banner
Genes Phenotypes Help, News, Blog

Gene: Sh3bgrl3 MGI:1920973

Log in to follow

Gene Summary

Name:
SH3 domain binding glutamic acid-rich protein-like 3
Synonyms:
1110004L05Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal epidermal immune compartment Sh3bgrl3tm2b(EUCOMM)Wtsi HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Anti-nuclear antibody assay

Images

6 Images

View images
DSS Histology

Images

8 Images

View images
Eye Morphology

Images Slit Lamp

2 Images

View images
Ear epidermis immunophenotyping

Images

12 Images

View images
Legacy Phenotype Associated Images
Sh3bgrl3tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
HOM, Female, WTSI

View all 70 images

Sh3bgrl3tm2b(EUCOMM)Wtsi
abnormal tail morphology, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
abnormal tail morphology, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
head, abnormal snout morphology, short snout, upturned snout, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
head, abnormal snout morphology, asymmetric snout, malocclusion, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
head, abnormal snout morphology, asymmetric snout, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
eyelids fail to open, HOM, Female, WTSI
Sh3bgrl3tm2b(EUCOMM)Wtsi
corneal vascularization, HOM, Female, WTSI

Human diseases caused by Sh3bgrl3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sh3bgrl3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hyperkeratosis with erythema, Diffuse palmoplantar hyperkeratosis ORPHA:86923
Hyperkeratosis Lenticularis Perstans
Hyperkeratosis lenticularis perstans OMIM:144150
Ichthyosis Hystrix, Lambert Type
Hyperkeratosis, Orthokeratotic hyperkeratosis OMIM:146600
Angioma Serpiginosum, Autosomal Dominant
Hyperkeratosis OMIM:106050
Papillomatosis, Confluent And Reticulated
Hyperkeratosis OMIM:167900
Palmoplantar Keratoderma-Deafness Syndrome
Hyperkeratosis, Palmoplantar keratoderma ORPHA:2202

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sh3bgrl3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sh3bgrl3.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Sh3bgrl3tm2b(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Sh3bgrl3tm2b(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Sh3bgrl3tm2b(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Sh3bgrl3tm2b(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Sh3bgrl3tm2b(EUCOMM)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sh3bgrl3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Sh3bgrl3tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Sh3bgrl3tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sh3bgrl3tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter