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Genes Phenotypes Help, News, Blog

Gene: Abcb6 MGI:1921354

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Gene Summary

Name:
ATP-binding cassette, sub-family B member 6
Synonyms:
1200005B17Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal vibrissa morphology Abcb6tm1a(KOMP)Wtsi HOM Early adult 8.64×10-08

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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X-ray

XRay Images Forepaw

14 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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Legacy Phenotype Associated Images
Abcb6tm1a(KOMP)Wtsi
HOM, Male, WTSI
Abcb6tm1a(KOMP)Wtsi
HOM, Male, WTSI
Abcb6tm1a(KOMP)Wtsi
HOM, Male, WTSI
Abcb6tm1a(KOMP)Wtsi
HOM, Male, WTSI
Abcb6tm1a(KOMP)Wtsi
HOM, Male, WTSI

View all 71 images

Human diseases caused by Abcb6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Abcb6 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Familial Pseudohyperkalemia
Reticulocytosis, Episodic hemolytic anemia, Stomatocytosis, Increased mean corpuscular volume ORPHA:90044
Microphthalmia, Isolated, With Coloboma 7
OMIM:614497
Dyschromatosis Universalis Hereditaria
ORPHA:241
Dyschromatosis Universalis Hereditaria 3
OMIM:615402
Pseudohyperkalemia, Familial, 2, Due To Red Cell Leak
OMIM:609153

The table below shows human diseases predicted to be associated to Abcb6 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fanconi Anemia, Complementation Group G
Abnormality of chromosome stability, Anemia, Neutropenia, Leukemia, Thrombocytopenia OMIM:614082
Transcobalamin Deficiency
Decreased circulating IgG level, Abnormality of chromosome stability, Pancytopenia, Decreased cir... ORPHA:859
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism ORPHA:31
Familial Pseudohyperkalemia
Reticulocytosis, Episodic hemolytic anemia, Stomatocytosis, Increased mean corpuscular volume ORPHA:90044
Microphthalmia, Isolated, With Coloboma 7
OMIM:614497
Dyschromatosis Universalis Hereditaria
ORPHA:241
Dyschromatosis Universalis Hereditaria 3
OMIM:615402
Pseudohyperkalemia, Familial, 2, Due To Red Cell Leak
OMIM:609153

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Abcb6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Abcb6.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Abcb6tm1a(KOMP)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Abcb6tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Abcb6tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Abcb6tm1a(KOMP)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Abcb6tm91916(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Abcb6tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Abcb6tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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