dyskeratosis Congenita
Telangiectasia of the skin, Malabsorption, Tracheoesophageal fistula, Esophageal stenosis, Anorec... ORPHA:1775
Congenital Heart Defects, Multiple Types, 8, With Or Without Heterotaxy
Double outlet right ventricle, High palate, Anomalous pulmonary venous return, Atrial septal defe... OMIM:619657
Holoprosencephaly 14
Hydrocephalus, Alobar holoprosencephaly, Aqueductal stenosis, Holoprosencephaly OMIM:619895
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Spinal dysraphism, Tethered cord OMIM:617660
Williams Syndrome
Abnormal cardiac septum morphology, Tracheoesophageal fistula, Sudden cardiac death, Ventricular ... ORPHA:904
Holoprosencephaly-Postaxial Polydactyly Syndrome
Hydrocephalus, Holoprosencephaly, Umbilical hernia, Encephalocele ORPHA:2166
Vacterl With Hydrocephalus
Tracheoesophageal fistula, Anal atresia, Esophageal atresia ORPHA:3412
Hydrocephalus, Holoprosencephaly, Spinal cord tumor, Spinal dysraphism, Branchial anomaly, Enceph... ORPHA:2162
Fanconi Anemia, Complementation Group L
Tracheoesophageal fistula, Anal atresia, Esophageal atresia, Cleft palate OMIM:614083
Neu-Laxova Syndrome 2
Spina bifida OMIM:616038
Sacral Defect With Anterior Meningocele
Myelomeningocele, Hydrocephalus, Tethered cord, Meningocele, Myeloschisis, Hydromyelia OMIM:600145
Ciliary Dyskinesia, Primary, 22
Situs inversus totalis, Dextrocardia, Bronchiectasis OMIM:615444
Heterotaxy, Visceral, 10, Autosomal, With Male Infertility
Situs inversus totalis, Dextrocardia OMIM:619607
Spondylocostal Dysostosis 4, Autosomal Recessive
Situs inversus totalis, Dextrocardia OMIM:613686
Scimitar Syndrome
Tricuspid atresia, Double outlet right ventricle, Anomalous pulmonary venous return, Atrial septa... ORPHA:185
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Treacher-Collins Syndrome
High palate, Cleft palate, Glossoptosis, Tracheoesophageal fistula, Patent ductus arteriosus, Rec... ORPHA:861
Phocomelia, Schinzel Type
Tracheoesophageal fistula, Anal atresia, High, narrow palate, Cleft palate ORPHA:2879
Poland Syndrome
Dextrocardia OMIM:173800
Penile Agenesis
Anal atresia, Atrial septal defect, Rectal fistula, Tracheoesophageal fistula, Ventricular septal... ORPHA:49
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Lobar holoprosencephaly OMIM:614701
Halperin-Birk Syndrome
Umbilical hernia, Semilobar holoprosencephaly OMIM:618651
Enlarged Parietal Foramina
Myelomeningocele, Occipital encephalocele ORPHA:60015
Catel-Manzke Syndrome
High palate, Cleft palate, Glossoptosis, Ventricular septal defect, Dextrocardia, Overriding aorta OMIM:616145
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Charge Syndrome
Abnormal cardiac septum morphology, Gastroesophageal reflux, Cleft palate, Abnormal soft palate m... ORPHA:138
Waardenburg Syndrome, Type 1
Myelomeningocele, Spina bifida OMIM:193500
Cardiac-Urogenital Syndrome
Atrial septal defect, Hypoplastic left heart, Scimitar anomaly, Intestinal malrotation, Tracheoma... OMIM:618280
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Exencephaly, Encephalocele ORPHA:2211
Vater/Vacterl Association
Anal atresia, Tracheoesophageal fistula, Tetralogy of Fallot, Ventricular septal defect, Patent d... OMIM:192350
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Charge Syndrome
Double outlet right ventricle, Anal atresia, Duodenal atresia, Secundum atrial septal defect, Atr... OMIM:214800
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2
Spinal dysraphism OMIM:603546
Townes-Brocks Syndrome 1
Anal atresia, Duodenal atresia, Atrial septal defect, Gastroesophageal reflux, Tracheoesophageal ... OMIM:107480
Jacobsen Syndrome
Hydrocephalus, Holoprosencephaly OMIM:147791
Limb Body Wall Complex
Myelomeningocele, Hydrocephalus, Short umbilical cord, Anencephaly, Spina bifida occulta, Encepha... ORPHA:2369
Primary Pulmonary Hypoplasia
Abnormal tracheal morphology, Dextrocardia, Secundum atrial septal defect, Cleft palate ORPHA:2257
Cloacal Exstrophy
Myelomeningocele, Spina bifida ORPHA:93929
Vitamin K Antagonist Embryofetopathy
Myelomeningocele, Hydrocephalus ORPHA:1914
Proximal 16P11.2 Microdeletion Syndrome
Atrial septal defect, Gastroesophageal reflux, Cleft palate, Abnormal aortic valve morphology, Py... ORPHA:261197
Pallister-Hall Syndrome
Neonatal death, Holoprosencephaly OMIM:146510
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Heterotaxy, Visceral, 12, Autosomal
Double outlet right ventricle, Double inlet right ventricle, Atrial septal defect, Hypoplastic le... OMIM:619702
Heterotaxy, Visceral, 1, X-Linked
Posteriorly placed anus, Atrioventricular canal defect, Ventricular septal defect, Cardiomegaly, ... OMIM:306955
Meacham Syndrome
Cardiac total anomalous pulmonary venous connection, Bicuspid aortic valve, Atrial septal defect,... OMIM:608978
Heterotaxy, Visceral, 5, Autosomal
Double outlet right ventricle, Duodenal atresia, Atrial septal defect, Double inlet left ventricl... OMIM:270100
Pagod Syndrome
Encephalocele, Spina bifida, Meningocele ORPHA:991
Nail-Patella Syndrome
Spina bifida OMIM:161200
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome
High palate, Dextrocardia, Tricuspid regurgitation, Atrioventricular canal defect OMIM:618929
Neurocutaneous Melanocytosis
Syringomyelia, Meningocele ORPHA:2481
Johanson-Blizzard Syndrome
Abnormal cardiac septum morphology, Malabsorption, Anal atresia, Dextrocardia, Anteriorly placed ... ORPHA:2315
Ulnar Hemimelia
Spinal dysraphism ORPHA:93320
Fibular Hemimelia
Spina bifida ORPHA:93323
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Situs inversus totalis, Dextrocardia, Hypertension OMIM:613095
Meckel Syndrome
Hydrocephalus, Anencephaly, Lobar holoprosencephaly, Encephalocele ORPHA:564
Marden-Walker Syndrome
High palate, High, narrow palate, Cleft palate, Pyloric stenosis, Dextrocardia, Zollinger-Ellison... OMIM:248700
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Basal Cell Nevus Syndrome
Hydrocephalus, Spina bifida OMIM:109400
Monosomy 13Q14
Holoprosencephaly ORPHA:1587
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly ORPHA:1052
Chromosome 13Q14 Deletion Syndrome
Umbilical hernia, Holoprosencephaly OMIM:613884
Neurofibromatosis, Type I
Hydrocephalus, Spina bifida, Aqueductal stenosis OMIM:162200
Arnold-Chiari Malformation Type Ii
Myelomeningocele, Hydrocephalus, Aqueductal stenosis, Meningocele, Syringomyelia ORPHA:1136
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Bardet-Biedl Syndrome 17
Situs inversus totalis, Dextrocardia OMIM:615994
Holoprosencephaly 9
Hydrocephalus, Holoprosencephaly OMIM:610829
Holoprosencephaly 13, X-Linked
Alobar holoprosencephaly, Semilobar holoprosencephaly OMIM:301043
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Holoprosencephaly 2
Semilobar holoprosencephaly, Alobar holoprosencephaly, Holoprosencephaly OMIM:157170
Split Cord Malformation
Myelomeningocele, Hydrocephalus, Cervical spina bifida, Tethered cord, Spinal cord tumor, Meningo... ORPHA:573278
Smith-Lemli-Opitz Syndrome
Holoprosencephaly ORPHA:818
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Hartsfield Syndrome
Lobar holoprosencephaly OMIM:615465
Autosomal Recessive Spondylocostal Dysostosis
Spina bifida occulta, Umbilical hernia, Meningocele ORPHA:2311
Orofaciodigital Syndrome Xiv
Occipital encephalocele, Holoprosencephaly OMIM:615948
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Lobar holoprosencephaly ORPHA:468631
Thoracoabdominal Syndrome
Patent ductus arteriosus, Transposition of the great arteries, Cleft palate, Ectopia cordis OMIM:313850
Neu-Laxova Syndrome 1
Short umbilical cord, Hydranencephaly, Small placenta, Spina bifida, Stillbirth OMIM:256520
Smith-Lemli-Opitz Syndrome
Hydrocephalus, Holoprosencephaly OMIM:270400
Joubert Syndrome With Ocular Defect
Dextrocardia, Aganglionic megacolon, Cleft palate ORPHA:220493
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida, Tethered cord OMIM:619480
Aicardi Syndrome
Spina bifida OMIM:304050
22Q11.2 Deletion Syndrome
Hydrocephalus, Arrhinencephaly, Umbilical hernia, Meningocele, Spina bifida, Occipital myelomenin... ORPHA:567
Chromosome 15Q25 Deletion Syndrome
Abnormal cardiac septum morphology, Cleft palate, Ventricular septal defect, Dextrocardia, Corona... OMIM:614294
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Campomelic Dysplasia
Spinal dysraphism, Hydrocephalus, Spina bifida OMIM:114290
Thrombocytopenia-Absent Radius Syndrome
Syringomyelia, Spina bifida OMIM:274000
Lateral Meningocele Syndrome
Dural ectasia, Syringomyelia, Umbilical hernia, Meningocele OMIM:130720
Lateral Meningocele Syndrome
Dural ectasia, Syringomyelia, Umbilical hernia, Meningocele ORPHA:2789
Jacobsen Syndrome
Spina bifida ORPHA:2308
8P Inverted Duplication/Deletion Syndrome
Dextrocardia, High, narrow palate, Tetralogy of Fallot, Abnormal heart morphology ORPHA:96092
Congenital Total Pulmonary Venous Return Anomaly
Supracardiac total anomalous pulmonary venous connection, Ventricular septal defect, Low-output c... ORPHA:99125
Acromelic Frontonasal Dysplasia
Encephalocele, Meningocele ORPHA:1827
Proboscis Lateralis
Holoprosencephaly ORPHA:141099
Koolen-De Vries Syndrome Due To A Point Mutation
Dural ectasia, Hydrocephalus, Spina bifida ORPHA:363965
17Q21.31 Microdeletion Syndrome
Dural ectasia, Hydrocephalus, Spina bifida ORPHA:363958
Holoprosencephaly 1
Ethmocephaly, Alobar holoprosencephaly OMIM:236100
Distal Trisomy 5Q
Ventricular septal defect, Dextrocardia ORPHA:96097
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Semilobar holoprosencephaly OMIM:301044
Ring Chromosome 7 Syndrome
Holoprosencephaly ORPHA:1449
Pallister-Hall Syndrome
Arrhinencephaly, Umbilical hernia, Holoprosencephaly ORPHA:672
Knobloch Syndrome
Pyloric stenosis, Dextrocardia, Patent ductus arteriosus ORPHA:1571
Cartilage-Hair Hypoplasia
Spinal dysraphism ORPHA:175
Marden-Walker Syndrome
Cleft palate, Abnormal anatomic location of the heart, Bifid uvula, Ventricular septal defect, De... ORPHA:2461
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly ORPHA:95494
Ellis Van Creveld Syndrome
Atrial septal defect, Atrioventricular canal defect, Ventricular septal defect, Situs inversus to... ORPHA:289
Biliary, Renal, Neurologic, And Skeletal Syndrome
Atrioventricular canal defect, Ventricular septal defect, Cor triatriatum, Esophageal varix, Card... OMIM:619534
Rubinstein-Taybi Syndrome 1
Spina bifida, Spina bifida occulta OMIM:180849
Exstrophy-Epispadias Complex
Hydrocephalus, Spina bifida ORPHA:322
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Constricting Bands, Congenital
Cleft palate, Ectopia cordis OMIM:217100
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Non-Syndromic Anorectal Malformation
Myelomeningocele, Syringomyelia, Tethered cord ORPHA:557
Kyphoscoliotic Ehlers-Danlos Syndrome
High palate, Bicuspid aortic valve, Subdural hemorrhage, Cerebral hemorrhage, Dextrocardia, Arter... ORPHA:536545
Meningocele ORPHA:46059
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Occipital encephalocele, Meningocele ORPHA:397715
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Meningocele ORPHA:1010
Microphthalmia, Syndromic 2
Double outlet right ventricle, Aortic valve stenosis, Atrial septal defect, Pulmonic stenosis, Bi... OMIM:300166
Tetrasomy 9P
High palate, Abnormal mitral valve morphology, Abnormal cardiac septum morphology, Cleft palate, ... ORPHA:3310
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Large placenta ORPHA:96334
Arima Syndrome
Occipital meningocele OMIM:243910
Restrictive Dermopathy
Atrial septal defect, Dextrocardia, Patent ductus arteriosus, Transposition of the great arteries... ORPHA:1662
Carpenter Syndrome 2
High palate, Narrow palate, Atrial septal defect, Tricuspid regurgitation, High, narrow palate, S... OMIM:614976
Knobloch Syndrome 1
Occipital meningocele, Occipital encephalocele, Spina bifida occulta OMIM:267750
Floating-Harbor Syndrome
Gastroesophageal reflux, Atrial septal defect, Tetralogy of Fallot, Mesocardia, Celiac disease ORPHA:2044
Oeis Complex
Myelomeningocele, Hydrocephalus, Tethered cord OMIM:258040
Floating-Harbor Syndrome
Mesocardia, Celiac disease, Atrial septal defect OMIM:136140
Marfan Syndrome
Dural ectasia, Meningocele ORPHA:558
Poland Syndrome
Dextrocardia, Atrial septal defect ORPHA:2911
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele OMIM:276820


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxp4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxp4.

No publications found that use IMPC mice or data for Foxp4.

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MGI Allele Allele Type Produced
Foxp4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Foxp4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Foxp4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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