Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

forkhead box P4
1200010K03Rik,  2310007G05Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Foxp4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Foxp4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Holoprosencephaly With Fetal Akinesia/Hypokinesia Sequence
Holoprosencephaly OMIM:306990
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Hydrocephalus, Congenital, 3, With Brain Anomalies
Holoprosencephaly, Hydranencephaly, Hydrocephalus OMIM:617967
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Laryngotracheoesophageal Cleft Type 4
Laryngomalacia, Tracheal stenosis, Intestinal atresia, Abnormal cardiac septum morphology, Trache... ORPHA:93941
Holoprosencephaly 5
Semilobar holoprosencephaly, Holoprosencephaly, Alobar holoprosencephaly, Lobar holoprosencephaly... OMIM:609637
Frontal Encephalocele
Spina bifida, Hydrocephalus ORPHA:1931
Delpire-Mcneill Syndrome
Dysphagia, Tracheoesophageal fistula, Ventricular septal defect OMIM:619083
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Congenital Alveolar Capillary Dysplasia
Pulmonary valve atresia, Atrial septal defect, Ventricular septal defect, Atrioventricular canal ... ORPHA:210122
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Vissers-Bodmer Syndrome
Holoprosencephaly OMIM:619033
Tracheoesophageal Fistula With Or Without Esophageal Atresia
Esophageal atresia, Tracheoesophageal fistula OMIM:189960
Neural Tube Defects, Susceptibility To
Myelomeningocele, Hydrocephalus, Anencephaly, Spina bifida occulta OMIM:182940
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
17Q12 Microduplication Syndrome
Atrial septal defect, Tracheoesophageal fistula, Cleft palate ORPHA:261272
Hemihyperplasia, Isolated
Myelomeningocele OMIM:235000
Methimazole Embryofetopathy
Tracheoesophageal fistula, Choanal atresia, Esophageal atresia, Ventricular septal defect ORPHA:1923
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Atrioventricular canal defect, Anal atresia, Tracheoesophageal fistula, Transposition of the grea... OMIM:314390
Atrioventricular Septal Defect, Susceptibility To, 2
Pulmonary artery atresia, Dextrocardia, Atrioventricular canal defect OMIM:606217
Holoprosencephaly OMIM:600674
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Holoprosencephaly, Hydrocephalus, Aqueductal stenosis ORPHA:2182
Nevus Comedonicus Syndrome
Spina bifida, Spina bifida occulta ORPHA:64754
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Caudal Duplication
Spina bifida, Myelomeningocele, Spinal cord lesion ORPHA:1756
Chiari Malformation Type Ii
Spina bifida, Cervical myelopathy, Syringomyelia, Myelomeningocele, Hydrocephalus OMIM:207950
Cervical spina bifida, Sirenomelia, Spinal dysraphism, Anencephaly, Myelomeningocele ORPHA:63260
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Split-Hand With Obstructive Uropathy, Spina Bifida, And Diaphragmatic Defects
Myelomeningocele, Hydrocephalus, Spina bifida occulta OMIM:183802
Ciliary Dyskinesia, Primary, 39
Recurrent lower respiratory tract infections, Dextrocardia, Double outlet right ventricle, Bronch... OMIM:618254
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Holoprosencephaly, Hydranencephaly ORPHA:2570
Heterotaxy, Visceral, 4, Autosomal
Atrioventricular canal defect, Dextrocardia, Ventricular septal defect OMIM:613751
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Aminopterin/Methotrexate Embryofetopathy
Holoprosencephaly, Spinal dysraphism, Anencephaly, Meningocele, Hydrocephalus ORPHA:1908
Congenital Contractural Arachnodactyly
Mitral valve prolapse, Intestinal malrotation, Duodenal atresia, High palate, Tracheoesophageal f... ORPHA:115
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly OMIM:612530
Isolated Hemihyperplasia
Myelomeningocele ORPHA:2128
Hereditary Mucoepithelial Dysplasia
Pulmonary fibrosis, Furrowed tongue, Anorectal anomaly, Tracheoesophageal fistula, Recurrent resp... ORPHA:1839
Congenital Tracheal Stenosis
Meckel diverticulum, Abnormal lung lobation, Abnormal stomach morphology, Morphological abnormali... ORPHA:141127
Ciliary Dyskinesia, Primary, 7
Dextrocardia, Situs inversus totalis, Bronchiectasis, Recurrent pneumonia OMIM:611884
Holoprosencephaly, Recurrent Infections, And Monocytosis
Holoprosencephaly OMIM:610680
Schisis Association
Spina bifida, Anencephaly ORPHA:63862
Congenital Hypothyroidism
Macroglossia, Arrhythmia, Hypotension, Abnormal pericardium morphology, Hypertension, Sinusitis, ... ORPHA:442
Ciliary Dyskinesia, Primary, 25
Situs inversus totalis, Bronchiectasis, Recurrent sinusitis, Dextrocardia, Sinusitis, Recurrent r... OMIM:615482
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Tracheoesophageal fistula, Patent ductus arteriosus, Esophageal atresia, Ventricular septal defect ORPHA:77298
Ciliary Dyskinesia, Primary, 20
Situs inversus totalis, Bronchiectasis, Absent outer dynein arms, Recurrent sinusitis, Atelectasi... OMIM:615067
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly OMIM:601357
Martinez-Frias Syndrome
Intestinal hypoplasia, Intestinal malrotation, Jejunal atresia, Duodenal atresia, Tracheoesophage... OMIM:601346
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Choanal atresia, Esophageal atresia, Duodenal atresia, Muscular ventricular septal defect, Trache... OMIM:619227
Distal Monosomy 13Q
Holoprosencephaly, Anencephaly ORPHA:1590
Thakker-Donnai Syndrome
Bulbous nose, Ventricular septal defect, Rectovaginal fistula, Anal atresia, Tetralogy of Fallot,... ORPHA:1780
Anaplastic Thyroid Carcinoma
Dysphagia, Laryngotracheal stenosis, Neoplasm of the lung, Hemoptysis, Tracheoesophageal fistula ORPHA:142
Ring Chromosome 21 Syndrome
Holoprosencephaly ORPHA:1445
Distal Monosomy 7Q36
Holoprosencephaly ORPHA:1636
Heterotaxy, Visceral, 2, Autosomal
Situs inversus totalis, Intestinal malrotation, Dextrocardia, Double outlet right ventricle, Meso... OMIM:605376
Holoprosencephaly ORPHA:83463
Esophageal Atresia
Morphological abnormality of the gastrointestinal tract, Laryngotracheomalacia, Choanal atresia, ... ORPHA:1199
Fanconi Anemia, Complementation Group B
Ventricular septal defect, Patent ductus arteriosus, Esophageal atresia, Duodenal atresia, Trache... OMIM:300514
Hartsfield Syndrome
Lobar holoprosencephaly ORPHA:2117
Vacterl/Vater Association
Laryngomalacia, Aplasia/Hypoplasia of the lungs, Anal atresia, Cleft palate, Anorectal anomaly, A... ORPHA:887
Infantile Myofibromatosis
Abnormal intestine morphology, Intestinal obstruction, Tracheoesophageal fistula, Neoplasm of the... ORPHA:2591
Thoraco-Abdominal Enteric Duplication
Meningocele, Diastomatomyelia ORPHA:1759
Czeizel-Losonci Syndrome
High palate, Dextrocardia, Pulmonary hypoplasia, Tracheoesophageal fistula ORPHA:2437
Ciliary Dyskinesia, Primary, 17
Situs inversus totalis, Bronchiectasis, Dextrocardia, Chronic sinusitis, Abnormal respiratory mot... OMIM:614679
Fanconi Anemia, Complementation Group L
Esophageal atresia, Wide nasal bridge, Anal atresia, Cleft palate, Tracheoesophageal fistula, Dep... OMIM:614083
Lambotte Syndrome
Semilobar holoprosencephaly OMIM:245552
Congenital Pseudoarthrosis Of The Clavicle
Dextrocardia, Situs inversus totalis ORPHA:66630
Thanatophoric Dysplasia Type 2
Holoprosencephaly, Hydrocephalus ORPHA:93274
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:3376
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Axial Mesodermal Dysplasia Spectrum
Morphological abnormality of the gastrointestinal tract, Gastroesophageal reflux, Aplasia/Hypopla... ORPHA:1834
Spina bifida, Sirenomelia ORPHA:3169
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Wildervanck Syndrome
Meningocele ORPHA:3456
Congenitally Corrected Transposition Of The Great Arteries
Premature atrial contractions, Cardiac conduction abnormality, Single ventricle, Supraventricular... ORPHA:216694
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
Ciliary Dyskinesia, Primary, 38
Situs inversus totalis, Bronchiectasis, Absent inner and outer dynein arms, Dextrocardia, Chronic... OMIM:618063
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Cervical spina bifida OMIM:600122
Spina bifida, Holoprosencephaly, Spinal dysraphism, Anencephaly, Syringomyelia, Myelomeningocele,... ORPHA:63259
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Dextrocardia With Unusual Facies And Microphthalmia
Prominent nose, Dextrocardia, Cleft palate OMIM:221950
Humero-Radial Synostosis
Meningocele ORPHA:3265
Short nose, Aganglionic megacolon, Esophageal atresia, Anal atresia, Anteverted nares, Tracheoeso... ORPHA:59315
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility
Dextrocardia, Situs inversus totalis OMIM:618948
Ciliary Dyskinesia, Primary, 30
Situs inversus totalis, Bronchiectasis, Absent outer dynein arms, Nasal polyposis, Chronic bronch... OMIM:616037
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Misalignment of the pulmonary veins, Pulmonary insufficiency, Intestinal malrotation, Patent duct... OMIM:265380
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Monosomy 18P
Holoprosencephaly ORPHA:1598
Toxic Epidermal Necrolysis
Intestinal perforation, Gastrointestinal hemorrhage, Abnormal pleura morphology, Dysphagia, Recur... ORPHA:537
Ciliary Dyskinesia, Primary, 2
Situs inversus totalis, Bronchiectasis, Nasal polyposis, Absent inner and outer dynein arms, Dext... OMIM:606763
Microgastria-Limb Reduction Defect Syndrome
Hiatus hernia, Esophagitis, Atrial septal defect, Truncus arteriosus, Perineal fistula, Gastroeso... ORPHA:2538
Opitz Gbbb Syndrome, Type Ii
Hiatus hernia, Atrial septal defect, Anal stenosis, Ventricular septal defect, Dysphagia, Patent ... OMIM:145410
Amish Lethal Microcephaly
Spina bifida ORPHA:99742
Myelomeningocele ORPHA:66637
Intellectual Disability-Myopathy-Short Stature-Endocrine Defect Syndrome
Prominent nasal bridge, Tracheoesophageal fistula ORPHA:3068
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Short Stature-Wormian Bones-Dextrocardia Syndrome
Patent ductus arteriosus, Wide nasal bridge, Dextrocardia, Anal atresia, High palate ORPHA:2863
Ciliary Dyskinesia, Primary, 37
Dextrocardia, Situs inversus totalis, Bronchiectasis OMIM:617577
Chronic Granulomatous Disease
Malabsorption, Sinusitis, Tracheoesophageal fistula, Pyloric stenosis, Recurrent respiratory infe... ORPHA:379
Heterotaxy, Visceral, 7, Autosomal
Atrial septal defect, Situs inversus totalis, Abnormal tricuspid valve morphology, Mitral atresia... OMIM:616749
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly ORPHA:2163
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly ORPHA:250999
Posterior Meningocele
Neural tube defect, Meningocele, Occipital meningocele, Hydromyelia, Lipomyelomeningocele, Hydroc... ORPHA:268810
Opitz Gbbb Syndrome
Ankyloglossia, Atrial septal defect, Abnormal heart morphology, Ventricular septal defect, Dyspha... ORPHA:2745
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Right Atrial Isomerism
Right atrial isomerism, Situs inversus totalis, Single ventricle, Atrial septal defect, Ventricul... OMIM:208530
Subependymal Nodular Heterotopia
Meningocele, Myelomeningocele ORPHA:101030
Solitary Median Maxillary Central Incisor
Holoprosencephaly OMIM:147250
Heterotaxy, Visceral, 5, Autosomal
Dextrocardia, Atrial septal defect, Transposition of the great arteries, Ventricular septal defect OMIM:270100
Mycophenolate Mofetil Embryopathy
Bifid nose, Tracheoesophageal fistula, Tracheomalacia, Ventricular septal defect ORPHA:268249
Spondylocostal Dysostosis 4, Autosomal Recessive
Myelomeningocele, Spina bifida occulta OMIM:613686
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi
Spinal dysraphism, Tethered cord OMIM:612918
Meckel diverticulum, Situs inversus totalis, Abnormal heart morphology, T-wave inversion, Abnorma... ORPHA:1666
Septo-Optic Dysplasia Spectrum
Tracheoesophageal fistula, Esophageal atresia, Cleft palate ORPHA:3157
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Meckel Syndrome, Type 2
Meningocele, Anencephaly OMIM:603194
Renal Agenesis, Bilateral
Abnormal intestine morphology, Pulmonary hypoplasia, Tracheoesophageal fistula, Cleft palate ORPHA:1848
Fountain Syndrome
Spina bifida, Spina bifida occulta ORPHA:3219
Acro-Renal-Mandibular Syndrome
Aplasia/Hypoplasia of the tongue, Pulmonary hypoplasia, High palate, Tracheoesophageal fistula, A... ORPHA:958
Fanconi Anemia
Meckel diverticulum, Atrial septal defect, Aplasia/Hypoplasia of the uvula, Aganglionic megacolon... ORPHA:84
Feingold Syndrome 1
Patent ductus arteriosus, Esophageal atresia, Wide nasal bridge, Duodenal atresia, High palate, A... OMIM:164280
Fanconi Anemia, Complementation Group D2
Tracheoesophageal fistula, Patent ductus arteriosus, Esophageal atresia, Abnormal heart morphology OMIM:227646
Scimitar Syndrome
Single ventricle, Patent ductus arteriosus, Bronchogenic cyst, Dextrocardia, Double outlet right ... ORPHA:185
Bardet-Biedl Syndrome 17
Dextrocardia, Situs inversus totalis OMIM:615994
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Dextrocardia, Situs inversus totalis, Hypertension OMIM:613095
Heterotaxy, Visceral, 6, Autosomal
Dextrocardia, Transposition of the great arteries OMIM:614779
49,Xxxxy Syndrome
Holoprosencephaly, Arrhinencephaly ORPHA:96264
Meckel Syndrome, Type 4
Meningocele, Hydrocephalus, Anencephaly OMIM:611134
Cerebrocostomandibular Syndrome
Meningocele, Spina bifida, Hydranencephaly, Myelomeningocele ORPHA:1393
Penile Agenesis
Atrial septal defect, Short nose, Rectal fistula, Ventricular septal defect, Anal atresia, Pulmon... ORPHA:49
46,Xx Disorder Of Sex Development-Anorectal Anomalies Syndrome
Anal atresia, Intestinal malrotation, Tracheoesophageal fistula ORPHA:2973
Cleft Lip/Palate-Deafness-Sacral Lipoma Syndrome
Meningocele ORPHA:2003
Chromosome 15Q25 Deletion Syndrome
Dextrocardia, Abnormal cardiac septum morphology, Cleft palate OMIM:614294
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida ORPHA:1120
Enlarged Parietal Foramina
Myelomeningocele ORPHA:60015
Vitamin K Antagonist Embryofetopathy
Myelomeningocele, Hydrocephalus ORPHA:1914
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
Holoprosencephaly, Hydrocephalus OMIM:612651
Diabetic Embryopathy
Spinal dysraphism, Hydrocephalus ORPHA:1926
Eosinophilic Esophagitis
Esophageal stenosis, Spontaneous esophageal perforation, Dysphagia, Gastroesophageal reflux, Abno... ORPHA:73247
Pelvis-Shoulder Dysplasia
Spina bifida, Hydranencephaly, Hydrocephalus ORPHA:2839
Lumbar Syndrome
Spina bifida, Myelomeningocele ORPHA:83628
Pseudotrisomy 13 Syndrome
Holoprosencephaly, Hydrocephalus OMIM:264480
Vacterl With Hydrocephalus
Tracheoesophageal fistula, Anal atresia, Esophageal atresia, Pulmonary hypoplasia ORPHA:3412
Trisomy 18
Holoprosencephaly, Spina bifida, Anencephaly ORPHA:3380
Microform Holoprosencephaly
Holoprosencephaly ORPHA:280200
16P13.11 Microdeletion Syndrome
Holoprosencephaly ORPHA:261236
Dyskeratosis Congenita
Oral leukoplakia, Esophageal stenosis, Recurrent respiratory infections, Telangiectasia of the sk... ORPHA:1775
Pancreatic Agenesis-Holoprosencephaly Syndrome
Semilobar holoprosencephaly, Holoprosencephaly ORPHA:556955
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Spinal dysraphism, Tethered cord OMIM:617660
Neurocutaneous Melanocytosis
Meningocele, Syringomyelia ORPHA:2481
Williams Syndrome
Abnormal endocardium morphology, Peripheral pulmonary artery stenosis, Patent ductus arteriosus, ... ORPHA:904
Phocomelia, Schinzel Type
Short nose, Anal atresia, Cleft palate, High, narrow palate, Tracheoesophageal fistula ORPHA:2879
Treacher-Collins Syndrome
Choanal atresia, Patent ductus arteriosus, Wide nasal bridge, Rectovaginal fistula, Glossoptosis,... ORPHA:861
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Holoprosencephaly, Hydrocephalus OMIM:253800
Heterotaxy, Visceral, 1, X-Linked
Posteriorly placed anus, Atrial septal defect, Single ventricle, Ventricular septal defect, Mitra... OMIM:306955
Vater/Vacterl Association
Abnormal nasopharynx morphology, Ventricular septal defect, Choanal atresia, Esophageal atresia, ... OMIM:192350
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Primary Pulmonary Hypoplasia
Secundum atrial septal defect, Abnormal pulmonary artery morphology, Dextrocardia, Pulmonary hypo... ORPHA:2257
Cardiac-Urogenital Syndrome
Scimitar anomaly, Atrial septal defect, Ventricular septal defect, Dysplastic tricuspid valve, In... OMIM:618280
Poland Syndrome
Dextrocardia OMIM:173800
Branchial anomaly, Holoprosencephaly, Spinal dysraphism, Spinal cord tumor, Hydrocephalus ORPHA:2162
Charge Syndrome
Abnormal soft palate morphology, Gastroesophageal reflux, Choanal atresia, Abnormal aortic valve ... ORPHA:138
Catel-Manzke Syndrome
Ventricular septal defect, Dextrocardia, Glossoptosis, Cleft palate, Overriding aorta, High palate OMIM:616145
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Charge Syndrome
Atrial septal defect, Anal stenosis, Ventricular septal defect, Dysphagia, Choanal atresia, Esoph... OMIM:214800
Arnold-Chiari Malformation Type Ii
Aqueductal stenosis, Meningocele, Syringomyelia, Myelomeningocele, Hydrocephalus ORPHA:1136
Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies
Semilobar holoprosencephaly, Umbilical hernia OMIM:618651
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Neonatal death, Hydrocephalus, Anencephaly OMIM:269860
Holoprosencephaly 7
Semilobar holoprosencephaly, Hydrocephalus, Alobar holoprosencephaly OMIM:610828
Sacral Defect With Anterior Meningocele
Meningocele OMIM:600145
Holoprosencephaly-Postaxial Polydactyly Syndrome
Holoprosencephaly, Hydrocephalus, Umbilical hernia ORPHA:2166
Hepatic Fibrosis-Renal Cysts-Intellectual Disability Syndrome
Meningocele ORPHA:2031
Jacobsen Syndrome
Holoprosencephaly, Hydrocephalus OMIM:147791
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2
Spinal dysraphism OMIM:603546
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Cloacal Exstrophy
Spina bifida, Myelomeningocele ORPHA:93929
Pallister-Hall Syndrome
Holoprosencephaly, Neonatal death OMIM:146510
Proximal 16P11.2 Microdeletion Syndrome
Atrial septal defect, Abnormal heart morphology, Gastroesophageal reflux, Abnormal aortic valve m... ORPHA:261197
Johanson-Blizzard Syndrome
Short nose, Underdeveloped nasal alae, Dextrocardia, Anal atresia, Abnormal cardiac septum morpho... ORPHA:2315
Marden-Walker Syndrome
Zollinger-Ellison syndrome, Dextrocardia, Pulmonary hypoplasia, Cleft palate, High palate, High, ... OMIM:248700
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Exencephaly ORPHA:2211
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome
Tricuspid regurgitation, Dextrocardia, Atrioventricular canal defect, High palate, Depressed nasa... OMIM:618929
Autosomal Recessive Spondylocostal Dysostosis
Meningocele, Umbilical hernia, Spina bifida occulta ORPHA:2311
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Fibular Hemimelia
Spina bifida ORPHA:93323
Holoprosencephaly 2
Holoprosencephaly OMIM:157170
Limb Body Wall Complex
Spina bifida, Short umbilical cord, Anencephaly, Spina bifida occulta, Myelomeningocele, Hydrocep... ORPHA:2369
Nail-Patella Syndrome
Spina bifida OMIM:161200
Ulnar Hemimelia
Spinal dysraphism ORPHA:93320
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Lateral Meningocele Syndrome
Meningocele, Dural ectasia, Syringomyelia, Umbilical hernia OMIM:130720
Lateral Meningocele Syndrome
Meningocele, Dural ectasia, Syringomyelia, Umbilical hernia ORPHA:2789
Phaver Syndrome
Myelomeningocele ORPHA:2876
Basal Cell Nevus Syndrome
Spina bifida, Hydrocephalus OMIM:109400
Monosomy 13Q14
Holoprosencephaly ORPHA:1587
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly ORPHA:1052
Neurofibromatosis, Type I
Spina bifida, Hydrocephalus, Aqueductal stenosis OMIM:162200
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Pagod Syndrome
Meningocele, Spina bifida ORPHA:991
Holoprosencephaly 13, X-Linked
Semilobar holoprosencephaly, Alobar holoprosencephaly OMIM:301043
Thoracoabdominal Syndrome
Patent ductus arteriosus, Ectopia cordis, Pulmonary hypoplasia, Cleft palate, Transposition of th... OMIM:313850
Holoprosencephaly 9
Holoprosencephaly, Hydrocephalus OMIM:610829
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia ORPHA:2092
Non-Syndromic Anorectal Malformation
Myelomeningocele, Syringomyelia, Tethered cord ORPHA:557
Congenital Total Pulmonary Venous Return Anomaly
Cardiac total anomalous pulmonary venous connection, Single ventricle, Patent ductus arteriosus, ... ORPHA:99125
15Q24 Microdeletion Syndrome
Myelomeningocele ORPHA:94065
Acromelic Frontonasal Dysplasia
Meningocele ORPHA:1827
Joubert Syndrome With Ocular Defect
Anteverted nares, Aganglionic megacolon, Dextrocardia, Cleft palate, Prominent nasal bridge ORPHA:220493
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Trisomy 8Q
Myelomeningocele ORPHA:1752
Distal Trisomy 5Q
Dextrocardia, Prominent nasal bridge, Short nose, Ventricular septal defect ORPHA:96097
Hartsfield Syndrome
Lobar holoprosencephaly OMIM:615465
Smith-Lemli-Opitz Syndrome
Holoprosencephaly, Hydrocephalus OMIM:270400
Smith-Lemli-Opitz Syndrome
Holoprosencephaly ORPHA:818
8P Inverted Duplication/Deletion Syndrome
Abnormal heart morphology, Wide nasal bridge, Dextrocardia, Tetralogy of Fallot, High, narrow pal... ORPHA:96092
Thrombocytopenia-Absent Radius Syndrome
Spina bifida OMIM:274000
Meckel Syndrome
Lobar holoprosencephaly, Hydrocephalus, Anencephaly ORPHA:564
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Lobar holoprosencephaly ORPHA:468631
Split Cord Malformation
Cervical spina bifida, Spinal cord tumor, Hydromyelia, Meningocele, Syringomyelia, Lipomyelomenin... ORPHA:573278
Neu-Laxova Syndrome 1
Spina bifida, Short umbilical cord, Stillbirth, Hydranencephaly, Small placenta OMIM:256520
Aicardi Syndrome
Spina bifida OMIM:304050
Waardenburg Syndrome
Myelomeningocele ORPHA:3440
22Q11.2 Deletion Syndrome
Spina bifida, Arrhinencephaly, Umbilical hernia, Meningocele, Hydrocephalus, Occipital myelomenin... ORPHA:567
Jacobsen Syndrome
Spina bifida ORPHA:2308
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Ellis Van Creveld Syndrome
Atrial septal defect, Situs inversus totalis, Ventricular septal defect, Abnormal heart valve mor... ORPHA:289
Koolen-De Vries Syndrome Due To A Point Mutation
Dural ectasia, Spina bifida, Hydrocephalus ORPHA:363965
17Q21.31 Microdeletion Syndrome
Dural ectasia, Spina bifida, Hydrocephalus ORPHA:363958
Meningocele ORPHA:46059
Holoprosencephaly 1
Alobar holoprosencephaly, Ethmocephaly OMIM:236100
Knobloch Syndrome
Dextrocardia, Pyloric stenosis, Patent ductus arteriosus, Depressed nasal bridge ORPHA:1571
Constricting Bands, Congenital
Ectopia cordis, Abnormal lung lobation, Cleft palate OMIM:217100
Orofaciodigital Syndrome Xiv
Holoprosencephaly OMIM:615948
Ring Chromosome 7 Syndrome
Holoprosencephaly ORPHA:1449
Marden-Walker Syndrome
Situs inversus totalis, Ventricular septal defect, Abnormal anatomic location of the heart, Dextr... ORPHA:2461
Otopalatodigital Syndrome Type 2
Myelomeningocele, Hydrocephalus ORPHA:90652
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly ORPHA:95494
Joubert Syndrome 1
Occipital myelomeningocele OMIM:213300
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Meningocele ORPHA:397715
Cartilage-Hair Hypoplasia
Spinal dysraphism ORPHA:175
Exstrophy-Epispadias Complex
Spina bifida, Hydrocephalus ORPHA:322
Orofaciodigital Syndrome I
Myelomeningocele, Hydrocephalus OMIM:311200
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Pallister-Hall Syndrome
Holoprosencephaly, Arrhinencephaly, Umbilical hernia ORPHA:672
Kyphoscoliotic Ehlers-Danlos Syndrome
Antenatal intracerebral hemorrhage, Subdural hemorrhage, Dextrocardia, Bicuspid aortic valve, Cer... ORPHA:536545
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Arima Syndrome
Occipital meningocele OMIM:243910
Carpenter Syndrome 2
Narrow naris, Narrow palate, Situs inversus totalis, Atrial septal defect, Patent ductus arterios... OMIM:614976
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Semilobar holoprosencephaly OMIM:301044
Myelomeningocele OMIM:607330
Oeis Complex
Myelomeningocele, Hydrocephalus, Tethered cord OMIM:258040
Floating-Harbor Syndrome
Atrial septal defect, Mesocardia, Celiac disease, Prominent nose OMIM:136140
Tetrasomy 9P
Median cleft lip and palate, Pericarditis, Bulbous nose, Patent foramen ovale, Abnormal mitral va... ORPHA:3310
Marfan Syndrome
Meningocele, Dural ectasia ORPHA:558
Microphthalmia, Syndromic 2
Atrial septal defect, Ventricular septal defect, Patent ductus arteriosus, Pulmonic stenosis, Aor... OMIM:300166
Restrictive Dermopathy
Atrial septal defect, Choanal atresia, Patent ductus arteriosus, Dextrocardia, Pulmonary hypoplas... ORPHA:1662
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Spinal dysraphism, Large placenta ORPHA:96334
Floating-Harbor Syndrome
Atrial septal defect, Gastroesophageal reflux, Mesocardia, Broad nasal tip, Tetralogy of Fallot, ... ORPHA:2044
Fraser Syndrome 1
Myelomeningocele, Hydrocephalus OMIM:219000
Focal Dermal Hypoplasia
Umbilical hernia, Myelomeningocele, Hydrocephalus, Spina bifida occulta OMIM:305600
Poland Syndrome
Dextrocardia, Atrial septal defect ORPHA:2911
Tibial Hemimelia
Myelomeningocele ORPHA:93322
Fraser Syndrome
Myelomeningocele, Umbilical hernia ORPHA:2052
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Occipital meningocele OMIM:276820


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Foxp4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Foxp4.

No publications found that use IMPC mice or data for Foxp4.

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MGI Allele Allele Type Produced
Foxp4tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Foxp4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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